LOCUS       NM_002865               3735 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB2A, member RAS oncogene family (RAB2A), transcript
            variant 1, mRNA.
ACCESSION   NM_002865
VERSION     NM_002865.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3735)
  AUTHORS   Shi,W., Chen,M., Pan,T., Chen,M., Cheng,Y., Hao,Y., Chen,S. and
            Tang,Y.
  TITLE     Integration of risk variants from GWAS with SARS-CoV-2 RNA
            interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19
  JOURNAL   Sci Rep 13 (1), 19194 (2023)
   PUBMED   37932299
  REMARK    GeneRIF: Integration of risk variants from GWAS with SARS-CoV-2 RNA
            interactome prioritizes FUBP1 and RAB2A as risk genes for COVID-19.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3735)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3735)
  AUTHORS   Meng,Y., Lin,S., Zhou,Y., Yi,X., Wu,P., Zhang,Q., Ge,W., Cao,C.,
            Gao,P., Zhi,W., Peng,T., Wei,J., Ding,W., Ma,D., Li,G., Yang,Q.,
            Guo,T., Zeng,X. and Wu,P.
  TITLE     RAB2A promotes cervical cancer progression as revealed by
            comprehensive analysis of HPV integration and proteome in
            longitudinal cervical samples
  JOURNAL   Clin Transl Med 12 (3), e767 (2022)
   PUBMED   35343109
  REMARK    GeneRIF: RAB2A promotes cervical cancer progression as revealed by
            comprehensive analysis of HPV integration and proteome in
            longitudinal cervical samples.
REFERENCE   4  (bases 1 to 3735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3735)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3735)
  AUTHORS   Tisdale,E.J. and Balch,W.E.
  TITLE     Rab2 is essential for the maturation of pre-Golgi intermediates
  JOURNAL   J Biol Chem 271 (46), 29372-29379 (1996)
   PUBMED   8910601
REFERENCE   7  (bases 1 to 3735)
  AUTHORS   Khosravi-Far,R., Lutz,R.J., Cox,A.D., Conroy,L., Bourne,J.R.,
            Sinensky,M., Balch,W.E., Buss,J.E. and Der,C.J.
  TITLE     Isoprenoid modification of rab proteins terminating in CC or CXC
            motifs
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6264-6268 (1991)
   PUBMED   1648736
REFERENCE   8  (bases 1 to 3735)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   9  (bases 1 to 3735)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
REFERENCE   10 (bases 1 to 3735)
  AUTHORS   Tachibana,K., Umezawa,A., Kato,S. and Takano,T.
  TITLE     Nucleotide sequence of a new YPT1-related human cDNA which belongs
            to the ras gene superfamily
  JOURNAL   Nucleic Acids Res 16 (21), 10368 (1988)
   PUBMED   3057444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA648682.1, X12953.1,
            AC068389.10 and AW301641.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002865.2.
            
            Summary: The protein encoded by this gene belongs to the Rab
            family, members of which are small molecular weight guanosine
            triphosphatases (GTPases) that contain highly conserved domains
            involved in GTP binding and hydrolysis. The Rabs are membrane-bound
            proteins, involved in vesicular fusion and trafficking. This
            protein is a resident of pre-Golgi intermediates, and is required
            for protein transport from the endoplasmic reticulum (ER) to the
            Golgi complex. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.36313.1,
                                           SRR1660803.21042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262646.12/ ENSP00000262646.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA648682.1         80-92
            14-1161             X12953.1           1-1148
            1162-3276           AC068389.10        51870-53984         c
            3277-3735           AW301641.1         1-459               c
FEATURES             Location/Qualifiers
     source          1..3735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1-q12.2"
     gene            1..3735
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /note="RAB2A, member RAS oncogene family"
                     /db_xref="GeneID:5862"
                     /db_xref="HGNC:HGNC:9763"
                     /db_xref="MIM:179509"
     exon            1..267
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..860
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /EC_number="3.6.5.2"
                     /note="isoform a is encoded by transcript variant 1; RAB2,
                     member RAS oncogene family; ras-related protein Rab-2A;
                     small GTP binding protein RAB2A"
                     /codon_start=1
                     /product="ras-related protein Rab-2A isoform a"
                     /protein_id="NP_002856.1"
                     /db_xref="CCDS:CCDS6175.1"
                     /db_xref="GeneID:5862"
                     /db_xref="HGNC:HGNC:9763"
                     /db_xref="MIM:179509"
                     /translation="MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFG
                     ARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLE
                     DARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAF
                     INTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC"
     exon            268..339
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..407
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..490
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..583
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..695
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..764
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..3735
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /note="hexamer: AATAAA"
     polyA_site      2090
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /note="major polyA site"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /note="hexamer: AATAAA"
     polyA_site      3187
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
     regulatory      3697..3702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
                     /note="hexamer: AATAAA"
     polyA_site      3718
                     /gene="RAB2A"
                     /gene_synonym="LHX; RAB2"
ORIGIN      
        1 attgttcggc tgggctcggt cgggcgctgt ctccctcggc tctgcgggtg tcagttcgtc
       61 cggcttcctc acagcccctc actcccggcg gctgacagca gcagcggcgg cggcgggcgg
      121 cgcctggcgt ttcgaggctg agcggcaccg gggttggggc gcggaggagg agcagcagcg
      181 ggaggaggag ccgtgtgccc tggcactgag cggccgcggc catggcgtac gcctatctct
      241 tcaagtacat cataatcggc gacacaggtg ttggtaaatc atgcttattg ctacagttta
      301 cagacaagag gtttcagcca gtgcatgacc ttactattgg tgtagagttc ggtgctcgaa
      361 tgataactat tgatgggaaa cagataaaac ttcagatatg ggatacggca gggcaagaat
      421 cctttcgttc catcacaagg tcgtattaca gaggtgcagc aggagcttta ctagtttacg
      481 atattacacg gagagataca ttcaaccact tgacaacctg gttagaagat gcccgccagc
      541 attccaattc caacatggtc attatgctta ttggaaataa aagtgattta gaatctagaa
      601 gagaagtaaa aaaagaagaa ggtgaagctt ttgcacgaga acatggactc atcttcatgg
      661 aaacgtctgc taagactgct tccaatgtag aagaggcatt tattaataca gcaaaagaaa
      721 tttatgaaaa aattcaagaa ggagtctttg acattaataa tgaggcaaat ggcattaaaa
      781 ttggccctca gcatgctgct accaatgcaa cacatgcagg caatcaggga ggacagcagg
      841 ctgggggcgg ctgctgttga gtctgttttt actgtctagc tgcccaacgg ggcctactca
      901 cttattcttt caccccctct cctcctgctc agctgagaca tgaaactatt tgaaatggct
      961 ttatgtcaca gaagacttta atccgtcaaa ttcttgtata actttgaata aatggttaat
     1021 gttcacttaa aagacagatt ttggagattg tattcatatc tatttgcatt tgatttctag
     1081 gtcaattgat gtgattattt ttgttaaatg ttgtcttgtg cccttaacta cgaactgaat
     1141 tgtattaaac actacaaagt catcttgagt attttaaatc ggtttgtgta gttaggtttc
     1201 ccaacatctg tggttaccta atgtttaata ttatagaact gtcctcagaa actttgtcaa
     1261 ttttcacggc tataaggaaa cagaaggact cttttaattc tgtatttatc atttactttc
     1321 tgtatatata gtttaataac ctgcttgggt gtaatttgcc aagcttgaat tctttaatgc
     1381 atttgcataa attctatact gtttagagct taaagctaca gaagcattgt taggaattgc
     1441 ttggacactg aattttaaac tttttgacat tgttaacaag catgttcatc ttttcttgtc
     1501 actagtccaa gaaaaatatg cttaatgtat attacaaagg ctttgtatat gttaacctgt
     1561 tttaatgcca aaagtttgct ttgtccacaa tttccttaag acctcttcag aaagggattt
     1621 gtttgcctta atgaatactg ttgggaaaaa acacagtata atgagtgaaa agggcagaag
     1681 caagaaattt ctacatctta gcgactccaa gaagaatgag tatccacatt tagatggcac
     1741 attatgagga ctttaatctt tccttaaaca caataatgtt ttcttttttc ttttattcac
     1801 atgatttcta agtatatttt tcatgcagga cagtttttca accttgatgt acagtgactg
     1861 tgtaaaattt ttctttcagt ggcaacctct ataatcttta aaatatggtg agcatcttgt
     1921 ctgttttgaa ggggatatga caataaatct atcagatgga aaatcctgtt acaaagtaga
     1981 aaagctttag taatttactc agtgtggtgg ttttatcctt tttttctttt tctcccttgg
     2041 tctataatga aattgttaca gcagtgcaaa ataaaatcct atgtataaaa gtgttctttt
     2101 tttttattat gaccacctct tttttaatgt atttttagtc cacttacagc ttttacatgg
     2161 gtttaagcat gttttttaaa agggtcagaa tggttaacac tcaacccttt ttaaaaattt
     2221 tgctaaaatg cgacaaatct caccatactg aaattatttt tgttgatggt gtaagcagtg
     2281 taagcaagtg ttttctcctg aactagcaca aaagcactta tgcctgaaag aaagcataaa
     2341 gaagttctaa ctctgaaact aactactttc atttcgctca tggccttcaa ctttctacag
     2401 gtcttccctg aagattcagc agtactctct caaaggtttg acagtactct tgtgggaaat
     2461 caccaaatgc tgtcatagtt ttgttttaac tgtctccttg agggcagagg gaagggtgag
     2521 agaaaatctg ttttcatggg tatttgtagt acagcctttt tttctttcaa gtggctgtat
     2581 caaattcact ggtcttacta atcactgtct ttaccagtga gtacaaaaag ttaaggcaac
     2641 taggacaggt actgctctat accaagaaga gaatgattct ttggaaattg ttatttttaa
     2701 gcttctgtta atttttccag aagtttagtg cgtttctttt ccatactttc tcccctaatt
     2761 cttttatttg aagaagagaa cttaatggca aataaacaac aaaccaggac atgcatttta
     2821 ataccctaag gaaaaatgga accctcaaat ataactcctc ccacaaccac cctaatgtgc
     2881 ctcagtctgg ggcagcaggt ggacttctca atagttcttt tccacattct ctacaaatca
     2941 catctaccgt taaggaatat gttatgaatc ctttctgtta attgagaaag caatgttatt
     3001 gtctgtgatt tccagtcttt gctcatttta ttatccctgt caaataatgt aatattggta
     3061 cctgcagttg aatttgtaat attgtaattg aatttttagt tgatcttcga tcagttttta
     3121 tagcatctat ggacatagaa aatcagtcac tgaaaaaaat aaacacagct ttcaatgtct
     3181 cactcaacat gtaacattca aaattgtgat cttcataaag acattgttac cattcgtctt
     3241 gcaaatttaa gacaactgaa tgaaaagcca attttttgaa agaatgtggc atataattag
     3301 atatacaact gaaacaggat atacaactgc atacaatttg tttttaatga tattttaaaa
     3361 tagcctgtta gcaggaaaat agtccctatt tatctgctaa tggtcaaaaa gagttaggat
     3421 ataaatcgta ccaaaatgtt tccaatcact cagaaaaact gattcatgtc tggctttgca
     3481 acaccttaaa catttattct gtcatagata gtaaagcccc atctcagttt atttagtcct
     3541 gaggttggca gcatggggtt tgactatatg agctaaaaga tacacaaaga gataacgctg
     3601 tttcataata aacaggaatt gactatacaa ataggtaaac cagcatatct acctgtattt
     3661 ctcagagttt agatgtgtgc tttatgttta cattaaaata aagcctaacg ccacagtaga
     3721 tcatctcata ctgca
//
