LOCUS       NM_003929               3308 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens RAB29, member RAS oncogene family (RAB29), transcript
            variant 1, mRNA.
ACCESSION   NM_003929
VERSION     NM_003929.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Nagai-Ito,Y., Xu,L., Ito,K., Kajihara,Y., Ito,G. and Tomita,T.
  TITLE     The atypical Rab GTPase associated with Parkinson's disease, Rab29,
            is localized to membranes
  JOURNAL   J Biol Chem 298 (10), 102499 (2022)
   PUBMED   36116551
  REMARK    GeneRIF: The atypical Rab GTPase associated with Parkinson's
            disease, Rab29, is localized to membranes.
REFERENCE   2  (bases 1 to 3308)
  AUTHORS   Wang,L., Zhang,T., Jiang,K., He,J., Liu,D., Gao,H. and Chen,G.
  TITLE     Expression of RAB7L1 in Patients with Pituitary Adenomas
  JOURNAL   Ann Clin Lab Sci 51 (2), 190-197 (2021)
   PUBMED   33941558
  REMARK    GeneRIF: Expression of RAB7L1 in Patients with Pituitary Adenomas.
REFERENCE   3  (bases 1 to 3308)
  AUTHORS   Rivero-Rios,P., Romo-Lozano,M., Fernandez,B., Fdez,E. and
            Hilfiker,S.
  TITLE     Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated
            Endolysosomal Trafficking Alterations
  JOURNAL   Cells 9 (7), 1719 (2020)
   PUBMED   32709066
  REMARK    GeneRIF: Distinct Roles for RAB10 and RAB29 in Pathogenic
            LRRK2-Mediated Endolysosomal Trafficking Alterations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3308)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3308)
  AUTHORS   Liu,T.W., Wu,Y.R., Chen,Y.C., Fung,H.C. and Chen,C.M.
  TITLE     Association of RIT2 and RAB7L1 with Parkinson's disease: a
            case-control study in a Taiwanese cohort and a meta-analysis in
            Asian populations
  JOURNAL   Neurobiol Aging 87, 140 (2020)
   PUBMED   31818509
  REMARK    GeneRIF: Association of RIT2 and RAB7L1 with Parkinson's disease: a
            case-control study in a Taiwanese cohort and a meta-analysis in
            Asian populations.
REFERENCE   6  (bases 1 to 3308)
  AUTHORS   Berger,K.L., Cooper,J.D., Heaton,N.S., Yoon,R., Oakland,T.E.,
            Jordan,T.X., Mateu,G., Grakoui,A. and Randall,G.
  TITLE     Roles for endocytic trafficking and phosphatidylinositol 4-kinase
            III alpha in hepatitis C virus replication
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7577-7582 (2009)
   PUBMED   19376974
REFERENCE   7  (bases 1 to 3308)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 3308)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   9  (bases 1 to 3308)
  AUTHORS   Helip-Wooley,A. and Thoene,J.G.
  TITLE     Sucrose-induced vacuolation results in increased expression of
            cholesterol biosynthesis and lysosomal genes
  JOURNAL   Exp Cell Res 292 (1), 89-100 (2004)
   PUBMED   14720509
REFERENCE   10 (bases 1 to 3308)
  AUTHORS   Shimizu,F., Katagiri,T., Suzuki,M., Watanabe,T.K., Okuno,S.,
            Kuga,Y., Nagata,M., Fujiwara,T., Nakamura,Y. and Takahashi,E.
  TITLE     Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1)
            encoding a small GTP-binding protein, a member of the RAS
            superfamily
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 261-263 (1997)
   PUBMED   9284931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA284582.1, DC365059.1, BX647960.1, AC119673.3 and CF528995.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003929.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.244959.1,
                                           SRR1803612.224561.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367139.8/ ENSP00000356107.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA284582.1         1-16
            17-480              DC365059.1         1-464
            481-1025            BX647960.1         446-990
            1026-3000           AC119673.3         95073-97047         c
            3001-3308           CF528995.1         17-324              c
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3308
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /note="RAB29, member RAS oncogene family"
                     /db_xref="GeneID:8934"
                     /db_xref="HGNC:HGNC:9789"
                     /db_xref="MIM:603949"
     exon            1..210
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..464
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..952
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-7L1; rab-7-like protein 1; RAB7,
                     member RAS oncogene family-like 1; ras-related protein
                     Rab-29"
                     /codon_start=1
                     /product="ras-related protein Rab-7L1 isoform 1"
                     /protein_id="NP_003920.1"
                     /db_xref="CCDS:CCDS1459.1"
                     /db_xref="GeneID:8934"
                     /db_xref="HGNC:HGNC:9789"
                     /db_xref="MIM:603949"
                     /translation="MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDF
                     ALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRW
                     KQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENK
                     NINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC"
     exon            465..536
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..718
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..840
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..3308
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /note="hexamer: AATAAA"
     polyA_site      3308
                     /gene="RAB29"
                     /gene_synonym="RAB7L; RAB7L1"
                     /note="major polyA site"
ORIGIN      
        1 agtgccacag gcaaccctgc acgtgacgct tgcggaggaa ggggagagag aggcgcgcgg
       61 gagggcgtct agggaatcga ggtgccggct gctccttcct cacaatttgg tttgtgctgc
      121 aaggggaggg tccccatcat ctggccccag tggtgtaagg agctgactgg gattcagtca
      181 ctgacttgga gccgctcggg ggaagtcccg cccagacagg cggtgggtgg gaatgcctca
      241 cttcagtttg aagagggtcc ggatccaaag gggttaaaac gagcgacccc cgatccccga
      301 ccacacttcc cgcctcccta aaacgcacac cccgctagcc atgggcagcc gcgaccacct
      361 gttcaaagtg ctggtggtgg gggacgccgc agtgggcaag acgtcgctgg tgcagcgata
      421 ttcccaggac agcttcagca aacactacaa gtccacggtg ggagtggatt ttgctctgaa
      481 ggttctccag tggtctgact acgagatagt gcggcttcag ctgtgggata ttgcagggca
      541 ggagcgcttc acctctatga cacgattgta ttatcgggat gcctctgcct gtgttattat
      601 gtttgacgtt accaatgcca ctaccttcag caacagccag aggtggaaac aggacctaga
      661 cagcaagctc acactaccca atggagagcc ggtgccctgc ctgctcttgg ccaacaagtg
      721 tgatctgtcc ccttgggcag tgagccggga ccagattgac cggttcagta aagagaacgg
      781 tttcacaggt tggacagaaa catcagtcaa ggagaacaaa aatattaatg aggctatgag
      841 agtcctcatt gaaaagatga tgagaaattc cacagaagat atcatgtctt tgtccaccca
      901 aggggactac atcaatctac aaaccaagtc ctccagctgg tcctgctgct agtagtgttt
      961 ggcttatttt ccatcccagt tctgggaggt cttttaagtc tcttcccttt ggttgcccac
     1021 ctgacaattt tattaagtac atttgaattg tctcctgact actgtccagt aaggaggccc
     1081 attgtcactt agaaaagaca cctggaaccc atgtgcattt ctgcatctcc tggattagcc
     1141 tttcacatgt tgctggctca cattagtgcc agttagtgcc ttcggtgtaa gatcttctca
     1201 tcagccctca atttgtgatc cggaatttta tgagaaggat tagaaatcag cacctgcgtt
     1261 ttagagatca taattctcac ctacttctga gcttattttt ccatttgata ttcattgata
     1321 tcatgacttc caattgagag gaaaatgaga tcaaatgtca tttcccaaat ttcttgtagg
     1381 ccgttgtttc agattctttc tgtcttggaa tgtaaacatc tgattctgga atgcagaagg
     1441 agggggtctg ggcatctgtg gatttttggc tactagaagt gtcccagaag tcactgtatt
     1501 tttgaaactt ctaacgtcat aattaagttt ctcttgtctt ggcatcaaga atagtcaagt
     1561 tttttggccg ggcatggtgg ctcatgcctg taatcccagc acttggggag gccaaggcag
     1621 gcggatcaca tgaggccagg aattcgagac caacctggtc agcatggcaa aaccccgtct
     1681 ctactaaaag tacaaaaatt agccaggcgt gatggcacgt gtctgtaatc ccagctactc
     1741 tggagactga ggtgggagaa tcgcttgaga ctgggaggca gaggttgcag tgaaccgaga
     1801 tcatgccacc gcacttcagc ctgggtgaca gagaaggact ccgtctcaaa aaaaaaagaa
     1861 aaaagaatag tcatttttaa actacctatc tcatgcaatg aaagcatttt cttccacaaa
     1921 gagcttaatc ctcatgatag gattgcctag tgtctcccat ttgcaggttt ctgggttgat
     1981 gtcttaatgc ataatactgc aagtgacatc agctggctgt gatgcttcga aataggtctg
     2041 ctcctcacag ctttgggaat ctgaatggaa gaagaaaaga gagaagttaa caacctccac
     2101 tggggcaact ttgtgaacac gtaggcactt agtcatagga aacatattat gtgcaggtcc
     2161 tagcctgggg gaggaaagta gatagacaga aaatcattag gtaatttaag tactaaattg
     2221 ggcagggctt tttagtatca aatcactact agaccattta atttgttaaa ttatctctag
     2281 gatggtgatt tataacctac ccaaagttat cgatattctt actaaactct gaggcctgaa
     2341 gttctgtgat agaccttaaa taagtgtcct aagtcagtgg ttcccaaatc tggctggtcg
     2401 ggaatacctg ggaagtttgt taaaattttt taaaaatgtt ttaagatttt tgggtcctga
     2461 gccagccgtg gtggctcaca cctgtaatcc cagcactttg ggaggctgag gcaggtggat
     2521 cgcctgaggt caggagttca agatcaacct ggccaacata ctgaaacccc gtctctacta
     2581 aaaataagaa aaattagctg ggcgtggtgg cgggcacctg taatcccagc tacttgggag
     2641 actgaggcag gagaatcgct tgaacctggg agttagaggt tgcagtgagc tgagatcaca
     2701 ccattgcgct tcagcctggg caacaagagt gaaactccat ctccaaaaaa aaaaaacaaa
     2761 aagaaaaaga tttttgggtc ccgacctcaa acctactgaa tcagaatttc tagggatgaa
     2821 gcctaggaat gtgttgttgt tttcagagct tccctggtga ttgtgataag cctggtttgg
     2881 aaaccattgc tggagaactt tgtaaagata cagagaccca gaccttttgt atttacattt
     2941 aaatacaaat acaaatcctg ggtttctata tattctgtta gcttttcagg tgattctgct
     3001 acacagacgt tgaaaaccac tgccctaaga aagagatcag aggccacata tcagagagaa
     3061 aagggaccaa accttcggtg gtttgttgtg tgtcgtttta atgccaatta ttttaacttg
     3121 cacagtcttc tgaaaccttg tattaatagt tctcttttgt attaccattt tcaggtaggg
     3181 ttttgatcac tatgattctg aagataatag tgaaatagtg aatttcattg atatgaagag
     3241 ataattgatt ttcattcatt ggtttgaaca cctgcaaaat cacaaataaa tgagaactaa
     3301 gtcttgta
//
