LOCUS       NM_004163               7003 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens RAB27B, member RAS oncogene family (RAB27B),
            transcript variant 1, mRNA.
ACCESSION   NM_004163 XR_110139 XR_111784 XR_115186
VERSION     NM_004163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7003)
  AUTHORS   Chen,Y., Wen,J., Li,Q., Peng,D., Liao,C., Ma,X., Wang,M., Niu,J.,
            Wang,D., Li,Y., Zhang,X., Zhou,H., Zou,J., Li,L. and Liu,L.
  TITLE     RAB27B-regulated exosomes mediate LSC maintenance via resistance to
            senescence and crosstalk with the microenvironment
  JOURNAL   Leukemia 38 (2), 266-280 (2024)
   PUBMED   38036630
  REMARK    GeneRIF: RAB27B-regulated exosomes mediate LSC maintenance via
            resistance to senescence and crosstalk with the microenvironment.
REFERENCE   2  (bases 1 to 7003)
  AUTHORS   Shan,J., Chang,L.Y., Li,D.J. and Wang,X.Q.
  TITLE     Rab27b promotes endometriosis by enhancing invasiveness of ESCs and
            promoting angiogenesis
  JOURNAL   Am J Reprod Immunol 90 (3), e13762 (2023)
   PUBMED   37641372
  REMARK    GeneRIF: Rab27b promotes endometriosis by enhancing invasiveness of
            ESCs and promoting angiogenesis.
REFERENCE   3  (bases 1 to 7003)
  AUTHORS   Ren,J.G., Xing,B., Lv,K., O'Keefe,R.A., Wu,M., Wang,R., Bauer,K.M.,
            Ghazaryan,A., Burslem,G.M., Zhang,J., O'Connell,R.M., Pillai,V.,
            Hexner,E.O., Philips,M.R. and Tong,W.
  TITLE     RAB27B controls palmitoylation-dependent NRAS trafficking and
            signaling in myeloid leukemia
  JOURNAL   J Clin Invest 133 (12), e165510 (2023)
   PUBMED   37317963
  REMARK    GeneRIF: RAB27B controls palmitoylation-dependent NRAS trafficking
            and signaling in myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7003)
  AUTHORS   Meneses,K.M., Pandya,P., Lindemann,J.A., Al-Qasrawi,D.S.,
            Argo,R.A., Weems,C.M., Beetler,D.J., Vijay,G.V., Yan,I.K.,
            Wolfram,J., Patel,T. and Justilien,V.
  TITLE     RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through
            Enhanced Extracellular Vesicle Secretion
  JOURNAL   Cancer Res Commun 3 (4), 607-620 (2023)
   PUBMED   37077938
  REMARK    GeneRIF: RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells
            Through Enhanced Extracellular Vesicle Secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7003)
  AUTHORS   Nambara,S., Masuda,T., Hirose,K., Hu,Q., Tobo,T., Ozato,Y.,
            Kurashige,J., Hiraki,Y., Hisamatsu,Y., Iguchi,T., Sugimachi,K.,
            Oki,E., Yoshizumi,T. and Mimori,K.
  TITLE     Rab27b, a Regulator of Exosome Secretion, Is Associated With
            Peritoneal Metastases in Gastric Cancer
  JOURNAL   Cancer Genomics Proteomics 20 (1), 30-39 (2023)
   PUBMED   36581340
  REMARK    GeneRIF: Rab27b, a Regulator of Exosome Secretion, Is Associated
            With Peritoneal Metastases in Gastric Cancer.
REFERENCE   6  (bases 1 to 7003)
  AUTHORS   Fukuda,M., Kuroda,T.S. and Mikoshiba,K.
  TITLE     Slac2-a/melanophilin, the missing link between Rab27 and myosin Va:
            implications of a tripartite protein complex for melanosome
            transport
  JOURNAL   J Biol Chem 277 (14), 12432-12436 (2002)
   PUBMED   11856727
REFERENCE   7  (bases 1 to 7003)
  AUTHORS   Ramalho,J.S., Tolmachova,T., Hume,A.N., McGuigan,A.,
            Gregory-Evans,C.Y., Huxley,C. and Seabra,M.C.
  TITLE     Chromosomal mapping, gene structure and characterization of the
            human and murine RAB27B gene
  JOURNAL   BMC Genet 2, 2 (2001)
   PUBMED   11178108
  REMARK    GeneRIF: Chromosomal mapping and gene structure of the RAB27B gene.
REFERENCE   8  (bases 1 to 7003)
  AUTHORS   Chen,D., Guo,J., Miki,T., Tachibana,M. and Gahl,W.A.
  TITLE     Molecular cloning and characterization of rab27a and rab27b, novel
            human rab proteins shared by melanocytes and platelets
  JOURNAL   Biochem Mol Med 60 (1), 27-37 (1997)
   PUBMED   9066979
REFERENCE   9  (bases 1 to 7003)
  AUTHORS   Nagata,K., Hattori,T., Hachiya,T., Takahashi,T. and Nozawa,Y.
  TITLE     Purification and characterization of a low M(r) GTP-binding
            protein, c25KG, from human platelet membranes
  JOURNAL   Biochim Biophys Acta 1160 (2), 193-198 (1992)
   PUBMED   1445946
REFERENCE   10 (bases 1 to 7003)
  AUTHORS   Nagata,K., Itoh,H., Katada,T., Takenaka,K., Ui,M., Kaziro,Y. and
            Nozawa,Y.
  TITLE     Purification, identification, and characterization of two
            GTP-binding proteins with molecular weights of 25,000 and 21,000 in
            human platelet cytosol. One is the rap1/smg21/Krev-1 protein and
            the other is a novel GTP-binding protein
  JOURNAL   J Biol Chem 264 (29), 17000-17005 (1989)
   PUBMED   2507536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF329499.1 and AC098848.7.
            
            On or before Jul 3, 2011 this sequence version replaced
            XR_115186.1, XR_111784.1, XR_110139.1, NM_004163.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329499.1, SRR1803612.60884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262094.10/ ENSP00000262094.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-963               AF329499.1         1-963
            964-7003            AC098848.7         8899-14938
FEATURES             Location/Qualifiers
     source          1..7003
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..7003
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /note="RAB27B, member RAS oncogene family"
                     /db_xref="GeneID:5874"
                     /db_xref="HGNC:HGNC:9767"
                     /db_xref="MIM:603869"
     exon            1..224
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     exon            225..396
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..900
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /EC_number="3.6.5.2"
                     /codon_start=1
                     /product="ras-related protein Rab-27B"
                     /protein_id="NP_004154.2"
                     /db_xref="CCDS:CCDS11958.1"
                     /db_xref="GeneID:5874"
                     /db_xref="HGNC:HGNC:9767"
                     /db_xref="MIM:603869"
                     /translation="MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGI
                     DFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLT
                     SQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYF
                     ETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC
                     "
     exon            397..482
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     exon            483..586
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     exon            587..710
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     exon            711..7003
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6978..6983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /note="hexamer: AATAAA"
     polyA_site      7003
                     /gene="RAB27B"
                     /gene_synonym="C25KG"
                     /note="major polyA site"
ORIGIN      
        1 actcgcagtc ctgacgggca ggggctgcgg accgcccggc cttggaccca tccggagcca
       61 caggttggag gagataagta gctgtccccg tgctcatcgc cctgtggagc agatcctgtc
      121 tccttgctga cggtggagcc cgggagttcc agggcttggg aaggggaagg aaacctctct
      181 gaaatctgac acctgctctc ccggcaagga aacttcgcag gctgaccgac caagaccatc
      241 actatgaccg atggagacta tgattatctg atcaaactcc tggccctcgg ggattcaggg
      301 gtggggaaga caacatttct ttatagatac acagataata aattcaatcc caaattcatc
      361 actacagtag gaatagactt tcgggaaaaa cgtgtggttt ataatgcaca aggaccgaat
      421 ggatcttcag ggaaagcatt taaagtgcat cttcagcttt gggacactgc gggacaagag
      481 cggttccgga gtctcaccac tgcatttttc agagacgcca tgggcttctt attaatgttt
      541 gacctcacca gtcaacagag cttcttaaat gtcagaaact ggatgagcca actgcaagca
      601 aatgcttatt gtgaaaatcc agatatagta ttaattggca acaaggcaga cctaccagat
      661 cagagggaag tcaatgaacg gcaagctcgg gaactggctg acaaatatgg cataccatat
      721 tttgaaacaa gtgcagcaac tggacagaat gtggagaaag ctgtagaaac ccttttggac
      781 ttaatcatga agcgaatgga acagtgtgtg gagaagacac aaatccctga tactgtcaat
      841 ggtggaaatt ctggaaactt ggatggggaa aagccaccag agaagaaatg tatctgctag
      901 actctacata gaaactgaac atcaagaacc ccaccaaaat attactttta aaaacaatga
      961 caaaccacac aattgttgtt gagtaaacca cgcacaatgg catgtctttc tttttctgcc
     1021 agaaaatcta ttttaagaaa ccagaatagt caacagtgtt caaaagaatt gactagttat
     1081 ccctgaggcc ctttcaaaca tgatcaaaga tttcccaatg tgatctcatc atcatggata
     1141 ctcaatttgt tttttcttat agagaaaatg agtatataag acaatataca agaagaaata
     1201 tcagtgagtt ttaaatcaga acaagttacc tgtcacattg aagaaaaggg taggcactaa
     1261 agggagaaca cagaaagaag aatttctaaa atattggatt tacttcttat attgagtcag
     1321 atgcatactt ttagatttgc attggggaaa atgtactagc taaaaatgga tacacaatga
     1381 agaattctat ttggctaatt aagaatgata tactatgtac acccaataag ctgtactaga
     1441 atgaataaat tactgataag gttacaaata ggtaaatgtc acacttctgt taaaatgcag
     1501 gaggtagtgt cataatgccg tctttatatt cttaataaat agcactttga caagaacagg
     1561 actgtaaatg atgaagtaca agacaaatac cctgggaaaa aaaatgaaag tatgagaaat
     1621 tggcatttct acagctgaaa ttcaatgtat ctgttagaga tgtctggaag ggttacttag
     1681 ccaaatttta ctcaagccaa ttaggagctg atattatcag ttggaattaa gagaactcca
     1741 gaggtttcca tttcaaacaa aattttagaa attggtttgg tgttcagctt cacatttcat
     1801 tttttcttag cacatgttga taaaatagtc acaaggagaa attaccagtt acggtttatt
     1861 aaatctcttt taaaatgcag tcaaggaaaa ctagccttga atttttttta gataaaataa
     1921 gatggtgata tgaaacaaaa agtggcaatt attgcaggtt tccttttagt ttacaaaagt
     1981 actggaaact aaatcatatt tcttccctcc aaatttcacc cattcctgac tttgaatcaa
     2041 ttgcagaaat gcaggtgtgt tactttgttg atcaataact ttggaacaat tatggatcaa
     2101 ttctatggtc actctgaatt ttcatgtcat taatcacata aaaattgata atacctcatt
     2161 ctgtattaca atatgatttt attttgccaa aggcaagaca cctatagttg agctgtattt
     2221 tgggggattg ggtgaggaag gacttctgat cttatctcaa caaaaaactg gccagtattt
     2281 ttgttaatgt aaagcttcct tttctttcta aaaaatagta acaaaattat ttttcattgg
     2341 cctattctgt tcttgtgtct aaactaacat tacattaatt tttaatctta gtttctgata
     2401 aacacaagcc attcctatca aaatattatt tatttcagtc aattttacca aataacaaag
     2461 acaatatatt ttcgtttttt tttattatga gcatatgatt ttttgacagg ctgtttcctc
     2521 gtcgtataga ttttttccaa tcaaacctac tttttccata ctctgtgcat attttttgtg
     2581 aagttataca cattgaagac cctaaaaatc ccagtccatc attcagctta cctctgcgaa
     2641 cttctatctg gtattgaatc agtttcagaa acacagacag atccaaggaa atgtctcttt
     2701 ataatgttct taggatggac tagacccata aatgtgccat gaatcaaaat attaataatt
     2761 tgaaagcttt catgctgtta gcccctgatg aaattctcag cattaactgg ccagctcctc
     2821 tgatttctgc agcatcgcaa caggttcgaa gatgggttgt ggctgggtat tccctcccat
     2881 ggtgtttcct ctgggatgct cttcattatc tcaatgcctg tgccatgaag atagaaaact
     2941 gtaagctaac atttaagatg tttcttctgg aaggaaagtg agcaggaaca agttatattg
     3001 ccactgctgt ggcaaatttt ggtgaacttt tggggtcatt atatcaattt tttctttgga
     3061 ttcaaattgt aatgtcccct gcatttcctt aatagggaat gtgaaacctt tataaaactc
     3121 taaaagtatt ctgttttgat atgtcttttt gtttctattc attttcagtt atatgattga
     3181 tttacttatg ccaagattct gtcactgtca gttatttaat gagtgttttt tcagggtctg
     3241 ttttaagatc attatttgat agctgtagca tgaagcagag gttgatgatg cccataattg
     3301 caagactatt cctgtaaaaa taacaattat tgggtaataa cttcaagagg aatgagaagt
     3361 gacaaaattg atttaaaata ttgttctact tataaataaa tgcttgatat aaaaaatttt
     3421 ctccataaag tttgacatct gaccccagat tctatgtaat cattattaga aattccttct
     3481 ctcattattt caggattagt agttctgtgt aattcatttt acaatttcaa attgttctgg
     3541 tgccataaag tatacagact actttaaaga tttccaaatc ccctaattta ccccacaaca
     3601 gcatgtaatt ttagccaaga tatgtcctgt tactaagtat ctcccaatgc tttagtaaaa
     3661 cgtatttagg agaaatgttg aaaatgtaca tgaagctcct ttctgatata gaaaccattt
     3721 ctggagtatt tacactggtt tgatgtttac attgctctaa ctcggtgcct cagatacctc
     3781 tgtgaccaaa tttgtctcca accacatagc tcatttccta taatgttata tcataggaag
     3841 ccctcacaga gacactaaca cagctaaaga tcttctgata ttatcagcaa gggatgcaag
     3901 gactttattg gaatctggag agtttaactg ccttctcttg gtctcctcac ttacttctta
     3961 tgaagttggc attacctgag actcttagct gtgattaggt acaagcttac cttttagggt
     4021 agaaaaagaa agatcatttg aaaaatgtat ctaaaataat ccagagaaca taatgtttgt
     4081 cttggtctga taatgataag aagtcaagga ttggcagaga aaatactaaa cgccaagagt
     4141 tgagcctgtg ggtctctcca taagagtttt aaaactcttg ccagttacca ctttatccaa
     4201 tttgctatca ttttcgtatt atcagctatc gccctgtaaa atattcaaaa ctagctattt
     4261 ctaaagtaaa cattttatct gttactttta accagatagg tgtctttgtc atccttctac
     4321 tataaattgt tctttgccaa cctgtacagg tagatgaacc aggcgagagt tttaatcagc
     4381 cttttcttgt cccctttgta agaaagagat gcttgccata gagaaggaca tgagtacatt
     4441 aaaaataatt taatagccac aatatgatgt tctttaagct gcaaattgag tacactggga
     4501 atcaacaaat ttgatgaagc ctgtctgtct cttcaccagt ggagtgagtg cagcagttag
     4561 aaagagaagc aatattgtgc aactggtgca gtggtgagtt aatcatagtg tataaccttg
     4621 tgttcatgaa acaggttgtt cattgttctg catctctctt catttaaaaa ggatacacaa
     4681 ttctttcctc attgcatatt acaccaaacg tttgagggaa aaatcctcat tcgtaaagga
     4741 ttttggatgt ataatctaaa actcaacaat aaagaaataa tattccaagt ctctggtttc
     4801 ctaagataca taataactgt ttataaagaa ggtctaagag ctgatatttg ccaaagtgat
     4861 agaagagttg ttttttcctc tctactacca agctttaaga cattaaaaga agtctagtgt
     4921 atttgaatat tttagagaaa gctttatcat tttttaagat gccaagatgc tgcctacgtt
     4981 tgcaaaagtt gtctaagaat tcaccatgag ctatattttc ttctggatct ttgaccaagg
     5041 tgatgtcagc ttatttctgg ggaaggtgtt gagctcttat acatgaaaat ggatataggc
     5101 tattctctgg gatgagtgtc atttcaatgc tttataaatc catgaagctg cttgtctcat
     5161 aaagtagaac tgatacaaat tttggttgga tatatagaga attttataaa tgtattgcct
     5221 tagaatttct gggtggagac ccaactacaa tgacattgtc atgccagaac tataaagata
     5281 attagagtta aaagttgttt aaattgtgcc cttaaataca gcagaacctg gagaaggtca
     5341 tacttcaaag gtcgattttg agtccgaata aagaaagacc tagtaacaga tagttttttt
     5401 ttgttcattt tcttctacca agtagaggtt tatgccctca gaactaaact agtaaaaata
     5461 tctgaacaaa aaacctttcg ttgttggcat aaaaatgtga tacacttaga gacattttgt
     5521 ttattgcata taaatctaat ttttccataa attagattta tgatattttc ataaagcact
     5581 tgattagttt ttcaaggcgt accatcacaa agatgctttc ctgcagagtt ctttgtatca
     5641 acagcctatg gttgagatgt tttctcattt cctgtagaga gagaatacca ctaacaaaca
     5701 aacaaaaact ttagtgccaa aatagtggaa ctattttgtc atcttttgag aaaaaaatat
     5761 acaaagaagt catcttttca ttaagtggat tccctggttc ctttccagct ggttgtggaa
     5821 gtaatggcta acatccttca gctgactttg tctacaagga ttattagcaa attctgtagg
     5881 agcaagcatg tctgacctta acttaatgga tcccttattc aatcagtggc ttctgtcttt
     5941 atgtctgttg gcatatcaaa atggtttctg ttcctagaaa agtaataaca tatgcttatc
     6001 tttattcttt ttccaggtga ttttgttttc aaatgctcct tgtgaaaaca cctagtgttg
     6061 tagaaaggaa agtggccaga aagaacaact tgggaccatg agtaggtcat taaatagctt
     6121 agtgatttat cctcatatag ggcttataaa ccctgtatgt gtttatatgt gcttcacaga
     6181 gttcgtgtca ggctcaaagg agatatgtat aagaaagtgg tttgtaaatt atgttccatt
     6241 tcataaatag acactattca caaactaaaa tctaataaaa aaccacagtt gtaatttaaa
     6301 ctgcttgata taaaaagagg tatcatagca gggaaaacac actaattttc atacagtaga
     6361 ggtattgaaa actgaaaatg ggaaggcaac ttgaagtcat tgtatttgat tgaaaatgtt
     6421 taatacatct cattattgac aaaatatgtc atcttgtatt tatttcaagg aaaccaatga
     6481 attctaggta gtatattaca agttggtcaa aatattccat gtacaaatag ggcttctgtg
     6541 tccatagcct tgtaagagat actgattgta tctgaaatta ttttttaaaa aaataaatta
     6601 tcctgcttta gttagtgtgt taaaagtaga cgatgttcta atataacact gaagtgcttc
     6661 attgtatccc aacagtttac cttcaagtaa tattatcttt atttttaggc taagcacgtt
     6721 tgattatttt gtctgtctcc tatatagatc tgttttgtct agtgctatga atgtaactta
     6781 aaactataaa cttgaagttt ttattctata tgccccttaa tagactgtgg ttcctgacgc
     6841 acactgttag gtcattattt tgttgtacca aagttctagt ggcttcagaa atcatagcat
     6901 ccaatgattt tttggtgtct ggctatgaat actatggttg agaattgtat tcagtgattg
     6961 tttctgcaca cttttcaaat aaaaaatgaa tttttatcaa tta
//
