LOCUS       NM_014353               1674 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAB26, member RAS oncogene family (RAB26), transcript
            variant 1, mRNA.
ACCESSION   NM_014353
VERSION     NM_014353.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Alizadeh,S., Khamse,S., Tajeddin,N., Khorram Khorshid,H.R.,
            Delbari,A. and Ohadi,M.
  TITLE     A GCC repeat in RAB26 undergoes natural selection in human and
            harbors divergent genotypes in late-onset Alzheimer's disease
  JOURNAL   Gene 893, 147968 (2024)
   PUBMED   37931854
  REMARK    GeneRIF: A GCC repeat in RAB26 undergoes natural selection in human
            and harbors divergent genotypes in late-onset Alzheimer's disease.
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   He,B.F., Wu,Y.X., Hu,W.P., Hua,J.L., Han,Y. and Zhang,J.
  TITLE     ROS induced the Rab26 promoter hypermethylation to promote
            cigarette smoking-induced airway epithelial inflammation of COPD
            through activation of MAPK signaling
  JOURNAL   Free Radic Biol Med 195, 359-370 (2023)
   PUBMED   36610560
  REMARK    GeneRIF: ROS induced the Rab26 promoter hypermethylation to promote
            cigarette smoking-induced airway epithelial inflammation of COPD
            through activation of MAPK signaling.
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Ren,H., Yang,B., Li,M., Lu,C. and Li,X.
  TITLE     RAB26 contributes to the progression of non-small cell lung cancer
            after being transcriptionally activated by SMAD3
  JOURNAL   Bioengineered 13 (4), 8064-8075 (2022)
   PUBMED   35291909
  REMARK    GeneRIF: RAB26 contributes to the progression of non-small cell
            lung cancer after being transcriptionally activated by SMAD3.
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   Liu,H., Zhou,Y., Qiu,H., Zhuang,R., Han,Y., Liu,X., Qiu,X.,
            Wang,Z., Xu,L., Tan,R., Hong,W. and Wang,T.
  TITLE     Rab26 suppresses migration and invasion of breast cancer cells
            through mediating autophagic degradation of phosphorylated Src
  JOURNAL   Cell Death Dis 12 (4), 284 (2021)
   PUBMED   33731709
  REMARK    GeneRIF: Rab26 suppresses migration and invasion of breast cancer
            cells through mediating autophagic degradation of phosphorylated
            Src.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Swick,L. and Kapatos,G.
  TITLE     A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein
            interactions
  JOURNAL   J Neurochem 97 (5), 1447-1455 (2006)
   PUBMED   16696853
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   Yoshie,S., Imai,A., Nashida,T. and Shimomura,H.
  TITLE     Expression, characterization, and localization of Rab26, a low
            molecular weight GTP-binding protein, in the rat parotid gland
  JOURNAL   Histochem Cell Biol 113 (4), 259-263 (2000)
   PUBMED   10857477
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Seki,N., Yoshikawa,T., Hattori,A., Miyajima,N., Muramatsu,M. and
            Saito,T.
  TITLE     cDNA cloning of a human RAB26-related gene encoding a Ras-like
            GTP-binding protein on chromosome 16p13.3 region
  JOURNAL   J Hum Genet 45 (5), 309-314 (2000)
   PUBMED   11043516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009065.8.
            
            On May 17, 2019 this sequence version replaced NM_014353.4.
            
            Summary: Members of the RAB protein family, including RAB26, are
            important regulators of vesicular fusion and trafficking. The RAB
            family of small G proteins regulates intercellular vesicle
            trafficking, including exocytosis, endocytosis, and recycling
            (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066913.1, SRR3476690.56018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000210187.11/ ENSP00000210187.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AC009065.8         128434-128787       c
            355-465             AC009065.8         127361-127471       c
            466-507             AC009065.8         125802-125843       c
            508-574             AC009065.8         125651-125717       c
            575-627             AC009065.8         125504-125556       c
            628-693             AC009065.8         124527-124592       c
            694-750             AC009065.8         124367-124423       c
            751-827             AC009065.8         124190-124266       c
            828-1674            AC009065.8         123247-124093       c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1674
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="RAB26, member RAS oncogene family"
                     /db_xref="GeneID:25837"
                     /db_xref="HGNC:HGNC:14259"
                     /db_xref="MIM:605455"
     exon            1..354
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..930
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ras-related protein Rab-26; Ras-related oncogene protein"
                     /codon_start=1
                     /product="ras-related protein Rab-26 isoform 1"
                     /protein_id="NP_055168.2"
                     /db_xref="CCDS:CCDS10460.1"
                     /db_xref="GeneID:25837"
                     /db_xref="HGNC:HGNC:14259"
                     /db_xref="MIM:605455"
                     /translation="MSRKKTPKSKGASTPAASTLPTANGARPARSGTALSGPDAPPNG
                     PLQPGRPSLGGGVDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFR
                     NKVLDVDGVKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLT
                     EIHEYAQHDVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAF
                     TAIAKELKQRSMKAPSEPRFRLHDYVKREGRGASCCRP"
     exon            355..465
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            466..507
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            508..574
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            575..627
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            628..693
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            694..750
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            751..827
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1674
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1629..1634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="hexamer: AATAAA"
     polyA_site      1649
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgagccg ggcgcccggg atgatgccgc cgccgccgcc gccgccgccg ccgccgccag
       61 gggaagggtt cgggtccggg tcgggctcgg cgggcgcggg gtgcgggacg gcccagggca
      121 cggcggctgc agcgggagca cactgagcgc ccgcccgcca tgtccaggaa gaagaccccc
      181 aagagcaaag gggccagcac ccccgctgcc tccacgctgc ccaccgccaa cggggcccga
      241 ccggcgcgct ccgggactgc gctttccggc cccgacgcgc cgcccaacgg gcccttgcag
      301 cccggccggc cctcgcttgg cggcggtgtc gacttctacg acgtcgcctt caaggtcatg
      361 ctggtggggg actcgggtgt ggggaagacc tgtctgctgg tgcgattcaa ggatggtgct
      421 ttcctggcgg ggaccttcat ctccaccgta ggcattgact tccggaacaa agttctggac
      481 gtggatggtg tgaaggtgaa gctgcagatg tgggacacag ctggtcagga gcggttccgc
      541 agtgttaccc atgcctacta ccgggatgct catgctctgc tgctgctcta cgatgtcacc
      601 aacaaggcct cctttgacaa catccaggcc tggctgaccg agatccacga gtacgcccag
      661 cacgacgtgg cgctcatgct gctggggaac aaggtggact ctgcccatga gcgtgtggtg
      721 aagagggagg acggggagaa gctggccaag gagtatggac tgcccttcat ggagaccagc
      781 gccaagacgg gcctcaacgt ggacttggcc ttcacagcca tagcaaagga gttgaagcag
      841 cgctccatga aggctcccag cgagccgcgc ttccggctgc atgattacgt taagagggag
      901 ggtcgagggg cctcctgctg ccgcccttga acctggctga gctcagtcct ctggaggaag
      961 ccgtccagtc cctagaaggc tggacagagg gtctccaggc ccttctgact ttgttgccca
     1021 gtggccaacg cccgagtgtc tgttttcagg agccccaggt caagccttgt cccttcctcc
     1081 tcccagcaac agtcccaaca agcaggcttc tgagagcccg tggccgcaca ctggccgcca
     1141 cggaaaagca gtcttctgca cgggacgggg agcggcaagt ggacagactt tgccacggtg
     1201 ctctgctgcc ccctcctggg cacgtccagg tgagggaggg ctggggctgg caccacgcac
     1261 agtgcctaac cctagaaaag ccatgtcttc agccgcacat gctcaggcag ctaagggagg
     1321 acgcctgccc acgcctggga cagaaggctt cactgctaat cacatcgtgc atctgtgtgt
     1381 cctgggagct gcctgctccc ggcccaccct ctaggaggct ctggctcaaa cagcaatagg
     1441 gtcttcctca ctgaccttgg aggatgcctg tggccttgtg ataaaatgtg ggaaatcaca
     1501 gaaaacacca gaaacaacaa ctgccagccc ggcctggcca caggtgaggt ctgtgatttc
     1561 cgagcacgct ccaccttgca ctcaacttgg ccttttgatt gcacaagcct ttgttttcag
     1621 tcctagtgaa taaagttgtg ttttctggag cgtctgtctc atctgttgaa aaaa
//
