LOCUS       NM_001308053            1688 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB26, member RAS oncogene family (RAB26), transcript
            variant 2, mRNA.
ACCESSION   NM_001308053 XM_011522449
VERSION     NM_001308053.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1688)
  AUTHORS   Alizadeh,S., Khamse,S., Tajeddin,N., Khorram Khorshid,H.R.,
            Delbari,A. and Ohadi,M.
  TITLE     A GCC repeat in RAB26 undergoes natural selection in human and
            harbors divergent genotypes in late-onset Alzheimer's disease
  JOURNAL   Gene 893, 147968 (2024)
   PUBMED   37931854
  REMARK    GeneRIF: A GCC repeat in RAB26 undergoes natural selection in human
            and harbors divergent genotypes in late-onset Alzheimer's disease.
REFERENCE   2  (bases 1 to 1688)
  AUTHORS   He,B.F., Wu,Y.X., Hu,W.P., Hua,J.L., Han,Y. and Zhang,J.
  TITLE     ROS induced the Rab26 promoter hypermethylation to promote
            cigarette smoking-induced airway epithelial inflammation of COPD
            through activation of MAPK signaling
  JOURNAL   Free Radic Biol Med 195, 359-370 (2023)
   PUBMED   36610560
  REMARK    GeneRIF: ROS induced the Rab26 promoter hypermethylation to promote
            cigarette smoking-induced airway epithelial inflammation of COPD
            through activation of MAPK signaling.
REFERENCE   3  (bases 1 to 1688)
  AUTHORS   Ren,H., Yang,B., Li,M., Lu,C. and Li,X.
  TITLE     RAB26 contributes to the progression of non-small cell lung cancer
            after being transcriptionally activated by SMAD3
  JOURNAL   Bioengineered 13 (4), 8064-8075 (2022)
   PUBMED   35291909
  REMARK    GeneRIF: RAB26 contributes to the progression of non-small cell
            lung cancer after being transcriptionally activated by SMAD3.
REFERENCE   4  (bases 1 to 1688)
  AUTHORS   Liu,H., Zhou,Y., Qiu,H., Zhuang,R., Han,Y., Liu,X., Qiu,X.,
            Wang,Z., Xu,L., Tan,R., Hong,W. and Wang,T.
  TITLE     Rab26 suppresses migration and invasion of breast cancer cells
            through mediating autophagic degradation of phosphorylated Src
  JOURNAL   Cell Death Dis 12 (4), 284 (2021)
   PUBMED   33731709
  REMARK    GeneRIF: Rab26 suppresses migration and invasion of breast cancer
            cells through mediating autophagic degradation of phosphorylated
            Src.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1688)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1688)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1688)
  AUTHORS   Swick,L. and Kapatos,G.
  TITLE     A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein
            interactions
  JOURNAL   J Neurochem 97 (5), 1447-1455 (2006)
   PUBMED   16696853
REFERENCE   8  (bases 1 to 1688)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   9  (bases 1 to 1688)
  AUTHORS   Yoshie,S., Imai,A., Nashida,T. and Shimomura,H.
  TITLE     Expression, characterization, and localization of Rab26, a low
            molecular weight GTP-binding protein, in the rat parotid gland
  JOURNAL   Histochem Cell Biol 113 (4), 259-263 (2000)
   PUBMED   10857477
REFERENCE   10 (bases 1 to 1688)
  AUTHORS   Seki,N., Yoshikawa,T., Hattori,A., Miyajima,N., Muramatsu,M. and
            Saito,T.
  TITLE     cDNA cloning of a human RAB26-related gene encoding a Ras-like
            GTP-binding protein on chromosome 16p13.3 region
  JOURNAL   J Hum Genet 45 (5), 309-314 (2000)
   PUBMED   11043516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009065.8, AK314110.1 and AB027137.1.
            
            On Apr 21, 2015 this sequence version replaced XM_011522449.1.
            
            Summary: Members of the RAB protein family, including RAB26, are
            important regulators of vesicular fusion and trafficking. The RAB
            family of small G proteins regulates intercellular vesicle
            trafficking, including exocytosis, endocytosis, and recycling
            (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM,
            Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region and uses a downstream start codon compared to variant
            1. The encoded isoform (2) has a shorter N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314110.1, SRR1803611.477794.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC009065.8         129245-129268       c
            25-944              AK314110.1         25-944
            945-1688            AB027137.1         577-1320
FEATURES             Location/Qualifiers
     source          1..1688
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1688
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="RAB26, member RAS oncogene family"
                     /db_xref="GeneID:25837"
                     /db_xref="HGNC:HGNC:14259"
                     /db_xref="MIM:605455"
     exon            1..181
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            182..368
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            369..479
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..944
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ras-related protein Rab-26; Ras-related oncogene protein"
                     /codon_start=1
                     /product="ras-related protein Rab-26 isoform 2"
                     /protein_id="NP_001294982.1"
                     /db_xref="CCDS:CCDS76806.1"
                     /db_xref="GeneID:25837"
                     /db_xref="HGNC:HGNC:14259"
                     /db_xref="MIM:605455"
                     /translation="MLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDG
                     VKVKLQMWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKASFDNIQAWLTEIHEYAQH
                     DVALMLLGNKVDSAHERVVKREDGEKLAKEYGLPFMETSAKTGLNVDLAFTAIAKELK
                     QRSMKAPSEPRFRLHDYVKREGRGASCCRP"
     exon            480..521
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            522..588
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            589..641
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            642..707
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            708..764
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            765..841
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1688
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1643..1648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="hexamer: AATAAA"
     polyA_site      1663
                     /gene="RAB26"
                     /gene_synonym="V46133"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgtttgc caagccaggg ctggagcttc ctggacccgc ctaccctgga ggggatggag
       61 cagtgaaggg caccgggcca agcgctaggc atctggggct aaggagacag aagcccgcgg
      121 tgcccgtcca tgcgggccct ctgccccagc acccacatct caggacaccc cttcctccca
      181 ggaagaagac ccccaagagc aaaggggcca gcacccccgc tgcctccacg ctgcccaccg
      241 ccaacggggc ccgaccggcg cgctccggga ctgcgctttc cggccccgac gcgccgccca
      301 acgggccctt gcagcccggc cggccctcgc ttggcggcgg tgtcgacttc tacgacgtcg
      361 ccttcaaggt catgctggtg ggggactcgg gtgtggggaa gacctgtctg ctggtgcgat
      421 tcaaggatgg tgctttcctg gcggggacct tcatctccac cgtaggcatt gacttccgga
      481 acaaagttct ggacgtggat ggtgtgaagg tgaagctgca gatgtgggac acagctggtc
      541 aggagcggtt ccgcagtgtt acccatgcct actaccggga tgctcatgct ctgctgctgc
      601 tctacgatgt caccaacaag gcctcctttg acaacatcca ggcctggctg accgagatcc
      661 acgagtacgc ccagcacgac gtggcgctca tgctgctggg gaacaaggtg gactctgccc
      721 atgagcgtgt ggtgaagagg gaggacgggg agaagctggc caaggagtat ggactgccct
      781 tcatggagac cagcgccaag acgggcctca acgtggactt ggccttcaca gccatagcaa
      841 aggagttgaa gcagcgctcc atgaaggctc ccagcgagcc gcgcttccgg ctgcatgatt
      901 acgttaagag ggagggtcga ggggcctcct gctgccgccc ttgaacctgg ctgagctcag
      961 tcctctggag gaagccgccc agtccctaga aggctggaca gagggtctcc aggcccttct
     1021 gactttgttg cccagtggcc aacgcccgag tgtctgtttt caggagcccc aggtcaagcc
     1081 ttgtcccttc ctcctcccag caacagtccc aacaagcagg cttctgagag cccgtggccg
     1141 cacactggcc gccacggaaa agcagtcttc tgcacgggac ggggagcggc aagtggacag
     1201 actttgccac ggtgctctgc tgccccctcc tgggcacgtc caggtgaggg agggctgggg
     1261 ctggcaccac gcacagtgcc taaccctaga aaagccatgt cttcagccgc acatgctcag
     1321 gcagctaagg gaggacgcct gcccacgcct gggacagaag gcttcactgc taatcacatc
     1381 gtgcatctgt gtgtcctggg agctgcctgc tcccggccca ccctctagga ggctctggct
     1441 caaacagcaa tagggtcttc ctcactgacc ttggaggatg cctgtggcct tgtgataaaa
     1501 tgtgggaaat cacagaaaac accagaaaca acaactgcca gcccggcctg gccacaggtg
     1561 aggtctgtga tttccgagca cgctccacct tgcactcaac ttggcctttt gattgcacaa
     1621 gcctttgttt tcagtcctag tgaataaagt tgtgttttct ggagcgtctg tctcatctgt
     1681 tgaaaaaa
//
