LOCUS       NM_020387               1100 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens RAB25, member RAS oncogene family (RAB25), transcript
            variant 1, mRNA.
ACCESSION   NM_020387
VERSION     NM_020387.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Joshi,P., Ayyagari,V., Kandel,S., Modur,V., Iqbal,M.F.,
            Robinson,K., Gao,J. and Rao,K.
  TITLE     Loss of RAB25 Cooperates with Oncogenes in the Transformation of
            Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low
            Tumors
  JOURNAL   Biomed Res Int 2024, 8544837 (2024)
   PUBMED   38803515
  REMARK    GeneRIF: Loss of RAB25 Cooperates with Oncogenes in the
            Transformation of Human Mammary Epithelial Cells (HMECs) to Give
            Rise to Claudin-Low Tumors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Zhang,Q., Zhang,Z., He,X., Liu,Z., Shen,L., Long,C., Wei,G. and
            Liu,X.
  TITLE     Expression of Rab25 is down-regulated in the foreskin of children
            with hypospadias
  JOURNAL   J Pediatr Urol 19 (5), 581 (2023)
   PUBMED   37246119
  REMARK    GeneRIF: Expression of Rab25 is down-regulated in the foreskin of
            children with hypospadias.
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Hu,C.H., Yang,X.J., Yu,L., Wang,L.Y., Zhao,X.C. and Han,C.H.
  TITLE     Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to
            promote prostate cancer progression via regulating Rab25
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (18), 9290-9302 (2020)
   PUBMED   33015770
  REMARK    GeneRIF: Long non-coding RNA LINC00173 serves as sponge for
            miR-338-3p to promote prostate cancer progression via regulating
            Rab25.
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Jeong,H., Lim,K.M., Kim,K.H., Cho,Y., Lee,B., Knowles,B.C.,
            Roland,J.T., Zwerner,J.P., Goldenring,J.R. and Nam,K.T.
  TITLE     Loss of Rab25 promotes the development of skin squamous cell
            carcinoma through the dysregulation of integrin trafficking
  JOURNAL   J Pathol 249 (2), 227-240 (2019)
   PUBMED   31144312
  REMARK    GeneRIF: Loss of Rab25 promotes the development and neoplastic
            transition of skin squamous cell carcinoma through dysregulation of
            integrin trafficking.
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
REFERENCE   7  (bases 1 to 1100)
  AUTHORS   Prekeris,R., Davies,J.M. and Scheller,R.H.
  TITLE     Identification of a novel Rab11/25 binding domain present in Eferin
            and Rip proteins
  JOURNAL   J Biol Chem 276 (42), 38966-38970 (2001)
   PUBMED   11481332
REFERENCE   8  (bases 1 to 1100)
  AUTHORS   Lapierre,L.A., Kumar,R., Hales,C.M., Navarre,J., Bhartur,S.G.,
            Burnette,J.O., Provance,D.W. Jr., Mercer,J.A., Bahler,M. and
            Goldenring,J.R.
  TITLE     Myosin vb is associated with plasma membrane recycling systems
  JOURNAL   Mol Biol Cell 12 (6), 1843-1857 (2001)
   PUBMED   11408590
REFERENCE   9  (bases 1 to 1100)
  AUTHORS   Ray,G.S., Lee,J.R., Nwokeji,K., Mills,L.R. and Goldenring,J.R.
  TITLE     Increased immunoreactivity for Rab11, a small GTP-binding protein,
            in low-grade dysplastic Barrett's epithelia
  JOURNAL   Lab Invest 77 (5), 503-511 (1997)
   PUBMED   9389793
REFERENCE   10 (bases 1 to 1100)
  AUTHORS   Goldenring,J.R., Shen,K.R., Vaughan,H.D. and Modlin,I.M.
  TITLE     Identification of a small GTP-binding protein, Rab25, expressed in
            the gastrointestinal mucosa, kidney, and lung
  JOURNAL   J Biol Chem 268 (25), 18419-18422 (1993)
   PUBMED   8360141
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP263750.1 and BC009831.2.
            
            On Nov 23, 2018 this sequence version replaced NM_020387.3.
            
            Summary: The protein encoded by this gene is a member of the RAS
            superfamily of small GTPases. The encoded protein is involved in
            membrane trafficking and cell survival. This gene has been found to
            be a tumor suppressor and an oncogene, depending on the context.
            Two variants, one protein-coding and the other not, have been found
            for this gene. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009831.2, AF274025.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361084.10/ ENSP00000354376.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP263750.1         12-26
            16-1100             BC009831.2         1-1085
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1100
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /note="RAB25, member RAS oncogene family"
                     /db_xref="GeneID:57111"
                     /db_xref="HGNC:HGNC:18238"
                     /db_xref="MIM:612942"
     exon            1..284
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..883
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /note="ras-related protein Rab-25"
                     /codon_start=1
                     /product="ras-related protein Rab-25 precursor"
                     /protein_id="NP_065120.2"
                     /db_xref="CCDS:CCDS41413.1"
                     /db_xref="GeneID:57111"
                     /db_xref="HGNC:HGNC:18238"
                     /db_xref="MIM:612942"
                     /translation="MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTT
                     IGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAV
                     VERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDST
                     NVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL"
     exon            285..480
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /inference="alignment:Splign:2.1.0"
     exon            481..674
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /inference="alignment:Splign:2.1.0"
     exon            675..755
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1100
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /note="hexamer: AATAAA"
     polyA_site      1100
                     /gene="RAB25"
                     /gene_synonym="CATX-8; RAB11C"
                     /note="major polyA site"
ORIGIN      
        1 ctcagcttcc gtcctctctg cttccttaca gcacccccac ctgccagagc tgatcctccc
       61 taggccctgc ctaaccttga gttggccccc aatccctctg gctgcagaag tccccttacc
      121 cccaatgaga ggaggggcag gaccagatct tttgagagct gagggttgag ggcattgagc
      181 caacacacag atttgtcgcc tctgtccccg aagacacctg caccctccat gcggagccaa
      241 gatggggaat ggaactgagg aagattataa ctttgtcttc aaggtggtgc tgatcggcga
      301 atcaggtgtg gggaagacca atctactctc ccgattcacg cgcaatgagt tcagccacga
      361 cagccgcacc accatcgggg ttgagttctc cacccgcact gtgatgttgg gcaccgctgc
      421 tgtcaaggct cagatctggg acacagctgg cctggagcgg taccgagcca tcacctcggc
      481 gtactatcgt ggtgcagtgg gggccctcct ggtgtttgac ctaaccaagc accagaccta
      541 tgctgtggtg gagcgatggc tgaaggagct ctatgaccat gctgaagcca cgatcgtcgt
      601 catgctcgtg ggtaacaaaa gtgacctcag ccaggcccgg gaagtgccca ctgaggaggc
      661 ccgaatgttc gctgaaaaca atggactgct cttcctggag acctcagccc tggactctac
      721 caatgttgag ctagcctttg agactgtcct gaaagaaatc tttgcgaagg tgtccaagca
      781 gagacagaac agcatccgga ccaatgccat cactctgggc agtgcccagg ctggacagga
      841 gcctggccct ggggagaaga gggcctgttg catcagcctc tgaccttggc cagcaccacc
      901 tgcccccact ggctttttgg tgccccttgt ccccacttca gccccaggac ctttccttgc
      961 cctttggttc cagatatcag actgttccct gttcacagca ccctcagggt cttaaggtct
     1021 tcatgcccta tcacaaatac ctcttttatc tgtccacccc tcacagacta ggaccctcaa
     1081 ataaagctgt tttatatcaa
//
