LOCUS       NM_001031677            1588 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB24, member RAS oncogene family (RAB24), transcript
            variant 1, mRNA.
ACCESSION   NM_001031677
VERSION     NM_001031677.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Seitz,S., Kwon,Y., Hartleben,G., Julg,J., Sekar,R., Krahmer,N.,
            Najafi,B., Loft,A., Gancheva,S., Stemmer,K., Feuchtinger,A., Hrabe
            de Angelis,M., Muller,T.D., Mann,M., Bluher,M., Roden,M., Berriel
            Diaz,M., Behrends,C., Gilleron,J., Herzig,S. and Zeigerer,A.
  TITLE     Hepatic Rab24 controls blood glucose homeostasis via improving
            mitochondrial plasticity
  JOURNAL   Nat Metab 1 (10), 1009-1026 (2019)
   PUBMED   32694843
  REMARK    GeneRIF: Hepatic Rab24 controls blood glucose homeostasis via
            improving mitochondrial plasticity.
REFERENCE   6  (bases 1 to 1588)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   7  (bases 1 to 1588)
  AUTHORS   Eathiraj,S., Pan,X., Ritacco,C. and Lambright,D.G.
  TITLE     Structural basis of family-wide Rab GTPase recognition by
            rabenosyn-5
  JOURNAL   Nature 436 (7049), 415-419 (2005)
   PUBMED   16034420
REFERENCE   8  (bases 1 to 1588)
  AUTHORS   Maltese,W.A., Soule,G., Gunning,W., Calomeni,E. and Alexander,B.
  TITLE     Mutant Rab24 GTPase is targeted to nuclear inclusions
  JOURNAL   BMC Cell Biol 3, 25 (2002)
   PUBMED   12323076
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1588)
  AUTHORS   Erdman,R.A., Shellenberger,K.E., Overmeyer,J.H. and Maltese,W.A.
  TITLE     Rab24 is an atypical member of the Rab GTPase family. Deficient
            GTPase activity, GDP dissociation inhibitor interaction, and
            prenylation of Rab24 expressed in cultured cells
  JOURNAL   J Biol Chem 275 (6), 3848-3856 (2000)
   PUBMED   10660536
REFERENCE   10 (bases 1 to 1588)
  AUTHORS   Olkkonen,V.M., Dupree,P., Killisch,I., Lutcke,A., Zerial,M. and
            Simons,K.
  TITLE     Molecular cloning and subcellular localization of three GTP-binding
            proteins of the rab subfamily
  JOURNAL   J Cell Sci 106 (Pt 4), 1249-1261 (1993)
   PUBMED   8126105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA898352.1, BC021263.2, AI868941.1, AF087904.1 and AV698158.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001031677.3.
            
            Summary: RAB24 is a small GTPase of the Rab subfamily of
            Ras-related proteins that regulate intracellular protein
            trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by
            OMIM, Aug 2009].
            
            Transcript Variant: This variant (1) encodes the functional
            protein. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.637072.1,
                                           SRR3476690.374624.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303251.11/ ENSP00000304376.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA898352.1         26-40
            16-1328             BC021263.2         1-1313
            1329-1475           AI868941.1         1-147               c
            1476-1581           AF087904.1         1235-1340
            1582-1588           AV698158.1         518-524
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1588
                     /gene="RAB24"
                     /note="RAB24, member RAS oncogene family"
                     /db_xref="GeneID:53917"
                     /db_xref="HGNC:HGNC:9765"
                     /db_xref="MIM:612415"
     exon            1..548
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1043
                     /gene="RAB24"
                     /codon_start=1
                     /product="ras-related protein Rab-24"
                     /protein_id="NP_001026847.1"
                     /db_xref="CCDS:CCDS34300.1"
                     /db_xref="GeneID:53917"
                     /db_xref="HGNC:HGNC:9765"
                     /db_xref="MIM:612415"
                     /translation="MSGQRVDVKVVMLGKEYVGKTSLVERYVHDRFLVGPYQNTIGAA
                     FVAKVMSVGDRTVTLGIWDTAGSERYEAMSRIYYRGAKAAIVCYDLTDSSSFERAKFW
                     VKELRSLEEGCQIYLCGTKSDLLEEDRRRRRVDFHDVQDYADNIKAQLFETSSKTGQS
                     VDELFQKVAEDYVSVAAFQVMTEDKGVDLGQKPNPYFYSCCHH"
     exon            549..617
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            618..696
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            697..764
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            765..864
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            865..915
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            916..978
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1588
                     /gene="RAB24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB24"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="RAB24"
                     /note="major polyA site"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB24"
                     /note="hexamer: AATAAA"
     polyA_site      1588
                     /gene="RAB24"
ORIGIN      
        1 ctctagcccc ctcccgcggg agtcgcggcg ctgcgggtag gagccgggtt gcgggagacc
       61 ccaggttcgg ttgggattcc cagccagaac ggagcttaag ccgggcaggc gagcgaatga
      121 cggagtagcg agctgcacgg cggcgtgctg cgctgttgag gacgctgtcc cgcgcgctcc
      181 caggccgccc cgaggcttgg ggtcttcgaa ggataatcgg cgcccggggc cgaacagcgg
      241 gggcacacgg ggcgctgccg aagtgcaagg ccacggccag agctcgagcc cgacgcgctg
      301 tctggagtcg taggttggcg ccgtttgggg tcggggtctg aggcttgggc gctgcctggg
      361 ccgagcggag atcggggttt gcctcccgtc cccgctcagg accctgacgt ggctgaagcg
      421 gccccgggag catgagcggg cagcgcgtgg acgtcaaggt ggtgatgctg ggcaaggagt
      481 acgtgggcaa gactagcctg gtggagcgct acgtgcacga ccgctttctg gtggggcctt
      541 atcagaacac catcggggcc gccttcgtgg ccaaggtgat gtcggtcgga gaccggactg
      601 tgacattagg tatttgggac acagcaggct ctgagcgcta tgaggccatg agtagaatct
      661 actatcgggg tgccaaggct gccatcgtct gctatgacct cacagacagc agcagctttg
      721 agcgagcaaa gttctgggtg aaggaactgc gcagcctaga ggagggctgc caaatctact
      781 tatgtggcac caagagtgac ctgctggaag aagaccggag gcgtcgacgt gtggacttcc
      841 acgacgtcca ggactatgca gacaatatca aagctcagct ctttgaaaca tccagcaaga
      901 caggccagag tgtggacgag ctcttccaga aagtggcaga ggattacgtc agtgtggctg
      961 ccttccaggt gatgacagag gacaagggcg tggatctggg ccagaagcca aacccctact
     1021 tctacagctg ttgtcatcac tgagtcagca ctcacctggc ctgggggaat taaaggaatt
     1081 ccccgtaagg gctggaccca gctcctttct gggcttgggt agtcaaatgt ctgagctacc
     1141 ccaggtcctc atgtcagcag agtggcgcct gcctgtgctg gcccatggaa cggagacagc
     1201 attgggctga ctgtgggcat gaggagggat aaggctgatt tggaccccag gcttctgccc
     1261 tggacagcac ttgtgtctgc agattattta agtggctttt gatctgtaaa taaaatcagt
     1321 gcactgtgca tcacacccag cccctttccc tgctgtgtgg attaggtgtc aagacaccta
     1381 gttcttcctg gggccacccg gctggcctca ctgcttatat taaggctcct cccaactctc
     1441 attttccttt ggaaaacaag acttttttcc ccatggttac cgctgagata ctggggctgt
     1501 agtagtataa aagctcacag ttccttctga gtgctgaaaa gagtgcatga gttgcttcga
     1561 aataaaaggg tcaagcattc ctacctga
//
