LOCUS       NM_016277               4830 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript
            variant 1, mRNA.
ACCESSION   NM_016277
VERSION     NM_016277.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4830)
  AUTHORS   Liu,S.J., Zang,Y.W., Huang,C.J. and Liu,Y.J.
  TITLE     Downregulation of Rab23 inhibits hepatocellular carcinoma by
            repressing SHH signaling pathway
  JOURNAL   Cancer Rep (Hoboken) 7 (1), e1921 (2024)
   PUBMED   37884351
  REMARK    GeneRIF: Downregulation of Rab23 inhibits hepatocellular carcinoma
            by repressing SHH signaling pathway.
REFERENCE   2  (bases 1 to 4830)
  AUTHORS   Yang,E., Hong,Y., Xuan,C., Xu,J., Ding,Q., Zhao,S., Ye,H., Fan,X.,
            Jiang,Z., Zhang,S. and Ding,X.
  TITLE     Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p
            Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells
  JOURNAL   Protein Pept Lett 30 (10), 877-890 (2023)
   PUBMED   38093594
  REMARK    GeneRIF: Biomarker of Pulmonary Inflammatory Response in LUAD:
            miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in
            A549 Cells.
REFERENCE   3  (bases 1 to 4830)
  AUTHORS   Khairat,R., Elhossini,R., Sobreira,N., Wohler,E., Otaify,G.,
            Mohamed,A.M., Abdel Raouf,E.R., Sayed,I., Aglan,M., Ismail,S. and
            Temtamy,S.A.
  TITLE     Expansion of the phenotypic and mutational spectrum of Carpenter
            syndrome
  JOURNAL   Eur J Med Genet 65 (1), 104377 (2022)
   PUBMED   34748996
  REMARK    GeneRIF: Expansion of the phenotypic and mutational spectrum of
            Carpenter syndrome.
REFERENCE   4  (bases 1 to 4830)
  AUTHORS   Du,W., Li,D., Xie,J. and Tang,P.
  TITLE     miR-367-3p downregulates Rab23 expression and inhibits Hedgehog
            signaling resulting in the inhibition of the proliferation,
            migration, and invasion of prostate cancer cells
  JOURNAL   Oncol Rep 46 (3) (2021)
   PUBMED   34278506
  REMARK    GeneRIF: miR3673p downregulates Rab23 expression and inhibits
            Hedgehog signaling resulting in the inhibition of the
            proliferation, migration, and invasion of prostate cancer cells.
REFERENCE   5  (bases 1 to 4830)
  AUTHORS   Wen,H.L., Xu,Z.M., Lin,S.Y., Wen,D. and Xie,J.P.
  TITLE     miR-597-3p inhibits invasion and migration of thyroid carcinoma
            SW579 cells by targeting RAB23
  JOURNAL   Endokrynol Pol 72 (1), 22-28 (2021)
   PUBMED   32856288
  REMARK    GeneRIF: miR-597-3p inhibits invasion and migration of thyroid
            carcinoma SW579 cells by targeting RAB23.
REFERENCE   6  (bases 1 to 4830)
  AUTHORS   Jenkins,D., Baynam,G., De Catte,L., Elcioglu,N., Gabbett,M.T.,
            Hudgins,L., Hurst,J.A., Jehee,F.S., Oley,C. and Wilkie,A.O.
  TITLE     Carpenter syndrome: extended RAB23 mutation spectrum and analysis
            of nonsense-mediated mRNA decay
  JOURNAL   Hum Mutat 32 (4), E2069-E2078 (2011)
   PUBMED   21412941
  REMARK    GeneRIF: Carpenter syndrome: extended RAB23 mutation spectrum and
            analysis of nonsense-mediated mRNA decay
REFERENCE   7  (bases 1 to 4830)
  AUTHORS   Liu,Y.J., Wang,Q., Li,W., Huang,X.H., Zhen,M.C., Huang,S.H.,
            Chen,L.Z., Xue,L. and Zhang,H.W.
  TITLE     Rab23 is a potential biological target for treating hepatocellular
            carcinoma
  JOURNAL   World J Gastroenterol 13 (7), 1010-1017 (2007)
   PUBMED   17373734
  REMARK    GeneRIF: Rab23 is overexpressed and/or activated in hepatocellular
            carcinoma (HCC). Rab23 may be both a HCC predictor and a target for
            treating HCC.
REFERENCE   8  (bases 1 to 4830)
  AUTHORS   Evans,T.M., Ferguson,C., Wainwright,B.J., Parton,R.G. and
            Wicking,C.
  TITLE     Rab23, a negative regulator of hedgehog signaling, localizes to the
            plasma membrane and the endocytic pathway
  JOURNAL   Traffic 4 (12), 869-884 (2003)
   PUBMED   14617350
REFERENCE   9  (bases 1 to 4830)
  AUTHORS   Marcos,I., Borrego,S. and Antinolo,G.
  TITLE     Molecular cloning and characterization of human RAB23, a member of
            the group of Rab GTPases
  JOURNAL   Int J Mol Med 12 (6), 983-987 (2003)
   PUBMED   14612978
REFERENCE   10 (bases 1 to 4830)
  AUTHORS   Imabayashi,H., Mori,T., Gojo,S., Kiyono,T., Sugiyama,T., Irie,R.,
            Isogai,T., Hata,J., Toyama,Y. and Umezawa,A.
  TITLE     Redifferentiation of dedifferentiated chondrocytes and
            chondrogenesis of human bone marrow stromal cells via chondrosphere
            formation with expression profiling by large-scale cDNA analysis
  JOURNAL   Exp Cell Res 288 (1), 35-50 (2003)
   PUBMED   12878157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA391757.1, BC015021.1 and
            AL031321.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016277.4.
            
            Summary: This gene encodes a small GTPase of the Ras superfamily.
            Rab proteins are involved in the regulation of diverse cellular
            functions associated with intracellular membrane trafficking,
            including autophagy and immune response to bacterial infection. The
            encoded protein may play a role in central nervous system
            development by antagonizing sonic hedgehog signaling. Disruption of
            this gene has been implicated in Carpenter syndrome as well as
            cancer. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.190731.1,
                                           SRR1660803.141309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000468148.6/ ENSP00000417610.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA391757.1         8-34
            28-2372             BC015021.1         1-2345
            2373-4830           AL031321.1         3850-6307           c
FEATURES             Location/Qualifiers
     source          1..4830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1-p11.2"
     gene            1..4830
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="RAB23, member RAS oncogene family"
                     /db_xref="GeneID:51715"
                     /db_xref="HGNC:HGNC:14263"
                     /db_xref="MIM:606144"
     exon            1..582
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            583..802
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     CDS             648..1361
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /EC_number="3.6.5.2"
                     /note="RAB family small GTP binding protein RAB 23"
                     /codon_start=1
                     /product="ras-related protein Rab-23"
                     /protein_id="NP_057361.3"
                     /db_xref="CCDS:CCDS4962.1"
                     /db_xref="GeneID:51715"
                     /db_xref="HGNC:HGNC:14263"
                     /db_xref="MIM:606144"
                     /translation="MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGV
                     DFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAVSS
                     WREKVVAEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKRLKLRFYRTSVKEDLNVNE
                     VFKYLAEKYLQKLKQQIAEDPELTHSSSNKIGVFNTSGGSHSGQNSGTLNGGDVINLR
                     PNKQRTKKNRNPFSSCSIP"
     exon            803..888
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1045
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1128
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1221
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..4830
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="hexamer: AATAAA"
     polyA_site      3039
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="major polyA site"
     regulatory      4807..4812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="hexamer: AATAAA"
     polyA_site      4830
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="major polyA site"
ORIGIN      
        1 atgctccgca gcgcggcggg tccacagatg aggggagtcg agactcccgc gccccaccac
       61 ccccggcgga gctgctgctg agccactcaa tctgagccct ggctactaat aaagttcgtt
      121 taaaaatcat aatcattctt aagagagcga aagagggtgc gaactagccg ctcggccccg
      181 cagggagagc tggcgcgtcg ggaggagaca gcggcggcag cggttgcgcc gcgaccagga
      241 ggagccggtg gcgccgggcg gcgggtccgc ggccggtggg ggacggtgag tagcggctcg
      301 cgctgcggtg cagcggcgct gcactcactc gccctctcca ggggctgggg gttcgtccgg
      361 ctccactggg gaagactcag cttctccccg gggtcccggg ttgtgcctta ctctccggag
      421 tgggcagggg tatcgagggc aggggcctcc cggcccggct cccccatccc ccggttcgga
      481 ccgccgagcg ccggctctcc cctccctgag caccgatccc aagttccagc tagagaaggt
      541 gggcggcagc gccagcccgg cgccccctcc cagctcccag cgatttgaga gggaagatct
      601 gatctcctag aattagagtt ggtacagaaa ccatttcagc tccaaaaatg ttggaggaag
      661 atatggaagt cgccataaag atggtggttg tagggaatgg agcagttgga aaatcaagta
      721 tgattcagcg atattgcaaa ggcattttta caaaagacta caagaaaacc attggagttg
      781 attttttgga gcgacaaatt caagttaatg atgaagatgt cagactaatg ttatgggaca
      841 ctgcaggtca ggaggaattt gatgcaatta caaaggccta ctatcgagga gcccaggctt
      901 gtgtgctcgt gttctctacc acagataggg aatcttttga agcagtttcc agttggagag
      961 agaaagtagt agccgaagtg ggagatatac caactgtact tgtgcaaaac aagattgatc
     1021 ttctggatga ttcttgtata aagaatgagg aagctgaggc actggcaaaa aggttaaagt
     1081 taagattcta cagaacatca gtgaaagaag atctaaatgt gaatgaagtt tttaagtatt
     1141 tggctgaaaa ataccttcag aaactcaaac aacaaatagc tgaggatcca gaactaacgc
     1201 attcaagtag taacaagatt ggtgtcttta atacatctgg tggaagtcac tccggtcaga
     1261 attcaggtac cctcaatggt ggagatgtca tcaatcttag acccaacaaa caaaggacca
     1321 agaaaaacag aaatcctttt agcagctgta gcatacccta agatgttttg ggaggaaaac
     1381 aattgaatta cattgtgcaa tgcattaaga aacccatcca gctgtcatgg tatgttacaa
     1441 ggttttcagc agactttgct cctaatggct ctctgaaagt gacagactta aatattgctc
     1501 tgcagtgctt ttcagaatgt agagtgagac ctctggtgga aaaattattg ccctgtggac
     1561 tcctttaatt ttttttacat tagacgaagc ttctcctgtt tgtaaaggaa tgctataaga
     1621 aatttcaaac acaggttttg cggaatttta aatgctggaa aacataaatg aaatgcctaa
     1681 atatattgtt acagatttta atactgtgga tcaaggaaag atagcaagca ttcttttcct
     1741 gaaattggtc atgtagcttt tctgcgaaat agtattgaat ctgaatactt tcacaaaata
     1801 atactgaaag gtaaacccta aatcttgcca gactgcatta gtattttggc attgaaactt
     1861 gtgcaatatc tgtgtaatgt agaatgtggg gtgtgcatgc agatgtctgg tactggagta
     1921 agctgaaggt atgtgcagta tttaagaaaa tgtacattct aattaattca cttataaaac
     1981 catttacata ttgtgtatat gtttttattt tcaaatgata aactctagac atatattttg
     2041 caaaatgagc ttgggtttaa aaagtgcttt gtgccaaaaa tatcatacct aatttttata
     2101 gtgctttact atcagaattt atattgttta ttatatcttt taaaagcagt aagcagtttt
     2161 catctgacag cgtagataaa agaggagtat aggaatttga atgctagagc atctcccagg
     2221 tgagccttat tgcagatctt tttgatatag tcacccataa gcatggtgag ctcctgctct
     2281 cataaggtca gccaaagccc cttaagaagg tacacagcac atctgcagtc attcaggagg
     2341 tcctgtgaag tgtggtgatg catctaacac cttttgctgc tcactgagaa cccagctttg
     2401 aacttacaag attacactaa ccatttttaa agtgcacaaa aatattatta ttagtcttaa
     2461 ctaaaattac atattttata atgccctgca actctaaacc atccttttgt ttacacattt
     2521 ttgtatggta ttttaagatt atcaatcact tcaacatttc tataaccttg tttgtatagc
     2581 actttctcaa gagctgtcag tcccacatac agaatcattt cttttacaaa atgatttaat
     2641 atgtaatcat gtgtcaggac ataaattttg tcacttggga cagtagcttt ccagctaaga
     2701 taattgcgtg aactctgtta aaactgatta tcactcatca atggctttat ttttaaccta
     2761 taaataaccc ctttcaatat acctggtttt tacagcattg caaaatctgt aaaaataact
     2821 tttattggaa aatgtcatga agtcattttt cattatttgt actaaacaat gttttatgta
     2881 ctccttttgt gttttatctt ttgtttttcc atctgtactc ccctcatcct cctaatgttg
     2941 agaaaatcaa atttcctggg tgtgtccttg ttaagtgatc aaaagtaaat gttctctttg
     3001 ccattttaga tggaaaaata aaaaaaatta aaaagtaaat ttttgctttt cattatattg
     3061 aaatgatctg gcattatcta tttcacagta atgtaaaatg cttattttta tgtcaccagt
     3121 tgtcaccact cccattgctg atagtgacat aggttttggg ggcaaaattc agttcctaac
     3181 aaacagtgga tactgctaat gagtcatctt ttctactctc ttcaattttc tactctctac
     3241 tctcctcttt aatttttgca caaaataata ctttgcaaca aatagtcttt tgtctttatt
     3301 ggcagaaaaa tcacttgtta tatgtgttct agttagttct ttttcatgtt agctgtgtgg
     3361 ctaaaagcgt gttacctttc tatatttaaa aaaagtaatc tctgaggata gttacagttc
     3421 ctgtaatata attttatgta cctagtttta tcttttttta aataagaact gaagagagag
     3481 ctttgttaca tatttgaatt tttaatttgc actgctgtat tttaaaccta accataatta
     3541 gtcatttaaa ataattaagt aggcctgaaa gtcagccatg ttaatttctc aatttaatca
     3601 attcttaaag ccttcaaaaa ttgacatttt ttttccaaga cccttcattc tcttaaataa
     3661 ctttaatttt atgaaaccat gtatactaaa gaaaaacttt tccaagattc caggtgattg
     3721 tgcatttgtg ctctaatcta cttttttaac attacggcta atcttttgcg tagacatatc
     3781 gctgtggaat aactgccata tttcagagtt cctcaggttt ccttttcctt ttccagtctc
     3841 tgtctatgaa ttaaatagta tatagaatga cccatataag gcaatatagt taaataaaac
     3901 caggttaaat gatttccttt gtatctgccc aaagttgata gcacacgtta ctttttcaaa
     3961 ataaagctaa aactaccaaa aagaggatga aaactttttc ctcattatgg agtgaagttc
     4021 taggtggttg ctttagaagt tggcagtgca gtgctcagaa ggaactctca ataaataaca
     4081 tgtactcctt ggacctgtga gttttaggaa actggacctt ttctgaagac cttagaatag
     4141 ggagttggcc ttaggaccta atgtcccaac ttagtgttgg acccttttaa tataagatat
     4201 tgttaattat tagcatactt ttcaaaacct ttgaaatagt tactgctaac ctgataaaat
     4261 gttcccatta atctatcatt agtctgtttc tctgaaaaca aaatgcattg atgaggtgaa
     4321 agcttgttcc acatggcacc tacctaatga acaggactta ctcagttttt aactgttaag
     4381 aatgtcacat gtactattgt cactccttag gttttcagct ataaaacatg taagtctctc
     4441 atcatacaga tgaattcatt tgctaacaaa atatttaaaa cccgcagtag actctgaaat
     4501 atccagtcat caaactcctg gctaactgga tgatttggct ataataatct ttattattat
     4561 tattttcatc tgtctctcga aatatctaca gtaggatgtt agtaaatggt cttttaaaag
     4621 caaaaaattg gggataaaag gaaaactgaa ttccttctat atttttatta ctaataaata
     4681 atgcttttgt aaatttgaat ggaaaaccac ttgtatgtat tgctatttgg ttgcagttac
     4741 actctggagc ttaatttaaa acactactct aaaaatttca tgaaggatga attccaataa
     4801 tcagaaaata aatgcatttc aaagctaaaa
//
