LOCUS       NM_001278668            4368 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens RAB23, member RAS oncogene family (RAB23), transcript
            variant 5, mRNA.
ACCESSION   NM_001278668
VERSION     NM_001278668.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4368)
  AUTHORS   Liu,S.J., Zang,Y.W., Huang,C.J. and Liu,Y.J.
  TITLE     Downregulation of Rab23 inhibits hepatocellular carcinoma by
            repressing SHH signaling pathway
  JOURNAL   Cancer Rep (Hoboken) 7 (1), e1921 (2024)
   PUBMED   37884351
  REMARK    GeneRIF: Downregulation of Rab23 inhibits hepatocellular carcinoma
            by repressing SHH signaling pathway.
REFERENCE   2  (bases 1 to 4368)
  AUTHORS   Yang,E., Hong,Y., Xuan,C., Xu,J., Ding,Q., Zhao,S., Ye,H., Fan,X.,
            Jiang,Z., Zhang,S. and Ding,X.
  TITLE     Biomarker of Pulmonary Inflammatory Response in LUAD: miR-584-5p
            Targets RAB23 to Suppress Inflammation Induced by LPS in A549 Cells
  JOURNAL   Protein Pept Lett 30 (10), 877-890 (2023)
   PUBMED   38093594
  REMARK    GeneRIF: Biomarker of Pulmonary Inflammatory Response in LUAD:
            miR-584-5p Targets RAB23 to Suppress Inflammation Induced by LPS in
            A549 Cells.
REFERENCE   3  (bases 1 to 4368)
  AUTHORS   Khairat,R., Elhossini,R., Sobreira,N., Wohler,E., Otaify,G.,
            Mohamed,A.M., Abdel Raouf,E.R., Sayed,I., Aglan,M., Ismail,S. and
            Temtamy,S.A.
  TITLE     Expansion of the phenotypic and mutational spectrum of Carpenter
            syndrome
  JOURNAL   Eur J Med Genet 65 (1), 104377 (2022)
   PUBMED   34748996
  REMARK    GeneRIF: Expansion of the phenotypic and mutational spectrum of
            Carpenter syndrome.
REFERENCE   4  (bases 1 to 4368)
  AUTHORS   Du,W., Li,D., Xie,J. and Tang,P.
  TITLE     miR-367-3p downregulates Rab23 expression and inhibits Hedgehog
            signaling resulting in the inhibition of the proliferation,
            migration, and invasion of prostate cancer cells
  JOURNAL   Oncol Rep 46 (3) (2021)
   PUBMED   34278506
  REMARK    GeneRIF: miR3673p downregulates Rab23 expression and inhibits
            Hedgehog signaling resulting in the inhibition of the
            proliferation, migration, and invasion of prostate cancer cells.
REFERENCE   5  (bases 1 to 4368)
  AUTHORS   Wen,H.L., Xu,Z.M., Lin,S.Y., Wen,D. and Xie,J.P.
  TITLE     miR-597-3p inhibits invasion and migration of thyroid carcinoma
            SW579 cells by targeting RAB23
  JOURNAL   Endokrynol Pol 72 (1), 22-28 (2021)
   PUBMED   32856288
  REMARK    GeneRIF: miR-597-3p inhibits invasion and migration of thyroid
            carcinoma SW579 cells by targeting RAB23.
REFERENCE   6  (bases 1 to 4368)
  AUTHORS   Jenkins,D., Baynam,G., De Catte,L., Elcioglu,N., Gabbett,M.T.,
            Hudgins,L., Hurst,J.A., Jehee,F.S., Oley,C. and Wilkie,A.O.
  TITLE     Carpenter syndrome: extended RAB23 mutation spectrum and analysis
            of nonsense-mediated mRNA decay
  JOURNAL   Hum Mutat 32 (4), E2069-E2078 (2011)
   PUBMED   21412941
  REMARK    GeneRIF: Carpenter syndrome: extended RAB23 mutation spectrum and
            analysis of nonsense-mediated mRNA decay
REFERENCE   7  (bases 1 to 4368)
  AUTHORS   Liu,Y.J., Wang,Q., Li,W., Huang,X.H., Zhen,M.C., Huang,S.H.,
            Chen,L.Z., Xue,L. and Zhang,H.W.
  TITLE     Rab23 is a potential biological target for treating hepatocellular
            carcinoma
  JOURNAL   World J Gastroenterol 13 (7), 1010-1017 (2007)
   PUBMED   17373734
  REMARK    GeneRIF: Rab23 is overexpressed and/or activated in hepatocellular
            carcinoma (HCC). Rab23 may be both a HCC predictor and a target for
            treating HCC.
REFERENCE   8  (bases 1 to 4368)
  AUTHORS   Evans,T.M., Ferguson,C., Wainwright,B.J., Parton,R.G. and
            Wicking,C.
  TITLE     Rab23, a negative regulator of hedgehog signaling, localizes to the
            plasma membrane and the endocytic pathway
  JOURNAL   Traffic 4 (12), 869-884 (2003)
   PUBMED   14617350
REFERENCE   9  (bases 1 to 4368)
  AUTHORS   Marcos,I., Borrego,S. and Antinolo,G.
  TITLE     Molecular cloning and characterization of human RAB23, a member of
            the group of Rab GTPases
  JOURNAL   Int J Mol Med 12 (6), 983-987 (2003)
   PUBMED   14612978
REFERENCE   10 (bases 1 to 4368)
  AUTHORS   Imabayashi,H., Mori,T., Gojo,S., Kiyono,T., Sugiyama,T., Irie,R.,
            Isogai,T., Hata,J., Toyama,Y. and Umezawa,A.
  TITLE     Redifferentiation of dedifferentiated chondrocytes and
            chondrogenesis of human bone marrow stromal cells via chondrosphere
            formation with expression profiling by large-scale cDNA analysis
  JOURNAL   Exp Cell Res 288 (1), 35-50 (2003)
   PUBMED   12878157
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031321.1, DA021294.1,
            AU280196.1 and BC015021.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001278668.1.
            
            Summary: This gene encodes a small GTPase of the Ras superfamily.
            Rab proteins are involved in the regulation of diverse cellular
            functions associated with intracellular membrane trafficking,
            including autophagy and immune response to bacterial infection. The
            encoded protein may play a role in central nervous system
            development by antagonizing sonic hedgehog signaling. Disruption of
            this gene has been implicated in Carpenter syndrome as well as
            cancer. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1-5 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2548201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL031321.1         38320-38320         c
            2-3                 DA021294.1         1-2
            4-565               AU280196.1         3-564
            566-1910            BC015021.1         1001-2345
            1911-4368           AL031321.1         3850-6307           c
FEATURES             Location/Qualifiers
     source          1..4368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1-p11.2"
     gene            1..4368
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="RAB23, member RAS oncogene family"
                     /db_xref="GeneID:51715"
                     /db_xref="HGNC:HGNC:14263"
                     /db_xref="MIM:606144"
     exon            1..120
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            121..340
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..899
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /EC_number="3.6.5.2"
                     /note="RAB family small GTP binding protein RAB 23"
                     /codon_start=1
                     /product="ras-related protein Rab-23"
                     /protein_id="NP_001265597.1"
                     /db_xref="CCDS:CCDS4962.1"
                     /db_xref="GeneID:51715"
                     /db_xref="HGNC:HGNC:14263"
                     /db_xref="MIM:606144"
                     /translation="MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKDYKKTIGV
                     DFLERQIQVNDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRESFEAVSS
                     WREKVVAEVGDIPTVLVQNKIDLLDDSCIKNEEAEALAKRLKLRFYRTSVKEDLNVNE
                     VFKYLAEKYLQKLKQQIAEDPELTHSSSNKIGVFNTSGGSHSGQNSGTLNGGDVINLR
                     PNKQRTKKNRNPFSSCSIP"
     exon            341..426
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            427..583
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            584..666
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            667..759
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     exon            760..4368
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2555..2560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="hexamer: AATAAA"
     polyA_site      2577
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="major polyA site"
     regulatory      4345..4350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="hexamer: AATAAA"
     polyA_site      4368
                     /gene="RAB23"
                     /gene_synonym="HSPC137"
                     /note="major polyA site"
ORIGIN      
        1 agtttcttgt tcatagagtg ctggaatatg aatgagccaa attgtgctgt tccattgaca
       61 ctggttgcta cagaattaac tttactcgga gatccgagga gccatcggca gttcccagga
      121 atttgagagg gaagatctga tctcctagaa ttagagttgg tacagaaacc atttcagctc
      181 caaaaatgtt ggaggaagat atggaagtcg ccataaagat ggtggttgta gggaatggag
      241 cagttggaaa atcaagtatg attcagcgat attgcaaagg catttttaca aaagactaca
      301 agaaaaccat tggagttgat tttttggagc gacaaattca agttaatgat gaagatgtca
      361 gactaatgtt atgggacact gcaggtcagg aggaatttga tgcaattaca aaggcctact
      421 atcgaggagc ccaggcttgt gtgctcgtgt tctctaccac agatagggaa tcttttgaag
      481 cagtttccag ttggagagag aaagtagtag ccgaagtggg agatatacca actgtacttg
      541 tgcaaaacaa gattgatctt ctggatgatt cttgtataaa gaatgaggaa gctgaggcac
      601 tggcaaaaag gttaaagtta agattctaca gaacatcagt gaaagaagat ctaaatgtga
      661 atgaagtttt taagtatttg gctgaaaaat accttcagaa actcaaacaa caaatagctg
      721 aggatccaga actaacgcat tcaagtagta acaagattgg tgtctttaat acatctggtg
      781 gaagtcactc cggtcagaat tcaggtaccc tcaatggtgg agatgtcatc aatcttagac
      841 ccaacaaaca aaggaccaag aaaaacagaa atccttttag cagctgtagc ataccctaag
      901 atgttttggg aggaaaacaa ttgaattaca ttgtgcaatg cattaagaaa cccatccagc
      961 tgtcatggta tgttacaagg ttttcagcag actttgctcc taatggctct ctgaaagtga
     1021 cagacttaaa tattgctctg cagtgctttt cagaatgtag agtgagacct ctggtggaaa
     1081 aattattgcc ctgtggactc ctttaatttt ttttacatta gacgaagctt ctcctgtttg
     1141 taaaggaatg ctataagaaa tttcaaacac aggttttgcg gaattttaaa tgctggaaaa
     1201 cataaatgaa atgcctaaat atattgttac agattttaat actgtggatc aaggaaagat
     1261 agcaagcatt cttttcctga aattggtcat gtagcttttc tgcgaaatag tattgaatct
     1321 gaatactttc acaaaataat actgaaaggt aaaccctaaa tcttgccaga ctgcattagt
     1381 attttggcat tgaaacttgt gcaatatctg tgtaatgtag aatgtggggt gtgcatgcag
     1441 atgtctggta ctggagtaag ctgaaggtat gtgcagtatt taagaaaatg tacattctaa
     1501 ttaattcact tataaaacca tttacatatt gtgtatatgt ttttattttc aaatgataaa
     1561 ctctagacat atattttgca aaatgagctt gggtttaaaa agtgctttgt gccaaaaata
     1621 tcatacctaa tttttatagt gctttactat cagaatttat attgtttatt atatctttta
     1681 aaagcagtaa gcagttttca tctgacagcg tagataaaag aggagtatag gaatttgaat
     1741 gctagagcat ctcccaggtg agccttattg cagatctttt tgatatagtc acccataagc
     1801 atggtgagct cctgctctca taaggtcagc caaagcccct taagaaggta cacagcacat
     1861 ctgcagtcat tcaggaggtc ctgtgaagtg tggtgatgca tctaacacct tttgctgctc
     1921 actgagaacc cagctttgaa cttacaagat tacactaacc atttttaaag tgcacaaaaa
     1981 tattattatt agtcttaact aaaattacat attttataat gccctgcaac tctaaaccat
     2041 ccttttgttt acacattttt gtatggtatt ttaagattat caatcacttc aacatttcta
     2101 taaccttgtt tgtatagcac tttctcaaga gctgtcagtc ccacatacag aatcatttct
     2161 tttacaaaat gatttaatat gtaatcatgt gtcaggacat aaattttgtc acttgggaca
     2221 gtagctttcc agctaagata attgcgtgaa ctctgttaaa actgattatc actcatcaat
     2281 ggctttattt ttaacctata aataacccct ttcaatatac ctggttttta cagcattgca
     2341 aaatctgtaa aaataacttt tattggaaaa tgtcatgaag tcatttttca ttatttgtac
     2401 taaacaatgt tttatgtact ccttttgtgt tttatctttt gtttttccat ctgtactccc
     2461 ctcatcctcc taatgttgag aaaatcaaat ttcctgggtg tgtccttgtt aagtgatcaa
     2521 aagtaaatgt tctctttgcc attttagatg gaaaaataaa aaaaattaaa aagtaaattt
     2581 ttgcttttca ttatattgaa atgatctggc attatctatt tcacagtaat gtaaaatgct
     2641 tatttttatg tcaccagttg tcaccactcc cattgctgat agtgacatag gttttggggg
     2701 caaaattcag ttcctaacaa acagtggata ctgctaatga gtcatctttt ctactctctt
     2761 caattttcta ctctctactc tcctctttaa tttttgcaca aaataatact ttgcaacaaa
     2821 tagtcttttg tctttattgg cagaaaaatc acttgttata tgtgttctag ttagttcttt
     2881 ttcatgttag ctgtgtggct aaaagcgtgt tacctttcta tatttaaaaa aagtaatctc
     2941 tgaggatagt tacagttcct gtaatataat tttatgtacc tagttttatc tttttttaaa
     3001 taagaactga agagagagct ttgttacata tttgaatttt taatttgcac tgctgtattt
     3061 taaacctaac cataattagt catttaaaat aattaagtag gcctgaaagt cagccatgtt
     3121 aatttctcaa tttaatcaat tcttaaagcc ttcaaaaatt gacatttttt ttccaagacc
     3181 cttcattctc ttaaataact ttaattttat gaaaccatgt atactaaaga aaaacttttc
     3241 caagattcca ggtgattgtg catttgtgct ctaatctact tttttaacat tacggctaat
     3301 cttttgcgta gacatatcgc tgtggaataa ctgccatatt tcagagttcc tcaggtttcc
     3361 ttttcctttt ccagtctctg tctatgaatt aaatagtata tagaatgacc catataaggc
     3421 aatatagtta aataaaacca ggttaaatga tttcctttgt atctgcccaa agttgatagc
     3481 acacgttact ttttcaaaat aaagctaaaa ctaccaaaaa gaggatgaaa actttttcct
     3541 cattatggag tgaagttcta ggtggttgct ttagaagttg gcagtgcagt gctcagaagg
     3601 aactctcaat aaataacatg tactccttgg acctgtgagt tttaggaaac tggacctttt
     3661 ctgaagacct tagaataggg agttggcctt aggacctaat gtcccaactt agtgttggac
     3721 ccttttaata taagatattg ttaattatta gcatactttt caaaaccttt gaaatagtta
     3781 ctgctaacct gataaaatgt tcccattaat ctatcattag tctgtttctc tgaaaacaaa
     3841 atgcattgat gaggtgaaag cttgttccac atggcaccta cctaatgaac aggacttact
     3901 cagtttttaa ctgttaagaa tgtcacatgt actattgtca ctccttaggt tttcagctat
     3961 aaaacatgta agtctctcat catacagatg aattcatttg ctaacaaaat atttaaaacc
     4021 cgcagtagac tctgaaatat ccagtcatca aactcctggc taactggatg atttggctat
     4081 aataatcttt attattatta ttttcatctg tctctcgaaa tatctacagt aggatgttag
     4141 taaatggtct tttaaaagca aaaaattggg gataaaagga aaactgaatt ccttctatat
     4201 ttttattact aataaataat gcttttgtaa atttgaatgg aaaaccactt gtatgtattg
     4261 ctatttggtt gcagttacac tctggagctt aatttaaaac actactctaa aaatttcatg
     4321 aaggatgaat tccaataatc agaaaataaa tgcatttcaa agctaaaa
//
