LOCUS       NM_020673               8651 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RAB22A, member RAS oncogene family (RAB22A), mRNA.
ACCESSION   NM_020673
VERSION     NM_020673.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8651)
  AUTHORS   Cao,P., Chen,H., Zhang,Y., Zhang,Q., Shi,M., Han,H., Wang,X.,
            Jin,L., Guo,B., Hao,R., Zhao,X., Li,Y., Gao,C., Liu,X., Wang,Y.,
            Yang,A., Yang,C., Si,A., Li,H., Song,Q., He,F. and Zhou,G.
  TITLE     Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma
            Through Reducing the Rab22A-Mediated Endolysosomal Trafficking and
            Degradation of EGFR
  JOURNAL   Adv Sci (Weinh) 11 (40), e2405459 (2024)
   PUBMED   39206796
  REMARK    GeneRIF: Genomic Amplification of TBC1D31 Promotes Hepatocellular
            Carcinoma Through Reducing the Rab22A-Mediated Endolysosomal
            Trafficking and Degradation of EGFR.
REFERENCE   2  (bases 1 to 8651)
  AUTHORS   Papanikolaou,N.A., Kakavoulia,M., Ladias,C. and Papavassiliou,A.G.
  TITLE     The ras-related protein RAB22A interacts with hypoxia-inducible
            factor 1-alpha (HIF-1alpha) in MDA-MB-231 breast cancer cells in
            hypoxia
  JOURNAL   Mol Biol Rep 51 (1), 564 (2024)
   PUBMED   38647725
  REMARK    GeneRIF: The ras-related protein RAB22A interacts with
            hypoxia-inducible factor 1-alpha (HIF-1alpha) in MDA-MB-231 breast
            cancer cells in hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8651)
  AUTHORS   Fan,B., Wang,L. and Wang,J.
  TITLE     RAB22A as a predictor of exosome secretion in the progression and
            relapse of multiple myeloma
  JOURNAL   Aging (Albany NY) 16 (5), 4169-4190 (2024)
   PUBMED   38431306
  REMARK    GeneRIF: RAB22A as a predictor of exosome secretion in the
            progression and relapse of multiple myeloma.
REFERENCE   4  (bases 1 to 8651)
  AUTHORS   Yin,X., Chen,H., Sun,G., Xu,Y. and Wang,L.
  TITLE     Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced
            Apoptosis, Inflammation, Oxidative Stress and Cholesterol
            Accumulation of Macrophages via Mediating RAB22A Expression by
            Targeting miR-377
  JOURNAL   Appl Biochem Biotechnol 195 (11), 6586-6606 (2023)
   PUBMED   36892682
  REMARK    GeneRIF: Circ-C16orf62 Regulates Oxidized low-density
            Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and
            Cholesterol Accumulation of Macrophages via Mediating RAB22A
            Expression by Targeting miR-377.
REFERENCE   5  (bases 1 to 8651)
  AUTHORS   Nakashima,S., Matsui,T. and Fukuda,M.
  TITLE     Vps9d1 regulates tubular endosome formation through specific
            activation of Rab22A
  JOURNAL   J Cell Sci 136 (6) (2023)
   PUBMED   36762583
  REMARK    GeneRIF: Vps9d1 regulates tubular endosome formation through
            specific activation of Rab22A.
REFERENCE   6  (bases 1 to 8651)
  AUTHORS   Kauppi,M., Simonsen,A., Bremnes,B., Vieira,A., Callaghan,J.,
            Stenmark,H. and Olkkonen,V.M.
  TITLE     The small GTPase Rab22 interacts with EEA1 and controls endosomal
            membrane trafficking
  JOURNAL   J Cell Sci 115 (Pt 5), 899-911 (2002)
   PUBMED   11870209
  REMARK    GeneRIF: Rab22a may regulate the dynamic interactions of endosomal
            compartments and it may be involved in the communication between
            the biosynthetic and early endocytic pathways.
REFERENCE   7  (bases 1 to 8651)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 8651)
  AUTHORS   Opdam,F.J., Kamps,G., Croes,H., van Bokhoven,H., Ginsel,L.A. and
            Fransen,J.A.
  TITLE     Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21
            is an apically located GTP-binding protein in polarised intestinal
            epithelial cells
  JOURNAL   Eur J Cell Biol 79 (5), 308-316 (2000)
   PUBMED   10887961
REFERENCE   9  (bases 1 to 8651)
  AUTHORS   Bucci,C., Chiariello,M., Lattero,D., Maiorano,M. and Bruni,C.B.
  TITLE     Interaction cloning and characterization of the cDNA encoding the
            human prenylated rab acceptor (PRA1)
  JOURNAL   Biochem Biophys Res Commun 258 (3), 657-662 (1999)
   PUBMED   10329441
REFERENCE   10 (bases 1 to 8651)
  AUTHORS   Bao,S., Zhu,J. and Garvey,W.T.
  TITLE     Cloning of Rab GTPases expressed in human skeletal muscle: studies
            in insulin-resistant subjects
  JOURNAL   Horm Metab Res 30 (11), 656-662 (1998)
   PUBMED   9918381
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB452461.1, BC015710.1,
            AL035455.30 and BC042545.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020673.2.
            
            Summary: The protein encoded by this gene is a member of the RAB
            family of small GTPases. The GTP-bound form of the encoded protein
            has been shown to interact with early-endosomal antigen 1, and may
            be involved in the trafficking of and interaction between endosomal
            compartments. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091180.1, AJ276210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244040.4/ ENSP00000244040.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                DB452461.1         1-75
            76-1816             BC015710.1         1-1741
            1817-8643           AL035455.30        60518-67344
            8644-8651           BC042545.1         2715-2722
FEATURES             Location/Qualifiers
     source          1..8651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..8651
                     /gene="RAB22A"
                     /note="RAB22A, member RAS oncogene family"
                     /db_xref="GeneID:57403"
                     /db_xref="HGNC:HGNC:9764"
                     /db_xref="MIM:612966"
     exon            1..298
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..847
                     /gene="RAB22A"
                     /note="GTP-binding protein RAB22A; rab-22"
                     /codon_start=1
                     /product="ras-related protein Rab-22A"
                     /protein_id="NP_065724.1"
                     /db_xref="CCDS:CCDS33497.1"
                     /db_xref="GeneID:57403"
                     /db_xref="HGNC:HGNC:9764"
                     /db_xref="MIM:612966"
                     /translation="MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMT
                     KTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKE
                     LRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFI
                     EISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC"
     exon            299..378
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     exon            379..460
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     exon            461..532
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     exon            533..639
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     exon            640..749
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     exon            750..8651
                     /gene="RAB22A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB22A"
                     /note="hexamer: AATAAA"
     polyA_site      1809
                     /gene="RAB22A"
                     /note="major polyA site"
     regulatory      8626..8631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB22A"
                     /note="hexamer: AATAAA"
     polyA_site      8651
                     /gene="RAB22A"
                     /note="major polyA site"
ORIGIN      
        1 aggtgacgcg gccggcgtcc caagatggcg gcggcggcgg ctcccggaag gccgcggcgg
       61 cgtcccggct gctaaggcgg gccccacgcg gctggcagcg gacaggccgg acctacggcc
      121 ggaggacggg cggcagccgc ctctgcgcgg accggggctg ggccgtgcgg cggcagcggc
      181 gccaggggat gctcttgctg ggcctggcct ctcccttctc aacttagggc ggcggcgggc
      241 ccgcgcccct ggctcccggg ccatggcgct gagggagctc aaagtgtgtc tgctcgggga
      301 tacaggtgta ggtaaatcga gtattgtgtg gcggtttgtg gaagacagtt ttgatccaaa
      361 catcaaccca acaatagggg catcttttat gaccaagact gtccagtacc aaaatgagct
      421 acataaattc ctaatctggg atacagctgg acaagaacga tttcgtgcct tagcaccaat
      481 gtactatcga gggtcggctg cagctataat cgtttatgat atcacaaaag aagagacatt
      541 ttcaacatta aagaattggg tgaaagagct tcgacagcat ggcccaccta atattgtagt
      601 tgccattgca ggaaataaat gtgatcttat cgatgtaaga gaagtcatgg agagagatgc
      661 aaaggactac gccgactcta ttcatgcaat ttttgtagag accagcgcaa aaaacgcgat
      721 aaacataaat gaactcttta tagaaattag tcgaagaatt ccatccactg acgccaacct
      781 gccatctggc ggtaagggct tcaaactccg aagacagcct tcagagccaa agcggagctg
      841 ctgctgaccg aacctcagcc tctcagactt gatgatgaag taggtggtcc tgaaagttaa
      901 caggagggct ggggtccctg ccaccagttt tcacctagcc agtcttgagt cttctccgtg
      961 caaaaaggat tcacagaaat ggaccagttc tgttctccaa agactgcagc aatgatattt
     1021 cagtctgtga acttctatta tgtaaagaat ctctagtgta caaagggact acatcgttgg
     1081 cttttgacct tgctgaaaag gaacatataa ttgtatggat ggtaggatta agttgttgag
     1141 tagttttgta atcaagattt tatgtaacat ttgtaaaggg aaaattagca cttttgtggt
     1201 tcttaaggga aaagaaacag accttgtgga gattataatt tccttggttt ctgttaccac
     1261 tgttagaggg agttgtatca tttaacatat agtaggatag tttaagtgta gggaggacaa
     1321 ttattgtctg aagctaaaat gggttattta taggactgat ggaaatgatt tcatctctgc
     1381 catctctaaa gcacttttca ttgaacatgt tagcctagga tacgtacagt aaattaacaa
     1441 tgatagcagc agatgcctag ctcatcctgg gtttgcttct gaccttgtca tgtgtgtgcc
     1501 accaaacacg ttattggcac ctttttaaat aagctctcat gatcaagatg gtgatggtag
     1561 agaagctgcc cggaataaac tgaatttcat atgttctaaa atgactagca atggtttaaa
     1621 aaggaagaag agtggaagtg aagaaggtgg tataaatgct gtcaattttt ttttaaccca
     1681 agtattttgg tggggaaaag caagtatcta ttgcttagca tatgtaaagt tgtagtctat
     1741 atttatgggg ccattgctta aagattataa attatgtaaa tacattaata aattctaagt
     1801 ttcatttgac attccattga atctcgcacc cagtcttgcg tatgcctgcc cagttttcag
     1861 cctcttaacg ggagactcaa gcacattggt attgtataaa ggtatagagc acttagctta
     1921 caatctttaa aggtttctct gccttccctt ctacccaccc gcctcccacc agatcccatc
     1981 tggaaatcat aataaagaca tatgccactt tgacaaacct gactagtcct tactagcctg
     2041 agggtaaaag attaagctcc aacctcaagt catttacctg gtcttggtaa taagtttctt
     2101 ttagcttgta cagcatcctc agaccaactg aggagctttc cttgttaaca atttagctta
     2161 tctttctgtt tcctttattt ttcccctgcc tctgttagtg gttaacactc ttttccctca
     2221 gggagcctaa tgaggttttt aatatcatct aaaaataaag cattgaagtg aagttggtga
     2281 aaatttgttc ctggtctaat ttggcaccct tccaacctga gtattgtagg ggaaggaaat
     2341 ttacaagatt taataggaaa tgaaacagct tgaatttcaa actaaattgt attttcagag
     2401 ctatcctgaa actgaacagc tgaaacttta aaaaataatt ggtattattt tgtgcccccc
     2461 acttaatatg gatagatttt aatgggaaaa ttataattca gattaaataa aaaacaattc
     2521 ccttttccct gttgtatatc ttaagcattt ggaatttttt ttatcttctg aaatcatata
     2581 aaaagaatgt cattagtaaa aattctaact tcgttttgtt taaaagacat gtggatgctc
     2641 catgccccta ggattttgct tcctccccgg tgctaaatta gcaagctcct agagaagcca
     2701 tgtgattccc agagccaggc gctttacacc taaagtagtt tgactttctt ctgtatacat
     2761 ccagatggat cccaggcatc cgggcaccac cctggtgtgt ccctagaatt cccactgctg
     2821 ggcctctatc tccatgacaa caaaataaaa acagaggttg cttgactcat taccaaagag
     2881 gcaaagcatg tgcgaccctt tctgtcttat tttaccaaaa gatggtgcaa atctatgacc
     2941 ttcacatttt ttccaccaca cccaccagta gctgttggtg attgcatggt gtctcggtgc
     3001 atggggaaag gcaaggtctt ctgagctcat cttaactggt gaggcatctg gatgtgtctg
     3061 atcttactgt gatgttttac tgtaccgagc ccaatgtggg tccatctcat cagccctttg
     3121 ctgatttcat gatttctcac cctccctccc atatgtaggg tgtgattctg ttttattata
     3181 gccacatgtt ttattaacag aatgagtgat atgaagcttg tacttatgca tttctcgggc
     3241 ctcttccctc attttcatca gtctgtctaa gaacttgact cggcactgtt tctcgtgtaa
     3301 tatccttcta atgcttagca acaacaacaa aaaattgctc tctcagatcc ataatccata
     3361 ctcagtgaaa gcagggaaaa aatattttca cttattttat ttgcttctaa aatgcaaaga
     3421 tgaatactaa agtcagaagc agtgtttcat tttgaacaca ttttggatta ttaagctgac
     3481 taagcaatga tctaatacac atttcatatt ttctttataa taatttctta tggagaagag
     3541 gctatatttc aaaggaattg agacatactc ccatctataa acatgtttgg ttttcttacg
     3601 atacagggcc atttttttaa aactctcagg actgaacaga agagaaaaat tattaattag
     3661 ctgctactgt atgttgattc ttttcggaga aattgaaata agctctttgc aggcgtccaa
     3721 tcctagaaac caatggtctc cagaactctc acacaagtgt ttttctgatt ctatgataac
     3781 taattaacca tcatctggtg attaaaagaa cataaagtaa gattatgatt aagtgtccat
     3841 cacctgcctg tcagccgtgg tcagaataag ttttacacga agcaggtgaa agatttagtt
     3901 cttttcaaag taacttattt tcttgtgacc cgtttatgat gttgtttgaa gtccctgttt
     3961 cccattgtgt acgcactttc tggatgtctg gaaggatcgg gacttttgtg tgagaggctt
     4021 gagcgcctcc tctatgtggg ctggtgtcct tcttgaagtt gtcaattcct cttattctta
     4081 aatatctaaa gggaaaggaa accaacttta atttcagaac ttctctttac gtcttgtatg
     4141 tatttctttt ctgttctcaa ggaggaaaat tggtctagga agccttctaa attaaactct
     4201 gggaaatata gtaatgaaaa tatcctttag ctaactttcc tgtaactgtc aaaccaaaat
     4261 gtcagtattt ttagggcatt gtgttaaaat aagcagttta gattccgacg acactgcact
     4321 aattggcatg tcagcctcca gctcagaaag gcatttgctc atggttacag gcatctttta
     4381 gattctaaga gtgagttaca gaattctttt tggtactttc acttattctt tcagaataca
     4441 tcaaggatgt gatttatggg cccttaagag tataagatat aggtgcacag tatgttactt
     4501 aagtaacgga tgagcccccc taaacatcca cgtgtctctg caggaacctg tgtaagtatt
     4561 gtgaaaaccc ttttcttcca gggaaaaatt attggaaatt ccttaactga gctatacttg
     4621 gtacttgctc tagaacattt gggaaatgac aaactcaggc tggctctcct ctctaacctc
     4681 actgggctat aaatgttcct tctaactctg taatgaaagt tcagtgacaa actagatagt
     4741 gaacctgtga aagtcattat ttacatttgc tttaaaggga cagttttacc gttcaacttc
     4801 aagagttttt ctacctcttt aacagttaat attttttaaa ggaagaaatg gaatgtacct
     4861 tcaggggtca agctgttaac tgtatacctg cctctagtta gcttggttta tcaaaaggat
     4921 ttttaaatga ttcaaggtaa tgtttaggat atttgtttta actcctgctg tgctgtgatt
     4981 taaaaaaaaa tagtctaaga aacaaattta tccatgagat aaacatcata ttttatagtt
     5041 ttagaaaaaa gggttggggg tggaatttag cctagaactt aaagaaacaa cctctgcgaa
     5101 tttctcttga cagcggagtt gcttgtcttg acttctaata atataaatcc aggcagtttg
     5161 attatccgat ttgcaagaaa ctttaatgga attctggggc atttgtcctg ttttatgtgc
     5221 aaatgaaagt ctaaaaaata tgaggaagat attacatttt tcaggagcct ccattttttc
     5281 agtctaagag aatgataagt gagaggccta ttgtgatgaa gttgcattgg acataatgtg
     5341 ggaagtgaat aaatagaacc aagaatcttc atctatctct gttggtcttt caggattctc
     5401 ttagcatata ggaaaatgat ttaccttcca gatctcgaag gacttccaat agcatagatc
     5461 aggtttaatt tgatggtcta taccatcaga aataactaat atctgttttc tttcctttta
     5521 gagtataatc aattatggat aggccagaat atttttggct tcaaaacaaa aggattcata
     5581 agcttaaaaa aacaaaaatc ccaaaccttc catctatccc ttttattacg ttgaacattt
     5641 tagatagtaa gattaagatg tatcattagt atatggtgaa attaaaaccg tggtgtctaa
     5701 cagatttaac aaaaagtgtt taatttactg caagttcatt tttagatctg tatggtgccc
     5761 agtactccac aaaatgcatc ataattgaaa caacaaaatt attttcatga gcaagaattc
     5821 aagtatcaag gcctatcagc caattaaaag ccgtaagata gtaatgattt tttttctttt
     5881 tttttttttt tcttttttta gatggagtct cactctgtcg cccaggctgg tatgcagtgg
     5941 cgcgatctca gctcactgca acctgtctcc tgggttcaag cagttctcct gcctcagcct
     6001 cctgagtagc tgggatgaca ggcgtgcacc accataccca gctaattttt gtatttttag
     6061 tagagatggg gtttcaccat gtttgccagg ctggtctcga actcctgacc tcaggtgatc
     6121 tgcttgcctc ggcttcgcaa cattctggga ttacagacgt gagccaccgc gcccaaccag
     6181 taacgatttt tttaaagggc ctttcttaat tgacagtttt aagctgtaga cattaatatt
     6241 ataacaaaca aaacatgcca gttttactga ttccgctttt tgcttgattc aggaactttt
     6301 cattgtttgg ggaagctttt gaatgcagta ctgtggagga aatcatcctt aaaatagcat
     6361 ttcacacata gggccaaaat tgaaattgtc aaggaaaccc ctcagcatct aacgtcatct
     6421 tgtagaagag ctgggcatac ctcttcctct aggccaattc agaggccact ggccacccaa
     6481 gtagagtggg gcccactggc atgagtagtc cctgtgccca tgcccatggt ggtgcttgac
     6541 tttgctttgg ggcttaatcc tagtatcatt tggccattaa tttttaatta agtttatact
     6601 tgaataatca gttttactcc tgaaaaattt tgaagccagc actgactttg tttatattca
     6661 cttaccttgt atatgaactt atgacattag agtttgtgaa actgtcttaa cgtggctcat
     6721 acacgtgatg tcagagggac tggtcagttc tttacagggt gaattaatcg gcagctggct
     6781 agtcagagca actgatgggt ggcttttttt tctttttttt tttgagacgg agtctcgctc
     6841 tgtcacccag gctggagtgt aagggcgcga tctcggctca ctgcaacctc cgcctcccag
     6901 gttcaagcaa ttctcctgcc tcagccacct gaatagctag gattacaggc gcccgccccc
     6961 acacccggct aatatttttt gtatttttag tagagacagg gtttcaccgt gttgatcagg
     7021 ctggtctcga actcctgacc tcacgatccg cccgcctcgg cctcccaaag tgctgggatt
     7081 acaggcgtga gtggtggccc tatttttaaa ccattcgtta cgctgtgtag acagagcttt
     7141 attgccctgg aaaagatttt ttttttaact ctcatgcagt tcagtctttc catcatttca
     7201 ctttgtgagt cactcacata attgtcaatc attcctctga ccttcttaag aatttacacc
     7261 ttaccgtctc tgtgattgaa gcagacttct cgctttattt cccttaggct catttttctg
     7321 tgggctctcc cttaaagaca catggccaca gacacctcct tcgcatatgt aatctgcctt
     7381 cccctgcggc cttccgtggt cacagcaaca gggactgctc accccctcca gctggggctt
     7441 ttctaacaag cacagtcaga aatgcgcagg cctggggttg gggatgaaca gaagttgatt
     7501 agtgggcaca gaaatacagt tagatagaag gaatagttcc agcattcgat attacagtag
     7561 ggagactgca tttaacaata attgattgta tatttgaaaa cagctagaag aataagaata
     7621 ttcccaacac aaagaaaaga taagcgaggt gaaggaaatc ccagttaccc tcattcagtc
     7681 cattacacat tcgatacagg tatcaaaata tcataggcac ctcaaagaca tgtacaactc
     7741 ttaatttaac atttttgaaa gaaaaaaaaa ccggccagag cattaaaaca aataaaataa
     7801 gaaacacaga ggccagtgtt aggtgaagaa ctccgctgct tcagaaagag aatagcagcg
     7861 ctcgcttacc gtgggaacac ggccagttaa caaaatgggt tttggttttt tgttttgttt
     7921 tgttttacca ttggtaataa gatagttaac ataagtggtc agaacttcgc tgaatttgta
     7981 ataaagcatt tgttaagcgt gtaaaagtcc aaattaaaag tcttgaagaa aaacagctat
     8041 ggcaatgagc ctagacattt ttcaaaaaaa aaagctaagc cgtcctacca gcaatctctc
     8101 tttctcctaa gaatgtcatg ccttctcaag acctgatgaa aggaataaga tatttgtgcc
     8161 tttttataaa agcatctatt acgaaagtaa aattcagttg cttacagttt tggccgcttt
     8221 gtagcactat tataaacagc ccaaatttat ggccttggac ttactgcatg acacatggcc
     8281 tggttacctg tcatggaatg ctgcagtggt ggtttgccaa gcttctgtgg atgtttgaag
     8341 actttatttt tgcagtctta accttgggct ggacctaagt gtatgtaaac catatgatgc
     8401 ctgtattgtt tatagatgct gacaaaagaa aactagacct tttgtttttt gttgtaagat
     8461 ttttgttttc atgcctatgc tcatagtaga tagtttgcaa atgaaagttg atttgccata
     8521 cttttaaata atattgtttt agcttgaata ttctataata cacttttata gagtataaca
     8581 tgctaaatca ctgttttgtt gtaagaaggg tgtaaacatt ttgttaataa aatgctatgt
     8641 ttacaaatat a
//
