LOCUS       NM_014999              15558 bp    mRNA    linear   PRI 10-SEP-2023
DEFINITION  Homo sapiens RAB21, member RAS oncogene family (RAB21), mRNA.
ACCESSION   NM_014999
VERSION     NM_014999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15558)
  AUTHORS   Li X, Ni J, Qing H and Quan Z.
  TITLE     The Regulatory Mechanism of Rab21 in Human Diseases
  JOURNAL   Mol Neurobiol 60 (10), 5944-5953 (2023)
   PUBMED   37369821
  REMARK    GeneRIF: The Regulatory Mechanism of Rab21 in Human Diseases.
            Review article
REFERENCE   2  (bases 1 to 15558)
  AUTHORS   Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, Zhang R, Tan J and Zhang X.
  TITLE     RAB21 controls autophagy and cellular energy homeostasis by
            regulating retromer-mediated recycling of SLC2A1/GLUT1
  JOURNAL   Autophagy 19 (4), 1070-1086 (2023)
   PUBMED   35993307
  REMARK    GeneRIF: RAB21 controls autophagy and cellular energy homeostasis
            by regulating retromer-mediated recycling of SLC2A1/GLUT1.
REFERENCE   3  (bases 1 to 15558)
  AUTHORS   Zhang K, Fang T, Zhao D, Cen F, Yan X and Jin X.
  TITLE     Circular RNA Circ_0008043 promotes the proliferation and metastasis
            of hepatocellular carcinoma cells by regulating the microRNA
            (miR)-326/RAB21 axis
  JOURNAL   Bioengineered 13 (3), 6600-6614 (2022)
   PUBMED   35220907
  REMARK    GeneRIF: Circular RNA Circ_0008043 promotes the proliferation and
            metastasis of hepatocellular carcinoma cells by regulating the
            microRNA (miR)-326/RAB21 axis.
REFERENCE   4  (bases 1 to 15558)
  AUTHORS   Liu P, Wu A, Li H, Zhang J, Ni J, Quan Z and Qing H.
  TITLE     Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway
            and the Autophagy-Lysosome Pathway
  JOURNAL   Int J Mol Sci 23 (3), 1131 (2022)
   PUBMED   35163051
  REMARK    GeneRIF: Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome
            Pathway and the Autophagy-Lysosome Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15558)
  AUTHORS   Del Olmo T, Lacarriere-Keita C, Normandin C, Jean D, Boisvert FM
            and Jean S.
  TITLE     RAB21 interacts with TMED10 and modulates its localization and
            abundance
  JOURNAL   Biol Open 8 (9) (2019)
   PUBMED   31455601
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15558)
  AUTHORS   Simpson JC, Griffiths G, Wessling-Resnick M, Fransen JA, Bennett H
            and Jones AT.
  TITLE     A role for the small GTPase Rab21 in the early endocytic pathway
  JOURNAL   J Cell Sci 117 (Pt 26), 6297-6311 (2004)
   PUBMED   15561770
REFERENCE   7  (bases 1 to 15558)
  AUTHORS   Pereira-Leal JB and Seabra MC.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
REFERENCE   8  (bases 1 to 15558)
  AUTHORS   Simpson JC, Wellenreuther R, Poustka A, Pepperkok R and Wiemann S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 15558)
  AUTHORS   Opdam FJ, Kamps G, Croes H, van Bokhoven H, Ginsel LA and Fransen
            JA.
  TITLE     Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21
            is an apically located GTP-binding protein in polarised intestinal
            epithelial cells
  JOURNAL   Eur J Cell Biol 79 (5), 308-316 (2000)
   PUBMED   10887961
REFERENCE   10 (bases 1 to 15558)
  AUTHORS   Bao S, Zhu J and Garvey WT.
  TITLE     Cloning of Rab GTPases expressed in human skeletal muscle: studies
            in insulin-resistant subjects
  JOURNAL   Horm Metab Res 30 (11), 656-662 (1998)
   PUBMED   9918381
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB990575.1, AF091035.1 and
            AC089984.23.
            
            On Nov 23, 2018 this sequence version replaced NM_014999.3.
            
            Summary: This gene belongs to the Rab family of monomeric GTPases,
            which are involved in the control of cellular membrane traffic. The
            encoded protein plays a role in the targeted trafficking of
            integrins via its association with integrin alpha tails. As a
            consequence, the encoded protein is involved in the regulation of
            cell adhesion and migration. Expression of this gene is associated
            with a poor prognosis for glioma patients. This gene is
            downregulated by the tumor suppressor miR-200b, and miRNA-200b is
            itself downregulated in glioma tissues. [provided by RefSeq, Nov
            2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.92650.1,
                                           SRR1803611.205270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261263.5/ ENSP00000261263.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CB990575.1         28-42
            16-2642             AF091035.1         4-2630
            2643-15558          AC089984.23        20616-33531
FEATURES             Location/Qualifiers
     source          1..15558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.1"
     gene            1..15558
                     /gene="RAB21"
                     /note="RAB21, member RAS oncogene family"
                     /db_xref="GeneID:23011"
                     /db_xref="HGNC:HGNC:18263"
                     /db_xref="MIM:612398"
     exon            1..426
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..945
                     /gene="RAB21"
                     /EC_number="3.6.5.2"
                     /note="GTP-binding protein RAB21"
                     /codon_start=1
                     /product="ras-related protein Rab-21"
                     /protein_id="NP_055814.1"
                     /db_xref="CCDS:CCDS9003.1"
                     /db_xref="GeneID:23011"
                     /db_xref="HGNC:HGNC:18263"
                     /db_xref="MIM:612398"
                     /translation="MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKF
                     NDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDIT
                     DEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYH
                     TSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSG
                     GGCCSSG"
     exon            427..486
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     exon            487..594
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     exon            595..658
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     exon            659..713
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     exon            714..802
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     exon            803..15558
                     /gene="RAB21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2682..2687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB21"
                     /note="hexamer: AGTAAA"
     polyA_site      2706
                     /gene="RAB21"
                     /note="major polyA site"
     regulatory      5256..5261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB21"
                     /note="hexamer: AATAAA"
     polyA_site      5277
                     /gene="RAB21"
     regulatory      5852..5857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB21"
                     /note="hexamer: AATAAA"
     polyA_site      5874
                     /gene="RAB21"
     regulatory      6013..6018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB21"
                     /note="hexamer: CATAAA"
     polyA_site      6032
                     /gene="RAB21"
     regulatory      15538..15543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB21"
                     /note="hexamer: AATAAA"
     polyA_site      15558
                     /gene="RAB21"
ORIGIN      
        1 gtaggaggaa ggagacgcca ttagagggag gcagagaggg atcgttcttc gcttttcctc
       61 cggtgcctga cgtggtgggc tggggccctt cattctcgga ctttccctca gcccttccag
      121 gcctcgcccg aggagggcgt ggggacagcg cccgggtcgg cggggccggg gcggtggggg
      181 ctgagccggc cgtggctgtg aaggcgctgc cgcggctgtc gggagggcgg cgcgacactc
      241 gggctcgggc ggccgggaag cgacgggatg gctgcggccg gcggcggcgg cggcggggcg
      301 gcggcggcgg gccgagccta ctcgttcaag gtggtgctgc tgggggaagg ctgcgtgggg
      361 aagacgtcgc tggtgctgcg ctactgcgag aacaagttta acgacaagca catcaccact
      421 ctgcaggcat cattcttaac aaagaagtta aatattggtg ggaaaagagt aaaccttgcc
      481 atatgggata cggcaggtca agagagattc catgcattgg gtccaattta ctacagagat
      541 tcaaatggag cgattttagt ttatgacata acagatgaag attcttttca gaaggtaaaa
      601 aactgggtca aagaattacg gaaaatgttg ggaaatgaaa tctgtttatg tatagttggt
      661 aataaaatag acttggaaaa ggagagacat gtttccattc aagaagcaga gtcgtatgca
      721 gaatctgtgg gagcaaaaca ttatcatact tcagccaaac agaacaaagg aattgaggaa
      781 ctctttcttg acctttgtaa aaggatgata gaaacagcac aagtggatga gagagcaaaa
      841 ggcaatggct ctagtcagcc gggaactgca aggcgaggtg tacagattat tgatgatgaa
      901 cctcaagccc agaccagtgg tggagggtgc tgttcttctg gataactgtt cacgcctaag
      961 aaattaaaag acagaacaaa actgtggatc attgccctca acatgaagac tgccatattc
     1021 caagtcacat tattttacca atggaattat agaattaaca gtattttaaa ttacgtttat
     1081 aacactgcag agaccttaag tgctaaactt agtggagttt gtgaccagag aattggcatt
     1141 ttctacaaat gttttttttt gttttttttt tgtttttttt tgtttttttt tgagacggag
     1201 tctcgctctg tcacccaggc tggagtgcac tggcttgatc tcggctcact gcaagctcca
     1261 cctcccaggt tcacgccatt ctcctgcctc agcctcccga gtagctggga ctataggcgc
     1321 ccaccacgac gcccggctaa ttttttgtat ttttagtaga gacggggttt caccaggtta
     1381 gccaggatgg tctcgatctc ctgaccttgt gatccgcccg cctcggcctc ccaaagtgct
     1441 gggattacag gcgtgagcca ccgtgcccgg cctacaaatg ttaacaaagc aattaccaat
     1501 ggccttttta catatttttt ctttaatgag gaataatatg catgtagaaa agacctactt
     1561 aaagtcttca tttatattct ttcaaatcaa atctttattt aataacttat atatgttgtt
     1621 ggaatggtta catttttgca gccctttgta ttttgtggta gttgaaattg tatcacttct
     1681 aaacagcaaa ctgtttttgt ttttaattag cagatatctg aagtactatt tttgcagggt
     1741 ttgcacaggc ccgtaactgt ctactacttt gatataatct gtatacatcc tgtatgctga
     1801 gctggtaaaa tacattgtaa attacatatt aaatatttta tctgctttta caagcgcaag
     1861 gtgcaaaaat atatacaata gtctcattga tgactgtaaa gtgaattaac atttggtgat
     1921 tatgcctagc ttttttgact aatataaaga tcatagctcc ccttcacttc tgtcttaact
     1981 tgaacatggc gtgtttaaat tttcatacat actttacttg aattattgct gttgtcacat
     2041 atttttgcct ctgtgagttc atctgatgat tgagcagtag catttgcctt ttgggttttt
     2101 tgtttgttat tatagaagag atgacttctg ctgattttgc tttagaatgg ttaccttaga
     2161 agaatttggg tggctcatgt tgaatttcac ttctgcaata gctttcattt tctcataggc
     2221 tttataagag atgggttcag tggtatgagc agaggaagag atcccagata gtagccagtt
     2281 aaccaagact cattcatata gcacgtagtt tatgttcctg aggcagcact tttagatcct
     2341 ttgtgagcaa gttctatttg ttcattgctt gccagagatg aacacagaat gttctgtttc
     2401 attttacaag aactatcctg agtttctgtg gatggaaaca ttacatgtaa tgcagatata
     2461 gtgaacactg gaaagattta ttaaagaatt atatttgtgt atactttata aattagtccc
     2521 tcattagatt tttttttctt aagcataaga ctgaacttaa atgtgttaat tttagtagaa
     2581 tcaggcactg ctcgcagaag gaacacagat tgtagagatt aacataaatt gttcttgttc
     2641 taatatatat attttttcat ttctgtcgtg cttggaaaac tagtaaatat tatgtctaag
     2701 ataaaatgga atggcccctg gatttacttc ttataagaag cagtagtatg taataaagct
     2761 attagcatga gcaattaaga ggctataaag agattatagt tacaaaagaa atactgccat
     2821 atttttaagt taataactta aaccttctca aatgggttaa aagttgaatg aattgacacc
     2881 ctgatgttat gatgttggaa ttttaactta aactgggagg cattctgtga gccttcactt
     2941 taccttcttt aattattgtc cttgctaaac tcaacacaga cttttctgtt atgtgttttt
     3001 gaggaagttg gggtgggaag agtcagggag ataagctaaa attgtcttct tttatggggt
     3061 aattgtactc tgtagtctct tggtttcctg tgaagttagt atttatgtgg gggtggggga
     3121 aggtagcaag aatcatgggt atcacggtac tttgtttttg acctcctggc tctttcagac
     3181 agagtgaaga aagcttttcc attcttactg ttgtagaagt agataggaaa taagcttttc
     3241 tcattacagt gaaatatgtt ttaaaaacta gagtagctgg gcacagaggc atgcatttgt
     3301 agggccagct acttgggaga gtgaggcagg aggatcactt gaggccagga tttcaaatcc
     3361 agcctaggta acactgagac ctccatctcg taaaaggcac aaaaactagt tagagatgaa
     3421 attgagcttt attttaaaaa aacgttctaa agcctgataa ttggagagct atacttcagc
     3481 ttttcatcct actttaatga aacagctaga taggaacctc tgctccagaa ttgccagata
     3541 attattggtg ggtcataact attcttcata tttttttttt cttttttctc ctttggtttc
     3601 tgtgttatct ttcttaacct cacgtatttc tttatccttt ttagtggggg cctgtaattg
     3661 aggctaattc aatagcaaca atagacaaca tgatatggct gctgtcactt tgaaacccaa
     3721 aaggtctttg ggtaggaata gagtaatgaa agaggaccag tcaacttcag tatatataca
     3781 aaggaaagac aaagagatga taaaccaagg ctgaggaaat ttttctgatg ctttcttcat
     3841 ttctctaata taccttttgc attctttttc tgataattgt gctattaggc agaagacaca
     3901 agttaccacg ttgtgtatta aaagcagtag gtaggttgtg ccagtatttt ttcagccagt
     3961 aagcatatac agttaactta tataattaaa aattggttta agatagtgat taaaaatacc
     4021 tgaatattat gttaaaagta tacaatcatt gtttctgtaa tgatgatggg tattctgctt
     4081 cttgtttttc attgtaatta caggggaaga ttgtttttga aaatgtatat tgccatgctt
     4141 ttggggtaag cagtaatgtg aaaagaaaaa agcattatgt tattgtatga aatataagtg
     4201 ttcagatttg ttttgtctgg ggtgttgcct aagaataccc taaagctatg gctgttactg
     4261 cattgaaatc tttttttttt ttaatagtag ccatatgtta ttagtggagt actttatatt
     4321 tgacattaaa gtgaagaaga agagtagtac ttcactttta ggtttttagt agtgaaagat
     4381 aaaattggaa aaatagggaa agagcatagg gaggaataga atggaagtca agtaaataaa
     4441 aaactacaac ctgacagttt tttaaatcac tttgaaaagt acattacttt tatcaaagag
     4501 tttctaatta aggcaaacta tgcattatgc caaatattaa gaacatttta aaaatggatt
     4561 gtgatactgt ttatttcttt aattatataa tttgcaattt tctgtattat aagtgctacc
     4621 aggattctag atagttgatc ttacatattc agatagtata gtttactctt ataattaccc
     4681 gttacgttat ctctaaaagt agtttgatct gtgcctttaa cttttagaat tcatcttttg
     4741 acttgtttgc cactgtagag ttttcagttt tctctgtaga ttcagtgtga caaagaggga
     4801 atacataatt tgtgaccatt taagatgctg atattttctg gaaaaggata tagatagtag
     4861 tagtgacccg caggagcctc acaataatgt ctaaagatat aaactgagta gatccctaag
     4921 tactcttctc taaattataa aatgcattac ctaggcttta atagttaaaa gctggaattt
     4981 attgaaccgc atctacttga tttcataata tgcattgatt ttagtatgtt gctgttctgt
     5041 tatctgtaat caactataac agagtaatat atttggtgtt ctggaccaaa attcgtgcta
     5101 cacatatgtc tgatggcctt taccttttca agaaaacagt tgcaattttg agcaaaattt
     5161 tcctagttgt aatattttaa tagtgttatg tattggaaaa aatttagaaa tactcctaag
     5221 agttttcaat ttcaagcaga aatgcttctc ttctaaataa ataccactta attgatagac
     5281 ctttagcagt tcttgtgcta tctaggattt atacattttt gcttttctgg aaaactgctt
     5341 tggcgcatta acctttctac tgcaacattt tctcttcagt agatatatga gtaaacatga
     5401 tgagttaatg ttacacagca tacccagtta ggtctcttat tcttaaagca tctttcttta
     5461 gaagtctgca catattttca aatgcatcat attaaaggca caagtcaaga ggaggtggag
     5521 ttgcctactt cagtggcctt tattcccact ataccagttc tcagtcttga ttttgatact
     5581 ttctggcaac tgtatcatct cttcactatc acgtatttta agaaaaagct aaggtgattt
     5641 ctttacattt gaacatgtgt agatcaatga gagaatggtg agggatagca aggataaagt
     5701 ataatgttga aaagtagaaa gaagtggtat ctgctaaact ctagctttag tagcaagcta
     5761 ttttaaggaa atcattgtat gtggtacttc ctagaaatat gaaagttcct cattttgtat
     5821 ttaattatgt aagaaaatgt tctaggaaaa gaataaaaaa catatattgt caaagtgccc
     5881 tttggtagtg ctcccaaatg gtagtaacta ttggtctcta gtatatactc ctcaaatatc
     5941 tttttgctat gtattaatat atctatatgt ttacatatag aaatacatag tgttgtgggt
     6001 tttaaatttt cacataaatt gtgtcttacc catgtgtttt gccatttgcc ttttctcttg
     6061 ccaacgtgtc taggagctct ttggtaaata cagacttttt cattttattt cctcccacat
     6121 ttctatggat gtgtcttgcc tttttctttt ttttttcttt ctttttttct tttttaaaat
     6181 agcctctgac tccatgaaac ctgaaaagga atctggtctg ttaggtggat ttcattagta
     6241 tccaaattta tttatttttt tatttcattt ttttgagaca gtctcgctgt gtcacccagg
     6301 ctggagtgtg gtggctcagt gatagttcac tgcatccttg aactcatgga ctcaagcaat
     6361 cctcttgcct cagccttctg agtagctggg actacatgtg taagccacca tgcctggcta
     6421 atttttgtat ttttcatttt tagtagagat gggaagtctt gctgtgttgc ccaggctggt
     6481 cttgaactcc tggcctcaac cattcctccc acttcagcct cccaaagtac tgagattaca
     6541 gatgtgagcc actaggccca gtcagtatca tagaatttaa atgcaagcca atgcttagac
     6601 agaatcaggg tctgctttaa gcatgtgaat caggaaacta gaaggcctct tgtaatgtat
     6661 ttgaagttca ttacttttgg ctgacggttg actgcttagt gtataaaatc taggagttaa
     6721 ctttagcaga ttcttttatc agaatacgtt ttttattgga gggaagaagg aaaaagagga
     6781 aaggtataac tgatggggaa aagtacaaga taaactaaaa caagtcttta tacaactctg
     6841 acagcaactc ccataacagg acatgatgct accaaaaatt caaacttgta tttgatctgt
     6901 gcctttaata tagagtaaaa acaaaagttc ctttttagat ctcccttccc tcatcatccc
     6961 acatcccttt ttagaggtaa ccattgttaa cagtttggtt tgtgtcttta ttatgcagtt
     7021 ttatatttat atttggcctt tgtaaatttt ccattccctg aatggaactt ctaccctata
     7081 tcaaattcca ccctcaactg accaatttac caaggccaac tagaatcata cttctttttc
     7141 tggaagtttt ttttgagaca gggtcttgct ttgccgcaca gactagaatg cagtagcatg
     7201 atcatagctc attgcagcct caaactcctg ggcttaagca atcctcccac ctcagacttc
     7261 gaagtagctg gtattacagg tgcataacac caccacccac gcctggctaa ttgttttgtt
     7321 ttttttgtgg agatggctct cactttgttg cccaggctgg tttttgaact agtttcaaag
     7381 tgatcctcct gccttggcct ctcaaagtac taggataaca gtcatgagcc accatgccca
     7441 ccctagaatc atactctttt aaagcaagtt aaatcagcag taatagttct ggaactagaa
     7501 gttaactact tactggactt ttgagatgta agtttaccat acatcaagct taaaaacttg
     7561 tagcgttctg ggaaagtcaa gtcaaactct tgaatgctat cctctgtgga aatagggttg
     7621 ggaaagagca atgtacaagt ccaagctcct taatacacat aaaactctgg gttgggctca
     7681 tcctcttggt gtattttcct acttggagag cattacagtg tccaacaatt tataggagct
     7741 tctctgcact gtcaagacta tagcttagca tatgtgtgct atgacacaag gttaaacgtg
     7801 tgccccagaa caaatgcatt tattcatgtt tgactttaaa tgaaaattca gaaagcaggt
     7861 taagcatata tgtgagttta ataattgttt ctgtatttta aaaaatttta aaacattcag
     7921 ctttttatga ctttggttag tttcactcat ttgttgagtg ccttctgtat gcccagtgca
     7981 caaactgcta tgtgcccagt gtacatacat gggagaacca gatagccaaa gtgccttcct
     8041 ttatcgttgg aacctagaga tgagctgata cctgttgcac atagtccaag atataagtaa
     8101 tttatctggg gatataaggt cacctgtgca cacatgttca cattctgtgt ttgatcagat
     8161 atgtacctgc caaacttttg gagtgagata attagaatga cagtagttga agctgacagt
     8221 gaatttgagg taaagctgga aagaatgttt ttgaattttg caaataatac attttcaagc
     8281 cagattaaaa ttgaataact tactttctag cttcaagggg gtaattaagt gatcctctaa
     8341 cccaaattgc ttttccaaat tttgtggtag cagtgaataa actgatgcct cctgcttatt
     8401 tagacagcag ccatttttgt ttggtttggt ttggttttgc ggtgattttt tttaacctag
     8461 aaaaaataca atttaaaaag caatcatgtt gttttctttg cctttgacag atgtggcctt
     8521 gtcaccacac agtaagccag aacacaatcc attcctgagt catagtagga tagtttgtgt
     8581 aattctaaat gcactctcca gtttaagagt gtgggtccct ttttttctat ctgaaattga
     8641 agatacaggt cagaaagatg gtttaatgaa tatgaatttt ctaaacatct tttcagtgtc
     8701 ttttaaggat atttttgata ttacaatata ataaagttaa atcatctagt cctcctggcc
     8761 cttctggtta gaaaatagag cgaaatcatc cgtttaaaca cacacacaca aactatccca
     8821 ttagttggtt atacacaagt tactttcatt cttactagtt cacaaaaggt tagtaaattt
     8881 agtgatttaa tgagttcttc aaaacataaa agtcctgtaa aggaaaagct agaggatgtg
     8941 agaggagtaa ttcatcccca tcaaaagatt ttagccaaaa gtagtggcat aagaaattta
     9001 tttatgcgaa agacataatt ttgggtgaac tttcttgaag atggtcagaa agggcattgt
     9061 taaaggaagg agatggtaga ttttgggttc tgggttctag gttctaggct aataatttac
     9121 tactttggta tgttgccttg aggctgacat ttgctgctct gctaagacta aagctggccc
     9181 tttccaatca aaagtgttaa aagctggctg ggagccatgg ctcatgcctg taatccagca
     9241 ctttgggagg ctgaggtggg tggatggatc ccttaaaccc aggaattcaa gaccagtgta
     9301 gacaacatgg cgaaacccca tctctatcca aaaatataca aaaattagcc aggtgtggtg
     9361 gtgtgtgcct gtagtctcag ctactcagga ggctgagatg ggaggattgc ttgagcctgg
     9421 gagttagagg atgcaatgag ctgaggtcgc accactgcac tccagcctgg acgacagagt
     9481 gaggccctgt ctcaaaaaaa gaaaaaagaa aaaaaaaagt taaaagttgt ggcatggtgg
     9541 ctcacgcctg taatcccagc acttttggag gctaaggcag gtggaccacc tgaggtcagg
     9601 agttcgagac cagcctggcc aacatggtga aaccctgtct ctactaaaaa caaaacaaaa
     9661 caaaaccata tatatattat atatatatat atatatatat tttttttttt tttttttttt
     9721 ttttttttga gacggagtct cgctctgtcc caggccagag tgcagtggcg ctatctcggc
     9781 tcactgcaag ctccggctcc cgagttcaca ccattctcct gcctcagcct cccgagtagc
     9841 tgggactaca ggcgcccgcc accacgcctg gctaattttt tgtatttttt tggtagagat
     9901 ggggtttcac cgtgttagcc aggatggtct ctatctcctg accttgttat ccgcccgcct
     9961 cggcctccca aagtgctggg attacaagcg tgagccaccg agcccagcta tatttataaa
    10021 tttatatata tttcatatat atattatata tatataaaat taaccgggca tggtagtgag
    10081 cccctgtaat cccagctact tgggaggctg aggcaggaga attgcttgaa cccaggagac
    10141 ggaggttgca gtgagcagac ctggtgccac tggactccag cctcggtgac agagtgagac
    10201 tctgtctcaa aaaaaaagtt aaaagttgtt aactagatgt cgaattattt tcatagtaat
    10261 caccatgtgt aagcaattct catctgtgga atgtttgaca gggataagat tattgaaaat
    10321 tggggggaat tttcttaaat atggaactaa gagctaaaga gttcaatgat gattaagacc
    10381 actagtctgg caagtgactt ttatttgtcc ttttctattg ataatgaatt ctaggaatat
    10441 ggatggattt cattagagaa ataaaaatga gcaagatttg tgattcagaa tattaaaagt
    10501 taagaatcca tgaatagccc cttaaaaata ttgtcaaagc atcatggtat ttgtagtggt
    10561 gcttaaaaaa gaagcagcag cagctgttct aagccaagca ctgcttgaaa acaaaacaaa
    10621 acagaacaaa accttatatt taataaaatg gagaaatttg ggaatgtccc tagcgtaata
    10681 atgccttcta ctgacattta aagtcagctt aaacatcatt agggaagact atgactgttt
    10741 ctatgacctc tagtcacaaa tttaactaat ttaaggttaa ctaatacctc tttcagagtt
    10801 gggcaaaaga agaaaaaaaa agcctttatt tgtgatcagt aaattataaa ttacacagaa
    10861 gcttccagct acctggtatt tgcatgaaga attctaaatt ttttatatgc cataattttt
    10921 agtaatgctg tccttgaatt cacttacatc tctgctctgg ttttttgaag ctcattagga
    10981 tgatacctgt catctcttgg aaacactgga actagagaac tggaggtgtt cacccccatt
    11041 ttttgctaca ttgttgaaaa ctgagtagaa ttttgtgtcc aaaaatcctt agtctgtgat
    11101 ggaatttttt aaagtatatg tgaagttttt tacttcttca gtttttcaag ataattttgc
    11161 tgtttttgct ttttatttat ttgcaactag aaattgcatg tgccagttac ttaatttaat
    11221 acatctaatg ggagattcaa agcaaaccat taaaactacc atataaactc aaatgaaatt
    11281 ttatgacatt ctaatgtaca tactcgccaa gaaatgctac aaggagcctc tctgcaaatg
    11341 cctgatgggg cactctgaga attaaacagg aaatggacag gaaaagaggc aaagcataga
    11401 atagcctctg tggtatacac acagacaatg taaaatccaa gaaatataag gtccaaggag
    11461 gaattggtta ttgaagtaga gaacctcatc atgagatttg agaatagctt tagagttact
    11521 cttgggatag tgtctcatgg ccctgtgagg gaactctaca aattttatcc attttgctgg
    11581 gcagttttaa gagctacttt ttgtctgtac tttccttaat tttcatatta tttctagctt
    11641 ttacttcatc ttatgaaaga ttaacttaga ggttagaatg cttacatttg caaatagcct
    11701 gaggaataaa tatgtgcttt atcaaagtgg aacttctgat tttctgtaat attaggatgg
    11761 acatgtgtct ggcttatcct tcctatctag gaaactggtg tcattaggaa atacgttaac
    11821 ataagatccc tgactataaa gtaagactta ttatcttgta tagtttgtag catttaatct
    11881 tctatttcag tgattggttt ggatctactt aattttaagc tttactggtc atttgtcccc
    11941 ctcatgttgt acctaataag tgtgtagttt ttaagtgaaa tcatacataa tttcaaggaa
    12001 actgctagag acaatgttga gtatcatcaa gaacatttaa tcaaacctgt tgactaagag
    12061 ctttagtttg gcttacaatt tcatatgtaa atccaagaaa aagacttgta agctaaaaag
    12121 cctgtttcgt tcggaaaaaa aagtacataa cattttaaag atttgtgaga ggaaaaaagc
    12181 attagatgcg atagaatgga ataatctctt tttagaagta aattagtttt tatttcattt
    12241 gtgggtggta ttgagaaaag tggtggaaat aaatacattg agcagattca gaatttaata
    12301 gacacttcgt gtttccattt tcataatggg ggttagtcat aaaccattct atgtggagca
    12361 ttttacaggg gctctgaaag gtatacaaaa tgtactacta taattaatgt cctcaaggaa
    12421 cttaaaaacc tattggaaga tttatttaac agaggtaaga gaatttggac ccattaaaaa
    12481 tggaggaaaa ggtaaagtta gtatttgtag atgatagtgc aaagcttaaa agggtcaact
    12541 gaaagtctct taaaacgaat acagtcactg ggtataaaat tcatcacaga aataaaaagc
    12601 tttcatttat aaaaacaaca gccagttaga agatataata gaagaaaagg ccccatttaa
    12661 agtaagacca aaggagagaa gatacctagg aataaacaag ttatatgcgt gaccacaaaa
    12721 ccaaaacttt gtatttcaca tgaaaataaa ttcaaacaca tggagatgca tatcatattc
    12781 ttggatagga agacaacata cacatttcag ttctctaaat tgaatgcaat cccaataaaa
    12841 atataaggat taaaaaaaaa aaaaactaga tcgctgattc caaagtttct ttgaggaaaa
    12901 aaaaaaaaaa aagcaagact agccaggaaa actgaaaaaa caatgaggaa agactggcct
    12961 tatgaaatat ttaaacaaga gagctccaat aattaaaaca gtctggaact ggcatatgac
    13021 tagacagatc attcaagcag aaggaaaatg aacccagata tgggaattta gtggaggaga
    13081 agtgatgttt cagctcagtg gggaaaatat ggtttattca ttaaaggtag taggacactt
    13141 gggtagctat agagaacaaa gctggattca tacctcataa accaaaatgc attccagttt
    13201 aaatatgaaa actgaaatgt ttaaagtacc caaagaggtt gtcagagaat ttttaaagat
    13261 tttagtgtgg taaaggattt cctgaatttg atataaaatt tggaatagaa tttacaataa
    13321 gaaatgataa tgttttcact ataaatttgt aacaataaat tattattatt tttgagatgg
    13381 agtctcactc tattgcccag gctagagggc agcggcatga tcttggctca ctgcaacctc
    13441 tgcctcccag gttcaagcaa ttattcctac cttagcctcc caagtagctg ggactacagg
    13501 tgtgcaccac cacacctggc taatttttgt atttttagta gagatggcgt ttcacagtgt
    13561 tggccagtct ggtcttgaat tcctgacctc aagtgatctg cccacctcga cctgccaaag
    13621 tgctgggatt ataggtgtga ggcaccatgc ccaacatata acaataaatt atatcactat
    13681 ataaaataaa ttcctcacag caaaaaacca ccataagcat agtctaaaga aaaatgacaa
    13741 atttggaaaa aatattttca aatcatatca tgcattgctt aatttataaa gaacacctag
    13801 aaatgaaaaa gtccaatgat ccaaaaagaa aaaggtacaa aattgtaaac agttttcaca
    13861 gaaaagaata aaatgattca agccggaaaa aaagttcaac tttattacta agagaagtat
    13921 aagacaaaac tatactgaga taccagtttt ttaacctatt aatcaagaaa gactttttag
    13981 ttttataaaa cattgtaata ttctagatat tattggtaag aatggaggga acaagtattt
    14041 ttgctgatag aggggtaaac tggaacaacc gctaaggatg acagtgaatt ctgaatttat
    14101 ttacccaatg tactcttcaa gttgcagagg ctgagaaatt attaaactgt tacccagaac
    14161 tttttatgca gatggggggg cagtctgaat gctaattaag ttttctcaac tatatgctct
    14221 ctcctcatga tttgaaaggc aaaagtgaag cagaggccaa gttttgaagt tcttgaatgt
    14281 tacgaggtag tgaaaaacgt ttccatgcag cagtgatcaa gtgtctatcg ttcagcttcc
    14341 tgaatatgga taggctgtgg tggtggcagc agcttcttaa tctgacattc caacccctag
    14401 attgtggtgt tacatcttct ttctccagct tcccaggagt gaaaggttgt agtggctggc
    14461 ctctggttcc cagcagggct ccatggtgac cagaggttgt agttccccca gtgaatcatg
    14521 tttgtgtcac tgtgggattc attcccatag gctcaactta gattcctaaa ccctgctcct
    14581 tcaacccttc cagtaacttt ataagcacca aattccattt aaaaagtgcc ttcctgttta
    14641 aaatatctat aatggcttct gtttcctgca ttgaaagctg actgatctgg agggcaattg
    14701 ggcaacagca atcaaaattg tcttttcttt tgacctagca gtttcacttc ttggaatata
    14761 tcctgtaaat atgcttatgt atgaaggaaa tgagtttgta caacgttttt caatgcagta
    14821 ttgtttgtaa attgacacca gtaggggaat agtaaaatca attactatgc atgcatataa
    14881 taaaatttta ggtagctata aaaaagagaa tgagaaagct ttgcatattt aaaagaaacc
    14941 atcaacagga atattaagtt tttaaaaaaa gccagggcag aacagtctgt atactgtata
    15001 ttttaaaatt gaacaagtat agtagacaat tgaagtatag taaagataaa attaattgca
    15061 caggccaggc acagtggttc acacctgtaa tcccagcatt ttgggaggcc aagatgggcg
    15121 gatcatatga ggtcaggagt tcaggaccag cctggcaaat acggtgaaat cccatctcta
    15181 ctaaaaatac aaaaattagc cgggtgtggt ggcaagcaac tataatccta actacttggg
    15241 aggctgaggc aggagaattg cttgaacccg ggaggcggag gttgcagtga gccaagatca
    15301 tgcccctgta ctccagcctg agcaacagag tgagactcta tctcaaaaaa aaaaaaaaaa
    15361 aaattaattg cacatgaagt atacaagttc gatctgtgaa accaccatca cagtgaagat
    15421 aattaacaca tccatcattc cacaaaattt ccttacactt tcttgtaatc ccttctccct
    15481 cccattcctg ctttctttaa actatagttt agtttgaatt ttctataatt ttatataaat
    15541 aaaatcatat aacatgta
//
