LOCUS       NM_017817               1507 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens RAB20, member RAS oncogene family (RAB20), mRNA.
ACCESSION   NM_017817
VERSION     NM_017817.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Liu,B.H.M., Tey,S.K., Mao,X., Ma,A.P.Y., Yeung,C.L.S., Wong,S.W.K.,
            Ng,T.H., Xu,Y., Yao,Y., Fung,E.Y.M., Tan,K.V., Khong,P.L., Ho,D.W.,
            Ng,I.O., Tang,A.H.N., Cai,S.H., Yun,J.P. and Yam,J.W.P.
  TITLE     TPI1-reduced extracellular vesicles mediated by Rab20
            downregulation promotes aerobic glycolysis to drive
            hepatocarcinogenesis
  JOURNAL   J Extracell Vesicles 10 (10), e12135 (2021)
   PUBMED   34401050
  REMARK    GeneRIF: TPI1-reduced extracellular vesicles mediated by Rab20
            downregulation promotes aerobic glycolysis to drive
            hepatocarcinogenesis.
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Sofer,T., Li,R., Joehanes,R., Lin,H., Gower,A.C., Wang,H.,
            Kurniansyah,N., Cade,B.E., Lee,J., Williams,S., Mehra,R.,
            Patel,S.R., Quan,S.F., Liu,Y., Rotter,J.I., Rich,S.S., Spira,A.,
            Levy,D., Gharib,S.A., Redline,S. and Gottlieb,D.J.
  TITLE     Low oxygen saturation during sleep reduces CD1D and RAB20
            expressions that are reversed by CPAP therapy
  JOURNAL   EBioMedicine 56, 102803 (2020)
   PUBMED   32512511
  REMARK    GeneRIF: Low oxygen saturation during sleep reduces CD1D and RAB20
            expressions that are reversed by CPAP therapy.
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Payne,J.L., Song,C., Ding,Y., Dhanyamraju,P.K., Bamme,Y.,
            Schramm,J.W., Desai,D., Sharma,A., Gowda,C. and Dovat,S.
  TITLE     Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute
            Lymphoblastic Leukemia
  JOURNAL   Int J Mol Sci 21 (5), 1718 (2020)
   PUBMED   32138279
  REMARK    GeneRIF: Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute
            Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Schnettger,L., Rodgers,A., Repnik,U., Lai,R.P., Pei,G., Verdoes,M.,
            Wilkinson,R.J., Young,D.B. and Gutierrez,M.G.
  TITLE     A Rab20-Dependent Membrane Trafficking Pathway Controls M.
            tuberculosis Replication by Regulating Phagosome Spaciousness and
            Integrity
  JOURNAL   Cell Host Microbe 21 (5), 619-628 (2017)
   PUBMED   28494243
  REMARK    GeneRIF: Rab20 is specifically and significantly upregulated in the
            sputum of human patients with active tuberculosis.
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Kubota,T., Koiwai,O., Hori,K., Watanabe,N. and Koiwai,K.
  TITLE     TdIF1 recognizes a specific DNA sequence through its
            Helix-Turn-Helix and AT-hook motifs to regulate gene transcription
  JOURNAL   PLoS One 8 (7), e66710 (2013)
   PUBMED   23874396
  REMARK    GeneRIF: TdIF1 associates with the RAB20 promoter, and RAB20 gene
            transcription is reduced in TdIF1-knocked-down cells, suggesting
            that TdIF1 stimulates RAB20 gene transcription.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Seto,S., Tsujimura,K. and Koide,Y.
  TITLE     Rab GTPases regulating phagosome maturation are differentially
            recruited to mycobacterial phagosomes
  JOURNAL   Traffic 12 (4), 407-420 (2011)
   PUBMED   21255211
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Das Sarma,J., Kaplan,B.E., Willemsen,D. and Koval,M.
  TITLE     Identification of rab20 as a potential regulator of connexin 43
            trafficking
  JOURNAL   Cell Commun Adhes 15 (1), 65-74 (2008)
   PUBMED   18649179
  REMARK    GeneRIF: Regulates connexin 43 intracellular transport.
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Amillet,J.M., Ferbus,D., Real,F.X., Antony,C., Muleris,M.,
            Gress,T.M. and Goubin,G.
  TITLE     Characterization of human Rab20 overexpressed in exocrine
            pancreatic carcinoma
  JOURNAL   Hum Pathol 37 (3), 256-263 (2006)
   PUBMED   16613320
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Pereira-Leal,J.B. and Seabra,M.C.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Lutcke,A., Parton,R.G., Murphy,C., Olkkonen,V.M., Dupree,P.,
            Valencia,A., Simons,K. and Zerial,M.
  TITLE     Cloning and subcellular localization of novel rab proteins reveals
            polarized and cell type-specific expression
  JOURNAL   J Cell Sci 107 (Pt 12), 3437-3448 (1994)
   PUBMED   7706395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026025.1, HY010547.1 and AK000436.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017817.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000436.1, BC026025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267328.5/ ENSP00000267328.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               BC026025.1         12-537
            527-555             HY010547.1         497-525
            556-1507            AK000436.1         558-1509
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..1507
                     /gene="RAB20"
                     /note="RAB20, member RAS oncogene family"
                     /db_xref="GeneID:55647"
                     /db_xref="HGNC:HGNC:18260"
     exon            1..375
                     /gene="RAB20"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..908
                     /gene="RAB20"
                     /codon_start=1
                     /product="ras-related protein Rab-20"
                     /protein_id="NP_060287.1"
                     /db_xref="CCDS:CCDS9512.1"
                     /db_xref="GeneID:55647"
                     /db_xref="HGNC:HGNC:18260"
                     /translation="MRKPDSKIVLLGDMNVGKTSLLQRYMERRFPDTVSTVGGAFYLK
                     QWRSYNISIWDTAGREQFHGLGSMYCRGAAAIILTYDVNHRQSLVELEDRFLGLTDTA
                     SKDCLFAIVGNKVDLTEEGALAGQEKEECSPNMDAGDRVSPRAPKQVQLEDAVALYKK
                     ILKYKMLDEQDVPAAEQMCFETSAKTGYNVDLLFETLFDLVVPMILQQRAERPSHTVD
                     ISSHKPPKRTRSGCCA"
     exon            376..1507
                     /gene="RAB20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB20"
                     /note="hexamer: ATTAAA"
     polyA_site      1507
                     /gene="RAB20"
                     /note="major polyA site"
ORIGIN      
        1 gctctgcacc cagctccttc ccgggcgcgc acacgcgctt cctctcttga gctcccgggc
       61 gtccggaggc gaaggtcccg gagcgttcac gagaatccgg gtcccggcga gtccggggtc
      121 cgctcctcca gctgcgccca gggcgcacga gccggccagc ctcggggaga gggcgcgggg
      181 gcgctggggg ttcttacggg aagatgagga agcccgacag caagatcgtg ctcctggggg
      241 acatgaacgt ggggaagacg tcgctgctgc agcggtatat ggagcggcgc ttcccggaca
      301 cggtcagcac ggtgggcggc gccttctacc tgaagcagtg gcgctcctac aacatctcca
      361 tctgggacac cgcagggcgg gagcagttcc acggcctggg ctccatgtac tgccgggggg
      421 cggccgccat catcctcacc tatgatgtga atcaccggca gagcctggtg gagctggagg
      481 accggttcct gggcctgaca gacacagcca gcaaagactg cctctttgcc atcgtgggga
      541 acaaagtgga cctcactgag gagggggcct tggcgggcca ggagaaggaa gagtgcagtc
      601 ccaatatgga cgctggggac cgtgtctccc caagggcacc taagcaggtg cagctggagg
      661 atgcggtggc cctttataaa aagatcctca agtacaagat gctggatgag caggatgtgc
      721 cggccgctga gcaaatgtgc tttgagacca gcgccaagac cggctacaat gtggacctcc
      781 tgtttgagac cctctttgac ctggtggtgc caatgatctt acagcagaga gctgagaggc
      841 cgtcacacac agtggatata tccagtcata agccacccaa gaggaccaga tctgggtgtt
      901 gtgcctgact ttcgagggcc tcctggactc agactgtgca tgttgggaag gggtctgacc
      961 aggcaagctg tgatctgaaa ggagcaagga acagcaagga attattttcc agaatgacac
     1021 ccgcagcaga atgttggagt ggaaatgatg gctggctatg aagaggaggt caacgtgtgt
     1081 ggtctcctca gtctctgtca gaggggtggg gaggtgggaa acaggaatcc tctgcaaagc
     1141 ccaatctgca gagtcgagac ccctggtgct ctctgccccg ctgcctggca ctggtccttt
     1201 gcagccagcc accaacggcc cccttgccct tgcagaggca gaagcctgcg tctgcacctg
     1261 cacctctgac cgtttcagca ccctgggttg ttaccacgtc ctacaactct gacatttctt
     1321 gttctcaagc gtttctcttc actgtgagtt gtctttggtc ctcccacttg gtacttgtat
     1381 cttgatgctt tataatcctg actctcgacg tgttcattta tacaaaatca ggaataactt
     1441 tgtttttata ctgattgcag caatgttggc tacatgtatt attaaagagg atttttggaa
     1501 caactta
//
