LOCUS       NM_030981               1901 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens RAB1B, member RAS oncogene family (RAB1B), mRNA.
ACCESSION   NM_030981 XM_001134089
VERSION     NM_030981.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Liang,J., Li,B. and Xia,Y.
  TITLE     MicroR-380-3p Reduces Sepsis-Induced Acute Kidney Injury via
            Regulating RAB1P to Restrain NF-kappaB Pathway
  JOURNAL   Tohoku J Exp Med 263 (1), 69-79 (2024)
   PUBMED   38220171
  REMARK    GeneRIF: MicroR-380-3p Reduces Sepsis-Induced Acute Kidney Injury
            via Regulating RAB1P to Restrain NF-kappaB Pathway.
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Xu,C., Sun,W., Liu,J., Pu,H. and Li,Y.
  TITLE     Circ_RBM23 knockdown suppresses chemoresistance, proliferation,
            migration and invasion of sorafenib-resistant HCC cells through
            miR-338-3p/RAB1B axis
  JOURNAL   Pathol Res Pract 245, 154435 (2023)
   PUBMED   37075641
  REMARK    GeneRIF: Circ_RBM23 knockdown suppresses chemoresistance,
            proliferation, migration and invasion of sorafenib-resistant HCC
            cells through miR-338-3p/RAB1B axis.
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Kaspers,M.S., Pogenberg,V., Pett,C., Ernst,S., Ecker,F.,
            Ochtrop,P., Groll,M., Hedberg,C. and Itzen,A.
  TITLE     Dephosphocholination by Legionella effector Lem3 functions through
            remodelling of the switch II region of Rab1b
  JOURNAL   Nat Commun 14 (1), 2245 (2023)
   PUBMED   37076474
  REMARK    GeneRIF: Dephosphocholination by Legionella effector Lem3 functions
            through remodelling of the switch II region of Rab1b.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   He,S.W., Liang,Y.L., Zhang,Y., Liu,X., Gong,S., Ye,M.L.,
            Huang,S.Y., Tan,X.R., Zhou,S.Q., Zhao,Y., Liu,N. and Li,Y.Q.
  TITLE     LINC00173 facilitates tumor progression by stimulating
            RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal carcinoma
  JOURNAL   Mol Oncol 17 (3), 518-533 (2023)
   PUBMED   36606322
  REMARK    GeneRIF: LINC00173 facilitates tumor progression by stimulating
            RAB1B-mediated PA2G4 and SDF4 secretion in nasopharyngeal
            carcinoma.
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Overmeyer,J.H., Wilson,A.L., Erdman,R.A. and Maltese,W.A.
  TITLE     The putative 'switch 2' domain of the Ras-related GTPase, Rab1B,
            plays an essential role in the interaction with Rab escort protein
  JOURNAL   Mol Biol Cell 9 (1), 223-235 (1998)
   PUBMED   9437002
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   Chen,D., Guo,J. and Gahl,W.A.
  TITLE     RAB GTPases expressed in human melanoma cells
  JOURNAL   Biochim Biophys Acta 1355 (1), 1-6 (1997)
   PUBMED   9030196
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Wilson,A.L., Sheridan,K.M., Erdman,R.A. and Maltese,W.A.
  TITLE     Prenylation of a Rab1B mutant with altered GTPase activity is
            impaired in cell-free systems but not in intact mammalian cells
  JOURNAL   Biochem J 318 (Pt 3) (Pt 3), 1007-1014 (1996)
   PUBMED   8836150
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Soldati,T., Rancano,C., Geissler,H. and Pfeffer,S.R.
  TITLE     Rab7 and Rab9 are recruited onto late endosomes by biochemically
            distinguishable processes
  JOURNAL   J Biol Chem 270 (43), 25541-25548 (1995)
   PUBMED   7592724
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Plutner,H., Cox,A.D., Pind,S., Khosravi-Far,R., Bourne,J.R.,
            Schwaninger,R., Der,C.J. and Balch,W.E.
  TITLE     Rab1b regulates vesicular transport between the endoplasmic
            reticulum and successive Golgi compartments
  JOURNAL   J Cell Biol 115 (1), 31-43 (1991)
   PUBMED   1918138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136635.1 and AP001107.5.
            
            On Nov 22, 2018 this sequence version replaced NM_030981.2.
            
            Summary: Members of the RAB protein family, such as RAB1B, are low
            molecular mass monomeric GTPases localized on the cytoplasmic
            surfaces of distinct membrane-bound organelles. RAB1B functions in
            the early secretory pathway and is essential for vesicle transport
            between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997
            [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied
            by OMIM, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136635.1, SRR3476690.30045.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311481.11/ ENSP00000310226.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-708               AL136635.1         7-714
            709-1901            AP001107.5         16556-17748
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1901
                     /gene="RAB1B"
                     /note="RAB1B, member RAS oncogene family"
                     /db_xref="GeneID:81876"
                     /db_xref="HGNC:HGNC:18370"
                     /db_xref="MIM:612565"
     exon            1..55
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..647
                     /gene="RAB1B"
                     /EC_number="3.6.5.2"
                     /note="small GTP-binding protein"
                     /codon_start=1
                     /product="ras-related protein Rab-1B"
                     /protein_id="NP_112243.1"
                     /db_xref="CCDS:CCDS31613.1"
                     /db_xref="GeneID:81876"
                     /db_xref="HGNC:HGNC:18370"
                     /db_xref="MIM:612565"
                     /translation="MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVD
                     FKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQW
                     LQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQ
                     AFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPAGGGCC"
     exon            56..128
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            129..224
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            225..320
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            321..452
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     exon            453..1901
                     /gene="RAB1B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1901
                     /gene="RAB1B"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgact gggagcgacc gagcgggccg ccgccgccgc catgaacccc gaatatgact
       61 acctgtttaa gctgcttttg attggcgact caggcgtggg caagtcatgc ctgctcctgc
      121 ggtttgctga tgacacgtac acagagagct acatcagcac catcggggtg gacttcaaga
      181 tccgaaccat cgagctggat ggcaaaacta tcaaacttca gatctgggac acagcgggcc
      241 aggaacggtt ccggaccatc acttccagct actaccgggg ggctcatggc atcatcgtgg
      301 tgtatgacgt cactgaccag gaatcctacg ccaacgtgaa gcagtggctg caggagattg
      361 accgctatgc cagcgagaac gtcaataagc tcctggtggg caacaagagc gacctcacca
      421 ccaagaaggt ggtggacaac accacagcca aggagtttgc agactctctg ggcatcccct
      481 tcttggagac gagcgccaag aatgccacca atgtcgagca ggcgttcatg accatggctg
      541 ctgaaatcaa aaagcggatg gggcctggag cagcctctgg gggcgagcgg cccaatctca
      601 agatcgacag cacccctgta aagccggctg gcggtggctg ttgctaggag gggcacatgg
      661 agtgggacag gagggggcac cttctccaga tgatgtccct ggagggggca ggaggtacct
      721 ccctctccct ctcctggggc atttgagtct gtggctttgg ggtgtcctgg gctccccatc
      781 tccttctggc ccatctgcct gctgccctga gccccggttc tgtcagggtc cctaagggag
      841 gacactcagg gcctgtggcc aggcagggcg gaggcctgct gtgctgttgc ctctaggtga
      901 ctttccaaga tgccccccta cacacctttc tttggaacga gggctcttct gtcggtgtcc
      961 ctcccacccc catgtatgct gcactgggtt ctctccttct tcttcctgct gtcctgccca
     1021 agaactgagg gtctccccgg cctctactgc cctggctgca gtcagtgccc agggcgagga
     1081 atgtggccag gggatccagg acctgggatc cagggccctg ggctggacct caggacaggc
     1141 atggaggcca caggggccca gcagcccacc ctttcctctc cccactgcct cctctccctt
     1201 cctacactcc cagctcgagc cgtccagctg cggtgggatc tgagtatatc tagggcgggt
     1261 gggcgggtag cagtgctggg cctgtgtctt gagcctggag ggagtctgct cctgccgccc
     1321 tctgccctgc cagagacaga cccatgcgct gcctgcccac cgtgcccctt tgtccccatg
     1381 tcaggcggag gcggaaggcc caccgtgcca gaggctgggc accagcctta accctcactc
     1441 tgctagcacc tcctcccttt ccccaaggta gcacatctgg ctcactcccc actccgtctc
     1501 tggagcccac cagggaaggc cctcatcccc tgccgctact tctctgggga atgtgggttc
     1561 catccaggat tgggggcctc tctgctcacc cactctgcac ccaggatcct agtcccctgc
     1621 cctctggcac agctgcttcc tgcaagaaag caagtctttg gtctccctga gaagccatgt
     1681 ccctcgtgct gtctcttgcc tgtcccacct gtgccctgcc ctccagcttg tatttaagtc
     1741 cctgggctgc ccccttgggg tgccccccgc tcccaggttc ccctctggtg tcatgtcagg
     1801 cattttgcaa ggaaaagcca cttggggaaa gatggaaaag gacaaaaaaa attaataaat
     1861 ttccattggc cctcgggtga gctgagggtt tttgcaagga a
//
