LOCUS       NM_004161               2448 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RAB1A, member RAS oncogene family (RAB1A), transcript
            variant 1, mRNA.
ACCESSION   NM_004161
VERSION     NM_004161.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Wang,J., Wang,T., Feng,Y.K., Liu,Y., Fu,B., Liu,X.T. and Wu,Q.Z.
  TITLE     Deubiquitinating enzyme PSMD7 promotes bladder cancer development:
            Involvement of RAB1A stabilization
  JOURNAL   Cell Signal 114, 110996 (2024)
   PUBMED   38040402
  REMARK    GeneRIF: Deubiquitinating enzyme PSMD7 promotes bladder cancer
            development: Involvement of RAB1A stabilization.
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Rios,J.J., Li,Y., Paria,N., Bohlender,R.J., Huff,C.,
            Rosenfeld,J.A., Liu,P., Bi,W., Haga,K., Fukuda,M., Vashisth,S.,
            Kaur,K., Chahrour,M.H., Bober,M.B., Duker,A.L., Ladha,F.A.,
            Hanchard,N.A., Atala,K., Khanshour,A.M., Smith,L., Wise,C.A. and
            Delgado,M.R.
  TITLE     RAB1A haploinsufficiency phenocopies the 2p14-p15 microdeletion and
            is associated with impaired neuronal differentiation
  JOURNAL   Am J Hum Genet 110 (12), 2103-2111 (2023)
   PUBMED   37924809
  REMARK    GeneRIF: RAB1A haploinsufficiency phenocopies the 2p14-p15
            microdeletion and is associated with impaired neuronal
            differentiation.
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Li,H., Cheng,Z., Jiang,B., Shao,X. and Xu,M.
  TITLE     Prognosis value and positive association of Rab1A/IL4Ralpha
            aberrant expression in gastric cancer
  JOURNAL   Sci Rep 13 (1), 6964 (2023)
   PUBMED   37117331
  REMARK    GeneRIF: Prognosis value and positive association of
            Rab1A/IL4Ralpha aberrant expression in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Chao,T.Y., Cheng,Y.Y., Wang,Z.Y., Fang,T.F., Chang,Y.R., Fuh,C.S.,
            Su,M.T., Su,Y.W., Hsu,P.H., Su,Y.C., Chang,Y.C., Lee,T.Y.,
            Chou,W.H., Middeldorp,J.M., Saraste,J. and Chen,M.R.
  TITLE     Subcellular Distribution of BALF2 and the Role of Rab1 in the
            Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment
            and Virion Release
  JOURNAL   Microbiol Spectr 11 (1), e0436922 (2023)
   PUBMED   36602343
  REMARK    GeneRIF: Subcellular Distribution of BALF2 and the Role of Rab1 in
            the Formation of Epstein-Barr Virus Cytoplasmic Assembly
            Compartment and Virion Release.
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Lv,T., He,D., Zhang,X., Guo,X., Li,Z., Zhang,A., Fan,B. and Wang,Z.
  TITLE     SGOL2 promotes prostate cancer progression by inhibiting RAB1A
            ubiquitination
  JOURNAL   Aging (Albany NY) 14 (24), 10050-10066 (2022)
   PUBMED   36566018
  REMARK    GeneRIF: SGOL2 promotes prostate cancer progression by inhibiting
            RAB1A ubiquitination.
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Farnsworth,C.C., Seabra,M.C., Ericsson,L.H., Gelb,M.H. and
            Glomset,J.A.
  TITLE     Rab geranylgeranyl transferase catalyzes the geranylgeranylation of
            adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11963-11967 (1994)
   PUBMED   7991565
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Cremers,F.P., Armstrong,S.A., Seabra,M.C., Brown,M.S. and
            Goldstein,J.L.
  TITLE     REP-2, a Rab escort protein encoded by the choroideremia-like gene
  JOURNAL   J Biol Chem 269 (3), 2111-2117 (1994)
   PUBMED   8294464
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Bailly,E., McCaffrey,M., Touchot,N., Zahraoui,A., Goud,B. and
            Bornens,M.
  TITLE     Phosphorylation of two small GTP-binding proteins of the Rab family
            by p34cdc2
  JOURNAL   Nature 350 (6320), 715-718 (1991)
   PUBMED   1902553
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Zahraoui,A., Touchot,N., Chardin,P. and Tavitian,A.
  TITLE     The human Rab genes encode a family of GTP-binding proteins related
            to yeast YPT1 and SEC4 products involved in secretion
  JOURNAL   J Biol Chem 264 (21), 12394-12401 (1989)
   PUBMED   2501306
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Vielh,E., Touchot,N., Zahraoui,A. and Tavitian,A.
  TITLE     Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT
            related protein
  JOURNAL   Nucleic Acids Res 17 (4), 1770 (1989)
   PUBMED   2493636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC352417.1, BC000905.2,
            AK055927.1 and AI768809.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004161.4.
            
            Summary: This gene encodes a member of the Ras superfamily of
            GTPases. Members of the gene family cycle between inactive
            GDP-bound and active GTP-bound forms. This small GTPase controls
            vesicle traffic from the endoplasmic reticulum to the Golgi
            apparatus. Multiple alternatively spliced transcript variants have
            been identified for this gene which encode different protein
            isoforms. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.216194.1,
                                           SRR1660803.3323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409784.8/ ENSP00000387286.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC352417.1         196-208
            14-1424             BC000905.2         1-1411
            1425-1913           AK055927.1         1235-1723
            1914-2448           AI768809.1         6-540               c
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..2448
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /note="RAB1A, member RAS oncogene family"
                     /db_xref="GeneID:5861"
                     /db_xref="HGNC:HGNC:9758"
                     /db_xref="MIM:179508"
     exon            1..214
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..809
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; Rab
                     GTPase YPT1 homolog; RAB1, member RAS oncogene family;
                     ras-related protein Rab-1A; GTP binding protein Rab1a;
                     YPT1-related protein"
                     /codon_start=1
                     /product="ras-related protein Rab-1A isoform 1"
                     /protein_id="NP_004152.1"
                     /db_xref="CCDS:CCDS46306.1"
                     /db_xref="GeneID:5861"
                     /db_xref="HGNC:HGNC:9758"
                     /db_xref="MIM:179508"
                     /translation="MSSMNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTI
                     GVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNV
                     KQWLQEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAKNATN
                     VEQSFMTMAAEIKKRMGPGATAGGAEKSNVKIQSTPVKQSGGGCC"
     exon            215..287
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..383
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..479
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..611
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..2448
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /note="hexamer: AATAAA"
     polyA_site      1424
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /note="major polyA site"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
                     /note="hexamer: AATAAA"
     polyA_site      2448
                     /gene="RAB1A"
                     /gene_synonym="RAB1; YPT1"
ORIGIN      
        1 attttgggtg gaagcgatag ctgagtggcg gcggctgctg attgtgttct aggggacgga
       61 gtaggggaag acgtttgctc tcccggaaca gcctatctca ttcctttctt tcgattaccc
      121 gtggcgcgga gagtcagggc ggcggctgcg gcagcaaggg cggcggtggc ggcggcggca
      181 gctgcagtga catgtccagc atgaatcccg aatatgatta tttattcaag ttacttctga
      241 ttggcgactc aggggttgga aagtcttgcc ttcttcttag gtttgcagat gatacatata
      301 cagaaagcta catcagcaca attggtgtgg atttcaaaat aagaactata gagttagacg
      361 ggaaaacaat caagcttcaa atatgggaca cagcaggcca ggaaagattt cgaacaatca
      421 cctccagtta ttacagagga gcccatggca tcatagttgt gtatgatgtg acagatcagg
      481 agtccttcaa taatgttaaa cagtggctgc aggaaataga tcgttatgcc agtgaaaatg
      541 tcaacaaatt gttggtaggg aacaaatgtg atctgaccac aaagaaagta gtagactaca
      601 caacagcgaa ggaatttgct gattcccttg gaattccgtt tttggaaacc agtgctaaga
      661 atgcaacgaa tgtagaacag tctttcatga cgatggcagc tgagattaaa aagcgaatgg
      721 gtcccggagc aacagctggt ggtgctgaga agtccaatgt taaaattcag agcactccag
      781 tcaagcagtc aggtggaggt tgctgctaaa atttgcctcc atccttttct cacagcaatg
      841 aatttgcaat ctgaacccaa gtgaaaaaac aaaattgcct gaattgtact gtatgtagct
      901 gcactacaac agattcttac cgtctccaca aaggtcagag attgtaaatg gtcaatactg
      961 actttttttt tattcccttg actcaagaca gctaacttca ttttcagaac tgttttaaac
     1021 ctttgtgtgc tggtttataa aataatgtgt gtaatccttg ttgctttcct gataccagac
     1081 tgtttcccgt ggttggttag aatatatttt gttttgatgt ttatattggc atgtttagat
     1141 gtcaggttta gtcttctgaa gatgaagttc agccattttg tatcaaacag cacaagcagt
     1201 gtctgtcact ttccatgcat aaagtttagt gagatgttat atgtaagatc tgatttgcta
     1261 gttcttcctt gtagagttat aaatggaaag attacactat ctgattaata gtttcttcat
     1321 actctgcata taatttgtgg ctgcagaata ttgtaatttg ttgcacacta tgtaacaaaa
     1381 caactgaaga tatgtttaat aaatattgta cttattggaa gtaatatcaa actgtatggt
     1441 gataagtatt gttttgattc ttatggttaa agggaaatag agccttgcat tatattcaac
     1501 acagccattt gtgtgtgcac aatgcaaact aaggtattct agacctatct tagagcagca
     1561 tccagtattt gctttctaga taatatgccc aataacatga cctagagggg cttctgtgct
     1621 gtgtagggat ttaaccaact tcagtggttc agggagctca aactatatgt aaaacaagtt
     1681 tagaatgtat gctatctagc ccgttatctc tgatccttct ctaaaaccat ttgaaatagc
     1741 ttcattgatc aacatttcat aaatgcatct gtggtagagg tagaaagcag cacctttcct
     1801 aattggcaaa tgatcagact aatgtgtgct aatgtttttc ttccatgctt tcagtcagat
     1861 tcaactattt tatcctccac agttgcttaa cttggtgttg gaggagggtt taagcattaa
     1921 gataggaagc aggaaatttg attgctctaa atttagaaat tatatcccta aaaattaaaa
     1981 catgaatact gggtggtaat gataattgag gcaaatgtat ttattttggt gacattttgc
     2041 atatatgaag attttctgaa ataggacctt caagatccta gggggttttg tttggttttt
     2101 aattgtgagg aataaaaaat cttctgccca cactggcatt ttaaggtgac tgaggtcaaa
     2161 cgttgtttcc ttaggttgaa atagcagcca aaacattctt cacgcagggg cttgggatat
     2221 ggctgctggc aacacatttt gttgtgggct ccttaattta atgataaaat ttaagctaaa
     2281 cacaagccaa aaatgaatag gtttttttaa tttttatttt tcactaaaca ggcaattgaa
     2341 atacatggta caaaaataag tggtaagata attgtaaaat gaaatggaca gaatattcaa
     2401 ttttccatct atgaaaattt cacaataaaa atcatagttt actttgta
//
