LOCUS       NM_001008749            2661 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens RAB19, member RAS oncogene family (RAB19), mRNA.
ACCESSION   NM_001008749 XM_376681 XM_379935
VERSION     NM_001008749.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Gao,Q., Liu,G., Huang,L., Zhang,Y., Zhang,X., Song,X. and Xing,X.
  TITLE     WDR38, a novel equatorial segment protein, interacts with the
            GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1561-1570 (2023)
   PUBMED   37635409
  REMARK    GeneRIF: WDR38, a novel equatorial segment protein, interacts with
            the GTPase protein RAB19 and Golgi protein GM130 to play roles in
            acrosome biogenesis.
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Hu,N. and Ji,H.
  TITLE     N6-methyladenosine (m6A)-mediated up-regulation of long noncoding
            RNA LINC01320 promotes the proliferation, migration, and invasion
            of gastric cancer via miR495-5p/RAB19 axis
  JOURNAL   Bioengineered 12 (1), 4081-4091 (2021)
   PUBMED   34288797
  REMARK    GeneRIF: N6-methyladenosine (m6A)-mediated up-regulation of long
            noncoding RNA LINC01320 promotes the proliferation, migration, and
            invasion of gastric cancer via miR495-5p/RAB19 axis.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY655778.1, DN996121.1, BC140796.1 and AC069335.17.
            
            On Jul 12, 2019 this sequence version replaced NM_001008749.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.29704.1,
                                           SRR14038196.3274789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537763.6/ ENSP00000440167.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DY655778.1         284-374             c
            92-630              DN996121.1         81-619
            631-937             BC140796.1         516-822
            938-2661            AC069335.17        18044-19767
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2661
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /note="RAB19, member RAS oncogene family"
                     /db_xref="GeneID:401409"
                     /db_xref="HGNC:HGNC:19982"
     exon            1..160
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /inference="alignment:Splign:2.1.0"
     exon            161..384
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..837
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /note="GTP-binding protein RAB19B"
                     /codon_start=1
                     /product="ras-related protein Rab-19"
                     /protein_id="NP_001008749.2"
                     /db_xref="CCDS:CCDS34762.2"
                     /db_xref="GeneID:401409"
                     /db_xref="HGNC:HGNC:19982"
                     /translation="MHFSSSARAADENFDYLFKIILIGDSNVGKTCVVQHFKSGVYTE
                     TQQNTIGVDFTVRSLDIDGKKVKMQVWDTAGQERFRTITQSYYRSAHAAIIAYDLTRR
                     STFESIPHWIHEIEKYGAANVVIMLIGNKCDLWEKRHVLFEDACTLAEKYGLLAVLET
                     SAKESKNIEEVFVLMAKELIARNSLHLYGESALNGLPLDSSPVLMAQGPSEKTHCTC"
     exon            385..568
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2661
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2634..2639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /note="hexamer: ATTAAA"
     polyA_site      2661
                     /gene="RAB19"
                     /gene_synonym="RAB19B"
                     /note="major polyA site"
ORIGIN      
        1 actttctcag gacgccaaac ccgacacctg gggccagaac tacacttccc accaagcagc
       61 gaggcaggag gaagaagggg gcactggggg gctgaaaagc aaacccagaa gaaagcgaaa
      121 acattacctg ctgaccagca gaggtgagag agcgagacag ttctgttcta ggtggcaaga
      181 accatgcact tctccagctc agccagggca gcagatgaga actttgacta tttgttcaag
      241 attatcctca ttggggattc caatgtgggg aagacgtgtg tggtgcagca tttcaagtct
      301 ggagtctaca ctgagacaca gcagaacacg attggagtgg actttaccgt gcgttccctt
      361 gatattgacg gcaaaaaagt gaagatgcag gtgtgggaca cagctggcca ggagcgcttc
      421 cgcaccatca cccaaagcta ctaccgcagt gcccacgcag ccatcatcgc ctatgacctc
      481 acccggcggt ccacgttcga gtccatccct cactggattc atgagataga gaaatatgga
      541 gctgcaaatg tggtcattat gctgattgga aataaatgtg acctctggga aaagcggcac
      601 gtcctgttcg aggatgcctg cacactggct gagaagtacg gcctcctggc cgttttggag
      661 acatctgcca aggagtcaaa gaacatagaa gaagtcttcg tgctcatggc caaggagctg
      721 atcgcgcgca acagcctgca cctatatggg gagagtgccc tgaacggcct ccccctggac
      781 tccagccccg ttcttatggc ccagggtcca agtgaaaaga cccactgcac ttgctaagat
      841 gtttgcaaag ccagttgcac ccaccaaaga ggccgcctct gaaaccaaag gtagccagga
      901 taccgtagtg ttgccccagt ggcgctttag accccagcgt ggacttgccg ctcaccccta
      961 atcctcccag tctggatggg ccacacttct cccttgactc acaccacagg tcatagctgc
     1021 tgactctcag gaaaaccagc accattgttt tcactgactc ttgactcctg gagaaggcag
     1081 gacttcaggc taggagaggg aggacgaagt gtactcttct cccctttcac ttttctgtct
     1141 ccctagagct tctgctgctt tctactgaat tttgtttctt gcttgaagaa gagggtagtg
     1201 aaggaaagga ggaaggcaaa acagcaagag agagaagagg ctgtttggaa cattctggaa
     1261 cagtttgaaa cagctcaggc agggagaatg gaacgaaagc ctgcaatgag aaaccagaat
     1321 gctgctatca ttttgttcct gacattcaca cctcaggtct tcactttggg gagcgaagcc
     1381 ttttagcaga aataccagaa gtaccatctt gccaaatggt caggaactgt ctgatagaga
     1441 tggaactgga attcactcta ttctagcagg gctgacttgg ccaccctctt gggatagggg
     1501 aagacacctg caattttttt tctttctttt tttttttttt ttttttgaga cagggtcata
     1561 ctctgtcacc caagctggag tatagtggtg ggatcttggc tcactgcaac ctctacctcc
     1621 tgggttcaag aggttctccc acctcagtct cccaagtggc tgggactaca gacacacgcc
     1681 accactcctg gctaattttt gtattttttg tagagacaag gtttcaccat gttgctcagg
     1741 ctgatcttga actcctgagc tcaggtgatc tgcccacctt ggcttcccaa agtgctggga
     1801 ttacaggcat gagccaccat gcctgttctt tttttttttt tttttttttg agactgagtc
     1861 tcactctgtc actcaggctg gaatgcagtg gcatgatctc ggctcactgc aacctcaacc
     1921 tccacctcct gggttcaagc aattctcctg cctcagcctc ccaagtagct gggactactg
     1981 gcactcacta ccacgcccag ctcatttttt ttgtatattt agtagagact gggtttcact
     2041 acgttggtca ggctggtctt gaactcctga cctcatgatc cacccgtctc ggcctcctaa
     2101 agtgctggga ttacaggcat gagccaccat gcccggccct tttttttttt tttttgagac
     2161 agagtttcgc tcttgttgcc caggctggag tgcaatggtg tgacctcggc tcactgcaac
     2221 ttctgccttc cagattcaag tgattctcct gcctcaacct ccctagtagc tgggattaca
     2281 gcctcccgcc accacgccta gctaattttt gtgtttttag tagaggcagg gtttcaccac
     2341 gttggccagg ctggtctcga actcctgacc tcatgatcca cctgtctcgt ggcctcccaa
     2401 agtgctggga ttacaggtgt gaaccaccgc acctggcctt tttttattat tattattgta
     2461 gaaatgaagt cttgctacgt tgcccaggct ggtctccaat tcctgagctc acaggtttct
     2521 cccacctcag cctcccaaag tgctgggatt acaggcatga gccaccatgc ctggcacaat
     2581 ttctttctag aacccaaatc atctgccaga tcagaagtca tttttaaatt aaaattaaat
     2641 tggttcatag atgaatatca a
//
