LOCUS       NM_021252               4875 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens RAB18, member RAS oncogene family (RAB18), transcript
            variant 1, mRNA.
ACCESSION   NM_021252
VERSION     NM_021252.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Deng,Y., Hahn,Q., Yu,L., Zhu,Z., Boyer,J.A., Wang,J., Kong,D.,
            Carey,L.M., Hepperla,A.J., Simon,J.M., Temple,B., Zhang,Z.,
            Zhang,Y., Santos,C., Frank,J.E., Herring,L.E., Wang,X.,
            Dokholyan,N.V., Campbell,S.L., Baldwin,A.S., Damania,B., Zhang,Q.
            and Liu,P.
  TITLE     2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling
            in cell migration control independent of innate immunity
  JOURNAL   Sci Adv 10 (42), eado7024 (2024)
   PUBMED   39413198
  REMARK    GeneRIF: 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB
            signaling in cell migration control independent of innate immunity.
            Erratum:[Sci Adv. 2025 Jan 17;11(3):eadv6581. doi:
            10.1126/sciadv.adv6581.. PMID: 39823348]
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Liu,J., Li,L., Xu,D., Li,Y., Chen,T., Liu,Y., Bao,Y., Wang,Y.,
            Yang,L., Li,P. and Xu,L.
  TITLE     Rab18 maintains homeostasis of subcutaneous adipose tissue to
            prevent obesity-induced metabolic disorders
  JOURNAL   Sci China Life Sci 67 (6), 1170-1182 (2024)
   PUBMED   38523235
  REMARK    GeneRIF: Rab18 maintains homeostasis of subcutaneous adipose tissue
            to prevent obesity-induced metabolic disorders.
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Lopez-Alcala,J., Soler-Vazquez,M.C., Tercero-Alcazar,C.,
            Sanchez-Ceinos,J., Guzman-Ruiz,R., Malagon,M.M. and Gordon,A.
  TITLE     Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum Interactions
            of Adipocytes under Obesogenic Conditions
  JOURNAL   Int J Mol Sci 24 (24), 17177 (2023)
   PUBMED   38139006
  REMARK    GeneRIF: Rab18 Drift in Lipid Droplet and Endoplasmic Reticulum
            Interactions of Adipocytes under Obesogenic Conditions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4875)
  AUTHORS   Yang,K. and Wang,Z.
  TITLE     Rab18 interacted with V-set and immunoglobulin domain-containing 4
            (VSIG4) to involve in the apoptosis of glioma and the sensitivity
            to temozolomide
  JOURNAL   Bioengineered 12 (1), 1391-1402 (2021)
   PUBMED   33904378
  REMARK    GeneRIF: Rab18 interacted with V-set and immunoglobulin
            domain-containing 4 (VSIG4) to involve in the apoptosis of glioma
            and the sensitivity to temozolomide.
REFERENCE   5  (bases 1 to 4875)
  AUTHORS   Abdel-Hamid,M.S., Abdel-Ghafar,S.F., Ismail,S.R., Desouky,L.M.,
            Issa,M.Y., Effat,L.K. and Zaki,M.S.
  TITLE     Micro and Martsolf syndromes in 34 new patients: Refining the
            phenotypic spectrum and further molecular insights
  JOURNAL   Clin Genet 98 (5), 445-456 (2020)
   PUBMED   32740904
  REMARK    GeneRIF: Micro and Martsolf syndromes in 34 new patients: Refining
            the phenotypic spectrum and further molecular insights.
            Review article
REFERENCE   6  (bases 1 to 4875)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   7  (bases 1 to 4875)
  AUTHORS   Schafer,U., Seibold,S., Schneider,A. and Neugebauer,E.
  TITLE     Isolation and characterisation of the human rab18 gene after
            stimulation of endothelial cells with histamine
  JOURNAL   FEBS Lett 466 (1), 148-154 (2000)
   PUBMED   10648831
REFERENCE   8  (bases 1 to 4875)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   9  (bases 1 to 4875)
  AUTHORS   Lutcke,A., Parton,R.G., Murphy,C., Olkkonen,V.M., Dupree,P.,
            Valencia,A., Simons,K. and Zerial,M.
  TITLE     Cloning and subcellular localization of novel rab proteins reveals
            polarized and cell type-specific expression
  JOURNAL   J Cell Sci 107 (Pt 12), 3437-3448 (1994)
   PUBMED   7706395
REFERENCE   10 (bases 1 to 4875)
  AUTHORS   Handley,M. and Sheridan,E.
  TITLE     RAB18 Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29300443
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN357871.1, BC015014.2,
            AL138920.11 and N56901.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_021252.4.
            
            Summary: The protein encoded by this gene is a member of a family
            of Ras-related small GTPases that regulate membrane trafficking in
            organelles and transport vesicles. Knockdown studies is zebrafish
            suggest that this protein may have a role in eye and brain
            development. Mutations in this gene are associated with Warburg
            micro syndrome type 3. Alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Jan 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029350.1, SRR1660809.102537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356940.11/ ENSP00000349415.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CN357871.1         200-215
            17-2806             BC015014.2         1-2790
            2807-4490           AL138920.11        124561-126244
            4491-4873           N56901.1           1-383               c
            4874-4875           AL138920.11        126628-126629
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.1"
     gene            1..4875
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="RAB18, member RAS oncogene family"
                     /db_xref="GeneID:22931"
                     /db_xref="HGNC:HGNC:14244"
                     /db_xref="MIM:602207"
     exon            1..134
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..687
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="isoform 1 is encoded by transcript variant 1; RAB18
                     small GTPase; ras-related protein Rab-18"
                     /codon_start=1
                     /product="ras-related protein Rab-18 isoform 1"
                     /protein_id="NP_067075.1"
                     /db_xref="CCDS:CCDS7155.1"
                     /db_xref="GeneID:22931"
                     /db_xref="HGNC:HGNC:14244"
                     /db_xref="MIM:602207"
                     /translation="MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVD
                     FKVKTISVDGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNW
                     LNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQC
                     AFEELVEKIIQTPGLWESENQNKGVKLSHREEGQGGGACGGYCSVL"
     exon            135..190
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     exon            191..252
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     exon            253..325
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..444
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     exon            445..511
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..4875
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1129..1134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="hexamer: AATAAA"
     polyA_site      1149
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="major polyA site"
     regulatory      2441..2446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="major polyA site"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="hexamer: AATAAA"
     polyA_site      2795
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="major polyA site"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
                     /note="hexamer: AATAAA"
     polyA_site      4875
                     /gene="RAB18"
                     /gene_synonym="RAB18LI1; WARBM3"
ORIGIN      
        1 actctgctga agggctgaga ggcgcacccg ggcggccagc tgggctcgga gcggaacggg
       61 gtcaggatgg acgaggacgt gctaaccacc ctgaagatcc tcatcatcgg cgagagtggg
      121 gtgggcaagt ccagcctgct cttgaggttc acagatgata cgtttgatcc agaacttgca
      181 gcaacaatag gtgttgactt taaggtgaaa acaatttcag tggatggaaa taaggctaaa
      241 cttgcaatat gggatactgc tggtcaagag aggtttagaa cattaactcc cagctattat
      301 agaggtgcac agggtgttat attagtttat gatgtcacaa gaagagatac atttgttaaa
      361 ctggataatt ggttaaatga attggaaaca tactgtacaa gaaatgacat agtaaacatg
      421 ctagttggaa ataaaatcga taaggaaaat cgtgaagtcg atagaaatga aggcctgaaa
      481 tttgcacgaa agcattccat gttatttata gaggcaagtg caaaaacctg tgatggtgta
      541 caatgtgcct ttgaagaact tgttgaaaag atcattcaga cccctggact gtgggaaagt
      601 gagaaccaga ataaaggagt caaactgtca cacagggaag aaggccaagg aggaggagcc
      661 tgtggtggtt attgctctgt gttataaact ctgggaaatt ccatctcttg catatttgat
      721 cagatagtga catctttctg tatataaact ctttaactgc tattttaggg accttgcagt
      781 ttgcacataa ttgttttata tcatagcagt aaatatttgc aagaaatccc actcatcgac
      841 cccgggtaaa atgttatggt aagcatgcac agtttgcagt ctacagtttt tttatgtagc
      901 acaaaatagg tgtaccttta taagtacatt caattttatg atttacattt atcatgtaat
      961 ttttaaaaaa atccatctat ctaggatatg ttgatacaaa gtctgctttt gctattcttt
     1021 ttgcttaaat actcctatca ttttctgaat tacttggtat ttagaactcc tagcaccacg
     1081 gggaagaata gaggtatcat caaacgtggc aaattttctt tcaggaataa taaagagcat
     1141 gattccacag cttttctggg atgtttgaga ttctttttta gtactaagca aaattctcat
     1201 cacagaatgt agcccaggcc aatttataac taaatctcta tttgttcgga tgatgcttct
     1261 aaaacagcat tgataggtta aagaagcttg gtatttttaa tttacttcaa tgattagctc
     1321 agttgcttaa ctggagtttt aatcctgtga tatgtacatt ggattcatga ctgtgcagca
     1381 tttttagtta tgtggtgttt ggcagaatga caataaggtt ttcccccatt ttggtttcag
     1441 gaggacatga atagtgtgtt tattgtaact cctcatacac ttttaaaacc aacatctttt
     1501 ttcataaatg ttggtagtgt ttgtccaggt accttaactg tagcttgtgt aatgttgatg
     1561 aatatctgta tcttacggct tccataatgg ctagttgata ttcaaaaacc tatttctgtg
     1621 ttttgagggg tggggaaaaa aaacactaag tgataatttg aaaaaggcat attgcttcca
     1681 gattctgatg tgtgagggaa aatactgtca caatgaaaat cttgacaatt tacttaacaa
     1741 gtaaccagta gttcatcaaa accaacttgt acagactaat aaatcttttt cacagtattc
     1801 agttttctca cctcttgcta ttgtatattg tagatttttt tcattcatgt gttatttaat
     1861 ttacactgat ctctgctatt ttaacccccc aaataagtta tttgtccttt aaggttggtt
     1921 actataatac ccctcagtaa gattccagta ttaatttctg ggcagtttgt tctctgtata
     1981 caattgcaaa tgataagcat ttttgtgagt gaccaccttt gcaatatgtt tgttaattta
     2041 cttcatgttg ggttctttct gaaatgtaca tctttacata taaaaacctc acattctact
     2101 tgatttacac ttcctagtct acattacatg tggttgaagg ttttatacat tctatatgct
     2161 tttactaaat atacaagatt tactactaga aatttggaga aagaacacta acacatgtac
     2221 ttgtgatttg ttcatgttat attaaaactt gagatttgtg tatttatgta gagtctgtat
     2281 tgacaagact gttgtttttt gctccttgag ctatataata atctgtgtat tggattgttg
     2341 tcttgatttg gtctaaattt gaatatatat gagttacttg aatataacaa aaatgaattt
     2401 tgtttgatag atttatattg taaccttttt ctagttcttg aataaatata gcctgctttc
     2461 cctagatgca tttgtgtagg aagtatatac atttccctat tactctcatc agctgaagaa
     2521 tatgtactat tgtgttactc aaattatgtg gctttcattt tgttgttttg ttgcaagctt
     2581 agtgttttgt agtggaggtt ttgtaaatga aacagttgta atatctaagg tcaggcacct
     2641 agtaacaggg ttttgttaat tcttttcaga atcattgaag cagtcttaaa gggtcttttg
     2701 cagatggtac aaattagaac aattagaata tagtattttg agttctagta gtactgagat
     2761 tgacccaaac aaataaaaaa ctattcaatt tctgagtaat agttaatatt tattgaaagc
     2821 ttccttggtg ccagatgcct ttctaagtgc tgaattatct cattaaacct cacagcaacc
     2881 ttaagagatt agtactccta ttatgcccat tttaaaggtg aggacaacac aatgtaggta
     2941 tgttaggtaa cccccaaaga tcacatagct actcagtcac tgagctggat tccagtcatg
     3001 gcatttttac ttctgagccc atactcttca ccatcgctca ttttacaatg ggtagttagt
     3061 taccagcttt ttgtaacaca accaagttaa ggcagttcca ctatttcttt atcactcttt
     3121 tgttatatgt aatagaagta tttcacactt ttgggttata gagtaaatcc catgatgtaa
     3181 acctacctca taagtcatgt gacataaaag ttaaggtagt ggagtaggtg gtcttatttc
     3241 tttcacctgc tcagagtgga ctgaaaatcc tgacttagaa aaggtacaaa gttaggggac
     3301 ttatggtacc ttcacttttt atgtgagaat agaaattatg gaaacagtaa tttgctcaaa
     3361 actgaaatct ggggtgatgt tttcatttca tgtatttgat tgccatccat aaactcatac
     3421 ttggtgttga cattctagct gagtgttgtg gaaatagact tgattttgat tcatcgtagc
     3481 ttgcatggtc aagagacatg attctctact aagggtgggg ctagcaccat agctcataaa
     3541 agaatccttc ttacaccagt acttgttctg cctgtgagtt ggcacagact tacctaataa
     3601 ccatagtgtc tttaagtaca acttaataca tattttttct gtgtattttt ttcaaatgaa
     3661 ctcaacaatt cttcaggtat tatagatcag agatcctctc catattcaag cattatgctt
     3721 ctctttcttg ggggtacatt tcactagtaa tacttaggaa gttattttgt ctttcctgta
     3781 tttccctagt taagtatagg ggtaaaaacg ttattcagct ttcagaagac attgttctga
     3841 ctccgaccct gccgtgtata ctcaactata tagacttcac cctgggtttt gcctaaactg
     3901 ttgaaagacg agaataaata gacatagaca ggctagctaa gtcaagacta ggggctaagg
     3961 aatatagaat cacccaggtc tttttttttt tttttaattt ttctctcctc agttgggaac
     4021 atctatcatg ctggaggact actgtgatgg ggctttacat tttactgttt tgttgctagc
     4081 ttattgtttc atacttggga atcagtcatg tttctgattg tggtataaag tttgcttaag
     4141 tgccccttag ttaaagctgt tcaatgaatg taagcacaca cacacctaca cacatatttt
     4201 gaatagtcgt gtgttcatgc ctgttctcag tcttgtcccc tttaccgttt ctcatgcagg
     4261 ttatttcttg cttttttttt ttttcctctt ttttaaccgg agaagcaaca aattacgtag
     4321 ttttttttgt gtttctttga ttactagtga gcttgagtac ttttaatatt ttattggata
     4381 tgtttgtgac tgactttaat ttcttgtttg tgtgtgctgt ggctgcccga tccagcacct
     4441 acttccttct cccaccatac cacccccacc cccacccctg caaacaattg gcatgtggtt
     4501 tgggtggcat tgtcacaccc tcggctttct agattaaccc agttaccttt tagcagtgcc
     4561 ccacttcccc agtagcaatg gttcaggggt aggcacctga cccagaccag actactgaga
     4621 taaagatgtt tgcctaggct ttttcaggag caattgaaga catcttgttg gagatagtgt
     4681 gctgggagga gtcacattct gaacttgctg cagctcgttt ttctaatata aaggaaccag
     4741 cctgaggcag taccagggtg agagggagtc tattggagcc cttgggaact tctggatcaa
     4801 attggacctg aattgagatc tatttctcag ctttcactta tgtgagccaa taaattcctt
     4861 ttttgttgaa ggcaa
//
