LOCUS       NM_022449               1603 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens RAB17, member RAS oncogene family (RAB17), transcript
            variant 1, mRNA.
ACCESSION   NM_022449
VERSION     NM_022449.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Zhou,X., Nie,M., Xin,X., Hua,T., Zhang,J., Shi,R., Dong,K., Shu,W.,
            Yan,B. and Wang,H.
  TITLE     RAB17 promotes endometrial cancer progression by inhibiting
            TFRC-dependent ferroptosis
  JOURNAL   Cell Death Dis 15 (9), 655 (2024)
   PUBMED   39242574
  REMARK    GeneRIF: RAB17 promotes endometrial cancer progression by
            inhibiting TFRC-dependent ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Ono,S., Otomo,A., Murakoshi,S., Mitsui,S., Sato,K., Fukuda,M. and
            Hadano,S.
  TITLE     ALS2, the small GTPase Rab17-interacting protein, regulates
            maturation and sorting of Rab17-associated endosomes
  JOURNAL   Biochem Biophys Res Commun 523 (4), 908-915 (2020)
   PUBMED   31959474
  REMARK    GeneRIF: ALS2, the small GTPase Rab17-interacting protein,
            regulates maturation and sorting of Rab17-associated endosomes.
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Wang,M., Wang,W., Ding,J., Wang,J. and Zhang,J.
  TITLE     Downregulation of Rab17 promotes cell proliferation and invasion in
            non-small cell lung cancer through STAT3/HIF-1alpha/VEGF signaling
  JOURNAL   Thorac Cancer 11 (2), 379-388 (2020)
   PUBMED   31841274
  REMARK    GeneRIF: Downregulation of Rab17 promotes cell proliferation and
            invasion in non-small cell lung cancer through
            STAT3/HIF-1alpha/VEGF signaling.
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Yin,C., Argintaru,D. and Heit,B.
  TITLE     Rab17 mediates intermixing of phagocytosed apoptotic cells with
            recycling endosomes
  JOURNAL   Small GTPases 10 (3), 218-226 (2019)
   PUBMED   28471261
  REMARK    GeneRIF: Rab17 is rapidly recruited to efferosomes, followed by
            migration of the efferosome to the cell center where it intermixes
            with lysosomes and undergoes Rab17-dependent vesiculation.
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Bucci,C., Chiariello,M., Lattero,D., Maiorano,M. and Bruni,C.B.
  TITLE     Interaction cloning and characterization of the cDNA encoding the
            human prenylated rab acceptor (PRA1)
  JOURNAL   Biochem Biophys Res Commun 258 (3), 657-662 (1999)
   PUBMED   10329441
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Hunziker,W. and Peters,P.J.
  TITLE     Rab17 localizes to recycling endosomes and regulates
            receptor-mediated transcytosis in epithelial cells
  JOURNAL   J Biol Chem 273 (25), 15734-15741 (1998)
   PUBMED   9624171
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Lutcke,A., Jansson,S., Parton,R.G., Chavrier,P., Valencia,A.,
            Huber,L.A., Lehtonen,E. and Zerial,M.
  TITLE     Rab17, a novel small GTPase, is specific for epithelial cells and
            is induced during cell polarization
  JOURNAL   J Cell Biol 121 (3), 553-564 (1993)
   PUBMED   8486736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC023661.2 and BC050426.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022449.3.
            
            Summary: The Rab subfamily of small GTPases plays an important role
            in the regulation of membrane trafficking. RAB17 is an epithelial
            cell-specific GTPase (Lutcke et al., 1993 [PubMed
            8486736]).[supplied by OMIM, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the full-length protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050426.1, AK022600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264601.8/ ENSP00000264601.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               BC023661.2         338-491
            155-1603            BC050426.1         145-1593
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1603
                     /gene="RAB17"
                     /note="RAB17, member RAS oncogene family"
                     /db_xref="GeneID:64284"
                     /db_xref="HGNC:HGNC:16523"
                     /db_xref="MIM:602206"
     exon            1..268
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     exon            269..428
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..910
                     /gene="RAB17"
                     /codon_start=1
                     /product="ras-related protein Rab-17"
                     /protein_id="NP_071894.1"
                     /db_xref="CCDS:CCDS2520.1"
                     /db_xref="GeneID:64284"
                     /db_xref="HGNC:HGNC:16523"
                     /db_xref="MIM:602206"
                     /translation="MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDF
                     KSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITR
                     KDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFME
                     TSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH"
     exon            429..580
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     exon            581..706
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     exon            707..800
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1603
                     /gene="RAB17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB17"
                     /note="hexamer: ATTAAA"
     polyA_site      1603
                     /gene="RAB17"
                     /note="major polyA site"
ORIGIN      
        1 gccctgaaac cttctgggag gagaagaggc ctgaccttgg cgctggggtc cagtgggcat
       61 tgctctggtc cgaggctgct gctcttgacc tctgctctgc ggctgttttc cattggagta
      121 gaggctcctc ctgtcctgtc ctgcctgtgg agggaagcaa accttcccct ggaccagaga
      181 gaggagaaag cggagacagg tagcaacgct gtggactggt gatgacaggc tcttcagctc
      241 cctgcaagtg accgggcctg gggaacaggg catggcacag gcacacagga ccccccagcc
      301 cagggctgcc cccagccagc cccgtgtgtt caagctggtt ctcctgggaa gtggctccgt
      361 gggtaagtcc agcttggctc ttcggtacgt gaagaacgac ttcaagagta tcctgcctac
      421 ggtgggctgt gcgttcttca caaaggtggt ggatgtgggt gccacctctc tgaagcttga
      481 gatctgggac acagctggcc aggagaagta ccacagcgtc tgccacctct acttcagggg
      541 tgccaacgct gcgcttctgg tgtacgacat caccaggaag gattccttcc tcaaggctca
      601 gcagtggctg aaggacctgg aggaggagct gcacccagga gaagtcctgg tgatgctggt
      661 gggcaacaag acggacctca gccaggagcg ggaggtgacc ttccaggaag ggaaggagtt
      721 tgccgacagc cagaagttgc tgttcatgga aacttcggcc aaactgaacc accaggtgtc
      781 ggaggtgttc aatacagtgg cccaagagct actgcagaga agcgacgagg agggccaggc
      841 tctacggggg gatgcagctg tggctctgaa caaggggccc gcgaggcagg ccaaatgctg
      901 cgcccactag gtgcagccac tcctgggggc tgtggggaag acaccccctg cctgggccat
      961 ggccagctct aggtggattc tgattcactg tcaatgctgg gttgctcccg agccctagat
     1021 gttcctggaa gttggccccc tttatgaaaa ccacttccca cagccagtgg gaactgccag
     1081 aggaagatct ggcgtcacat ggctcccagg aaagtgctgt gccctatccc cactgatacc
     1141 atctgattcc ccgatgcctg tgcctgttcc acctggacgg tggccccctc agcctggcag
     1201 cctctggaca gagaggaagg aaggattgga aaagtccccg cagcacagcg acggtgggaa
     1261 gatgccttac gtctgatctt gatgggggca ctggcctgga gcctgggccc acctgcttct
     1321 ggggggttgg ggagcaggcc agatggaggt ggtggtgcca ggaagaaatg gagcgatgac
     1381 tgactgtggg gtgggcccag gatttccaca tcttggtgaa gttgcccctg ggaagggcag
     1441 ctgggggcag tggcgccagt tcccttccat ggtctcccgg ctggcaatgt ggtgaagctg
     1501 agtttctgtc caatgagcag gaagattctg agacatttcg cctgagatat aagttgtact
     1561 gcgtatgcag tttttcctcc aaaaattaaa ttgcttttga caa
//
