LOCUS       NM_001308154            3437 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens RAB15, member RAS oncogene family (RAB15), transcript
            variant 2, mRNA.
ACCESSION   NM_001308154 XM_005267597
VERSION     NM_001308154.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Yang,N., Li,M., Qin,S., Duan,N., Li,X., Zhou,Y., Wang,M., Jin,Y.,
            Wu,W. and Cheng,Z.
  TITLE     Ehrlichia chaffeensis Etf-3 Induces Host RAB15 Upregulation for
            Bacterial Intracellular Growth
  JOURNAL   Int J Mol Sci 25 (5), 2551 (2024)
   PUBMED   38473798
  REMARK    GeneRIF: Ehrlichia chaffeensis Etf-3 Induces Host RAB15
            Upregulation for Bacterial Intracellular Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Zografou,S., Basagiannis,D., Papafotika,A., Shirakawa,R.,
            Horiuchi,H., Auerbach,D., Fukuda,M. and Christoforidis,S.
  TITLE     A complete Rab screening reveals novel insights in Weibel-Palade
            body exocytosis
  JOURNAL   J Cell Sci 125 (Pt 20), 4780-4790 (2012)
   PUBMED   22899725
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Pham,T.V., Hartomo,T.B., Lee,M.J., Hasegawa,D., Ishida,T.,
            Kawasaki,K., Kosaka,Y., Yamamoto,T., Morikawa,S., Yamamoto,N.,
            Kubokawa,I., Mori,T., Yanai,T., Hayakawa,A., Takeshima,Y.,
            Iijima,K., Matsuo,M., Nishio,H. and Nishimura,N.
  TITLE     Rab15 alternative splicing is altered in spheres of neuroblastoma
            cells
  JOURNAL   Oncol Rep 27 (6), 2045-2049 (2012)
   PUBMED   22427180
  REMARK    GeneRIF: identified 4 Rab15 isoforms, Rab15CN, Rab15AN1, Rab15AN2
            and Rab15AN3 in neuroblastoma cells and demonstrated that Rab15
            isoform balance was significantly decreased in spheres of
            neuroblastoma cells; study suggests Rab15 alternative splicing may
            serve as a biomarker to discriminate tumor-initiating cells (TICs)
            from non-TICs in neuroblastoma
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Nishimura,N., Van Huyen Pham,T., Hartomo,T.B., Lee,M.J.,
            Hasegawa,D., Takeda,H., Kawasaki,K., Kosaka,Y., Yamamoto,T.,
            Morikawa,S., Yamamoto,N., Kubokawa,I., Mori,T., Yanai,T.,
            Hayakawa,A., Takeshima,Y., Nishio,H. and Matsuo,M.
  TITLE     Rab15 expression correlates with retinoic acid-induced
            differentiation of neuroblastoma cells
  JOURNAL   Oncol Rep 26 (1), 145-151 (2011)
   PUBMED   21491086
  REMARK    GeneRIF: Rab15 expression correlates with retinoic acid-induced
            differentiation of neuroblastoma cells
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3437)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 3437)
  AUTHORS   Strick,D.J., Francescutti,D.M., Zhao,Y. and Elferink,L.A.
  TITLE     Mammalian suppressor of Sec4 modulates the inhibitory effect of
            Rab15 during early endocytosis
  JOURNAL   J Biol Chem 277 (36), 32722-32729 (2002)
   PUBMED   12105226
REFERENCE   8  (bases 1 to 3437)
  AUTHORS   Pereira-Leal,J.B. and Seabra,M.C.
  TITLE     Evolution of the Rab family of small GTP-binding proteins
  JOURNAL   J Mol Biol 313 (4), 889-901 (2001)
   PUBMED   11697911
REFERENCE   9  (bases 1 to 3437)
  AUTHORS   Zuk,P.A. and Elferink,L.A.
  TITLE     Rab15 differentially regulates early endocytic trafficking
  JOURNAL   J Biol Chem 275 (35), 26754-26764 (2000)
   PUBMED   10837464
REFERENCE   10 (bases 1 to 3437)
  AUTHORS   Zuk,P.A. and Elferink,L.A.
  TITLE     Rab15 mediates an early endocytic event in Chinese hamster ovary
            cells
  JOURNAL   J Biol Chem 274 (32), 22303-22312 (1999)
   PUBMED   10428799
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139022.4, AB678452.1, AB678453.1, BX248046.1 and AI096837.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001308154.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            that results in a frameshift and novel 3' coding region compared to
            variant 1. It encodes isoform 2, which is longer than and has a
            novel C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.452251.1,
                                           SRR14038194.3474810.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533601.7/ ENSP00000434103.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL139022.4         133847-134025
            180-196             AB678452.1         1-17
            197-951             AB678453.1         1-755
            952-3403            BX248046.1         700-3151
            3404-3437           AI096837.1         27-60               c
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..3437
                     /gene="RAB15"
                     /note="RAB15, member RAS oncogene family"
                     /db_xref="GeneID:376267"
                     /db_xref="HGNC:HGNC:20150"
                     /db_xref="MIM:619547"
     exon            1..384
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..899
                     /gene="RAB15"
                     /note="isoform 2 is encoded by transcript variant 2;
                     RAB15, member RAS onocogene family"
                     /codon_start=1
                     /product="ras-related protein Rab-15 isoform 2"
                     /protein_id="NP_001295083.1"
                     /db_xref="CCDS:CCDS76691.1"
                     /db_xref="GeneID:376267"
                     /db_xref="HGNC:HGNC:20150"
                     /db_xref="MIM:619547"
                     /translation="MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVD
                     FKMKTIEVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKW
                     VSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAKEYGMDFYETSACTNLNIKE
                     SFTRLTELVLQAHRKELEGLRMRASNELALAELEEEEGKPEGPANSSKTCWC"
     exon            385..445
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     exon            446..506
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     exon            507..584
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     exon            585..674
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     exon            675..740
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     exon            741..3437
                     /gene="RAB15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB15"
                     /note="hexamer: AATAAA"
     polyA_site      3437
                     /gene="RAB15"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcccac cgcctcgcgc cagcccagcc gagccgagcc gagccgagcg ggcgccgcgc
       61 cgggctcccg ccgcagccgc gcttcccggc acccagcgag cgagtgggca ggcgggcggg
      121 cgaggcagcc gcgggggccg ggcccggcgt cctcctcgcc gcccgcagcg tccccgggcg
      181 ggcgcgggcc gcgatggcag cggcggagca gggctgagcc cgctgcccgc ccgcagttcc
      241 cggccccgct ggccccagtc atggcgaagc agtacgatgt gctgttccgg ctgctgctga
      301 tcggggactc cggggtgggc aagacctgcc tgctgtgccg cttcaccgac aacgagttcc
      361 actcctcgca catctccacc atcggtgttg actttaagat gaagaccata gaggtagacg
      421 gcatcaaagt gcggatacag atctgggaca ctgcagggca ggagagatac cagaccatca
      481 caaagcagta ctatcggcgg gcccagggga tatttttggt ctatgacatt agcagcgagc
      541 gctcttacca gcacatcatg aagtgggtca gtgacgtgga tgagtacgca ccagaaggcg
      601 tccagaagat ccttattggg aataaggctg atgaggagca gaaacggcag gtgggaagag
      661 agcaagggca gcagctggcg aaggagtatg gcatggactt ctatgaaaca agtgcctgca
      721 ccaacctcaa cattaaagag tcattcacgc gtctgacaga gctggtgctg caggcccata
      781 ggaaggagct ggaaggcctc cggatgcgtg ccagcaatga gttggcactg gcagagctgg
      841 aggaggagga gggcaaaccc gagggcccag cgaactcttc gaaaacctgc tggtgctgag
      901 tcctgtgtgg ggcaccccac acgacacccc tcttccctca ggaggcccgt gggcagacag
      961 gggagccggg gctttgccct gctgctgtcc tctcgtgtga tgaccctatt gagtatcagt
     1021 agccactact ccccctgcct ggccctgaga gcggctctgc tgtcatctca agcagcccct
     1081 gtccccagcc cgtccaccct ggagtggtct tcttcagcct gtttccccag ccacaggcct
     1141 gctacgaccc ccacgatgtg ccgcaagcac tgtctcacca tcccgcaccc accagacaac
     1201 agccagggct ggagtccagg ccactttcag ctgctccttt ctccgtgcat cgtgtctctt
     1261 ctctgctttt tctctcttcc cccacttctc tttctctgac ccctcccctc cggtgcgttt
     1321 cgtatcaaag ctcctcaaac cccgtccccc gtgtgtcctg ctgtgtgcag ctcgctcttt
     1381 ccttccttcc taagctatcc aaggggatgg acccaggctc gtggggaggt tccacccttg
     1441 gatccaggaa gaaccctcca ccctgcctcg tgggtgggcc aaaggctaca gggtgcttct
     1501 tcctcttccc ccacccccac tgtccctcat gtgccatggg cctgcctccc cagtgacctg
     1561 cgaaagtgga gcatcgaggt aggagggaaa cggcaaccag ggagtcctcg agcctggggc
     1621 tgccctacct ctacccattc cccgaccaga gctttgccct tgcttggctg cccgcctgcc
     1681 tctttgggga actgagctca gaggcaggtg cttcagagaa ggaaacaaaa tgaggggtgg
     1741 cagggataaa aagtcacctc cattctctac ctcccatgca gcatgaacac aatttctctc
     1801 cacctggctc ccaaatttaa agatgtggac caaggcctgt gggtactcca ggggcaagga
     1861 gagccctggg gtcagtgaca ctgtcaggcc aaccatgcac tccacaaagg ggagcatttg
     1921 gaaatgaagg actagctcct atgtatcagg ttaagagcaa gggagagctg gccagggaca
     1981 gcagtttgca cagcagaggg gaatgtagca acagcagggc ctcctaggcc ccatcttcca
     2041 tttcttaggt aagaagagca tttcctcaga ctcccaggcg gaggactgag cctagccttc
     2101 agcaaccaag gttctcctgg gacccaaagt ttatgggaga agggcaaaga cttcatggga
     2161 agagagaagg aaggccctgg gtagaaacgc ttggtgctgt tctctttggc ctttaagaca
     2221 aagcgctcat cttgccctct acctcctgat aggcttgagg gtttgccaac cacactgtgg
     2281 ctacaggtgg agggaagagg actccttcct ccagagtgct atgttcagga agtttcttta
     2341 accccatatg gcccaagagt agctcgtagg aggcccttta aagacggaac aagtaattta
     2401 ccagttctac tggggttcct gcccaccgtc ccaaggtggg cgaggcctag gaagagggtc
     2461 attcttaagc cacacattag ctgcactgcg tggctgcagc caaaacaaag aactgggtgt
     2521 tgagtattca tcaactaaga accaaaatcc agggcactca tatgtgaagg ataagaacct
     2581 cacttcctta ctcctccaaa aagaagtggg gaaagaacca tcaaaccttt cctcctgact
     2641 taccaaacca ggaaaacagc aggagagggt ggctcaggac ttagggacag ggtatagctt
     2701 agatggtgga aagcaaagga gagcaggaag ttgtaaatca ctggctaatg agaaaaggag
     2761 acagctaact ctaggatgaa gctgtgacta ggctggagtt gcttccttga agatgggact
     2821 ccttgggtat caagacctat gccacatcac actggggcta gggaagtagg tgatgccagc
     2881 cctcaagtct gtcttcagcc agggacttga gaagttatat tgggcagtgg ctccaatctg
     2941 tggaccagta tttcagcttt ccctgaagat caggcagggt gccattcatt gtctttctct
     3001 cctagccccc tcaggaaaga aggactatat ttgtactgta ccctaggggt tctggaaggg
     3061 aaaacatgga atcaggattc tatagactga taggccctat ccacaagggc catgactggg
     3121 aaaaggtatg ggagcagaag gagaattggg attttagggt gcagctacgc tcaccctaaa
     3181 cttttggtgg cctggggcat gtcttgaggc ccagactgtt aaccaggctc tgctggcctg
     3241 tttactcgtc accacctctg cacctgctgt cttgagactc catccagccc caggcacgcc
     3301 acctgctcct gagcctccac tatctccctg tgacgggtga acttcgtgta ctgtgtctcg
     3361 ggtccatata tgaattgtga gcagggttca tctattttaa acacagatgt ttacaaaata
     3421 aagattattt caaacca
//
