LOCUS       NM_016322               4149 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens RAB14, member RAS oncogene family (RAB14), mRNA.
ACCESSION   NM_016322
VERSION     NM_016322.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4149)
  AUTHORS   Li,Y., Zhang,Y., Lu,X., Li,R., Peng,J. and Xu,Y.
  TITLE     Circular RNA IARS modulates the progression and ferroptosis of
            osteosarcoma via sponging miR-188-5p from RAB14
  JOURNAL   Neoplasma 71 (3), 279-288 (2024)
   PUBMED   38958715
  REMARK    GeneRIF: Circular RNA IARS modulates the progression and
            ferroptosis of osteosarcoma via sponging miR-188-5p from RAB14.
REFERENCE   2  (bases 1 to 4149)
  AUTHORS   Baek,C.H., Kim,H., Moon,S.Y. and Yang,W.S.
  TITLE     AMPK boosts ADAM10 shedding activity in human aortic endothelial
            cells by promoting Rab14-dependent ADAM10 cell surface
            translocation
  JOURNAL   Biochem Biophys Res Commun 675, 54-60 (2023)
   PUBMED   37451218
  REMARK    GeneRIF: AMPK boosts ADAM10 shedding activity in human aortic
            endothelial cells by promoting Rab14-dependent ADAM10 cell surface
            translocation.
REFERENCE   3  (bases 1 to 4149)
  AUTHORS   Rawat,S., Chatterjee,D., Marwaha,R., Charak,G., Kumar,G., Shaw,S.,
            Khatter,D., Sharma,S., de Heus,C., Liv,N., Klumperman,J., Tuli,A.
            and Sharma,M.
  TITLE     RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval
            for cargo sorting to lysosomes
  JOURNAL   J Cell Biol 222 (1) (2023)
   PUBMED   36282215
REFERENCE   4  (bases 1 to 4149)
  AUTHORS   Phatak,P., Burrows,W.M., Creed,T.M., Youssef,M., Lee,G. and
            Donahue,J.M.
  TITLE     MiR-214-3p targets Ras-related protein 14 (RAB14) to inhibit
            cellular migration and invasion in esophageal Cancer cells
  JOURNAL   BMC Cancer 22 (1), 1265 (2022)
   PUBMED   36471277
  REMARK    GeneRIF: MiR-214-3p targets Ras-related protein 14 (RAB14) to
            inhibit cellular migration and invasion in esophageal Cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4149)
  AUTHORS   Wang,L., Zhu,L., Zheng,Z., Meng,L., Liu,H., Wang,K., Chen,J., Li,P.
            and Yang,H.
  TITLE     Mevalonate pathway orchestrates insulin signaling via RAB14
            geranylgeranylation-mediated phosphorylation of AKT to regulate
            hepatic glucose metabolism
  JOURNAL   Metabolism 128, 155120 (2022)
   PUBMED   34995578
  REMARK    GeneRIF: Mevalonate pathway orchestrates insulin signaling via
            RAB14 geranylgeranylation-mediated phosphorylation of AKT to
            regulate hepatic glucose metabolism.
REFERENCE   6  (bases 1 to 4149)
  AUTHORS   Predic,J., Soskic,V., Bradley,D. and Godovac-Zimmermann,J.
  TITLE     Monitoring of gene expression by functional proteomics: response of
            human lung fibroblast cells to stimulation by endothelin-1
  JOURNAL   Biochemistry 41 (3), 1070-1078 (2002)
   PUBMED   11790131
REFERENCE   7  (bases 1 to 4149)
  AUTHORS   Garin,J., Diez,R., Kieffer,S., Dermine,J.F., Duclos,S., Gagnon,E.,
            Sadoul,R., Rondeau,C. and Desjardins,M.
  TITLE     The phagosome proteome: insight into phagosome functions
  JOURNAL   J Cell Biol 152 (1), 165-180 (2001)
   PUBMED   11149929
REFERENCE   8  (bases 1 to 4149)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 4149)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 4149)
  AUTHORS   de Leeuw,H.P., Koster,P.M., Calafat,J., Janssen,H., van
            Zonneveld,A.J., van Mourik,J.A. and Voorberg,J.
  TITLE     Small GTP-binding proteins in human endothelial cells
  JOURNAL   Br J Haematol 103 (1), 15-19 (1998)
   PUBMED   9792283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA404780.1, BC006081.1, AL137068.10 and AL162081.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016322.3.
            
            Summary: RAB14 belongs to the large RAB family of low molecular
            mass GTPases that are involved in intracellular membrane
            trafficking. These proteins act as molecular switches that flip
            between an inactive GDP-bound state and an active GTP-bound state
            in which they recruit downstream effector proteins onto membranes
            (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023524.1, SRR1803614.117979.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373840.9/ ENSP00000362946.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA404780.1         219-229
            12-999              BC006081.1         1-988
            1000-1607           AL137068.10        100058-100665       c
            1608-4145           AL162081.1         1552-4089
            4146-4149           AL137068.10        97516-97519         c
FEATURES             Location/Qualifiers
     source          1..4149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..4149
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="RAB14, member RAS oncogene family"
                     /db_xref="GeneID:51552"
                     /db_xref="HGNC:HGNC:16524"
                     /db_xref="MIM:612673"
     exon            1..231
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            232..290
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..886
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /EC_number="3.6.5.2"
                     /note="F protein-binding protein 1; bA165P4.3 (member RAS
                     oncogene family); small GTP binding protein RAB14"
                     /codon_start=1
                     /product="ras-related protein Rab-14"
                     /protein_id="NP_057406.2"
                     /db_xref="CCDS:CCDS6827.1"
                     /db_xref="GeneID:51552"
                     /db_xref="HGNC:HGNC:16524"
                     /db_xref="MIM:612673"
                     /translation="MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTI
                     GVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHL
                     SSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGEN
                     VEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC"
     exon            291..344
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            345..522
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            523..589
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            590..677
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            678..708
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     exon            709..4149
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="hexamer: AATAAA"
     polyA_site      1636
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="major polyA site"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="hexamer: AATAAA"
     polyA_site      2579
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="major polyA site"
     polyA_site      2937
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="major polyA site"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="hexamer: ATTAAA"
     polyA_site      3013
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
     regulatory      4126..4131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
                     /note="hexamer: AATAAA"
     polyA_site      4149
                     /gene="RAB14"
                     /gene_synonym="FBP; RAB-14"
ORIGIN      
        1 atcttggacc agcccgagga agatactgag ggagcacagg agcagtcacc gctgccactg
       61 ctactgccgc tactgctgcc ggcgcgtctg cacctctcgg cctgccagtg tacctgccgg
      121 cgcctcggtc gaccgccccc gccccctctc ccgctgcgtc cgcactcctg ttcctggtcc
      181 tgacgccccc ctcccgcccg gaaagctgcc cagccaccag caacccccca gtgccaccat
      241 ggcaactgca ccatacaact actcttacat ctttaaatat attattattg gggacatggg
      301 agtaggaaaa tcttgcttgc ttcatcaatt tacagaaaaa aaatttatgg ctgattgtcc
      361 tcacacaatt ggtgttgaat ttggtacaag aataatcgaa gttagtggcc aaaaaataaa
      421 actgcagatt tgggatacgg caggacagga gcgatttagg gctgttacac ggagctacta
      481 cagaggagct gcgggagctc ttatggtcta tgatatcact agaagaagta catataacca
      541 cttaagcagc tggttgacag atgcaaggaa tctcaccaat ccaaatactg taataattct
      601 cataggaaat aaagcagatt tggaggcaca gagagatgtt acatatgaag aagccaaaca
      661 gtttgctgaa gaaaatggct tattgttcct cgaagcgagt gcaaaaacgg gagagaatgt
      721 agaagatgcc ttccttgagg ctgccaagaa aatctatcag aacattcagg atggaagctt
      781 ggatctgaat gctgctgagt ctggtgtaca acacaaacct tcagccccgc agggaggccg
      841 gctaaccagt gaaccccaac cccagagaga aggctgtggc tgctagtgac ctctttgctg
      901 tggcccctca tttgaccttt cacctctgtc tgttggaagc agtacttttt actgcctcat
      961 tgtcttctgt acatcttact gggtttaatt aaaaaaaaag aaaaaactct gttgtaaaaa
     1021 cagtttaaca caatactaaa ctgctaaaca actagatgta atcaggttat caaaggcaag
     1081 tagagtaata aatctctcct gcatggtaaa tctagacttt ttttccccct tgtcctcgtg
     1141 ataagtatgt caccaatata tgatttaaac cgagcactga tgctggactt catgattttt
     1201 accctccctt tggcaaggct ttgtctcact gtacggttta atttggtgat atcttaagcc
     1261 tttcttccca tccttaactg ttcaagtatg tctgttgtaa ccaataagtt tattgctgtg
     1321 aaattacttc tgatggtaga gaaggggttc tataactgct tttgttttgt tttggataaa
     1381 tttcctgttg tgtgggtggc atttttctta acgagatttg cttctgtctt agcctcacac
     1441 agggaaaata tccatttatc ttctctctcg tgcttaatta atagctttat ctttttttat
     1501 accattttat ccttttctct ttaacagaaa gtaaatatgt ataaaatttg aaggaatcga
     1561 actaacaata cattctgtgt atattatttt aatgaagaaa ataaattgat tactggcatt
     1621 ggaacagtat aaaataccag tttgtacagt atgacctata tgtgaccatg ttactccctt
     1681 ccatttcaca caaagaaata gacacaactg cagttcacaa gtagtactgg ctccacccct
     1741 tggtgctggc agtgtttggg gacattatgc tggaaagagc tcctagcatc agaggattaa
     1801 cactagcaga ttctgttcca tctttgcact gttgcttacc tgctgatttt cttaactgtt
     1861 cttgtgcaat cgacaatgtg ctaacctgct tttctctttt tgtaaacgtt tttgcattac
     1921 aggctgcatt cttgccttac tgtatagaaa aagaaaaaag gctgggttta ctattgcaca
     1981 ttttaagctt ttataccttt atcttcttgg aatggtcaga ttctgaactg gacagtcaga
     2041 accacaggtc tgctgttaag ggattttaaa ttgtgcattt ttaaccctac agtgaaataa
     2101 cttaagatat ccctgtgttc acagtgtgag gggctgtttt atgtcatgtt ggcataaatt
     2161 gttttgtaaa agggaaagtg tttctaaagg tgtttcagcg cttgtgctga tacaaagtaa
     2221 gttattactt tgcaccaggt ggtttggcca ctgaattaat actgtatagc aagagaaaca
     2281 atcttatttt tttggacaac atgttttatt aagttcttca tttctgttga ttttttttat
     2341 tgcatttatg attcagtggc tgggaattga gaatttattt gaaatagaat aggtaacacc
     2401 tcagcgtact atagaaaatg cactcagctc aactgctgtg tttaaaatac acattttaaa
     2461 tccctcttta cagacactaa cataaaagta catctttctg ggttgtaaac atgtggtagt
     2521 accagagtat tgtatagtca atgttaaata aaagccaaaa ctggaatgtg cagaaagtag
     2581 gctttggtta atttgtggat tcatttttat ttttgtcttt gtttaacttt ttaaaaaata
     2641 agatttctgg agtagattgg tatattctgt taaagactta cagtgatcca ttttgcttac
     2701 actgttgcat cacaagggac tcacccaggg accatgacct gctggtgtgt gtgtatattt
     2761 acaaaaacaa aacaaacaaa ccacccattg ggatataagg tagcaatcac aaactaaaga
     2821 ctgcggcttg ttgaggtgca ataccctgac tcccaaagtt agttacagtg ggttttattg
     2881 tttttgtgac tgaaggattt attcagactg ctgtactctt catttgatgt aacaaaatgc
     2941 tattaatcta aatatttgta aataaagtac ctgtatctag attaaattaa aattggttgc
     3001 attattttct gaactataat agggtttttc ttcaggtgaa caatttgacg tgtcatcagt
     3061 ttttattgca gcactgtcca tattcattgt ataaagagag gtctacgtat gtagcatata
     3121 aaaccacatc actaagtaat agacccacag ctttattctt gtgtttacat tacccttgaa
     3181 atgttttcag tcaacccttt tcagtgtaag atcagcacat ttggtggctg atgctgttct
     3241 cctttgactg taccgggagc cagattctat catatgcatg tgtaatcccc tgtaatacac
     3301 tcaggtgctc acaaatagag cagattgtca tattgtaaca tgcgtgtgcc agacaccggg
     3361 cagtacactt tggaaagaat gtgaaatcct tttaattttt aatccatagc ttactgcttg
     3421 tgcagtcacc tgcctcttga ggttgctcat tgcccttgga cctgtgagga ggccttcaga
     3481 ttagtaattg gtgcttagta ctatttatgc ttaaatagat cttccagtac aatgttgaag
     3541 tcttttttat ggataataac gtgtttgatg gagtaactta ttattttttt ttggttggtg
     3601 gtttacacgt taatagaggt agtacaattt ctttggaaag gtgtcttttg aagccagctg
     3661 ttaagcttca tacattacct cccttctcaa attcggtaag acagtagttt tggggaactt
     3721 ttttgcccat gtgtctttta agtgtgattt taaaaaaatg agtggttcag ttcattcccc
     3781 taaacagaag aaaagaccaa ataattacct tccattcctc ttcatgtggg aatatagaga
     3841 gggttcatgt ggcattttag agaaaagata atttatcctc attcaacaca ggcccagaaa
     3901 attgtgtccc agaaggatgt cagtaattgt gactaggcca ggccttttag cattttgcta
     3961 agacttgaaa caaaaaatgt aaatacaaaa gaaatcaagt tttgttttga aagatgcctt
     4021 ctagaactta ctgtgtatta ataaattgtc actttcattg tctttattgt aactccattg
     4081 atcccgtatc ttaacggttc acgtctagcc aaataactgt tttggaataa aaaccttggt
     4141 ggtgaggga
//
