LOCUS       NM_002870               1164 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens RAB13, member RAS oncogene family (RAB13), transcript
            variant 1, mRNA.
ACCESSION   NM_002870
VERSION     NM_002870.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Zhu,Q., Chen,D., Li,S., Xiong,W., Lei,X., Liu,W. and Hu,Y.
  TITLE     RAB13 regulates macrophage polarization in sepsis
  JOURNAL   Sci Rep 14 (1), 20400 (2024)
   PUBMED   39223234
  REMARK    GeneRIF: RAB13 regulates macrophage polarization in sepsis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Guo,J., Han,X., Li,J., Li,Z., Yi,J., Gao,Y., Zhao,X. and Yue,W.
  TITLE     Single-cell transcriptomics in ovarian cancer identify a
            metastasis-associated cell cluster overexpressed RAB13
  JOURNAL   J Transl Med 21 (1), 254 (2023)
   PUBMED   37046345
  REMARK    GeneRIF: Single-cell transcriptomics in ovarian cancer identify a
            metastasis-associated cell cluster overexpressed RAB13.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Jiang,C., Liu,Z., Yuan,J., Wu,Z., Kong,L., Yang,J. and Lv,T.
  TITLE     Construction of Two Independent RAB Family-Based Scoring Systems
            Based on Machine Learning Algorithms and Definition of RAB13 as a
            Novel Therapeutic Target for Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 24 (5), 4335 (2023)
   PUBMED   36901767
  REMARK    GeneRIF: Construction of Two Independent RAB Family-Based Scoring
            Systems Based on Machine Learning Algorithms and Definition of
            RAB13 as a Novel Therapeutic Target for Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Zhang,Z.D., Li,H.X., Gan,H., Tang,Z., Guo,Y.Y., Yao,S.Q., Liuyu,T.,
            Zhong,B. and Lin,D.
  TITLE     RNF115 Inhibits the Post-ER Trafficking of TLRs and TLRs-Mediated
            Immune Responses by Catalyzing K11-Linked Ubiquitination of RAB1A
            and RAB13
  JOURNAL   Adv Sci (Weinh) 9 (16), e2105391 (2022)
   PUBMED   35343654
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Su,W., Liao,M., Tan,H., Chen,Y., Zhao,R., Jin,W., Zhu,S., Zhang,Y.,
            He,L. and Liu,B.
  TITLE     Identification of autophagic target RAB13 with small-molecule
            inhibitor in low-grade glioma via integrated multi-omics approaches
            coupled with virtual screening of traditional Chinese medicine
            databases
  JOURNAL   Cell Prolif 54 (12), e13135 (2021)
   PUBMED   34632655
  REMARK    GeneRIF: Identification of autophagic target RAB13 with
            small-molecule inhibitor in low-grade glioma via integrated
            multi-omics approaches coupled with virtual screening of
            traditional Chinese medicine databases.
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Bao,S., Zhu,J. and Garvey,W.T.
  TITLE     Cloning of Rab GTPases expressed in human skeletal muscle: studies
            in insulin-resistant subjects
  JOURNAL   Horm Metab Res 30 (11), 656-662 (1998)
   PUBMED   9918381
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Marzesco,A.M., Galli,T., Louvard,D. and Zahraoui,A.
  TITLE     The rod cGMP phosphodiesterase delta subunit dissociates the small
            GTPase Rab13 from membranes
  JOURNAL   J Biol Chem 273 (35), 22340-22345 (1998)
   PUBMED   9712853
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Leek,J.P., Hamlin,P.J., Wilton,J. and Lench,N.J.
  TITLE     Assignment of the Rab13 gene (RAB13) to human chromosome band 12q13
            by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 210-211 (1997)
   PUBMED   9605854
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Zahraoui,A., Joberty,G., Arpin,M., Fontaine,J.J., Hellio,R.,
            Tavitian,A. and Louvard,D.
  TITLE     A small rab GTPase is distributed in cytoplasmic vesicles in non
            polarized cells but colocalizes with the tight junction marker ZO-1
            in polarized epithelial cells
  JOURNAL   J Cell Biol 124 (1-2), 101-115 (1994)
   PUBMED   8294494
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   Joberty,G., Tavitian,A. and Zahraoui,A.
  TITLE     Isoprenylation of Rab proteins possessing a C-terminal CaaX motif
  JOURNAL   FEBS Lett 330 (3), 323-328 (1993)
   PUBMED   8375503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC094846.1, BC000799.1 and
            AK291580.1.
            
            On Aug 31, 2019 this sequence version replaced NM_002870.4.
            
            Summary: This gene is a member of the Rab family of small G
            proteins and plays a role in regulating membrane trafficking
            between trans-Golgi network (TGN) and recycling endosomes (RE). The
            encoded protein is involved in the assembly of tight junctions,
            which are components of the apical junctional complex (AJC) of
            epithelial cells. The AJC plays a role in forming a barrier between
            luminal contents and the underlying tissue. Additional functions
            associated with the protein include endocytic recycling of
            occludin, regulation of epithelial cell scattering, neuronal
            regeneration and regulation of neurite outgrowth. Alternately
            spliced transcript variants have been observed for this gene. A
            pseudogene associated with this gene is located on chromosome 12.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000799.1, AK291580.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368575.5/ ENSP00000357564.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-870               BC094846.1         23-892
            871-1163            BC000799.1         862-1154
            1164-1164           AK291580.1         1121-1121
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1164
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /note="RAB13, member RAS oncogene family"
                     /db_xref="GeneID:5872"
                     /db_xref="HGNC:HGNC:9762"
                     /db_xref="MIM:602672"
     exon            1..227
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..715
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAS-associated protein RAB13; ras-related protein Rab-13;
                     growth-inhibiting gene 4 protein; cell growth-inhibiting
                     gene 4 protein"
                     /codon_start=1
                     /product="ras-related protein Rab-13 isoform 1"
                     /protein_id="NP_002861.1"
                     /db_xref="CCDS:CCDS1058.1"
                     /db_xref="GeneID:5872"
                     /db_xref="HGNC:HGNC:9762"
                     /db_xref="MIM:602672"
                     /translation="MAKAYDHLFKLLLIGDSGVGKTCLIIRFAEDNFNNTYISTIGID
                     FKIRTVDIEGKKIKLQVWDTAGQERFKTITTAYYRGAMGIILVYDITDEKSFENIQNW
                     MKSIKENASAGVERLLLGNKCDMEAKRKVQKEQADKLAREHGIRFFETSAKSSMNVDE
                     AFSSLARDILLKSGGRRSGNGNKPPSTDLKTCDKKNTNKCSLG"
     exon            228..288
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            289..349
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            350..427
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            428..517
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            518..583
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            584..637
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1164
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      856
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /note="major polyA site"
     polyA_site      879
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /note="major polyA site"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /note="hexamer: ATTAAA"
     polyA_site      1164
                     /gene="RAB13"
                     /gene_synonym="GIG4"
                     /note="major polyA site"
ORIGIN      
        1 cttcctggcc tgggctccgt gccgctctgt ttgccaaccg tccagtcccg cctaccagtg
       61 ccgggcgctc cccacccctc ccccggctcc cccggtgtcc gccatggcca aagcctacga
      121 ccacctcttc aagttgctgc tgatcgggga ctcgggggtg ggcaagactt gtctgatcat
      181 tcgctttgca gaggacaact tcaacaacac ttacatctcc accatcggaa ttgatttcaa
      241 gatccgcact gtggatatag aggggaagaa gatcaaacta caagtctggg acacggctgg
      301 ccaagagcgg ttcaagacaa taactactgc ctactaccgt ggagccatgg gcattatcct
      361 agtatacgac atcacggatg agaaatcttt cgagaatatt cagaactgga tgaaaagcat
      421 caaggagaat gcctcggctg gggtggagcg cctcttgctg gggaacaaat gtgacatgga
      481 ggccaagagg aaggtgcaga aggagcaggc cgataagttg gctcgagagc atggaatccg
      541 atttttcgaa actagtgcta aatccagtat gaatgtggat gaggctttta gttccctggc
      601 ccgggacatc ttgctcaagt caggaggccg gagatcagga aacggcaaca agcctcccag
      661 tactgacctg aaaacttgtg acaagaagaa caccaacaag tgctccctgg gctgaggacc
      721 ctttcttgcc tccccacccc ggaagctgaa cctgagggag acaacggcag agggagtgag
      781 caggggagaa atagcagagg ggcttggagg gtcacatagg tagatggtaa agagaatgag
      841 gagaaaaagg agaaaaggga aaagcagaaa ggaaaaaaag gaagagagag gaagggagaa
      901 gggagaggaa tgaattgagg aagtgaaaga aggcaaggag gtaggaagag agggaggagg
      961 aaaggaagga gagatgcctc aggcttcaga ccttacctgg gttttcaggg caaacataaa
     1021 tgtaaataca ctgatttatt ctgttactag atcaggtttt agggtcctgc aaaaggctag
     1081 ctcggcacta cactagggaa tttgctcctg ttctgtcact tgtcatggtc tttcttggta
     1141 ttaaaggcca ccatttgcac aaat
//
