LOCUS       NM_032932               8571 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RAB11 family interacting protein 4 (RAB11FIP4),
            transcript variant 1, mRNA.
ACCESSION   NM_032932
VERSION     NM_032932.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8571)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 8571)
  AUTHORS   Wang,J.Z., Yang,S.X., Ye,F., Xia,X.P., Shao,X.X., Xia,S.L.,
            Zheng,B. and Xu,C.L.
  TITLE     Hypoxia-induced Rab11-family interacting protein 4 expression
            promotes migration and invasion of colon cancer and correlates with
            poor prognosis
  JOURNAL   Mol Med Rep 17 (3), 3797-3806 (2018)
   PUBMED   29257314
  REMARK    GeneRIF: Rab11-FIP4 expression promotes migration and invasion of
            colon cancer cells and correlates with poor prognosis.
REFERENCE   3  (bases 1 to 8571)
  AUTHORS   He,Y., Ye,M., Zhou,L., Shan,Y., Lu,G., Zhou,Y., Zhong,J., Zheng,J.,
            Xue,Z. and Cai,Z.
  TITLE     High Rab11-FIP4 expression predicts poor prognosis and exhibits
            tumor promotion in pancreatic cancer
  JOURNAL   Int J Oncol 50 (2), 396-404 (2017)
   PUBMED   28035375
  REMARK    GeneRIF: Our findings suggest that overexpression of Rab11-FIP4
            predicts poor clinical outcomes for pancreatic cancer and
            contributes to pancreatic tumor progression.
REFERENCE   4  (bases 1 to 8571)
  AUTHORS   Hu,F., Deng,X., Yang,X., Jin,H., Gu,D., Lv,X., Wang,C., Zhang,Y.,
            Huo,X., Shen,Q., Luo,Q., Zhao,F., Ge,T., Zhao,F., Chu,W., Shu,H.,
            Yao,M., Fan,J. and Qin,W.
  TITLE     Hypoxia upregulates Rab11-family interacting protein 4 through
            HIF-1alpha to promote the metastasis of hepatocellular carcinoma
  JOURNAL   Oncogene 34 (49), 6007-6017 (2015)
   PUBMED   25745995
  REMARK    GeneRIF: Results show the expression of Rab11-FIP4 upregulated in
            hepatocellular carcinoma (HCC) and correlated with poor prognosis.
            Rab11-FIP4 dramatically contributed to HCC metastasis via
            phosphorylation of PRAS40.
REFERENCE   5  (bases 1 to 8571)
  AUTHORS   Makyio,H., Ohgi,M., Takei,T., Takahashi,S., Takatsu,H., Katoh,Y.,
            Hanai,A., Ueda,T., Kanaho,Y., Xie,Y., Shin,H.W., Kamikubo,H.,
            Kataoka,M., Kawasaki,M., Kato,R., Wakatsuki,S. and Nakayama,K.
  TITLE     Structural basis for Arf6-MKLP1 complex formation on the Flemming
            body responsible for cytokinesis
  JOURNAL   EMBO J 31 (11), 2590-2603 (2012)
   PUBMED   22522702
REFERENCE   6  (bases 1 to 8571)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
REFERENCE   7  (bases 1 to 8571)
  AUTHORS   Wallace,D.M., Lindsay,A.J., Hendrick,A.G. and McCaffrey,M.W.
  TITLE     Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its
            overexpression condenses the Rab11 positive compartment in HeLa
            cells
  JOURNAL   Biochem Biophys Res Commun 299 (5), 770-779 (2002)
   PUBMED   12470645
  REMARK    GeneRIF: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner
            and its overexpression condenses the Rab11 positive compartment in
            HeLa cells.
REFERENCE   8  (bases 1 to 8571)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
REFERENCE   9  (bases 1 to 8571)
  AUTHORS   Jenne,D.E., Tinschert,S., Reimann,H., Lasinger,W., Thiel,G.,
            Hameister,H. and Kehrer-Sawatzki,H.
  TITLE     Molecular characterization and gene content of breakpoint
            boundaries in patients with neurofibromatosis type 1 with 17q11.2
            microdeletions
  JOURNAL   Am J Hum Genet 69 (3), 516-527 (2001)
   PUBMED   11468690
REFERENCE   10 (bases 1 to 8571)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY169244.1, BC093914.1,
            AJ314646.2 and BC047674.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032932.5.
            
            Summary: The protein encoded by this gene interacts with RAB11 and
            is thought to be involved in bringing recycling endosome membranes
            to the cleavage furrow in late cytokinesis. Hypoxic conditions can
            lead to an upregulation of the encoded protein and enhance the
            metastatic potential of hepatocellular carcinoma. [provided by
            RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ314646.2, AY169244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621161.5/ ENSP00000482620.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AY169244.1         52-390
            340-1947            BC093914.1         194-1801
            1948-3497           AY169244.1         1999-3548
            3498-4727           AJ314646.2         3238-4467
            4728-5623           AY169244.1         4779-5674
            5624-7000           AJ314646.2         5364-6740
            7001-8570           AJ314646.2         6742-8311
            8571-8571           BC047674.2         1174-1174
FEATURES             Location/Qualifiers
     source          1..8571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..8571
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /note="RAB11 family interacting protein 4"
                     /db_xref="GeneID:84440"
                     /db_xref="HGNC:HGNC:30267"
                     /db_xref="MIM:611999"
     exon            1..337
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2092
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /note="isoform 1 is encoded by transcript variant 1; rab11
                     family-interacting protein 4; arfophilin-2; RAB11 family
                     interacting protein 4 (class II)"
                     /codon_start=1
                     /product="rab11 family-interacting protein 4 isoform 1"
                     /protein_id="NP_116321.2"
                     /db_xref="CCDS:CCDS11267.1"
                     /db_xref="GeneID:84440"
                     /db_xref="HGNC:HGNC:30267"
                     /db_xref="MIM:611999"
                     /translation="MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAAL
                     GLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPC
                     APEIPDCVEQGSEVTGPTFADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPME
                     STQSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFED
                     YGEGDDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQ
                     CCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSID
                     SCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETT
                     AEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKL
                     DEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELE
                     HLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQ
                     ILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILA
                     ILDHNPSILEIKH"
     exon            338..425
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            426..514
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            515..741
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            742..936
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1071
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1107
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1207
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1311
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1452
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1534
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1672
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1831
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1975
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..8571
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /note="hexamer: AATATA"
     polyA_site      3415
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
     regulatory      8551..8556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /note="hexamer: AATAAA"
     polyA_site      8571
                     /gene="RAB11FIP4"
                     /gene_synonym="FIP4-Rab11; RAB11-FIP4"
                     /note="major polyA site"
ORIGIN      
        1 ggagcggctg gggctgcggc gccgctgctg acacggatcg gccgcggccg ccaccgggcg
       61 gaggctgcgc ggcgcagacc cagacgggcg gccccggagg gcgcgcggcg atggcggcgg
      121 cgggcaggcg gcgggcgcgg cgggcgaggg gtccgggctg agctgcgggc cggcccggat
      181 ggcgggcggc gcgggctggt cgggcgcccc cgcggctctg ctgcgctccg tgcgccgcct
      241 gcgcgaggtg ttcgaggtgt gcggccgcga ccccgacggc ttcctgcgcg tggagcgcgt
      301 cgcggcgctc ggactgcgct tcggccaggg cgaggaggtg gaaaaacttg tgaaatattt
      361 ggatcccaac gacctgggga gaatcaactt caaggacttt tgccgggggg tgttcgccat
      421 gaaagggtgc gaggagctgc tgaaggatgt gctgtcggtg gagagcgcgg ggacgctgcc
      481 gtgcgcgcca gagatcccag actgcgtgga gcagggcagc gaggtcacag gccccacctt
      541 tgctgatggc gagctcatcc ccagggaacc cggctttttt cccgaggacg aggaggaggc
      601 tatgacgctg gcgccacctg agggccccca ggagttgtac acagacagcc ccatggagag
      661 cactcagagc ctggaggggt ctgtcgggag tcctgccgag aaggacgggg gacttggggg
      721 cctgtttctg ccagaagaca agtccctggt ccacactcca tccatgacga cctcagacct
      781 ttctacacac tccaccacct cgctcatcag caatgaggag cagtttgaag actatgggga
      841 gggtgacgat gtggactgtg cccccagcag cccttgcccc gatgatgaga ccaggaccaa
      901 cgtctactcg gacctggggt cttcggtgtc ttccagtgcg gggcagacgc ctaggaaaat
      961 gcggcacgtg tacaacagcg aattgctaga tgtttactgc tctcaatgct gcaagaaaat
     1021 caacctgctc aatgacttgg aagcccgact gaaaaacctg aaggccaaca gccccaaccg
     1081 aaagatctcc agcacggcct ttggacggca gctcatgcac agcagcaact tcagcagcag
     1141 caatggcagc accgaagacc tgttccggga cagcattgac tcttgcgaca atgacatcac
     1201 agagaaggta agcttcctgg aaaagaaggt gacagagctg gagaatgaca gcctgaccaa
     1261 tggggacctg aagagcaagc tgaagcaaga gaacacacag ctggtgcaca gggtgcatga
     1321 gctggaggag atggtgaagg atcaggagac cacggccgag caggctctgg aggaggaggc
     1381 gcggcgccac cgcgaggcct acggcaagct ggagagggag aaggctaccg aggtggagct
     1441 gctcaatgcc agggtgcagc agttggagga agaaaataca gagcttagaa caacagtgac
     1501 tcggctcaag tctcaaacag agaaactgga tgaggagcgg cagcgcatgt ctgaccgtct
     1561 ggaggacacc agcctgcggc tcaaagatga gatggacctg tacaagcgca tgatggacaa
     1621 gctgcgacag aaccgccttg agttccagaa ggagcgggag gcgacgcagg agctcatcga
     1681 ggacttgcgg aaggagctgg agcacctgca gatgtacaag ctggactgcg agcggccagg
     1741 caggggccgc agtgcctcct ctggcctagg cgagttcaat gccagggccc gcgaggtgga
     1801 gctcgagcac gaggtcaagc ggctcaagca ggagaattat aagctgcggg atcagaacga
     1861 cgacttgaat gggcagattt tgagcctcag cctctacgaa gcaaaaaacc tctttgctgc
     1921 ccagactaaa gcccagtctc tggctgcgga gatagacacc gcctcgcgcg atgagctaat
     1981 ggaagccctg aaggagcagg aggagatcaa cttccggctg aggcagtaca tggacaagat
     2041 tatcctcgcc atcctggacc acaatccctc catcctcgag atcaaacact aaggcacggg
     2101 gctggctgca gagcagcctt aggaccctgg gaccaagggc agaccctgcc caaggatgca
     2161 ggcctaagcc gggcctcaca ctcacactgt aaatgtctct ctggccacca tgcgttacgt
     2221 gtacccgtgt atatgtgggg aggctgtgca cacgagcgag gggtgagtgg ccgtggctgt
     2281 gggcagcatc cacacggtta gccgtgcatg cactttgtgg cccctttgca aggggcagag
     2341 ggtactggaa gtgggaggag gcaaggtctg ctatcaggag ttactgtaaa aacaagaact
     2401 ggaagctcgt gtttccggta ctgggtaaaa tgattctacc tctggggata aggattcaca
     2461 ttcgctctag tacgatgggc tctttcaccc cactcctagt ccccttggga gtgggagcaa
     2521 aattgtgatc tttcctagga gtttgaatgc cccatatttg tgtcctcgcc agctctttgg
     2581 ccacctttca agccccagtg ttcaagctca gagaggatga aggggcatct ggagggtcca
     2641 tgagatgggg ccctcaccaa atgccttggc caccggccag cagccctctg tgatgtgtgt
     2701 gcagagtgaa cagaggactc aggtttcata gcagctagtg cggggcatcc tcatcctgta
     2761 cctatagagt tcgtgcactc ccccatccat gctacctacc tccccgtttc tgtttcagtt
     2821 ttaagacaat gaagcagcat tcactgcgtc attgtaacat gaagggataa aaatgaagga
     2881 gaaggagggt ttgggatggg tgtctaaggc aggagttgac atcgggcaac caaagaaatg
     2941 agttttgggg aggaacacaa ctcccatccc agtcagtttc cttcccatgg ctgcatctta
     3001 agatggatgc acggagaaac cgtctgcctg gctccctgtc ttcattctcc acgcagcctg
     3061 gtgatggcag gcctgggttt ggatttcaga atcctagctc cgggctccac tcgtgtggca
     3121 gcaagactgc ttcgttccag cgtttagaaa cacacctgta tttgattctc agccagggga
     3181 gcactcgctg cactggtggg aggcggttgg gaaagttgca ggaaaacctt agtcttccat
     3241 ccttctgacc catggtggaa attcacacca tggattttta atggatcttt gttctaggca
     3301 gctgggaata gacatggtac ttaccttaga gttttccaat ttatctcaat tttatatggc
     3361 ttgtgattca ttttcttaat ccaaatatat ataaacgtgt gtggtcttat tcttccccct
     3421 gcagtttctt gctttcttca gcacatctta tagtatgaga aggaaggttt gggcatgttg
     3481 ggaagggcgg tggaggggga gttgcagaaa gagagggcag tgagggtgag gagaggggat
     3541 ctggggactt gggtgtgaca cctgcttgac agaggcaggg ctgtggccag gaccaacctt
     3601 caattccatt ccaatcagcc tttgcatttg ttggatctcg tggcttcttt ttaatctttt
     3661 gttggggatt agtttcatgc tgcacataat ggggttgcac tggtctgacc caggactttg
     3721 gagccaccca cactgggaag actaggctag gcagtcggtc ttctaggagt ttctcagccc
     3781 cttaggacgc gggtctcctt gggctccccc aagggttctg cgaagaggca gtggaagaag
     3841 gcatgaggag agggtctctt gagaatttgc caataggaag gagtggccac ggctgaaagg
     3901 aacaagacag atcctgacat agctttggcc tgggtgttag gtcagaagga gtactggtgc
     3961 gtgggggcct taccccaggg ttgagtattt tatctgtaaa atgttatctg ccctttggct
     4021 gcattggaat ttcagagaag gctgcagagg cctgggttac acagcctgag tcacaacgtg
     4081 ggaaggaatc tctgccacgg gaaaggtggg cggaagcagc tggcagcctg gggcgtgctt
     4141 caggctcctc cctctaaggg gcgccatggg aacaggctcc ggagggagcc ggcgtctgaa
     4201 aggcccccgg gacctgctgc agtgccagag gggcctctgg agcaggcctg gcttttaaat
     4261 ggggggctga attccagctc acacacacct caagtccaac cttactttct tcagccagaa
     4321 tacatttctt gtaaaacctg gcttgttgct tggcttttaa agatggtgta tgtttgtaaa
     4381 aatattcttc tgggctcaaa agctagcttg agggggcaga tgccccaggt gtcccagctc
     4441 cacagcccct ggcagatccc agaccccttg gtggcaggtc ccagagccta ggtggtagga
     4501 gcttgatctt tgtttctgcc cttacccctc agtagtgggg ctgcgaggta gtagacagga
     4561 tgcccagtta agtttgaatt tcagatagaa aataatttta gaataaatat gttctatcta
     4621 atacatggga cagatgttat ttttagagat aggatcttgc tctgttgccc aggctggagt
     4681 gtagtggtat gatcatagct caccacaacc ttgaactccc aggctcaagc gatcctcccg
     4741 ccttaactgc ctgagtagct gggactacag gcatgcacca ccacgcccag ctaatttttc
     4801 ttattttttg tagagacagg gtctcactgt gttgcctcac tcgagctgct gacctcaagt
     4861 gatcctccca cctcagcctg ccaaagcact gggattacag gcatgagcca ccatgcctgg
     4921 ccaggacata tttgaaatgg ggagatttta aaaattctga tgattagact gaatcctcag
     4981 acgttctggt ttgattgttg tgggtgtagc ccaggcatgg gattttttaa agagctgctc
     5041 aggtaattcc aatttaattg cgtgtcctac ttgggttttt tgtttgtttt tattgttttt
     5101 gctaaacctg gcaaccctac cgagtaggga ttagcagtaa cttatctgaa atttagaggt
     5161 gttttggggg tggggcgagg gtttctgtag tagactcaga ttttacatgg ccctgagctg
     5221 cccttgcgtt cagttggaag ccacgcaaaa tgaactgaac caggagtgag cttcgtgtac
     5281 attatctatt agaaaatgaa gtaccttctg gttcagctag tccctgtgcg ttgagaggct
     5341 ttaagaaact tctagtaaaa atgttttttt cttttagctt tgaattggcc agagtttatc
     5401 ctagattatt ttattttaaa ttggtagaat tctttgcgaa ctgtcacaga gaaattcctt
     5461 ttcatgactt tatttctgac ctattaaaac atgaacaggc caggcatggt ggctcacgcc
     5521 tgtaatccta gcacttggga ggcagtggca ggcggatcac ttgagctcag gagtcctaaa
     5581 ccagcctggg caacatagtg ataccttgtc tctaccaaaa gttaaaaaaa aaaaaaaaaa
     5641 agctcaagaa cctgcacgag ggcctaaaac agtgggctca gctttggctg tgcattggaa
     5701 tcacctgggg agatttgtaa gcttctgctg tctgggctga acccccagag gttcggattg
     5761 aattggtgtg gggtgtggtc caggcatcga gatgtgtaaa gacctcccca ggtgatgata
     5821 tgcagtccga ggttgagact gccctgtcct gcaaggtcgt tggccagagg tagaggaaac
     5881 tggtcaaagt ggctgttggg cttgtcaagc ccgtggctga atgacagtga gctctcttgc
     5941 tgggagggtt ccttttcctg ttgttgaatg gtcctggcct gcaggatggg aggccagatg
     6001 ccttcaggag ctggtggatc cagctgttct caccagcctg gaggttagca gaccagagtg
     6061 ggtgggcagg accttggcct ggtgcccctg gaatcagtgg gtggcatgtg ttgggatata
     6121 ctggctacag gctcatctca aagagcaggt agaacagagt cagcagggaa ctgacaggtg
     6181 gggctgtccc cctgaaagca gccgcagaaa cagctgccac ctatttgcat agctgagcag
     6241 gaggacatac tgtctttgtg ggttttgctt ctggtctgtt tcctgactgg gttgataaag
     6301 ggagtcccag ctcgttccct gttagccaaa ccagcatcct actcacacac cggacactcc
     6361 aggtgctagt ccactggtgc tggtgttcag gggagttggg gggggggggc gcggggacag
     6421 aagcgcgggt tcttggttcc aatgagggac ttagcagaag cctccagggg ccagcagggc
     6481 caggtgaaac tgggagaaat gaagccctct gtgtcctgtg tgtgtggtgg ggtttaatgc
     6541 attagcaaat ttaaacttaa aaactaactc taggccgggc acggtggctc acacctgtaa
     6601 tcccagcact ttgggaggcc aaggcaggtg gattgcctga gctcaggagt tcgagaccag
     6661 cctggacaac atggtgaaac tcttgtcttt atttttttaa aaaaacaaaa agtaactttc
     6721 gatgtgatca taccaggaaa gttttgcgtg gtcaccatgc caagaaaatg actttggttg
     6781 cccagcagat ccacagcgac tctttctcaa gggctactgt ggattctaga ttgaggaaag
     6841 gggccactta ggactcagtg ctggtatcct ccacagtcct ttctcccaga ctctggccct
     6901 ccctttggga cccaggaaat cccctctagg gtgacgctgc tggctaggaa gactgaggtc
     6961 tgctgcgcca aggggcctca agttagaagg gccatgccgt cagtggatga ctttgagcgc
     7021 tgatcctagg gacctgccag gtcctcactt cctgccctgg gtgcacacat gaatggggca
     7081 gccagcagga agcgggagag gctggaacca ggagcctgcc ctacctgcat ggcaggacaa
     7141 ctctgaggcc cttctgccat attctctgct acccaccaga gaaaataggc tgccttctag
     7201 aaagatttgt ttctaaaagc gtagaccctg gggaagtata atgtcaccat gctcaccagg
     7261 cgaggtttcc catatgacct ccctgccccg acctcgtagg ttgctccttt ccccatctgt
     7321 aaggtagaga tgtctgcccc ggagctacca gctggggatg gcatccaggc catgtctcct
     7381 gcaggatcca agtgctgttg tccccagggt gaccctgcct cctgctgggg cccatccgct
     7441 ttgctgtgct gcacaggctg ttttcatctg catggtttgg ggtctttgtc cttgtgcctt
     7501 ttcttcccca tcgccactgt acaggatttt ccacattgcc cactgcctcc ttttctacat
     7561 cgtctcatct ccctggcctt tcccgagccc tgtaaatgtg tactttttca acgtgcctcc
     7621 cccaggtgag gccagctctc ccgggcacat tcgtccacaa ggatcaggcc ccacttaccc
     7681 ttggctcgct cagcctgtag acttggtaac tttgtacaga atctttcatt attgtcttaa
     7741 gcatgggggg ctaggaccca cttagtccct cctccagcct gcagctaatt taggagcctt
     7801 gcattccaga aaagggcaac tttgtgtaaa gcagcttctc ccacagagct ttccctgcat
     7861 tgttagtgat gtcgggcaaa gcatcactct ttaacctggg gcattggccc cagcagggat
     7921 atcatgggac cgcagccgct ccgtgcactg tctctgcccc cagaggaagc cctgtccatg
     7981 gttcctggtg cacggccaca ggcctgcctt gaggccacca catctggtgt ctagaacagc
     8041 tgcgggcccc acttgggcag aaggaagagg tgctagctgc tgcccctgcc tgctgtgaac
     8101 acctgcccag cccttccttg tctgctgagg tgctcagacc agagtgccat taaataccaa
     8161 ctgatgtcac ggagcggacg gtgcattgcc aaggactcac agctgtgggc tcccttccag
     8221 ctcctcccac tttcttggct gggtcttctg aggcctacgt ggaatgaact acacatgtgg
     8281 cctcatgccc aagggtttgt tagatggcct ctgactctgt gggattcaac ttgacttttt
     8341 tgccccagga ggctctgtct ggaaacaggc ttagctttag tgctggggtg ggacctgccc
     8401 tgtgggcccc agggagggga cagtgggggt gaggccctga ggctgtccag ggtctgagct
     8461 ctttgcctcc aacctgcttc tgccccaaaa ggaacaggct gttggtggca ggctcctccc
     8521 ggggagctgt actgtacaga ccaaggtgta aataaacagt ttgctcttct c
//
