LOCUS       NM_014700               4801 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB11 family interacting protein 3 (RAB11FIP3),
            transcript variant 1, mRNA.
ACCESSION   NM_014700
VERSION     NM_014700.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4801)
  AUTHORS   Weng,N., Zhou,C., Zhou,Y., Zhong,Y., Jia,Z., Rao,X., Qiu,H.,
            Zeng,G., Jin,X., Zhang,J., Zhuang,Z., Liang,Z., Deng,Y., Li,Q.,
            Yang,S., Luo,H., Wang,H. and Wu,X.
  TITLE     IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer
            via facilitating PD-L1 endosome recycling
  JOURNAL   Cancer Lett 584, 216618 (2024)
   PUBMED   38211652
  REMARK    GeneRIF: IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in
            gastric cancer via facilitating PD-L1 endosome recycling.
REFERENCE   2  (bases 1 to 4801)
  AUTHORS   Walia,V., Cuenca,A., Vetter,M., Insinna,C., Perera,S., Lu,Q.,
            Ritt,D.A., Semler,E., Specht,S., Stauffer,J., Morrison,D.K.,
            Lorentzen,E. and Westlake,C.J.
  TITLE     Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis
  JOURNAL   Dev Cell 50 (2), 229-246 (2019)
   PUBMED   31204173
REFERENCE   3  (bases 1 to 4801)
  AUTHORS   Tong,D., Liang,Y.N., Stepanova,A.A., Liu,Y., Li,X., Wang,L.,
            Zhang,F. and Vasilyeva,N.V.
  TITLE     Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate
            breast cancer progression via promoting epithelial growth factor
            receptor recycling
  JOURNAL   Tumour Biol 39 (2), 1010428317691010 (2017)
   PUBMED   28215104
  REMARK    GeneRIF: RAB11FIP3 combines with Eps15 homology domain 1 to promote
            the endocytosis recycling of phosphorylation of epithelial growth
            factor receptor.
REFERENCE   4  (bases 1 to 4801)
  AUTHORS   Bouchet,J., Del Rio-Iniguez,I., Lasserre,R., Aguera-Gonzalez,S.,
            Cuche,C., Danckaert,A., McCaffrey,M.W., Di Bartolo,V. and
            Alcover,A.
  TITLE     Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with
            actin remodeling and T-cell activation
  JOURNAL   EMBO J 35 (11), 1160-1174 (2016)
   PUBMED   27154205
  REMARK    GeneRIF: Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic
            with actin remodeling and T-cell activation
REFERENCE   5  (bases 1 to 4801)
  AUTHORS   Vetter,M., Stehle,R., Basquin,C. and Lorentzen,E.
  TITLE     Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3
            and Rabin8 effectors to Rab11
  JOURNAL   Nat Struct Mol Biol 22 (9), 695-702 (2015)
   PUBMED   26258637
REFERENCE   6  (bases 1 to 4801)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
REFERENCE   7  (bases 1 to 4801)
  AUTHORS   Prekeris,R., Davies,J.M. and Scheller,R.H.
  TITLE     Identification of a novel Rab11/25 binding domain present in Eferin
            and Rip proteins
  JOURNAL   J Biol Chem 276 (42), 38966-38970 (2001)
   PUBMED   11481332
REFERENCE   8  (bases 1 to 4801)
  AUTHORS   Shin,O.H., Couvillon,A.D. and Exton,J.H.
  TITLE     Arfophilin is a common target of both class II and class III
            ADP-ribosylation factors
  JOURNAL   Biochemistry 40 (36), 10846-10852 (2001)
   PUBMED   11535061
REFERENCE   9  (bases 1 to 4801)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   10 (bases 1 to 4801)
  AUTHORS   Shin,O.H., Ross,A.H., Mihai,I. and Exton,J.H.
  TITLE     Identification of arfophilin, a target protein for GTP-bound class
            II ADP-ribosylation factors
  JOURNAL   J Biol Chem 274 (51), 36609-36615 (1999)
   PUBMED   10593962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL023881.24, BC051360.1 and Z98882.4.
            
            On Nov 22, 2018 this sequence version replaced NM_014700.3.
            
            Summary: Proteins of the large Rab GTPase family (see RAB1A; MIM
            179508) have regulatory roles in the formation, targeting, and
            fusion of intracellular transport vesicles. RAB11FIP3 is one of
            many proteins that interact with and regulate Rab GTPases (Hales et
            al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051360.1, AB014565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262305.9/ ENSP00000262305.4
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL023881.24        24895-24913
            20-333              BC051360.1         1-314
            334-334             AL023881.24        25228-25228
            335-447             BC051360.1         315-427
            448-448             AL023881.24        25342-25342
            449-4271            BC051360.1         429-4251
            4272-4801           Z98882.4           27464-27993
FEATURES             Location/Qualifiers
     source          1..4801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4801
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /note="RAB11 family interacting protein 3"
                     /db_xref="GeneID:9727"
                     /db_xref="HGNC:HGNC:17224"
                     /db_xref="MIM:608738"
     exon            1..1072
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2629
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /EC_number="2.7.4.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eferin; RAB11 family interacting protein 3 (class II);
                     rab11 family-interacting protein 3; arfophilin-1; EF
                     hands-containing Rab-interacting protein; cytoplasmic
                     adaptor for RAR and TR; MU-MB-17.148"
                     /codon_start=1
                     /product="rab11 family-interacting protein 3 isoform 1"
                     /protein_id="NP_055515.1"
                     /db_xref="CCDS:CCDS32351.1"
                     /db_xref="GeneID:9727"
                     /db_xref="HGNC:HGNC:17224"
                     /db_xref="MIM:608738"
                     /translation="MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAP
                     VGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGPRDPGPSAPPPRSGPRGQLAS
                     PDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDV
                     FSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDG
                     DGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCY
                     GGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHP
                     ELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFED
                     YGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARYLHQSGALTMEALEDP
                     SPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQL
                     KEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLK
                     ANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIED
                     LRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNE
                     ELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDR
                     IIVAIMETNPSILEVK"
     exon            1073..1166
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1261
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1473
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1623
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1659
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1753
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1857
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1998
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2080
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2218
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2374
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2515
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..4801
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4252..4257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /note="hexamer: ATTAAA"
     polyA_site      4275
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /note="major polyA site"
     regulatory      4784..4789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
                     /note="hexamer: AATAAA"
     polyA_site      4801
                     /gene="RAB11FIP3"
                     /gene_synonym="CART1; FIP3; FIP3-Rab11; Rab11-FIP3"
ORIGIN      
        1 agcctcctta gtctcctcat cctgcttcac aggctccgcg gcctccggcc tcctcggccc
       61 ccgtcccccg gcctcctcgg cccccgtccc ccgccatccg ccgcccggat cctcgccgcc
      121 ctccctaggc cgccccgccg ccatgggcct gcgcccgccg cgccgccggg ccgagggcag
      181 ctgaggcgcg gtgcgaagat gggcgaggac agagcagggc ccgagcgcca gccccagcag
      241 cccgggcgcc ccgcgcgcgc ccgcccgcgc cgccgagggg atgcccgcgc ccgccgccgc
      301 gccctgagcg cctttgtctg ccgcccgcgc ccttccgcac cactagcctc tcgggagcat
      361 ggcgtcggcc ccgccggcct cgcccccggg ctcggagccg ccggggcccg acccggagcc
      421 gggcgggccg gacgggccgg gggcggcaca actggctccg ggccctgcgg agctacgcct
      481 cggagcgccc gtcggcggcc ccgacccgca gtccccgggc ctggatgagc ctgcgcccgg
      541 ggccgctgca gatggcgggg cgcgttggag cgccgggccg gccccggggc tggagggagg
      601 cccgcgagac cccgggccgt ccgccccgcc gccgcgctcc ggcccgcggg ggcagcttgc
      661 gagccccgac gccccgggcc cagggccgcg ctccgaagcg ccgcttccag aactcgaccc
      721 gttgttctcc tggactgagg agcccgagga gtgtggcccc gcgagctgcc cggagagcgc
      781 gcctttccgc ttgcaggggt ccagcagcag ccaccgagcg cggggcgagg tcgacgtctt
      841 ctctcccttc cccgcgccca cggcgggcga gctggcgctg gagcaaggtc ccgggtcccc
      901 gccgcagccc tcggacctca gccagaccca cccccttccg agcgagcccg tggggagtca
      961 ggaggacggc ccccgcctcc gagccgtgtt cgatgccctg gacggggatg gggacggttt
     1021 cgtccgcatc gaggacttca tccagtttgc tacggtctac ggggcagagc aggtgaagga
     1081 cttaactaag tacttggatc ccagtgggct cggcgtgatc agctttgaag acttctacca
     1141 agggatcaca gccatcagaa acggagatcc tgatggccag tgctacggtg gtgtcgcttc
     1201 tgcccaagat gaggagcccc tggcctgccc ggacgagttc gatgacttcg tcacctatga
     1261 ggccaacgag gtgacggaca gcgcgtacat gggctccgag agcacctaca gtgagtgtga
     1321 gaccttcacg gacgaggaca ccagcaccct ggtgcaccct gagctgcaac ctgaagggga
     1381 cgcagacagt gccggcggct cggccgtgcc ctctgagtgc ctggacgcca tggaggagcc
     1441 cgaccatggt gccctgctgc tgctcccagg caggcctcac ccccatggcc agtctgtcat
     1501 cacggtgatc gggggcgagg agcactttga ggactacggt gaaggcagtg aggcggagct
     1561 gtccccagag accctatgca acgggcagct gggctgcagt gaccccgctt tcctcacgcc
     1621 cagtccgaca aagcggctct ccagcaagaa ggtggcaagg tacctgcacc agtcaggggc
     1681 cctgaccatg gaggccctgg aggacccttc ccccgagctc atggagggcc cagaggagga
     1741 cattgctgac aaggttgtct tcctggaaag gcgtgtgctg gagctggaaa aggacacggc
     1801 agccaccggt gagcaacaca gccgcctgag gcaggagaac ctgcagctgg tgcacagagc
     1861 aaacgccctg gaggagcagc tgaaggagca ggagctgaga gcctgcgaga tggtcctgga
     1921 agagacccgg cgtcagaagg agctcctgtg caagatggag agggagaaga gcattgagat
     1981 cgagaacctg cagaccaggc tacagcaact ggacgaggag aacagtgaac tccggtcctg
     2041 cacgccctgt ctgaaggcca acattgagcg tctggaggag gagaagcaga agctgttgga
     2101 tgagatagag tcgctgacgc tgcggctcag tgaagagcag gagaacaaga ggagaatggg
     2161 ggacaggctg agtcacgaga ggcaccagtt ccagagggac aaggaggcca cccaggagct
     2221 gatcgaggac ctccgaaagc agctggagca cctgcagctc ctcaagctgg aggccgagca
     2281 gcggcggggc cgcagcagca gcatgggcct gcaggagtac cacagccgcg cccgggagag
     2341 cgagctggag caggaggtcc gcaggctgaa gcaggacaac cgcaacctga aggagcagaa
     2401 cgaggagctg aacgggcaga tcattaccct cagcatccag ggcgccaaga gcctcttctc
     2461 cacagccttc tctgagtccc tggctgcaga gatcagctcc gtctcccgag atgagctcat
     2521 ggaggcgatt cagaagcagg aggagatcaa cttccgcctg caggactaca tcgacaggat
     2581 catcgtggcc atcatggaga ccaacccgtc catcctggag gtcaagtaga ggcaggaagg
     2641 tccagcctga gctggattcg ggactccaac accctggagt ggttccgtca gaccatgagg
     2701 agccaagacc agcaggtccc acagccgaca gtgcccagag catgcaggga accctcgtgc
     2761 agctgagctg gggccgccaa agaccggggc tgccaaaggg gcagagggtg gtggagagga
     2821 gagggagaaa gggaagtccc agggcccggg gtccacagag gatgagggtt gtggcagggc
     2881 cgtccatcag cgctgacctt ccgggggccc agagcttccc agccctgagt caagctggcc
     2941 atgaacgcgt acacttcagt tcagcaggat gggctggaga gcctctctgt gcagcggtgt
     3001 ggggtgagcc ctgctgtggc ctccttgtgg tggtccctct tcccacgtgc agccctgttg
     3061 ggaagaaagg aagaaaacag gtccctccag gggtgctgct gcctaagcca cccacataag
     3121 tacgctggtg ccgtgtcacc catgttgagc cgctcctgat ggctgacggg ctcccagacc
     3181 ctcacctcgg acatggtggt gggggaagga cgggtgggca aggctggtgc gttccccagc
     3241 tctccctacg ctgctcgggc cattgcccag ccagatgtgg tcacctcagt ccagctctgg
     3301 ggcctccagg ccatgtggct gttcccacgg cccagtcctc gctgcagtaa cccctggggg
     3361 ctctgaccac ctatgggggc cgggcaggag cctctggggc ctccactccg acatcaggac
     3421 ctgagatgac cgctgtgtgg cgctctctcc ctgggcaggg tggatgccac aggcccctct
     3481 ggctcccagg tgctgcttct ccacaggtgc ggcctggccc ggcctcctaa aggccacacc
     3541 ctccccacgc acttcccagg ccagaatcca aacatcggga accctgtttt cttctgggtg
     3601 tgtctcactt agaaatcgtg gttcttcccc gagggtgcat gttgcaggag ggagagggca
     3661 gggaagactc acagcagagc aggagggggc ctgtgcttct cggggtctgc accccaggca
     3721 cagcggtgtc accccgcagg accgcgggcc tgccccaacc cccagcattc ccgggtgggc
     3781 ccagacccca tcaccaagac tggccacccg ctgcgtgtgt gtgcgcgcgc gtgtacgtgt
     3841 ggccccacat ccgccgcctt ccacgctagg atgtaagagg tcgcctccta ttgtacattt
     3901 ggggaaagcc ttgggtgtaa atcagtgtaa acttggagga gagatttttc tatcatgtag
     3961 agtaggtatt ttttatagat tgaaggttga tcaatttttt aatactttca agagaaaact
     4021 gtgtatacac atgaaatata tatatatata tatatatata tatgtataat atataaagac
     4081 tggcaccctg cctctctgtg cccaggccca gccctggtga catggcacca ctcagcagtg
     4141 ctgtcactgt aagcatggac tcccaggaga cagtgtggga aacgctcctg ctttaattcc
     4201 ccgagaaacg gctcttcctg cctggatgca ggagggcagg ggccaccaca gattaaagct
     4261 gttactgcac acgcagaggc cggcttcttc ctccaggggg gccacagggt ggggtgggag
     4321 tcttctgggc ctggcccagc ttccctcaag gcgtccgagg ccatcagttg tctgagctca
     4381 gaacccagca gacctgcctg gctctgcagc ttggtcagac taagaccctt ccaaggccgt
     4441 aggattgcac ctccaggccc agtggagcct ggcagctttc cagccaggtt ctggatcctg
     4501 acgagctgct gagacagcat caaggtgggg caggtggggc ggggcaaatt gggcagcaca
     4561 gggctgtgtg ggcatcaggg ctctgggtca cacgcctctg gggacgtacg tcccatgtcg
     4621 ggagagccgt caaaacgtcc ccgggattaa gagaagagtg gggggcaggg cgcagaggct
     4681 cacgccataa tctcagcact ttgggaggcc aaggcaggag gatcgcttga acccgggagt
     4741 tcaagaccag cctgggcaac atagcaaggc cccatctcta aaaaataaaa aattaaccag
     4801 g
//
