LOCUS       NM_014904               6399 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens RAB11 family interacting protein 2 (RAB11FIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_014904
VERSION     NM_014904.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6399)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 6399)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 6399)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6399)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 6399)
  AUTHORS   Kearney,A.M. and Khan,A.R.
  TITLE     Crystal structure of the Rab-binding domain of Rab11
            family-interacting protein 2
  JOURNAL   Acta Crystallogr F Struct Biol Commun 76 (Pt 8), 357-363 (2020)
   PUBMED   32744247
  REMARK    GeneRIF: Crystal structure of the Rab-binding domain of Rab11
            family-interacting protein 2.
REFERENCE   6  (bases 1 to 6399)
  AUTHORS   Cullis,D.N., Philip,B., Baleja,J.D. and Feig,L.A.
  TITLE     Rab11-FIP2, an adaptor protein connecting cellular components
            involved in internalization and recycling of epidermal growth
            factor receptors
  JOURNAL   J Biol Chem 277 (51), 49158-49166 (2002)
   PUBMED   12364336
REFERENCE   7  (bases 1 to 6399)
  AUTHORS   Lindsay,A.J. and McCaffrey,M.W.
  TITLE     Rab11-FIP2 functions in transferrin recycling and associates with
            endosomal membranes via its COOH-terminal domain
  JOURNAL   J Biol Chem 277 (30), 27193-27199 (2002)
   PUBMED   11994279
  REMARK    GeneRIF: Rab11-FIP2 functions downstream of Rab11 in endosomal
            trafficking.
REFERENCE   8  (bases 1 to 6399)
  AUTHORS   Wallace,D.M., Lindsay,A.J., Hendrick,A.G. and McCaffrey,M.W.
  TITLE     The novel Rab11-FIP/Rip/RCP family of proteins displays extensive
            homo- and hetero-interacting abilities
  JOURNAL   Biochem Biophys Res Commun 292 (4), 909-915 (2002)
   PUBMED   11944901
REFERENCE   9  (bases 1 to 6399)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
REFERENCE   10 (bases 1 to 6399)
  AUTHORS   Prekeris,R., Davies,J.M. and Scheller,R.H.
  TITLE     Identification of a novel Rab11/25 binding domain present in Eferin
            and Rip proteins
  JOURNAL   J Biol Chem 276 (42), 38966-38970 (2001)
   PUBMED   11481332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022395.4, AB023158.1 and BM975322.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014904.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.101601.1,
                                           SRR1660805.220069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355624.8/ ENSP00000347839.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC022395.4         121362-121699
            339-425             AB023158.1         1-87
            426-482             AB023158.1         89-145
            483-483             AC022395.4         121844-121844
            484-2274            AB023158.1         146-1936
            2275-2275           AC022395.4         159263-159263
            2276-3616           AB023158.1         1938-3278
            3617-4975           AC022395.4         160605-161963
            4976-6397           AB023158.1         4638-6059
            6398-6399           BM975322.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..6399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.11"
     gene            1..6399
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /note="RAB11 family interacting protein 2"
                     /db_xref="GeneID:22841"
                     /db_xref="HGNC:HGNC:29152"
                     /db_xref="MIM:608599"
     exon            1..1131
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             779..2317
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /note="isoform 1 is encoded by transcript variant 1; rab11
                     family-interacting protein 2; RAB11 family interacting
                     protein 2 (class I)"
                     /codon_start=1
                     /product="rab11 family-interacting protein 2 isoform 1"
                     /protein_id="NP_055719.1"
                     /db_xref="CCDS:CCDS7602.1"
                     /db_xref="GeneID:22841"
                     /db_xref="HGNC:HGNC:29152"
                     /db_xref="MIM:608599"
                     /translation="MMLSEQAQKWFPTHVQVTVLQAKDLKPKGKSGTNDTYTIIQLGK
                     EKYSTSVAEKTLEPVWKEEASFELPGLLIQGSPEKYILFLIVMHRSLVGLDKFLGQVA
                     INLNDIFEDKQRRKTEWFRLESKQGKRIKNRGEIKVNIQFMRNNMTASMFDLSMKDKT
                     RSPFAKLKDKMKGRKNDGTFSDTSSAIIPSTHMPDANSEFSSGEIQMKSKPKKPFLLG
                     PQRLSSAHSMSDLSGSHMSSEKLKAGTIGQTHLLGHQLDSFGTVPESGSLKSPHRRTL
                     SFDTSKMNQPDSIVDEGELCFGRQNDPFTNVTASLPQKFATLPRKKNPFEESSETWDS
                     SMNLFSKPIEIRKENKREKREKVSLFERVTGKKDSRRSDKLNNGGSDSPCDLKSPNAF
                     SENRQDYFDYESTNPFTAKFRASNIMPSSSFHMSPTSNEDLRKIPDSNPFDATAGYRS
                     LTYEEVLQELVKHKELLRRKDTHIRELEDYIDNLLVRVMEETPSILRVPYEPSRKAGK
                     FSNS"
     exon            1132..1574
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..2043
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2089
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..6399
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6380..6385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /note="hexamer: ATTAAA"
     polyA_site      6399
                     /gene="RAB11FIP2"
                     /gene_synonym="nRip11; Rab11-FIP2"
                     /note="major polyA site"
ORIGIN      
        1 acgttcccga gaccaacatg gagaaggcca acccggaagt gccgccgcag ccgcccgccc
       61 ggtgttagga gccgccggcc gggccaggcc gaaccaagcg cccgcagccc tgcagcccgc
      121 tgcccgcccc acgtcccgcc ggcgccgggg cggccgcgtt ccccgccctc ccccactcca
      181 cccctggcta cccgctcccg cccgagagga ggagctgagg cgagggggag gaggaggagg
      241 gagaggtttg cgagagggag cgaggccgcg ttagccgccg gcggttcgta ttaccggggt
      301 cgggaggagg agccgggccg agcctgcgga cgaacgccgg gcgggcggga ggcgcggagg
      361 cagcggaggc tgctcggccg caaggaggca ggcgggaggc caggggtgca gaattggggc
      421 gggggctccc ttcacccccg cagccctccg cccgggtccg tgtggccagg cctcacgtgc
      481 cccgcaggcc tggggaaggt ggagacaggg gcgggggtcc gcgcagaggc ctgcacggcg
      541 cggccaggtg atggtgggcc tctgtgtttc tccagacgaa aggggacccc cggagcggcc
      601 gtgcccctgg gctgcccccg cgaggcgttt tgacatcagc catagggaag tcggggagcc
      661 ctgagcctgc ctgtttccgt taagtgtcct taggatgcag tgattaagga attaggctct
      721 ccctccggga ggggcactgc ctgtgctagg gaactcgggg gcagagaaac aggacaggat
      781 gatgctgtcc gagcaagccc aaaagtggtt tccaacccac gtgcaggtca cagtgctcca
      841 agccaaagat ctgaagccaa aaggcaaaag tggtaccaat gacacataca ctataattca
      901 gctgggcaag gaaaagtact ccacctctgt agctgagaaa acccttgagc cagtttggaa
      961 ggaggaggcc tctttcgagc tacctggatt gctaattcag ggaagtccag agaaatacat
     1021 tcttttcctt atagttatgc acaggtccct ggtgggtctg gataaatttt tagggcaggt
     1081 ggcaatcaat ctcaatgaca tctttgagga caaacaaaga aggaaaacag agtggtttag
     1141 attagaatcc aaacaaggaa aacgaatcaa aaacaggggt gagataaagg tcaatattca
     1201 gtttatgagg aacaatatga ccgcaagtat gtttgactta tcaatgaagg acaaaaccag
     1261 atctcctttt gcaaagttaa aagataagat gaagggtaga aaaaatgatg gaacattttc
     1321 tgatacgtct tctgcaatca ttccaagtac tcacatgccc gatgccaata gtgaattttc
     1381 aagtggtgaa atacagatga aatccaaacc aaaaaagcct tttctcttgg gtcctcagcg
     1441 actctcgtca gcgcattcaa tgtctgattt atctgggtcc catatgtctt ctgagaaact
     1501 gaaggctggc accataggtc aaacacatct tctcggacac cagttagatt cctttggaac
     1561 agttccagaa agtggaagtc tcaaatctcc acacagaaga acattaagct ttgatacttc
     1621 taaaatgaac caacctgaca gcattgtgga tgaaggtgaa ttgtgtttcg gaagacaaaa
     1681 tgacccattt acaaatgtga ctgcttcatt accccaaaaa tttgcaacac tgccaaggaa
     1741 gaaaaatcca tttgaagaaa gcagcgaaac atgggacagc agcatgaatt tattttcaaa
     1801 accaattgaa ataagaaaag aaaataaaag agagaaaagg gagaaagtta gcctgtttga
     1861 aagagtgact ggaaaaaaag atagcagaag atctgataaa cttaacaatg ggggatctga
     1921 tagcccttgt gacttgaaat cacctaatgc atttagtgaa aatcgccagg actattttga
     1981 ttatgagtca accaatccat ttacagcaaa attcagggct tcaaatataa tgccatcttc
     2041 aagttttcat atgagtccaa caagcaatga agacctcagg aaaatcccgg acagcaaccc
     2101 ctttgatgcc actgcagggt atcgtagtct gacctatgaa gaggttctac aggagctggt
     2161 gaaacacaaa gaactcctta ggaggaaaga cacccacatc cgggaactcg aggactacat
     2221 cgacaacctc cttgtaaggg taatggaaga aacgcccagt attctcagag tgccgtatga
     2281 accatccagg aaagctggca aattctctaa cagttaataa agccaattgt attgtattga
     2341 taattggaca aagagagaga aagaaagaag gaaggaagga aaaacttgtt actgaaagag
     2401 actacactat caggtttcat tacatattct cctttattgt gaagagtagt tttacctgta
     2461 aatattagca gggactatca agagtgacct ttgaagcaag ctaaatcatt taaatgttta
     2521 aattgaaaat gggccagatt ctcaatgaat aagtggttcc ttaggactca ctcaggtgct
     2581 ggtactgacc cactaatctg ccataggccc agaaatatct tcagaagtac gtgagttgtt
     2641 cctcaggaat agatttttca taaagcagaa ttgatcctgt ggctggtttc tcagaaatca
     2701 gtttgtagaa atatttagct tcaggaatac tgctcgttat aaacactact aaaaaaacag
     2761 tttatatttt atatacacat atgtacatga atatatatat attcatgtat cttgtatata
     2821 aaatataggc atatacctca tatatacatg tgtttttaga acatttagaa acaattgatt
     2881 gcctctaaag ttaggctacc aatttcttga tttgaaaatg tgtgtgctct attgatgcaa
     2941 gacaagtcat ccttcctact gtcatggttt gttatagaga agctgcttca aatcactctt
     3001 gactacatgg accttggttt caaagtgagc tgctatatat tattctagca tcaaagtttt
     3061 tctctttccc caaaagtgat gatctcaagt ccttttttaa agaatgacaa attttaggag
     3121 acttcattaa cttcataaca gcatgaattt atttgaatta attaacattt gagtttgttt
     3181 aaggtataag cagaagataa gctaatatag cttgttttgt tgaaattctg catgccttta
     3241 aatcactagc aaagcaaata ttataaagtt atatctgaaa ataattgtgg gaagtatgtg
     3301 attgcctggt gtgtctgata acccaaagca gcgggcagat tccaggaatg aagaattagg
     3361 cttggtttca ggttacataa ataatagagc agatggttgc ctttgggtct tgaaccaaaa
     3421 taagacttac taaaggaaga gtgagttttt agaagagaac tttacgagcg tgacattatg
     3481 cattactcca catccaccct ttaagaattg atttattaca aaattatgtt ctattttaaa
     3541 gtccactccc ccaaaatact gatttcttcc atggattatt tttatatgat ttgtacaaat
     3601 tttttctgaa atttaaattg acaagcaatg ttataaaaat attgctaatc ttctgcttat
     3661 ttttcagcct ttaaagtctg aaatactata aaacactgag agtatctatg tctttctgaa
     3721 tttaaaatga aaattcatgt ccatatggag acttacatat tccccaatct ttccatgaat
     3781 tgcatttttt tctaatactt atctctgtta agactccatt gaaagttaaa caaaaagccg
     3841 atataatagt ttgggttttt tttttttgct tattttagta ttttgaatca gagaatactt
     3901 ggccaagctc gtatttgtaa actaaaaccc cttgttattt gtatcttctg catttcagtt
     3961 ttactgtaag aacatacatt ttgaaattat gaacattttt ttcataaaaa ttaaatgctt
     4021 taagaaatgg agaaggaaaa atagctttta tcaatttttt tctcctcaag attctgtaat
     4081 aaacctcaaa gtctggtgta gaatggtatt ttcccgtttg aggtcttggt agtttttttt
     4141 ttttttttaa acatggtgcc acttttaatt aactaaatgt tacaaaattc tcagcatttg
     4201 tttttgtctg gtagtattat tgagtctttt catacacttc ttaaaatgtg aaaatctatg
     4261 ttttcagtat tatgacagta tctgcagata ctataataat atgctttggc caaatttgct
     4321 gtttatagag tgaaccaaga tgtcagtttt gtattgggga tatgttttac ataaatagaa
     4381 ctcatttaaa agtatggttc aagtactgct cttcttttta tggggaaatt gatttttaag
     4441 gagcgattct tttcctatat aaaagctatt gaggcttagc tttattcata catgagtgat
     4501 ttggttataa ctcaatcaaa atttttatct ttaaatctga gacaagtatt atatttaaaa
     4561 ctagatctat taatacattc atcactgcct gaaaatttgc tgttctaatg tttgtgaatt
     4621 ttcactcatt acctagagta aacttattgc atattttcat aatcagtcaa aataataaaa
     4681 ctaaaaacaa aaagtaaaaa ttagttccca agtaaatata tcagtgtttc ctgtgtttgg
     4741 gcagaagtgc aaagtagttt taatttctca cgttgtagaa aaagaggcca aaaaggtcac
     4801 cttagtttat ttttccaaaa cataacttta ggtattctaa tgtattttgt tagttgctta
     4861 gaaatggaaa taaaatatat gtgcttatta aataatgcac agtacactag attatagagt
     4921 ttatttttgc ttttatgctt taaagaatgc atgcccaaaa cactactacc aacaagagga
     4981 ttttttaaaa tcacagaatt gatatttatc tcaagactat cttaagctaa tgtacttctg
     5041 ttacataatt aaactatttc tgctattatt tttaaagcag tattatttta taaccaattc
     5101 taaaattcag ctttaaaaat attgaacata ccttcctacc acttacgctt caagtttcat
     5161 ttattgaata ccagggtcat atcttagaat tgtatataaa acaacatgta acccattcat
     5221 gaaaaacgtt tttaagtatt gctttttgct gctatgttct gcattgagcc tagttttgcc
     5281 attgtcccct gaatgtagta ttatctatag attatacata actacatcta ttgcttttgg
     5341 tggtaaatca agatttagtt gtaattttcc agctgtgaaa atgttgcctt gtatttaaaa
     5401 gggtttcatg aatggaaacc taagtaaaac taagctcatt agtgacagac ttgttttctt
     5461 cttgttattc ctccagcaac tccctcacca ccacgcctcc ctgcctacca tccccggaag
     5521 ggtgcttatt ctttaacaaa gagaatctaa aaaaaaaaac aaaaaactgt tgtctaatat
     5581 atctacagta aatgttacac tagagctttt attttcctct gtagcttttc agaagaagca
     5641 atttaccttg gatttgtaaa tcaagctgaa acttttttga tgttcatgta ctcatatgtc
     5701 ttgtaggtgg taggtgtcac ttgtgtgtat gtgtaagtga agtatgatgc atgctcattc
     5761 acttggtccc tttgaaataa gggaaaggat cacagtgctg ctgggccatg atggtatgta
     5821 gaagggtctg tcagcacaca tggaaagccc ccatttgcac agatgtagaa ctttaataat
     5881 ccagatgcaa tcattggaag tatttaatat gcaattggta gcaccttagc taattaatct
     5941 gcatatgaag cattttctga tatatttaat aagaggtata gaagctcttc aagcattaaa
     6001 atagagttga tgtttcattc catttgtttt atccatcaaa aaatgcactc tcacagtgga
     6061 gttgaagtct aatacatgat acatgtgggc ctgttagtct tcgaagcttc cagatggttt
     6121 gtgttttgag gtacaaaaaa atgctgcaga tctagaaatg catatattta gcgggtattt
     6181 gaaagataga agcattattt ataactgaag agtataacac ttatcttctt aagtaaatgc
     6241 tctcataact tgtatacatt tttgcaggta caaattcaaa agtatgtaag cattgtataa
     6301 tgtgacaatt gtataattta tgtaatctga tgcatgaatc agaattttta tataatatat
     6361 gattattgac ttatagttga ttaaagtgtt taaacttaa
//
