LOCUS       NM_001002814            8185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RAB11 family interacting protein 1 (RAB11FIP1),
            transcript variant 3, mRNA.
ACCESSION   NM_001002814
VERSION     NM_001002814.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8185)
  AUTHORS   Bhattacharya,S., Sarker,S., Das,S., Ahir,M., Chattopadhyay,S.,
            Ghosh,S. and Adhikary,A.
  TITLE     microRNA-205 represses breast cancer metastasis by perturbing the
            rab coupling protein [RCP]-mediated integrin beta1 recycling on the
            membrane
  JOURNAL   Apoptosis 29 (1-2), 191-209 (2024)
   PUBMED   37945815
  REMARK    GeneRIF: microRNA-205 represses breast cancer metastasis by
            perturbing the rab coupling protein [RCP]-mediated integrin beta1
            recycling on the membrane.
REFERENCE   2  (bases 1 to 8185)
  AUTHORS   Fernandez-de Cespedes,M.V., Hoffman,H.K., Carter,H., Simons,L.M.,
            Naing,L., Ablan,S.D., Scheiblin,D.A., Hultquist,J.F., van
            Engelenburg,S.B. and Freed,E.O.
  TITLE     Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+ T
            Cells, but Its Role Is Cell Type Dependent in Immortalized Human
            T-Cell Lines
  JOURNAL   J Virol 96 (23), e0087622 (2022)
   PUBMED   36354340
  REMARK    GeneRIF: Rab11-FIP1C Is Dispensable for HIV-1 Replication in
            Primary CD4[+] T Cells, but Its Role Is Cell Type Dependent in
            Immortalized Human T-Cell Lines.
REFERENCE   3  (bases 1 to 8185)
  AUTHORS   Fan,X., Zhou,D., Zhao,B., Sha,H., Li,M., Li,X., Yang,J. and Yan,H.
  TITLE     Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through
            TRIM21-Mediated Polyubiquitination
  JOURNAL   Int J Mol Sci 22 (19), 10466 (2021)
   PUBMED   34638806
  REMARK    GeneRIF: Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis
            through TRIM21-Mediated Polyubiquitination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8185)
  AUTHORS   Iannantuono,N.V.G. and Emery,G.
  TITLE     Rab11FIP1 maintains Rab35 at the intercellular bridge to promote
            actin removal and abscission
  JOURNAL   J Cell Sci 134 (12) (2021)
   PUBMED   34152390
  REMARK    GeneRIF: Rab11FIP1 maintains Rab35 at the intercellular bridge to
            promote actin removal and abscission.
REFERENCE   5  (bases 1 to 8185)
  AUTHORS   Alvarez-Arce,A., Lee-Rivera,I., Lopez,E. and Lopez-Colome,A.M.
  TITLE     Thrombin-activated PAR1 membrane expression is regulated by
            Rab11a-RCP complex dissociation
  JOURNAL   Cell Signal 75, 109748 (2020)
   PUBMED   32860953
  REMARK    GeneRIF: Thrombin-activated PAR1 membrane expression is regulated
            by Rab11a-RCP complex dissociation.
REFERENCE   6  (bases 1 to 8185)
  AUTHORS   Peden,A.A., Schonteich,E., Chun,J., Junutula,J.R., Scheller,R.H.
            and Prekeris,R.
  TITLE     The RCP-Rab11 complex regulates endocytic protein sorting
  JOURNAL   Mol Biol Cell 15 (8), 3530-3541 (2004)
   PUBMED   15181150
  REMARK    GeneRIF: RCP functions primarily as a Rab11 binding protein that
            regulates protein sorting in tubular endosomes.
REFERENCE   7  (bases 1 to 8185)
  AUTHORS   Theriault,C., Rochdi,M.D. and Parent,J.L.
  TITLE     Role of the Rab11-associated intracellular pool of receptors formed
            by constitutive endocytosis of the beta isoform of the thromboxane
            A2 receptor (TP beta)
  JOURNAL   Biochemistry 43 (19), 5600-5607 (2004)
   PUBMED   15134434
  REMARK    GeneRIF: Receptor cell surface expression and endocytosis
            experiments reveal that the small GTPase Rab11 protein is a
            determinant factor in controlling thromboxane A2 receptor beta
            isoform recycling back to the cell surface.
REFERENCE   8  (bases 1 to 8185)
  AUTHORS   Wallace,D.M., Lindsay,A.J., Hendrick,A.G. and McCaffrey,M.W.
  TITLE     The novel Rab11-FIP/Rip/RCP family of proteins displays extensive
            homo- and hetero-interacting abilities
  JOURNAL   Biochem Biophys Res Commun 292 (4), 909-915 (2002)
   PUBMED   11944901
REFERENCE   9  (bases 1 to 8185)
  AUTHORS   Lindsay,A.J., Hendrick,A.G., Cantalupo,G., Senic-Matuglia,F.,
            Goud,B., Bucci,C. and McCaffrey,M.W.
  TITLE     Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein
  JOURNAL   J Biol Chem 277 (14), 12190-12199 (2002)
   PUBMED   11786538
  REMARK    GeneRIF: Rab coupling protein (RCP), a novel Rab4 and Rab11
            effector protein
REFERENCE   10 (bases 1 to 8185)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026275.1, AY280968.1, AC130304.12 and BC077720.1.
            
            On May 17, 2019 this sequence version replaced NM_001002814.2.
            
            Summary: This gene encodes one of the Rab11-family interacting
            proteins (Rab11-FIPs), which play a role in the Rab-11 mediated
            recycling of vesicles. The encoded protein may be involved in
            endocytic sorting, trafficking of proteins including integrin
            subunits and epidermal growth factor receptor (EGFR), and transport
            between the recycling endosome and the trans-Golgi network.
            Alternative splicing results in multiple transcript variants. A
            pseudogene is described on the X chromosome. [provided by RefSeq,
            Dec 2013].
            
            Transcript Variant: This variant (3) represents the longer
            transcript and encodes the longer isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226111.1, SRR7346977.2954641.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330843.9/ ENSP00000331342.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK026275.1         1-43
            44-1913             AY280968.1         1-1870
            1914-2008           AC130304.12        67358-67452
            2009-3607           AY280968.1         1966-3564
            3608-5250           BC077720.1         1676-3318
            5251-8185           AC130304.12        78750-81684
FEATURES             Location/Qualifiers
     source          1..8185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..8185
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /note="RAB11 family interacting protein 1"
                     /db_xref="GeneID:80223"
                     /db_xref="HGNC:HGNC:30265"
                     /db_xref="MIM:608737"
     exon            1..427
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..3908
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /note="isoform 3 is encoded by transcript variant 3;
                     Rab-interacting recycling protein; Rab effector protein;
                     RAB11 coupling protein; RAB11 family interacting protein 1
                     (class I)"
                     /codon_start=1
                     /product="rab11 family-interacting protein 1 isoform 3"
                     /protein_id="NP_001002814.2"
                     /db_xref="CCDS:CCDS34882.1"
                     /db_xref="GeneID:80223"
                     /db_xref="HGNC:HGNC:30265"
                     /db_xref="MIM:608737"
                     /translation="MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAV
                     IQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDK
                     FLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDL
                     SMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIK
                     TLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHK
                     RTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGE
                     IKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKS
                     MTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGS
                     EGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDV
                     QITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPP
                     LPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAK
                     SEGPPLLPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEK
                     NTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSP
                     VGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNL
                     RKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPES
                     PHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPLFRME
                     GEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERI
                     DQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDF
                     RLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPG
                     TSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRK
                     PLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENL
                     NNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRV
                     MEETPNILRIPTQVGKKAGKM"
     exon            428..870
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1678
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..3580
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3689
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..8185
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7830..7835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /note="hexamer: AATAAA"
     polyA_site      7854
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /note="major polyA site"
     regulatory      7884..7889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
                     /note="hexamer: AATAAA"
     polyA_site      7913
                     /gene="RAB11FIP1"
                     /gene_synonym="NOEL1A; rab11-FIP1; RCP"
ORIGIN      
        1 gtggaggccg ccagtcgcgg cgatcttctc ctcgcttctg gagtgttatc gtcaccatgt
       61 ccctaatggt ctcggctggc cggggcctgg gggccgtgtg gtccccaacc cacgtgcagg
      121 tgacggtgct gcaggcgcgg ggcctgcggg ccaagggccc cgggggcacg agcgacgcgt
      181 acgcggtgat ccaggtgggc aaggagaagt acgccacctc cgtgtcggag cgcagcctgg
      241 gcgcgcccgt gtggcgcgag gaggccacct tcgagctgcc atcgctgctg tcctccggac
      301 ccgcggccgc cgccaccctg cagctcaccg tgctgcaccg cgcgctgctc ggcctcgaca
      361 agttcctggg ccgcgccgag gtggacctgc gggatctgca ccgcgaccag ggccgcagga
      421 agacgcagtg gtataagttg aaatccaaac caggaaagaa ggacaaggag cgaggagaaa
      481 ttgaggttga catccagttt atgagaaaca acatgactgc cagcatgttt gacctttcta
      541 tgaaagacaa gtctcggaat ccatttggaa agctgaagga caagatcaag gggaagaata
      601 aggacagtgg gtcagacacc gcctccgcca tcatccctag cacgacacct tcggtcgaca
      661 gtgatgatga gtctgtggtt aaagacaaga aaaagaaatc aaagatcaag accttacttt
      721 ccaagtcaaa tttgcagaag acgcctcttt cccagtccat gtctgtcctg ccgacttcaa
      781 agccagaaaa agtgctgctt cgtcccggag actttcagtc ccagtgggat gaagatgaca
      841 atgaggatga gtcctcctcg gcctcggatg tcatgtctca caagagaaca gcgagtacgg
      901 atcttaagca actgaaccag gtcaacttta cccttcccaa gaaggaagga ctttcctttc
      961 ttggtggcct tcggtctaag aatgatgtcc tttcccgctc taatgtctgc atcaatggga
     1021 accatgttta cctggagcag ccagaagcca agggtgagat caaggatagc agcccgtcct
     1081 cctccccatc ccccaagggc ttcagaaaga agcatttgtt ctcttctaca gagaacctgg
     1141 cggctgggtc ttggaaggag cctgctgaag gaggtgggct gtcttctgac aggcagctct
     1201 ccgaatcttc caccaaggac tccttgaagt ctatgaccct gccgtcctac cgacctgccc
     1261 cactggtcag tggggacctc agggaaaaca tggcccccgc aaactcagag gccacaaaag
     1321 aagctaagga gagcaagaag ccagagagca ggaggtcctc tttgctgtct ctgatgacgg
     1381 ggaagaagga tgtggctaag ggcagtgaag gtgaaaaccc tctcacggtc ccagggaggg
     1441 agaaggaagg catgctgatg ggggttaagc cgggggagga cgcatcgggg cctgctgaag
     1501 accttgtgag aagatctgag aaagatactg cagctgttgt ctccagacag ggcagctccc
     1561 tgaacctctt tgaagatgtg cagatcacag aaccagaagc tgagccagag tccaagtctg
     1621 aaccgagacc tccaatttcc tctccgaggg ctccccagac cagagctgtc aagccccgac
     1681 tggaagtgtc tccagaggcg caacccacag ccaggcttcc ttcccctact gactcccctt
     1741 cctctcttcc tcctcttcct tctagctctg gccaggcatc tgtcccctct gaattgggac
     1801 atggtgcaga cacacagtcc tctgagagtc cttctgtctt ctcctctctc tcatctccca
     1861 tagcagctcc catttccaca tccactccaa ttgaaagctg gcctctcgta gacaggggcc
     1921 aggccaagtc tgaaggacca cccttgctcc ctaaggcaga gttgcaaact gagagtttaa
     1981 caccggttcc aaattctggt tcttctgccc tgggatcact tttcaaacag ccatcctttc
     2041 cagcaaataa agggacagaa gattctctga tgggcaggac ccgtgagaca ggcacagaga
     2101 agaacaccag cagccttgag ttggaggagt ctctcccaga gcagcctgaa acagggcgac
     2161 aagaggaaga acttccgaga ttcccctgca aaaaacaaga ctacagccca tcatctggag
     2221 aagcccagga agtaccgttt gccctttcac tcagcagtga tggagctgtg agccctgttg
     2281 gggagcttgc agcaggagga gacagagact tggagagtca ggctgggtct cttgtggaga
     2341 gcaaagccag ggatgcagct gaagaagtgg cgccccctct tcccatggga gcatcagtcc
     2401 cttccattga ttccatgatg cggaagctgg aagagatggg tctgaacctc cgcaaggacc
     2461 agaagaaaac caagaagcgt gtgtcatttt ctgagcagct cttcacggaa gaggcagtgg
     2521 cgggggctgc cttgctggtg gaaggacaca gcagttgtcc ccaggagctg aaccctgcat
     2581 ggtctgttgc tggaaacgcg tctgacggag agcctcctga gtctccccac gcagaggact
     2641 cagaaaggga atcggtgacc acacctgggc cagcgacgtg tggtgcgcca gcctccccag
     2701 cggatcacct cctcctcccc tcccaggagg agagtttctc cgaagtcccc atgagtgaag
     2761 caagctcagc gaaagacact ccactcttta ggatggaggg agaggatgcc cttgtgactc
     2821 agtatcagag caaagccagt gaccacgaag gtttattgtc tgaccccttg agtgaccttc
     2881 agttggtctc agattttaaa tctccaatca tggccgatct gaacttaagc cttccttcca
     2941 ttcctgaagt cgcatcggat gatgaaagaa tagatcaggt tgaagatgac ggagatcagg
     3001 ttgaagatga tggagagaca gcaaagtcgt caactctgga cataggagct ttgtccttgg
     3061 gcttggtagt cccctgtcct gagaggggaa aggggcccag tggcgaggca gataggttgg
     3121 tactggggga gggcctgtgt gatttcaggc tgcaagcacc ccaggcatct gtgacagctc
     3181 cttcagagca gaccacagag ttcggaattc acaaaccaca tcttggcaag agctcaagct
     3241 tggataaaca gctgccaggc cccagtggtg gtgaggaaga aaaaccgatg ggaaatggga
     3301 gtccaagccc gcctcctggc acatccctgg acaatcctgt acccagcccc tccccttctg
     3361 agatctttcc tgtcacacac tctttcccca gctctgcaca ttctgacact caccacacca
     3421 gcacagcaga atctcaaaaa aaagccacag cagagggctc cgctggtaga gttgaaaatt
     3481 ttggcaagag gaagccactc ctccaggcct gggtctcacc ctcggagaca catccagtct
     3541 cagctcagcc aggcgctgga actgggtcag ccaagcacag acttcatcct gtgaagccaa
     3601 tgaatgcaat ggccaccaag gttgctaact gcagcttggg aactgccacc atcatcagtg
     3661 agaacttgaa caatgaggtc atgatgaaga aatacagccc ctcggaccct gcatttgcat
     3721 atgcgcagct gacccacgat gagctgattc agctggtcct caaacagaag gaaacgataa
     3781 gcaagaagga gttccaggtc cgcgagctgg aagactacat tgacaacctg cttgtcaggg
     3841 tcatggaaga aacccccaat atcctccgca tcccgactca ggttggcaaa aaagcaggaa
     3901 agatgtaaat cagcagaaaa aaaacaccga gacgtttctg tgacttcact ttcacctgct
     3961 ccaggggtca aggacttgcc ttgcctgata accagccagc aggctccgaa tcaccatctc
     4021 cctcacatgt tatccggcaa gagtgaattc taccaatgga agccaggtta atgattacaa
     4081 ttaatctttt actgtacatt cccaaggctt tagttttaaa tgccactgtg cctttaacaa
     4141 ggttgtaaat attttatgcc caccagagat gtggtcataa gatctgatcc tgagccagag
     4201 attcagatgg cacaggaagt attcatgtat tttaacactg gggttttctt tctttcatac
     4261 tgagattttt tttcagtatg tatcctccag ctcttaaagc ttacctgaga aagctttaaa
     4321 tgagaaaagg accatgcgat tggtgctgtg ttacatacac atactttctt ggcttctgag
     4381 tagctcaggt gtggcttttg gctgcagatg ttaaattttg ataccatgta aacctaccca
     4441 gcttctcaga cttgggtctt gttttttgat gggaacagag gtgtttagag aaagcctctg
     4501 agtatgcctt tcagattttg aacaagcggc cttttctaaa catcgacttc tactactctc
     4561 tagccttaaa ataccttctg cttagatcca gggcccttct actggagata ggaaaagtag
     4621 aattcaggaa ttaaaagaat tactctttat tcaatttgag gaacttggtg aaagcccctc
     4681 ctcttatgac agccaggttc ctgctggcta gaccagccta ttcagcgctt tgctagggga
     4741 ttgggtggtc cacgcactcg ctaatacagt tctccaggtg tggaatgatg tcaatacgat
     4801 tgcttggcct tttccccctg tgcctttgct cggtgctctg gtttcctcag caacactcct
     4861 tgtaaggggc agagacaggg tccaccaact ccccaagatg aagaagcccc ttcaggccag
     4921 tcgtggtggc tcatgcctgt aatcccagca ctttgcaagg ccgaggaggg tggatcactt
     4981 gaggtcagga gttcgagacc agcctgacca acatggcgaa accccatctc tactaaaaat
     5041 acaaaaatta gcttggcatg gtggtgcgtg cctgtaatcc cagctactcg ggaggctggg
     5101 gcaggagaat tgcttgaact tgggagatgg aggctgcagc gagccaagat cgtgccactg
     5161 cactccagcc tgggcaagag tttttttaag actcttaaaa aaagagcctg ggcaattttt
     5221 ttaagactct gtcttaaaaa aaactaaaaa gaaaaaaaga agccccttca ctctacaggg
     5281 gacaggagac catggattgg accccaaagg gattgaactg catctgcatg tctgtccttt
     5341 gaacactttc tctccctgcc caaaaggaaa cccaaattat ttgtgggata ctggggaaat
     5401 tgtagtgaag ggcttaatgt agttaataaa agttaaaagt cagtagaaaa caggtgcctc
     5461 agccttcaaa tggttgcttt ttttccattt tccctcatga atagactcac cagcatttta
     5521 cccccttgtt ataaaactgt gcagagcaag aagatgatac ttatttttga atttgtattt
     5581 ttaaaactag atttatagac tttttttttt tttaactagg gcacttgctt ccttcttagc
     5641 taaaagcacc agctgagatt tttcaggtaa ttttgttgtt actcacttaa gactggaatt
     5701 agaatgtttc tggtatttct catttttttc cctggctatg atagaatctc atctaatctt
     5761 gacatctctc ctaggggaag aatatcacag gctaatagcg tggttggggg tgaagatgat
     5821 agcagttatt aaatcaggaa tctcttttat gtgtgtcctt gttacattga ggttaagaga
     5881 caaaatcatt ggcagtgcaa tctctttcca ggatttcgtt tgctgtggca ttggttatat
     5941 cagagcactt taatctgaag gatgatactg taacttgatt tatctaatta gcttttaatt
     6001 atctacagct attttatttt atttaattct ctcctacagt actgggacca ctgtaaactt
     6061 ctcagatgac ttgtattttt gtagtgctat gaaatttatt tacatactta taaagaaaac
     6121 tgtatgttca cttgaactct gaaaatgtac atgtatggct ggacgcggtg gctcacgcct
     6181 gtaatcccag cactttggga ggctgaggcg ggtgaatcac ttgattgagg tcaggagttc
     6241 gagaccagcc tggccaacat ggcaaaaccc cgtctctact aaaaaataca gaaattagct
     6301 gggtgtggtg gcagacagct gtaatctcag ctgctcggga ggctgaggca caagaatcgc
     6361 ttgagccagg gaggtggagg ttgcagtgag ctgagatcac atcattgcac tccagcctgg
     6421 gcaacgggcg agactctgtc tcaaaaaaaa gaaagaaaga aaaggtacat gtatatattt
     6481 gtcctgcatt atgtttttta cttgatataa atgtattttt actgtgatag tccaagtgcc
     6541 ctggggggca ggtgtgctct atgtggttct tcttccattg gagagctggc gtagagatct
     6601 gcagtgttca caaggatgtt ggtttggaga tgtctgctgc taggacctgg ggtgtgtgac
     6661 tcagtccata tgagagggac atctgggtgg aggagtaaat tcctgtgctc tgaaatgcca
     6721 cttggtagct ctggacaatg aaggacaatt gactcaaggg tgcctggctt ctgctgctgc
     6781 tgggaaaaaa ttcagtttat agcattcctg cacctcccaa agtagataac ctggaggtca
     6841 ttcagttaac aactgtccct gaggactcag ttttggggga ggggttatct gggagaagct
     6901 ttagcctgtt ctgagccatt aggagacatt agtgaattgg agcactggag aatcctacaa
     6961 atggcctatg tctcagaaga gctgggacct ccttccagct gctgcagatg ctgacaggcc
     7021 ctgggaggct gctgtgctct ggagaagctg gagcagctca tttcttggcc tagcctggct
     7081 gcctcagaaa gagcagtcag gacttgaggg aagcatcaaa ttctataccc ataaactgca
     7141 gttggaagtc agctttttga aatgtccagc ctttgcccaa ttgtttcaga tcatctcatg
     7201 cctcaggctt tggcaggtat cctgccctcc atcttattcc agtgtgttca cctcatcaag
     7261 gcagcagagt ggatgaagga gtaagtctgc cctttgccat actgaacagc tgtggacccc
     7321 gattggtgag ggctctgcat atgcctgtat gaaggagata caggtgtgtg tgcacatgcc
     7381 ggtatgaaga agacacaggc atgtgcttct cagttttgct aacagtggga gctcaacggg
     7441 gcagagggag gaaggtccat gatgctcagc cacatactgt agagagaggc aatttaatgt
     7501 taaatgacgc accatcctcc ctcccaccct tctcccagtc aacttttttt ctttttctag
     7561 aactactaat tatctctcaa ggctgaaaaa ttaattgcct taggtggaga acttaattcc
     7621 tagtatccac caaacttaac tccgtatctc catatggtgt ctccatatct actgtgtgag
     7681 ctacttaact gacgccctct tcctccaact gaaggatcgc ccaacgtttt tggattatag
     7741 aattattatt tcctgctttc tttctttggg acttttgaat ttctttggtt tcgtttttaa
     7801 gaagtaaccc aacatttcct acaacactaa ataaaatggt acttaccttt caaagatttg
     7861 tgtctgtagt ttggtatggg tgcaataaaa atttattttg tcttcctgga aaacctctct
     7921 tggtgggggt ggggggatga ccagtgtttc tcatcccatg agggtctctc actgggattt
     7981 ctgttgctgc catcttgcct ggttcccagg agtcccaagg ccctttttct caaagaggac
     8041 ggacatgtct ggtcccttcg gatgcaccct tcatcttggc ctgagggacc atggcactgg
     8101 ccagagaaac tgagttggaa cgtgctgccc ccttttcctt tgcagccggt acccttggct
     8161 gagcatttgg acagggtctt tcctc
//
