LOCUS       NM_004218               1590 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RAB11B, member RAS oncogene family (RAB11B), mRNA.
ACCESSION   NM_004218
VERSION     NM_004218.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1590)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1590)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1590)
  AUTHORS   Kitano,M., Kizuka,Y., Sobajima,T., Nakano,M., Nakajima,K.,
            Misaki,R., Itoyama,S., Harada,Y., Harada,A., Miyoshi,E. and
            Taniguchi,N.
  TITLE     Rab11-mediated post-Golgi transport of the sialyltransferase
            ST3GAL4 suggests a new mechanism for regulating glycosylation
  JOURNAL   J Biol Chem 296, 100354 (2021)
   PUBMED   33524390
  REMARK    GeneRIF: Rab11-mediated post-Golgi transport of the
            sialyltransferase ST3GAL4 suggests a new mechanism for regulating
            glycosylation.
REFERENCE   4  (bases 1 to 1590)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1590)
  AUTHORS   Howe,E.N., Burnette,M.D., Justice,M.E., Schnepp,P.M., Hedrick,V.,
            Clancy,J.W., Guldner,I.H., Lamere,A.T., Li,J., Aryal,U.K.,
            D'Souza-Schorey,C., Zartman,J.J. and Zhang,S.
  TITLE     Rab11b-mediated integrin recycling promotes brain metastatic
            adaptation and outgrowth
  JOURNAL   Nat Commun 11 (1), 3017 (2020)
   PUBMED   32541798
  REMARK    GeneRIF: Rab11b-mediated integrin recycling promotes brain
            metastatic adaptation and outgrowth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1590)
  AUTHORS   Hales,C.M., Griner,R., Hobdy-Henderson,K.C., Dorn,M.C., Hardy,D.,
            Kumar,R., Navarre,J., Chan,E.K., Lapierre,L.A. and Goldenring,J.R.
  TITLE     Identification and characterization of a family of
            Rab11-interacting proteins
  JOURNAL   J Biol Chem 276 (42), 39067-39075 (2001)
   PUBMED   11495908
REFERENCE   7  (bases 1 to 1590)
  AUTHORS   Prekeris,R., Davies,J.M. and Scheller,R.H.
  TITLE     Identification of a novel Rab11/25 binding domain present in Eferin
            and Rip proteins
  JOURNAL   J Biol Chem 276 (42), 38966-38970 (2001)
   PUBMED   11481332
REFERENCE   8  (bases 1 to 1590)
  AUTHORS   Lapierre,L.A., Kumar,R., Hales,C.M., Navarre,J., Bhartur,S.G.,
            Burnette,J.O., Provance,D.W. Jr., Mercer,J.A., Bahler,M. and
            Goldenring,J.R.
  TITLE     Myosin vb is associated with plasma membrane recycling systems
  JOURNAL   Mol Biol Cell 12 (6), 1843-1857 (2001)
   PUBMED   11408590
REFERENCE   9  (bases 1 to 1590)
  AUTHORS   Schlierf,B., Fey,G.H., Hauber,J., Hocke,G.M. and Rosorius,O.
  TITLE     Rab11b is essential for recycling of transferrin to the plasma
            membrane
  JOURNAL   Exp Cell Res 259 (1), 257-265 (2000)
   PUBMED   10942597
REFERENCE   10 (bases 1 to 1590)
  AUTHORS   Zhu,A.X., Zhao,Y. and Flier,J.S.
  TITLE     Molecular cloning of two small GTP-binding proteins from human
            skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1875-1882 (1994)
   PUBMED   7811277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136469.2.
            
            On Nov 23, 2018 this sequence version replaced NM_004218.3.
            
            Summary: The Ras superfamily of small GTP-binding proteins, which
            includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see
            MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508)
            families, is involved in controlling a diverse set of essential
            cellular functions. The Rab family, including RAB11B, appears to
            play a critical role in regulating exocytotic and endocytotic
            pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied
            by OMIM, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.185080.1,
                                           SRR3476690.808131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328024.11/ ENSP00000333547.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC136469.2         107092-107188       c
            98-293              AC136469.2         97490-97685         c
            294-487             AC136469.2         95269-95462         c
            488-568             AC136469.2         94983-95063         c
            569-1590            AC136469.2         93114-94135         c
FEATURES             Location/Qualifiers
     source          1..1590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1590
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /note="RAB11B, member RAS oncogene family"
                     /db_xref="GeneID:9230"
                     /db_xref="HGNC:HGNC:9761"
                     /db_xref="MIM:604198"
     exon            1..97
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..714
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /EC_number="3.6.5.2"
                     /note="RAB11B, member of RAS oncogene family; GTP-binding
                     protein YPT3"
                     /codon_start=1
                     /product="ras-related protein Rab-11B"
                     /protein_id="NP_004209.2"
                     /db_xref="CCDS:CCDS12201.1"
                     /db_xref="GeneID:9230"
                     /db_xref="HGNC:HGNC:9761"
                     /db_xref="MIM:604198"
                     /translation="MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTI
                     GVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENV
                     ERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTN
                     VEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL
                     "
     exon            98..293
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /inference="alignment:Splign:2.1.0"
     exon            294..487
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /inference="alignment:Splign:2.1.0"
     exon            488..568
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /inference="alignment:Splign:2.1.0"
     exon            569..1590
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1485
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /note="major polyA site"
     polyA_site      1590
                     /gene="RAB11B"
                     /gene_synonym="H-YPT3; NDAGSCW"
                     /note="major polyA site"
ORIGIN      
        1 gtcgggtgtt tgtggtgggg ctgcggagtc gccgatcccg ccggaagcgc caggacaatg
       61 gggacccggg acgacgagta cgactaccta ttcaaagtgg tgctcatcgg ggactcaggc
      121 gtgggcaaga gcaacctgct gtcgcgcttc acccgcaacg agttcaacct ggagagcaag
      181 agcaccatcg gcgtggagtt cgccacccgc agcatccagg tggacggcaa gaccatcaag
      241 gcgcagatct gggacaccgc tggccaggag cgctaccgcg ccatcacctc cgcgtactac
      301 cgtggtgcag tgggcgccct gctggtgtac gacatcgcca agcacctgac ctatgagaac
      361 gtggagcgct ggctgaagga gctgcgggac cacgcagaca gcaacatcgt catcatgctg
      421 gtgggcaaca agagtgacct gcgccacctg cgggctgtgc ccactgacga ggcccgcgcc
      481 ttcgcagaaa agaacaactt gtccttcatc gagacctcag ccttggattc cactaacgta
      541 gaggaagcat tcaagaacat cctcacagag atctaccgca tcgtgtcaca gaaacagatc
      601 gcagaccgcg ctgcccacga cgagtccccg gggaacaacg tggtggacat cagcgtgccg
      661 cccaccacgg acggacagaa gcccaacaag ctgcagtgct gccagaacct gtgacccctg
      721 cgcctccacc cagcgtgcgt gcacgtcctc cgcccgcccc cgccacggta tcctctggcc
      781 cctccctgct gtccctctgt ggccggctcg ttccagccct cccagtgagc tctgcacggc
      841 cgggccgggg cccaggaagg acaggagcca gtgctacccc gtcctgcccg gggaaaagct
      901 agaagccccg gtttgctgca cccatgaaac tcgggtcccc acagcgtctt ggcggggtgg
      961 ggagggcggc aggatggacg gggctggcca gaggcgagga ggacgggcgg acggcgccgc
     1021 cttctcccct tttccttggc cgactctagg gagcgattgc ctccctccct ccgtgaccgg
     1081 gtggcccagc cagcccgtcg tccccaccca gaaccgtgct ctgggccaaa gcccgaagaa
     1141 ccaggcagcg ggggccgggg caggcggacc ccccgggctc tcagcgccca cccgctcctc
     1201 cgcacacagc agctcgcaca ggcctcccac ctctgcctgt tgattgatgc agggagaagc
     1261 ccgtcccccc ctctcccctc tcccctcccc tctcctgcac gcaacgcgcc ctctcggccc
     1321 tccctgtccc cctcctctgt ctcgtctccc catctggtct ggaacctgtt tgcaagtgaa
     1381 gcaatatctc cgtgttttgt atatacaacc gctcttgtag cctttggttt ttgttaatgt
     1441 agagaaacac agattcttta tacactttgt aagatttacg ccaaacccca gctctcgatc
     1501 tcttcttctc cctgtggccc ctgcgctgtt gccccgtccc cgtcaccccg cccgttactg
     1561 aaatgtataa tctgacttcc tgtacagaaa
//
