LOCUS       NM_004663               4895 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RAB11A, member RAS oncogene family (RAB11A),
            transcript variant 1, mRNA.
ACCESSION   NM_004663
VERSION     NM_004663.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4895)
  AUTHORS   Borroto,M.C., Patel,H., Srivastava,S., Swanson,L.C., Keren,B.,
            Whalen,S., Mignot,C., Wang,X., Chen,Q., Rosenfeld,J.A., McLean,S.,
            Littlejohn,R.O., Emrick,L., Burrage,L.C., Attali,R., Lesca,G.,
            Acquaviva-Bourdain,C., Sarret,C., Seaver,L.H., Platzer,K.,
            Bartolomaeus,T., Wunsch,C., Fischer,S., Rodriguez Barreto,A.M.,
            Granadillo,J.L., Schreiner,E., Brunet,T., Schatz,U.A.,
            Thiffault,I., Mullegama,S.V., Michaud,J.L., Hamdan,F.F.,
            Rossignol,E. and Campeau,P.M.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Cohort Expansion and Genotype-Phenotype Analysis of
            RAB11A-Associated Neurodevelopmental Disorder
  JOURNAL   Pediatr Neurol 160, 45-53 (2024)
   PUBMED   39181022
  REMARK    GeneRIF: Cohort Expansion and Genotype-Phenotype Analysis of
            RAB11A-Associated Neurodevelopmental Disorder.
REFERENCE   2  (bases 1 to 4895)
  AUTHORS   Mason,J.D., Marks,E., Fan,S.J., McCormick,K., Wilson,C.,
            Harris,A.L., Hamdy,F.C., Cunningham,C. and Goberdhan,D.C.I.
  TITLE     Stress-induced Rab11a-exosomes induce amphiregulin-mediated
            cetuximab resistance in colorectal cancer
  JOURNAL   J Extracell Vesicles 13 (6), e12465 (2024)
   PUBMED   38887984
  REMARK    GeneRIF: Stress-induced Rab11a-exosomes induce
            amphiregulin-mediated cetuximab resistance in colorectal cancer.
REFERENCE   3  (bases 1 to 4895)
  AUTHORS   Hall,B.A., Senior,K.E., Ocampo,N.T. and Samanta,D.
  TITLE     Coxiella burnetii-containing vacuoles interact with host recycling
            endosomal proteins Rab11a and Rab35 for vacuolar expansion and
            bacterial growth
  JOURNAL   Front Cell Infect Microbiol 14, 1394019 (2024)
   PUBMED   38841112
  REMARK    GeneRIF: Coxiella burnetii-containing vacuoles interact with host
            recycling endosomal proteins Rab11a and Rab35 for vacuolar
            expansion and bacterial growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4895)
  AUTHORS   Yoshida,K., Htike,K., Eguchi,T., Kawai,H., Eain,H.S., Tran,M.T.,
            Sogawa,C., Umemori,K., Ogawa,T., Kanemoto,H., Ono,K., Nagatsuka,H.,
            Sasaki,A., Ibaragi,S. and Okamoto,K.
  TITLE     Rab11 suppresses head and neck carcinoma by regulating EGFR and
            EpCAM exosome secretion
  JOURNAL   J Oral Biosci 66 (1), 205-216 (2024)
   PUBMED   38072191
  REMARK    GeneRIF: Rab11 suppresses head and neck carcinoma by regulating
            EGFR and EpCAM exosome secretion.
REFERENCE   5  (bases 1 to 4895)
  AUTHORS   Meng,T., Chen,X., He,Z., Huang,H., Lin,S., Liu,K., Bai,G., Liu,H.,
            Xu,M., Zhuang,H., Zhang,Y., Waqas,A., Liu,Q., Zhang,C., Sun,X.D.,
            Huang,H., Umair,M., Yan,Y. and Feng,D.
  TITLE     ATP9A deficiency causes ADHD and aberrant endosomal recycling via
            modulating RAB5 and RAB11 activity
  JOURNAL   Mol Psychiatry 28 (3), 1219-1231 (2023)
   PUBMED   36604604
REFERENCE   6  (bases 1 to 4895)
  AUTHORS   Zeng,J., Ren,M., Gravotta,D., De Lemos-Chiarandini,C., Lui,M.,
            Erdjument-Bromage,H., Tempst,P., Xu,G., Shen,T.H., Morimoto,T.,
            Adesnik,M. and Sabatini,D.D.
  TITLE     Identification of a putative effector protein for rab11 that
            participates in transferrin recycling
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 2840-2845 (1999)
   PUBMED   10077598
REFERENCE   7  (bases 1 to 4895)
  AUTHORS   Gromov,P. and Celis,J.E.
  TITLE     Rab11a is modified in vivo by isoprenoid geranylgeranyl
  JOURNAL   Electrophoresis 19 (10), 1803-1807 (1998)
   PUBMED   9719562
REFERENCE   8  (bases 1 to 4895)
  AUTHORS   Gromov,P.S., Celis,J.E., Hansen,C., Tommerup,N., Gromova,I. and
            Madsen,P.
  TITLE     Human rab11a: transcription, chromosome mapping and effect on the
            expression levels of host GTP-binding proteins
  JOURNAL   FEBS Lett 429 (3), 359-364 (1998)
   PUBMED   9662449
REFERENCE   9  (bases 1 to 4895)
  AUTHORS   Sakurada,K., Uchida,K., Yamaguchi,K., Aisaka,K., Ito,S., Ohmori,T.,
            Takeyama,Y., Ueda,T., Hori,Y., Ohyanagi,H. et al.
  TITLE     Molecular cloning and characterization of a ras p21-like
            GTP-binding protein (24KG) from rat liver
  JOURNAL   Biochem Biophys Res Commun 177 (3), 1224-1232 (1991)
   PUBMED   1711847
REFERENCE   10 (bases 1 to 4895)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E.E., D'Eustachio,P. and Rush,M.G.
  TITLE     Identification and characterization of a human homolog of the
            Schizosaccharomyces pombe ras-like gene YPT-3
  JOURNAL   Oncogene 6 (1), 3-9 (1991)
   PUBMED   1704119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300743.1, BC013348.2,
            AC084854.11 and BC047114.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004663.4.
            
            Summary: The protein encoded by this gene belongs to the Rab family
            of the small GTPase superfamily. It is associated with both
            constitutive and regulated secretory pathways, and may be involved
            in protein transport. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, May
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.46051.1,
                                           SRR1803615.256575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261890.7/ ENSP00000261890.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DC300743.1         43-43
            2-1607              BC013348.2         1-1606
            1608-4870           AC084854.11        125721-128983
            4871-4895           BC047114.1         1195-1219
FEATURES             Location/Qualifiers
     source          1..4895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..4895
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="RAB11A, member RAS oncogene family"
                     /db_xref="GeneID:8766"
                     /db_xref="HGNC:HGNC:9760"
                     /db_xref="MIM:605570"
     exon            1..135
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..746
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; RAB
                     11A, member oncogene family; ras-related protein Rab-11A;
                     rab-11"
                     /codon_start=1
                     /product="ras-related protein Rab-11A isoform 1"
                     /protein_id="NP_004654.1"
                     /db_xref="CCDS:CCDS10212.1"
                     /db_xref="GeneID:8766"
                     /db_xref="HGNC:HGNC:9760"
                     /db_xref="MIM:605570"
                     /translation="MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTI
                     GVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENV
                     ERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTN
                     VEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI"
     exon            136..331
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /inference="alignment:Splign:2.1.0"
     exon            332..525
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /inference="alignment:Splign:2.1.0"
     exon            526..606
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /inference="alignment:Splign:2.1.0"
     exon            607..4895
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      806..811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="hexamer: AATATA"
     polyA_site      829
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="major polyA site"
     regulatory      965..970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="hexamer: AATAAA"
     polyA_site      990
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="major polyA site"
     regulatory      2338..2343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="hexamer: AATAAA"
     polyA_site      2357
                     /gene="RAB11A"
                     /gene_synonym="YL8"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="hexamer: AGTAAA"
     polyA_site      2473
                     /gene="RAB11A"
                     /gene_synonym="YL8"
     regulatory      4862..4867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB11A"
                     /gene_synonym="YL8"
                     /note="hexamer: AATATA"
     polyA_site      4895
                     /gene="RAB11A"
                     /gene_synonym="YL8"
ORIGIN      
        1 agttgaagct cggcgctcgg gttacccctg cagcgacgcc ccctggtccc acagatacca
       61 ctgctgctcc cgccctttcg ctcctcggcc gcgcaatggg cacccgcgac gacgagtacg
      121 actacctctt taaagttgtc cttattggag attctggtgt tggaaagagt aatctcctgt
      181 ctcgatttac tcgaaatgag tttaatctgg aaagcaagag caccattgga gtagagtttg
      241 caacaagaag catccaggtt gatggaaaaa caataaaggc acagatatgg gacacagcag
      301 ggcaagagcg atatcgagct ataacatcag catattatcg tggagctgta ggtgccttat
      361 tggtttatga cattgctaaa catctcacat atgaaaatgt agagcgatgg ctgaaagaac
      421 tgagagatca tgctgatagt aacattgtta tcatgcttgt gggcaataag agtgatctac
      481 gtcatctcag ggcagttcct acagatgaag caagagcttt tgcagaaaag aatggtttgt
      541 cattcattga aacttcggcc ctagactcta caaatgtaga agctgctttt cagacaattt
      601 taacagagat ttaccgcatt gtttctcaga agcaaatgtc agacagacgc gaaaatgaca
      661 tgtctccaag caacaatgtg gttcctattc atgttccacc aaccactgaa aacaagccaa
      721 aggtgcagtg ctgtcagaac atctaaggca tttctcttct cccctagaag gctgtgtata
      781 gtccatttcc caggtctgag atttaaatat atttgtaatt cttgtgtcac ttttgtgttt
      841 tattacttca tacttatgaa tttttccatg tcctaagtct tttgatttta gctttataaa
      901 atcatccact tgtcccgaat gactgcagct ttttttcatg ctatggcttc actagcctta
      961 gtttaataaa ctgaatgttt ggattcctca gttattgttt acttttcatc atggaagcct
     1021 gtcactgtat gtaggacata atagaacttg atcacttgaa gctcagacct attggtcttg
     1081 atcaaatcaa actaagaaga ccttagaaat aagctaccat tttgccacag agcagcttat
     1141 aggtaataca ctcttctctc agtgcagtgt acatttccac aaatctaaga attgccctat
     1201 aaacatagca ggattttgag agcttgaaaa ttttccatta ttctggacat gaatttctaa
     1261 aatgccttaa taggtttatg tagttgagta aattttgttt tttaattttt gtaagcatca
     1321 aagttgatta gagagggggg cactttttct ggagaattct cttagtaaac acaaaagatt
     1381 gttacggttt cattagtagt atggttgtgg ggccataagt taaacagtgc tgcctggtag
     1441 gctgggaact gaagagactt gtggtattcc atctcgggtg cctctgttgg caatgatcag
     1501 gcagcccaaa agatttaaat gatctataat aatttccaag cggtagatta tgtggcattt
     1561 tattgctcag gcaataattg gtttaatgct ggtagtgtca aattttgaag tgttaatttt
     1621 gtcttagaac cttccagtaa gtgaaataca acctagtttt atcaccatat ccaccagcag
     1681 gcatggataa ttattttaac aatgctaata tttgagtttt gcagtatatt atagaatata
     1741 gtccagttaa atctttggtt tcagtatgtc tgaagagtac agtgagaggt taatttctgc
     1801 tcaagtggta ccacttaaag gcatgtattc ttttagtatg taaaatgaaa tagtaccttg
     1861 agtttaaata gaatgcattt aggcattgta gagatctgaa atagttttct tccactacat
     1921 tgttgaaatc aatgaagcaa ttagtttctc attcagaaat gtgcacacta atatttagtt
     1981 ttgctttctc gtggataata ttaagcactt actctgcagt ttcctggaag ttgtgtcaac
     2041 tgcagtgata ctattcagga tggtgggaaa tccccaaaaa tatgtatgtg tgggcttgct
     2101 tagattacta tatttcatag ttaatctttt gtctcttgcg gtgctcatga tgtgtggggc
     2161 acacggaagg cattgctgta gtcagtcatt ttggttttct tctatagcca ttttattatt
     2221 ttagtgtatt agttatgaag ataatattat ctatttgtaa attgctactt tgtattttat
     2281 gcatgctctg taatttgatt tttttttagt tattgatttg gattatattc acattctaat
     2341 aaacagttat agggggatta tttcttatgc tgtcagatta catttttcct ttgagtgctt
     2401 tgggtgcagc cgtggaatcc tgatgtaaaa gcataggttc ttgcattact gagtaaacat
     2461 tgaattggga gcatcagtgt gtgaattcag ctttgatttt agaactgcag ttcaattatg
     2521 ctttccttgg aaaaagtatg tccaaaaaca ttaggaaagt agtgtgtatt ttcatatata
     2581 acagtgtcac cagacccagg aaaagaaacc atctctattt tattgaaagt tggtggtaga
     2641 ttttttacaa agtaaggaga aaagagaaaa actaaatagt gaattgaaaa tgaataaagt
     2701 aaacttagaa tttttaccca agtgtagact taaatgttgc tttgagtatg gctggatctt
     2761 gggagaattc caggaaatat taggtattag aaaatgactt tgattgcatt tcagcaggtg
     2821 tctttattct gagtagtatc ttaggagaca aactgtctca agcaagaaac aataaatttt
     2881 taaatattat gacagttcag ggcttaaggc agtttagaag tattttgcta cttgaccttg
     2941 attttcagtt attttaactt tgaatttttt tttttttttt tgagacggag tcttgctctg
     3001 ttgcccaggc tggagtacaa tggcaccatc tcagctcact gcaagctcca cctccagggt
     3061 tcatgccatt ctcctgcctc agcctcccga gtagctggga ttataggcgc cagccaccac
     3121 gactggctaa ttttttgtat ttttagtaga gacggggttt caccatgtta gccagggtgg
     3181 tctcgatctc ctgacctggt gatacaccca cctcggcctc ccaaagtgct gggattaaag
     3241 gcgtgagcca ccgtgcctgg ccttgaattt ttttttaacc tgttatatag tctcctgaat
     3301 agttagccat ggtgccttga tttaatctta tgtcattgtt ctcaaatgcc atgatttctc
     3361 tttaatagta gttgtcatta tgtaagggta agttattgcc catttaattg taattataag
     3421 aagaggtgcc agctagtgac cttacatcag tgatctttta agttctgaag ggttctgcag
     3481 aaaagttaca cttcttgagt ttgggttgcc catcagagct ggtcacattt ctttgatcat
     3541 tgaaaaaatg aatatcttaa tttttgtctt tgctgactgg tatttataaa atacaaatgc
     3601 ttttagtggg ttgagctgtt gtgataatct cttccatcta ccttagagaa gaagctgtac
     3661 tatttagaca gttttggcca acactagaag caaaagaatt caaaggctgg gtggatattt
     3721 aagaacttat tctaacctgt caggtttcaa tttgtggggc ttggtttaac agaggaaaaa
     3781 aatataaatt gattttctga tgtctcacaa atatcacata cctggaaaaa aattaaaaca
     3841 aaaaatgaat tttgtaaaag gttatgtatg acttccattt gctctgtaaa aaaatgaaca
     3901 aagattgtga aaggatcctc ttccaccaca tcatttaatg ggttagcgga acagataggg
     3961 agctatgaca ctagcaccaa agagagattt ttcttctggt tgggtggtgc tggtgccacg
     4021 cccctttctg ggatttgaca agtctttccc actcacctat acaatatgcc aaatcaactg
     4081 gagttgtcat tctaatgttt taaagaatga ttgggttccc ccaaactgta ggaggtcgat
     4141 ggtaacaata aagtgataca aaatgcttat gtcattataa tttatgtaag ggagaccatt
     4201 aggctgagaa tcaatatgat tgaggttatc tattctcctg aaaagtgaat tggagaataa
     4261 agaaagaata tttgaaagga tgttgtgtac taggcaatat actagcatgt attagaaaat
     4321 acggtaaact gtgggttaga agagtgaaag tagctggtat gatagagcac tggactgagt
     4381 aacgaagaga ttctagtcat ggctcttgtg gtcatttcat ttttgagcct cacattcttc
     4441 caattaatga gggtaccaga ttaaataaac tctggggatt catcccaatt cgaactctgt
     4501 aattctctga atgaactctc tcttcaatta aagccaaatt attaacattt taactcaagt
     4561 ttaaatttaa tagagaagtc aaaatgaggt atgcactttg tggaatgttt ttggtcttat
     4621 cacaataacc tgattaaaat ggtgccttta tttccatgtt tactccttta aataagatga
     4681 aagctttcag aacatttatt tgcaaaatga ctgtcaatat caacaatatg catcaaagta
     4741 ccatatatgc taagggagag gagcacttga tgggctgcta tgttaactgt aaattgagaa
     4801 ctgcttgttt tatggctttt gctgttaaaa aaaaactgct ggcttttaat atgtacttta
     4861 aaatatactc atgtctggga gagaactttt aaaaa
//
