LOCUS       NM_016131               3561 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens RAB10, member RAS oncogene family (RAB10), mRNA.
ACCESSION   NM_016131
VERSION     NM_016131.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Xu,L., Wang,A. and Guan,H.
  TITLE     microRNA-106b-5p and Rab10: Potential Markers of Acute Myeloid
            Leukemia
  JOURNAL   Cancer Biother Radiopharm 39 (7), 492-501 (2024)
   PUBMED   38949985
  REMARK    GeneRIF: microRNA-106b-5p and Rab10: Potential Markers of Acute
            Myeloid Leukemia.
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Schrder,L.F., Peng,W., Gao,G., Wong,Y.C., Schwake,M. and Krainc,D.
  TITLE     VPS13C regulates phospho-Rab10-mediated lysosomal function in human
            dopaminergic neurons
  JOURNAL   J Cell Biol 223 (5) (2024)
   PUBMED   38358348
  REMARK    GeneRIF: VPS13C regulates phospho-Rab10-mediated lysosomal function
            in human dopaminergic neurons.
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Cheng,X., Wu,C., Xu,H., Zou,R., Li,T. and Ye,S.
  TITLE     miR-557 inhibits hepatocellular carcinoma progression through
            Wnt/beta-catenin signaling pathway by targeting RAB10
  JOURNAL   Aging (Albany NY) 16 (4), 3716-3733 (2024)
   PUBMED   38364252
  REMARK    GeneRIF: miR-557 inhibits hepatocellular carcinoma progression
            through Wnt/beta-catenin signaling pathway by targeting RAB10.
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Mamais,A., Sanyal,A., Fajfer,A., Zykoski,C.G., Guldin,M.,
            Riley-DiPaolo,A., Subrahmanian,N., Gibbs,W., Lin,S. and LaVoie,M.J.
  TITLE     The LRRK2 kinase substrates RAB8a and RAB10 contribute
            complementary but distinct disease-relevant phenotypes in human
            neurons
  JOURNAL   Stem Cell Reports 19 (2), 163-173 (2024)
   PUBMED   38307024
  REMARK    GeneRIF: The LRRK2 kinase substrates RAB8a and RAB10 contribute
            complementary but distinct disease-relevant phenotypes in human
            neurons.
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Lapierre,L.A., Roland,J.T., Manning,E.H., Caldwell,C., Glenn,H.L.,
            Vidalain,P.O., Tangy,F., Hogue,B.G., de Haan,C.A.M. and
            Goldenring,J.R.
  TITLE     Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a
            Myosin Vb Splice Variant and Rab10
  JOURNAL   Cells 13 (2), 126 (2024)
   PUBMED   38247817
  REMARK    GeneRIF: Coronavirus M Protein Trafficking in Epithelial Cells
            Utilizes a Myosin Vb Splice Variant and Rab10.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   8  (bases 1 to 3561)
  AUTHORS   Bao,S., Zhu,J. and Garvey,W.T.
  TITLE     Cloning of Rab GTPases expressed in human skeletal muscle: studies
            in insulin-resistant subjects
  JOURNAL   Horm Metab Res 30 (11), 656-662 (1998)
   PUBMED   9918381
REFERENCE   9  (bases 1 to 3561)
  AUTHORS   Chen,Y.T., Holcomb,C. and Moore,H.P.
  TITLE     Expression and localization of two low molecular weight GTP-binding
            proteins, Rab8 and Rab10, by epitope tag
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6508-6512 (1993)
   PUBMED   7688123
REFERENCE   10 (bases 1 to 3561)
  AUTHORS   Araki,W., Ohno,K., Matsunaga,K., Nakamura,H., Sugimoto,C. and
            Shimada,T.
  TITLE     [Two sisters with pseudoidiopathic hypoparathyroidism presenting
            extensive intracranial calcification]
  JOURNAL   Nihon Naika Gakkai Zasshi 78 (1), 81-82 (1989)
   PUBMED   2732579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013449.8 and AC011742.3.
            
            On Nov 23, 2018 this sequence version replaced NM_016131.4.
            
            Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020)
            superfamily of small GTPases. RAB proteins localize to exocytic and
            endocytic compartments and regulate intracellular vesicle
            trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM,
            Mar 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1082642.1,
                                           SRR1803614.59988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264710.5/ ENSP00000264710.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-652               AC013449.8         104670-105321
            653-713             AC011742.3         48451-48511
            714-852             AC011742.3         59557-59695
            853-942             AC011742.3         76933-77022
            943-1044            AC011742.3         77639-77740
            1045-3561           AC011742.3         84727-87243
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3561
                     /gene="RAB10"
                     /note="RAB10, member RAS oncogene family"
                     /db_xref="GeneID:10890"
                     /db_xref="HGNC:HGNC:9759"
                     /db_xref="MIM:612672"
     exon            1..652
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1128
                     /gene="RAB10"
                     /EC_number="3.6.5.2"
                     /note="ras-related GTP-binding protein; GTP-binding
                     protein RAB10"
                     /codon_start=1
                     /product="ras-related protein Rab-10"
                     /protein_id="NP_057215.3"
                     /db_xref="CCDS:CCDS1720.1"
                     /db_xref="GeneID:10890"
                     /db_xref="HGNC:HGNC:9759"
                     /db_xref="MIM:612672"
                     /translation="MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGI
                     DFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISK
                     WLRNIDEHANEDVERMLLGNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIE
                     KAFLTLAEDILRKTPVKEPNSENVDISSGGGVTGWKSKCC"
     exon            653..713
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     exon            714..852
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     exon            853..942
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1044
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..3561
                     /gene="RAB10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1186..1191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB10"
                     /note="hexamer: AATAAA"
     polyA_site      1217
                     /gene="RAB10"
                     /note="major polyA site"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB10"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="RAB10"
                     /note="major polyA site"
     regulatory      3538..3543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RAB10"
                     /note="hexamer: TATAAA"
     polyA_site      3561
                     /gene="RAB10"
ORIGIN      
        1 gtctcaggca gcgcgcacgc cggcgtgaga gggcacgggg aaaaggtggc tctggccggg
       61 gtggctcggt ttcctggggc tatgtaactg agctcgtcga cttaggggtc cttcttcgct
      121 gccctcgccg cgtgctagca gggagtttcc gctcgggaga gagactgtcc tcacgcccgc
      181 tgcgcctcct cgacggcaga gcaggcttgc tcgcccgtgg gagcgtcccg gccgagaagc
      241 cctgaggggg gaggggaggc cattttgtcc cgaccgactc cccggaaccg ggcggacggg
      301 ctgggagagg ctgcggagcc gcggtcgccg ccctcggagg cactggacgc cgccactgtc
      361 ggggcttcct caaagctgtt cgtaggtcgc ccgcgccgtc tcgagccttt ttcccacgct
      421 tccccggtcc tccggcctga gaacgcccga gtgaggagtt ggccgtagtg agagggaccg
      481 atcccttggg gccgccggcg gcgagagccc gagccgctcc tcccaatggc gaagaagacg
      541 tacgacctgc ttttcaagct gctcctgatc ggggattccg gagtggggaa gacctgcgtc
      601 ctttttcgtt tttcggatga tgccttcaat actaccttta tttccaccat aggaatagac
      661 ttcaagatca aaacagttga attacaagga aagaagatca agctacagat atgggataca
      721 gcaggccagg agcgatttca caccatcaca acctcctact acagaggcgc aatgggtatc
      781 atgctagtat atgacatcac caatggtaaa agttttgaaa acatcagcaa atggcttaga
      841 aacatagatg agcatgccaa tgaagatgtg gaaagaatgt tactaggaaa caagtgtgat
      901 atggacgaca aaagagttgt acctaaagga aaaggagaac agattgcaag ggagcatggt
      961 attaggtttt ttgagactag tgcaaaagca aatataaaca tcgaaaaggc gttcctcacg
     1021 ttagctgaag atatccttcg aaagacccct gtaaaagagc ccaacagtga aaatgtagat
     1081 atcagcagtg gaggaggcgt gacaggctgg aagagcaaat gctgctgagc attctcctgt
     1141 tccatcagtt gccatccact accccgtttt ctcttcttgc tgcaaaataa accactctgt
     1201 ccatttttaa ctctaaacag atatttttgt ttctcatctt aactatccaa gccacctatt
     1261 ttatttgttc tttcatctgt gactgcttgc tgactttatc ataattttct tcaaacaaaa
     1321 aaatgtatag aaaaatcatg tctgtgagtt catttttaaa tgtacttgct cagctcaact
     1381 gcatttcagt tgtattatag tccagttctt atcaacatta aaacctatag caatcatttc
     1441 aaatctattc tgcaaattgt ataagaataa agttagaatt aacaatttta ttttgtacaa
     1501 cagtggaatt ttctgtcatg gataatgtgc ttgagtccct ataatctata gacatgtgat
     1561 agcaaaagaa acaaacaaaa gccaggaaaa cactcatttt cgccttgaat atgtaaatgg
     1621 gattaatttt gtcctgtgcc ttatgtggaa aggaacttct ttggttttcc ttttttgttc
     1681 tggtggaagc atgtgcagga gacatatcat ccaaacataa accattaaaa tgtttgtggt
     1741 ttgcttggct gtaattttca aagtagttaa ttgaggacaa agggtaatgc agaagtgata
     1801 gctttggttt gctgagtctt gttttaagtg gccttgatat ttaaaactat tcctgccacc
     1861 atttcttctc cttggccact tcttccttgc gtctccctgc atgctgcttt atttgcttct
     1921 ccctccccaa ccacctcatg gtatatttaa gagtgaaagg gacaaactag taggtttgtc
     1981 aagtttaata taaagcactg atgtaacttg ctaggtaaac ggaaagataa gttctaactg
     2041 cctactatcc aatgtcagtt aattggtgtc ttcccccctc atttgctctc ttccctaaaa
     2101 tgtgtcccag atgccttcat ttgctgtttt acttctatgt tctgcttttc ctcctctctt
     2161 tgttcccttc ctgtctatcc attgagttta tgaaatggaa gagttaactg catgcactag
     2221 tgtttggagg gtgttgtggt ttgtctttct aattaggtgt atagcctatt cactttccta
     2281 gaataaatct cttaacctaa atttgagtag tctgcatttt ggcaactcct ctagcagctt
     2341 ggtagcctag tacaggttgt ttttttaaaa aaggaaaagc aggaaggagg agtgaatttt
     2401 attaacatgt ttgccaaatg tattgagatt tggcctctga agaacacttt ttcagtgtta
     2461 agtttcttta ccttaagatt cagaaatact ttagaatatt attaatttta agtcctgtct
     2521 ttacatcctt ttggaaaact tgtattacca tgggtttgga aaaaggacaa cgaaaggctt
     2581 ttcatgtaaa gataagatct ttagctatct ctaaccctgt ccttttttca ctgcattttt
     2641 tctagttttg cttcattgct tatcattagg atagggtaag tgaagtttgc tatgctgcta
     2701 gcatcctaag atgatacctt tgttgaaaga attgtgaata gcatgattca tttctagcag
     2761 aggctgagtt taggacagca gcttccattg agaagtcttt ctgtgtcgtg aatagcattt
     2821 taatgacctc ttggctcaca taagcaaaca acatagggac gtatctgcta tgaaaatcca
     2881 caaatttttc agatagtgcc ctaaaaacaa ttttatatgc ctcactggtt gttattctta
     2941 ggttattccc acacttgact ttatcattgt ttactactag taaaaagcag cattgccaaa
     3001 taatccctaa ttttccacta aaaatataat gaaatgatgt taagcttttt gaaaagttta
     3061 ggttaaacct actgttgtta gattaatgta tttgttgctt ccctttatct ggaatgtggc
     3121 attagctttt ttattttaac cctctttaat tcttattcaa ttccatgact taaggttgga
     3181 gagctaaaca ctgggatttt tggataacag actgacagtt ttgcataatt ataatcggca
     3241 ttgtacatag aaaggatatg gctacctttt gttaaatctg cactttctaa atatcaaaaa
     3301 agggaaatga agtataaatc aatttttgta taatctgttt gaaacatgag ttttatttgc
     3361 ttaatattag ggctttgccc cttttctgta agtctcttgg gatcctgtgt agaagctgtt
     3421 ctcattaaac accaaacagt taagtccatt ctctggtact agctacaaat tcggtttcat
     3481 attctactta acaatttaaa taaactgaaa tatttctaga tggtctactt ctgttcatat
     3541 aaaaacaaaa cttgatttcc a
//
