LOCUS       NM_178491               1323 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens R3H domain containing like (R3HDML), mRNA.
ACCESSION   NM_178491
VERSION     NM_178491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1323)
  AUTHORS   Cho,Y.S., Chen,C.H., Hu,C., Long,J., Ong,R.T., Sim,X., Takeuchi,F.,
            Wu,Y., Go,M.J., Yamauchi,T., Chang,Y.C., Kwak,S.H., Ma,R.C.,
            Yamamoto,K., Adair,L.S., Aung,T., Cai,Q., Chang,L.C., Chen,Y.T.,
            Gao,Y., Hu,F.B., Kim,H.L., Kim,S., Kim,Y.J., Lee,J.J., Lee,N.R.,
            Li,Y., Liu,J.J., Lu,W., Nakamura,J., Nakashima,E., Ng,D.P.,
            Tay,W.T., Tsai,F.J., Wong,T.Y., Yokota,M., Zheng,W., Zhang,R.,
            Wang,C., So,W.Y., Ohnaka,K., Ikegami,H., Hara,K., Cho,Y.M.,
            Cho,N.H., Chang,T.J., Bao,Y., Hedman,A.K., Morris,A.P.,
            McCarthy,M.I., Takayanagi,R., Park,K.S., Jia,W., Chuang,L.M.,
            Chan,J.C., Maeda,S., Kadowaki,T., Lee,J.Y., Wu,J.Y., Teo,Y.Y.,
            Tai,E.S., Shu,X.O., Mohlke,K.L., Kato,N., Han,B.G. and Seielstad,M.
  CONSRTM   DIAGRAM Consortium; MuTHER Consortium
  TITLE     Meta-analysis of genome-wide association studies identifies eight
            new loci for type 2 diabetes in east Asians
  JOURNAL   Nat Genet 44 (1), 67-72 (2011)
   PUBMED   22158537
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1323)
  AUTHORS   Bigdeli,T.B., Maher,B.S., Zhao,Z., Oord,E.J., Thiselton,D.L.,
            Sun,J., Webb,B.T., Amdur,R.L., Wormley,B., O'Neill,F.A., Walsh,D.,
            Riley,B.P., Kendler,K.S. and Fanous,A.H.
  TITLE     Comprehensive gene-based association study of a chromosome 20
            linked region implicates novel risk loci for depressive symptoms in
            psychotic illness
  JOURNAL   PLoS One 6 (12), e21440 (2011)
   PUBMED   22220189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL117382.28.
            
            On Nov 26, 2019 this sequence version replaced NM_178491.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107048.2 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145245,
                                           SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217043.4/ ENSP00000217043.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               AL117382.28        69387-69762
            377-495             AL117382.28        73540-73658
            496-628             AL117382.28        75721-75853
            629-744             AL117382.28        77607-77722
            745-1323            AL117382.28        83004-83582
FEATURES             Location/Qualifiers
     source          1..1323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1323
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /note="R3H domain containing like"
                     /db_xref="GeneID:140902"
                     /db_xref="HGNC:HGNC:16249"
     exon            1..376
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..877
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /note="peptidase inhibitor R3HDML; cysteine-rich secretory
                     protein R3HDML"
                     /codon_start=1
                     /product="peptidase inhibitor R3HDML precursor"
                     /protein_id="NP_848586.1"
                     /db_xref="CCDS:CCDS13329.1"
                     /db_xref="GeneID:140902"
                     /db_xref="HGNC:HGNC:16249"
                     /translation="MPLLPSTVGLAGLLFWAGQAVNALIMPNATPAPAQPESTAMRLL
                     SGLEVPRYRRKRHISVRDMNALLDYHNHIRASVYPPAANMEYMVWDKRLARAAEAWAT
                     QCIWAHGPSQLMRYVGQNLSIHSGQYRSVVDLMKSWSEEKWHYLFPAPRDCNPHCPWR
                     CDGPTCSHYTQMVWASSNRLGCAIHTCSSISVWGNTWHRAAYLVCNYAIKGNWIGESP
                     YKMGKPCSSCPPSYQGSCNSNMCFKGLKSNKFTWF"
     exon            377..495
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            496..628
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..744
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1323
                     /gene="R3HDML"
                     /gene_synonym="dJ881L22.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcctctggg tcggcactgt tggagaacgc tcagggtctg gtgctctcgt gcctgcccct
       61 tccaggcagc cggctctgat tgcacaaggc agacctgtga ctcctccatc cagctatgcc
      121 cctgctgccc agcaccgtgg gcctggcagg cctgctcttc tgggctggcc aggcagtgaa
      181 cgccttgata atgcctaatg ctaccccagc cccggcccag cccgagagca cggctatgcg
      241 gctcctgagt ggcctggagg tgcccaggta ccgccggaag cgccacatct ctgtgagaga
      301 catgaatgcc ttactggatt atcacaacca catccgggcc agtgtgtacc cacctgccgc
      361 caacatggaa tacatggtct gggacaagcg gctggccagg gctgccgaag cctgggccac
      421 ccagtgcatc tgggcacatg ggccttcaca gctgatgaga tacgtgggcc agaacctctc
      481 catccattct ggccagtacc ggtccgtagt ggatctcatg aagtcctggt ctgaggagaa
      541 gtggcattac ttgtttccgg ccccaaggga ctgtaaccca cactgcccct ggcgctgcga
      601 tggccccacc tgctcccatt atacccagat ggtgtgggca tcctccaatc ggctgggctg
      661 tgccatccac acctgtagta gcatcagtgt ctggggcaac acctggcatc gggcggcata
      721 cctggtctgc aactatgcca ttaagggcaa ctggattggc gagtccccgt acaagatggg
      781 aaagccgtgc tcctcctgtc cccccagtta tcaaggcagc tgcaatagca acatgtgctt
      841 caaggggctg aaatccaaca agttcacgtg gttctgaatt ttctctgggc tttggtgcgc
      901 ctccagctgg gcctgaccct ccatgtcctg ccctcaaaaa actgggtgga gaaataattg
      961 tttctttaaa ggatatgagt tagaatcacc ccctgttgaa ttttccctcc tagatcccct
     1021 tcttaaatgt ccaacatggg tcaaaagaaa atgacctcct tgccttcctt ctttcctagt
     1081 tgcatctttc ttttcttggg cctctgggaa agagccctgc atctttcatt aattcggttc
     1141 tcagagaacc aaggctggaa ggcatagaac tggcaccttg ggaccaggca taatggctca
     1201 cacctataat cccagtattt tgggaggctg aggtgggaga atcacttgag tcctggagtt
     1261 ggagaacagc ctggaaagcc tggcgatacc ccatctctat ttagaaacaa acaaacaaac
     1321 aaa
//
