LOCUS       NM_138774               1803 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens R3H domain containing 4 (R3HDM4), mRNA.
ACCESSION   NM_138774
VERSION     NM_138774.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1803)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005379.1 and BC012775.2.
            
            On Nov 22, 2018 this sequence version replaced NM_138774.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012775.2, SRR3476690.1065571.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361574.10/ ENSP00000355385.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC005379.1         7755-7773           c
            20-1803             BC012775.2         1-1784
FEATURES             Location/Qualifiers
     source          1..1803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1803
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /note="R3H domain containing 4"
                     /db_xref="GeneID:91300"
                     /db_xref="HGNC:HGNC:28270"
     exon            1..133
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..869
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /note="R3H domain-containing protein C19orf22"
                     /codon_start=1
                     /product="R3H domain-containing protein 4"
                     /protein_id="NP_620129.2"
                     /db_xref="CCDS:CCDS12048.1"
                     /db_xref="GeneID:91300"
                     /db_xref="HGNC:HGNC:28270"
                     /translation="MVALENPECGPEAAEGTPGGRRLLPLPSCLPALASSQVKRLSAS
                     RRKQHFINQAVRNSDLVPKAKGRKSLQRLENTQYLLTLLETDGGLPGLEDGDLAPPAS
                     PGIFAEACNNATYVEVWNDFMNRSGEEQERVLRYLEDEGRSKARRRGPGRGEDRRRED
                     PAYTPRECFQRISRRLRAVLKRSRIPMETLETWEERLLRFFSVSPQAVYTAMLDNSFE
                     RLLLHAVCQYMDLISASADLEGKRQMKVSNRHLDFLPPGLLLSAYLEQHS"
     exon            134..288
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            289..413
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            414..537
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            538..623
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            624..709
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            710..765
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1803
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="R3HDM4"
                     /gene_synonym="C19orf22"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgcc cggcccggtg aaggccctgc cgggcggcgg cggcggcgac agcgtgcgag
       61 ccatggtcgc gctggagaac cccgagtgcg gcccggaggc ggcggagggc accccgggcg
      121 ggcggcggct gctgcccctt cccagctgcc tgcctgccct agccagctcc caggtgaaga
      181 gactctcggc ttccaggcgg aaacagcact tcatcaacca ggcagtgcgg aactcagacc
      241 tcgtgcccaa ggccaagggg cggaagagcc tccagcgcct ggagaacacc cagtacctcc
      301 tgaccctgct ggagacagac gggggcctgc ctggcctgga ggatggggac ttggcacccc
      361 ctgcatcacc aggcatcttt gccgaggcct gcaacaacgc cacctatgtg gaggtctgga
      421 acgatttcat gaaccgctcc ggggaggagc aggagcgggt tcttcgctac ctggaggatg
      481 agggcaggag caaggcgcgg aggaggggcc ctggccgtgg ggaggaccgg aggagagagg
      541 accccgccta tacaccccgc gagtgcttcc agcgcatcag ccggcgtctg cgagccgtcc
      601 tcaagcgcag ccgcatcccc atggaaacgc tggagacctg ggaggagcgg ctgcttcggt
      661 tcttctccgt gtccccccag gccgtgtaca cagcaatgct agacaacagc ttcgagaggc
      721 ttctgctgca cgctgtctgc cagtacatgg acctcatctc ggccagtgct gacctggagg
      781 ggaagcggca gatgaaggtc agtaatcggc acctggattt cctgccgccg gggctgctcc
      841 tgtccgccta cctggagcag cacagctgat ggcggccccg cggagacccc gctgccacct
      901 cgcccagcca tcaagccctc cgataccttc ggctaaaata tctttcatat ttttagaatt
      961 tgtcctcgga aacctttttc gcttggggtg gtctctctca ctctgccccc tcctcacgca
     1021 gctcttggca gtcaacagac gctggcggct ggggctgccc atgccatccc agctccaagc
     1081 ttcccactcc gggacttgtg tttgggtggg gagacctgac ctgggcatgt tcctgtttct
     1141 tcatcgttga gcttttctgg cccggtctga agctcaagtg aggaggggga ggctgggttt
     1201 ttatcacttt taatgaattt ggtgtgattt gttgtagatt tttaaatttc ccttttggag
     1261 agaaaaacca aaaaaactcg ccccactggt aaaacatggg tcttggtccc agcccctgct
     1321 cagcccctcc cagtttttag cttgaatgag ggtggggtct ctgggaccct gcccctcatg
     1381 ccagaagcat cttgtgttgt atatgtgtgc gcgcgtgtgc cctgagaccc aggacagaag
     1441 ccacggtcct aagagccggt tttatcctcg tcattctgcg tgtcctcccc cacgccacct
     1501 gtgtcggggc tcagggtctc ctgctttata tgagccccct tcctttcctc ccctccttta
     1561 tgctgggggt ccaggacttc cagccagaag cctctgccct tgcactacct tgtctgtcac
     1621 cccatcccgt gtcccctcgt cccccagcct gactcctgcc tgatagctcc tgtgtcccca
     1681 tgctggtcct cctggcccag gctgcaggag ccaggctggg gggcctccgc acccccttgc
     1741 tgcgtgtggg taattgtgtt ttgggggaaa gtggggaatt taataaattt ctggtgctct
     1801 ggc
//
