LOCUS       NP_078914                415 aa            linear   PRI 20-SEP-2024
DEFINITION  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1 [Homo
            sapiens].
ACCESSION   NP_078914
VERSION     NP_078914.1
DBSOURCE    REFSEQ: accession NM_024638.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Sievers,K., Welp,L., Urlaub,H. and Ficner,R.
  TITLE     Structural and functional insights into human tRNA guanine
            transgylcosylase
  JOURNAL   RNA Biol 18 (sup1), 382-396 (2021)
   PUBMED   34241577
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Chen,Y.C., Brooks,A.F., Goodenough-Lashua,D.M., Kittendorf,J.D.,
            Showalter,H.D. and Garcia,G.A.
  TITLE     Evolution of eukaryal tRNA-guanine transglycosylase: insight gained
            from the heterocyclic substrate recognition by the wild-type and
            mutant human and Escherichia coli tRNA-guanine transglycosylases
  JOURNAL   Nucleic Acids Res 39 (7), 2834-2844 (2011)
   PUBMED   21131277
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Chen,Y.C., Kelly,V.P., Stachura,S.V. and Garcia,G.A.
  TITLE     Characterization of the human tRNA-guanine transglycosylase:
            confirmation of the heterodimeric subunit structure
  JOURNAL   RNA 16 (5), 958-968 (2010)
   PUBMED   20354154
  REMARK    GeneRIF: TGT is composed of a catalytic subunit, QTRT1, and QTRTD1,
            not USP14. QTRTD1 has been implicated as the salvage enzyme that
            generates free queuine from QMP.
REFERENCE   5  (residues 1 to 415)
  AUTHORS   Boland,C., Hayes,P., Santa-Maria,I., Nishimura,S. and Kelly,V.P.
  TITLE     Queuosine formation in eukaryotic tRNA occurs via a
            mitochondria-localized heteromeric transglycosylase
  JOURNAL   J Biol Chem 284 (27), 18218-18227 (2009)
   PUBMED   19414587
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC400836.1, BC039265.1 and
            BC034559.2.
            
            Summary: This gene encodes a subunit of tRNA-guanine
            transglycosylase. tRNA-guanine transglycosylase is a heterodimeric
            enzyme complex that plays a critical role in tRNA modification by
            synthesizing the 7-deazaguanosine queuosine, which is found in
            tRNAs that code for asparagine, aspartic acid, histidine, and
            tyrosine. The encoded protein may play a role in the queuosine
            5'-monophosphate salvage pathway. Alternatively spliced transcript
            variants encoding multiple isoforms have been observed for this
            gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039265.1, SRR1803617.78016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281273.8/ ENSP00000281273.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     Protein         1..415
                     /product="queuine tRNA-ribosyltransferase accessory
                     subunit 2 isoform 1"
                     /EC_number="2.4.2.29"
                     /note="queuine tRNA-ribosyltransferase domain containing
                     1"
                     /calculated_mol_wt=46582
     Region          13..413
                     /region_name="TGT"
                     /note="Queuine tRNA-ribosyltransferase; pfam01702"
                     /db_xref="CDD:460299"
     CDS             1..415
                     /gene="QTRT2"
                     /gene_synonym="QTRTD1"
                     /coded_by="NM_024638.4:258..1505"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33828.1"
                     /db_xref="GeneID:79691"
                     /db_xref="HGNC:HGNC:25771"
ORIGIN      
        1 mklsltkvvn gcrlgkiknl gktgdhtmdi pgcllytktg saphlthhtl hnihgvpama
       61 qltlsslaeh hevlteykeg vgkfigmpes llycslhdpv spcpagyvtn ksvsvwsvag
      121 rvemtvskfm aiqkalqpdw fqclsdgevs ckeatsikrv rksvdrsllf ldnclrlqee
      181 sevlqksvii gvieggdvme erlrsareta krpvggflld gfqgnpttle arlrllssvt
      241 aelpedkprl isgvsrpdev leciergvdl fesffpyqvt ergcaltfsf dyqpnpeetl
      301 lqqngtqeei kcmdqikkie ttgcnqeits feinlkekky qedfnplvrg cscyccknht
      361 rayihhllvt nellagvllm mhnfehyfgf fhyirealks dklaqlkeli hrqas
//
