LOCUS       NM_181701               4501 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens quiescin sulfhydryl oxidase 2 (QSOX2), mRNA.
ACCESSION   NM_181701
VERSION     NM_181701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Maharaj,A.V., Ishida,M., Rybak,A., Elfeky,R., Andrews,A., Joshi,A.,
            Elmslie,F., Joensuu,A., Kantojarvi,K., Jia,R.Y., Perry,J.R.B.,
            O'Toole,E.A., McGuffin,L.J., Hwa,V. and Storr,H.L.
  TITLE     QSOX2 Deficiency-induced short stature, gastrointestinal
            dysmotility and immune dysfunction
  JOURNAL   Nat Commun 15 (1), 8420 (2024)
   PUBMED   39341815
  REMARK    GeneRIF: QSOX2 Deficiency-induced short stature, gastrointestinal
            dysmotility and immune dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4501)
  AUTHORS   Hunter,C., Derksen,T., Makhsous,S., Doll,M., Perez,S.R., Scott,N.E.
            and Willis,L.M.
  TITLE     Site-specific immobilization of the endosialidase reveals QSOX2 is
            a novel polysialylated protein
  JOURNAL   Glycobiology 34 (5) (2024)
   PUBMED   38489772
  REMARK    GeneRIF: Site-specific immobilization of the endosialidase reveals
            QSOX2 is a novel polysialylated protein.
REFERENCE   3  (bases 1 to 4501)
  AUTHORS   Nazempour,N., Taleqani,M.H., Taheri,N., Haji Ali Asgary
            Najafabadi,A.H., Shokrollahi,A., Zamani,A., Fattahi Dolatabadi,N.,
            Peymani,M. and Mahdevar,M.
  TITLE     The role of cell surface proteins gene expression in diagnosis,
            prognosis, and drug resistance of colorectal cancer: In silico
            analysis and validation
  JOURNAL   Exp Mol Pathol 123, 104688 (2021)
   PUBMED   34592197
  REMARK    GeneRIF: The role of cell surface proteins gene expression in
            diagnosis, prognosis, and drug resistance of colorectal cancer: In
            silico analysis and validation.
REFERENCE   4  (bases 1 to 4501)
  AUTHORS   Ried,C.L., Scharnagl,C. and Langosch,D.
  TITLE     Entrapment of Water at the Transmembrane Helix-Helix Interface of
            Quiescin Sulfhydryl Oxidase 2
  JOURNAL   Biochemistry 55 (9), 1287-1290 (2016)
   PUBMED   26894260
  REMARK    GeneRIF: Self-interaction of the transmembrane helix of QSOX2 rests
            on a motif of conserved amino acids compromising one face of the
            helix.
REFERENCE   5  (bases 1 to 4501)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   6  (bases 1 to 4501)
  AUTHORS   Okada,Y., Kamatani,Y., Takahashi,A., Matsuda,K., Hosono,N.,
            Ohmiya,H., Daigo,Y., Yamamoto,K., Kubo,M., Nakamura,Y. and
            Kamatani,N.
  TITLE     A genome-wide association study in 19 633 Japanese subjects
            identified LHX3-QSOX2 and IGF1 as adult height loci
  JOURNAL   Hum Mol Genet 19 (11), 2303-2312 (2010)
   PUBMED   20189936
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4501)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 4501)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 4501)
  AUTHORS   Wittke,I., Wiedemeyer,R., Pillmann,A., Savelyeva,L., Westermann,F.
            and Schwab,M.
  TITLE     Neuroblastoma-derived sulfhydryl oxidase, a new member of the
            sulfhydryl oxidase/Quiescin6 family, regulates sensitization to
            interferon gamma-induced cell death in human neuroblastoma cells
  JOURNAL   Cancer Res 63 (22), 7742-7752 (2003)
   PUBMED   14633699
  REMARK    GeneRIF: Results identify SOXN as a major player in Regulating the
            sensitization of neuroblastoma cells for IFN-gamma-induced
            apoptosis.
REFERENCE   10 (bases 1 to 4501)
  AUTHORS   Thorpe,C., Hoober,K.L., Raje,S., Glynn,N.M., Burnside,J., Turi,G.K.
            and Coppock,D.L.
  TITLE     Sulfhydryl oxidases: emerging catalysts of protein disulfide bond
            formation in eukaryotes
  JOURNAL   Arch Biochem Biophys 405 (1), 1-12 (2002)
   PUBMED   12176051
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR392000.2 and AL138781.13.
            
            On Jul 25, 2019 this sequence version replaced NM_181701.3.
            
            Summary: QSOX2 is a member of the sulfhydryl oxidase/quiescin-6
            (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of
            neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell
            death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM,
            Jun 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1358027.1,
                                           SRR12921934.3740848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358701.10/ ENSP00000351536.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               CR392000.2         2433-2769           c
            338-438             AL138781.13        136649-136749       c
            439-487             AL138781.13        134736-134784       c
            488-593             AL138781.13        133882-133987       c
            594-684             AL138781.13        133638-133728       c
            685-830             AL138781.13        131671-131816       c
            831-965             AL138781.13        128905-129039       c
            966-1095            AL138781.13        128554-128683       c
            1096-1218           AL138781.13        126475-126597       c
            1219-1369           AL138781.13        125029-125179       c
            1370-1558           AL138781.13        121139-121327       c
            1559-4501           AL138781.13        116208-119150       c
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..4501
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /note="quiescin sulfhydryl oxidase 2"
                     /db_xref="GeneID:169714"
                     /db_xref="HGNC:HGNC:30249"
                     /db_xref="MIM:612860"
     exon            1..337
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2106
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /EC_number="1.8.3.2"
                     /note="neuroblastoma-derived sulfhydryl oxidase; quiescin
                     Q6-like 1; sulfhydryl oxidase 2; quiescin Q6-like protein
                     1; quiescin Q6 sulfhydryl oxidase 2; thiol oxidase 2"
                     /codon_start=1
                     /product="sulfhydryl oxidase 2 precursor"
                     /protein_id="NP_859052.3"
                     /db_xref="CCDS:CCDS35178.1"
                     /db_xref="GeneID:169714"
                     /db_xref="HGNC:HGNC:30249"
                     /db_xref="MIM:612860"
                     /translation="MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAA
                     VGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWR
                     ALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKG
                     PDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESN
                     SSYLGREVILDLIPYESIVVTRALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVK
                     PLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKSKLYTVDLESGLHYL
                     LRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYN
                     AVLDLVNNKMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDAL
                     VGTGFEDDPQAVLQTMRRYVHTFFGCKECGEHFEEMAKESMDSVKTPDQAILWLWKKH
                     NMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQHYGRDN
                     LLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPES
                     LHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFF
                     RVRSRRWKVKHHHPAV"
     exon            338..438
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            439..487
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            488..593
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            594..684
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            685..830
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            831..965
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1095
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1218
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1369
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1558
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..4501
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4479..4484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /note="hexamer: AAGAAA"
     polyA_site      4501
                     /gene="QSOX2"
                     /gene_synonym="QSCN6L1; SOXN"
                     /note="major polyA site"
ORIGIN      
        1 acttccaaca tggcggcggc cggggcggcg gtggcgcgca gcccgggaat cggagcggga
       61 cctgcgctga gagcccggcg ctcgcccccg ccgcgggccg cacggctgcc gcggctgcta
      121 gtgctgctag cggcggcggc ggtggggccg ggcgcgggcg gtgcggcgcg gctgtaccgc
      181 gcgggcgagg acgccgtgtg ggtgctggac agcggcagcg tgcgcggggc caccgccaac
      241 agctcggccg cgtggctcgt gcagttctac tcgtcgtggt gtggccactg catcggctac
      301 gcgcccactt ggcgggccct ggctggggat gtgcgagact gggccagtgc cattcgcgtc
      361 gcagctctgg actgcatgga agagaagaac caggccgtgt gccatgacta cgacatccac
      421 ttctacccca ccttccggta ttttaaagca tttacaaagg agtttacaac tggagaaaat
      481 tttaaaggac ctgaccgaga gctgcgaaca gtcagacaga cgatgattga cttcctgcag
      541 aaccacacgg aaggaagccg gccccctgcc tgcccgcgcc tagaccccat tcagcccagt
      601 gatgttcttt cccttcttga caaccgtggc agccattacg tggctattgt ctttgaaagc
      661 aacagctcct accttggacg ggaggtgatc ttagacctga tcccgtatga aagcatcgtg
      721 gtgacccgag cactggacgg ggacaaagca tttctggaga aacttggtgt ttcttcagtc
      781 ccttcgtgtt acctgatcta cccaaatggg tcgcatggat tgattaacgt cgtgaagcct
      841 ctgcgggcct tcttttcgtc ttatttgaag tcattgccgg atgtgaggaa aaaatcgctt
      901 cccttgcctg aaaagccaca caaagaagaa aattcagaaa tcgtggtttg gagagaattt
      961 gacaagtcga agctgtacac ggtggacctg gagtcagggc tacactacct cctgcgggtg
     1021 gagctggcag cccacaagtc cctggccgga gcagagctga agacgctcaa ggactttgtg
     1081 actgtcttgg ccaagctgtt ccctggacgg ccgccagtca agaagctgtt ggagatgctg
     1141 caggagtggc tggccagcct tcccctggac aggatcccct acaacgccgt gcttgacctg
     1201 gtcaacaaca agatgcggat ttctggaata ttccttacta atcacataaa gtgggttgga
     1261 tgtcaaggaa gccgatctga gttgaggggt tacccgtgtt ctctctggaa actgttccac
     1321 actttgactg ttgaagcctc gacccaccca gatgcactgg ttggcacagg ctttgaagac
     1381 gacccccagg ctgtgctgca gacaatgagg aggtacgttc acaccttctt tgggtgtaag
     1441 gaatgtggtg agcactttga ggaaatggct aaagaatcca tggactcggt gaaaacccca
     1501 gaccaagcca tcctctggct gtggaagaag cataatatgg tgaacggccg cctggcaggc
     1561 catctgagtg aggatccccg gtttccaaag cttcagtggc ccactccgga cctctgccca
     1621 gcctgccatg aggaaattaa gggcctggcc agctgggatg aaggccacgt gctcacattc
     1681 ttgaagcagc actatggccg cgacaacctc ttagacacgt attccgcaga ccagggggat
     1741 tccagtgaag gaggaaccct ggccaggggt gaggaagagg agaaaagact cactccccca
     1801 gaggtgtccc atggagaccg agacacccag agcgtccgtc cacctggtgc actgggcccc
     1861 aggcctgccc ttccagagag cttgcatcac agcttggacg ggaaactcca gagtctggat
     1921 gggcccgggg cccacaagga ggtgggcggg gccgcaccct tcctcggggt tgacttctcc
     1981 agcctggaca tgagtctctg tgtcgtgctg tacgtggctt catccctgtt cctcatggtg
     2041 atgtacttct tcttccgggt gaggtccagg cggtggaagg tcaagcacca ccacccggcc
     2101 gtgtgagtgc ccgggtgctg ccagccacgg cggaagctcc cttggaggca gccctgcccc
     2161 gtgccacctg cagctttaat atttatgatc agggatttta taaacatgcg ggcctggttt
     2221 cacatcggat ggcacctttt ggcttcaaag tcctggtttt acaaacgctc ttctaacaag
     2281 ggaagaacac ggggtaattt tgtggggata tttgcattcc tggcgtactc aagtctgttc
     2341 atgctccttt tgcaggtctt acagcaaaaa gacttctgta tttttactct tctagatgtg
     2401 aaaagagggt gcagagtcca ggccagatag tcttccccac acactttcat ctcgtttcct
     2461 ccactccgcc ccatcctgca gggccttgtt tttgtatttg gagaacctcg cccatccccc
     2521 ccgcggctcc tggctccccc ccactcccct cgctccccct ccccccgctc cccccacgcc
     2581 ccctgctcca ggctgccaag tgttttcctt tagccgggcg gggacagaca gagccggaag
     2641 cgcagtcggc ctctgcagcc cctccaagca agtgctccag ggactatcct gtgtttgtag
     2701 ctgcttccct agggcaggtt cctgagggct ctccttgttc ctccgggtgt tcgacaccag
     2761 acgtggggat ttcaacaggg gaggagccaa ggaattctgt ggctgtgctg cgtttcagaa
     2821 aataaccccc agaggccttg ggctgtggac ctgggggttg gaaggatggg ggctcattta
     2881 accctcagag gcagcgcctt tgtctgtcta tctggtgaca agagagagac aagtaaatgg
     2941 gggccgttgg gacggcgggt gcctggaggg cagctctggg ctcagcgggc agtgcttaga
     3001 gcacaggccc ctctgttggg ggatggggag gagagcagtc tgcccttggg agcgtaggcc
     3061 ccagggagac ttctaaagcc ccccctgtcg tctgctcttc acccagcacc acagaggcac
     3121 ctgctgcaca cacaagcatc tcactcggcc cacggagggg gccaggcttc ctttgcctga
     3181 agctgttttg ggaagggtct ccacacaggc actgatctcc caagcttttg tcatgatgtc
     3241 ttttaccatt tgataatttt aaacattgtt tttaaaccca aaacatttag tggtccgttg
     3301 cctctgaaga tgtaaacaaa caaatacact atttctggga acatttatat tgagattctt
     3361 tgtggctatt ggtgtgtctc acaggcaaaa tttgatttgg ctaaaatagg ctcagatgta
     3421 tttgtgtgcc cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgagagagag
     3481 agagactttg acggttgtag atattttttc cgctttgcct actttatgtt gtataatcat
     3541 gtgtttacta acaagttgat gacatggatg tattcataag accatgtaat attgatgtga
     3601 ttgttgtcgc ttgagaaaaa aaggcaacag ctgattcttt caacaactgt cacagaatgg
     3661 ctgggctgag aacgctgccc agggccctgc agctggcggg agaggtgtct ggtgggagcg
     3721 gtgtctggtg cgtcagcctg ctgcttcgtg tctcactcga gagttgcttc tggtttcaca
     3781 ctttttaacc cctctgtgct ttagcagccg tgaccttgcc ttcattgctt catccagtgc
     3841 aggcctgggt tattgaagac accaaagtgt ttctcttcca gtttgaaaac caggcaggtt
     3901 tacacgtggg tttcagtgta tttgcctttg aacccttcaa actaaacttt agccttttgg
     3961 ctggtgttga atgtctttag ctggggtgac ctggagtgac ctgggacggt gttgtggttt
     4021 accgtctcca gcttcagcct ttccagaaac ccttgtggag ggcagtgttg gctgcaggtt
     4081 tcatcatatt gcagtttgag gtcaccacta tttggggaac aagcttgcgt cctgctgagg
     4141 ggcaggattt tcagcagagc gtcggtgggg ctgggccgtc gtggaggtgg ccccaggagt
     4201 catatggcca tactcagaca caccttgtgt ggcctgctca gagctggatg ccacctttag
     4261 gcaatgttta gagtctattt tctaaagttt taagtatttt aagaggtatt gagactaatg
     4321 aatataatag ttcagtaatt taaatgctta tttattttca gtggaaggat ttttattaaa
     4381 aagaagctaa ttgacatgga aatgtcagtg aaatttctta cctgcaagga aagtgaacat
     4441 tttgtattta agtaaactat aatgtgcaca ttttaataaa gaaatctgac atttgaaaaa
     4501 a
//
