LOCUS       NM_001388453            5972 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens glutamine rich 2 (QRICH2), transcript variant 3, mRNA.
ACCESSION   NM_001388453 XM_005257728
VERSION     NM_001388453.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5972)
  AUTHORS   Zhang,G., Li,D., Tu,C., Meng,L., Tan,Y., Ji,Z., Cheng,J., Lu,G.,
            Lin,G., Zhang,H., Sun,J., Wang,M., Du,J. and Xu,W.
  TITLE     Loss-of-function missense variant of AKAP4 induced male infertility
            through reduced interaction with QRICH2 during sperm flagella
            development
  JOURNAL   Hum Mol Genet 31 (2), 219-231 (2021)
   PUBMED   34415320
  REMARK    GeneRIF: Loss-of-function missense variant of AKAP4 induced male
            infertility through reduced interaction with QRICH2 during sperm
            flagella development.
REFERENCE   2  (bases 1 to 5972)
  AUTHORS   Kherraf,Z.E., Cazin,C., Coutton,C., Amiri-Yekta,A., Martinez,G.,
            Boguenet,M., Fourati Ben Mustapha,S., Kharouf,M., Gourabi,H.,
            Hosseini,S.H., Daneshipour,A., Toure,A., Thierry-Mieg,N.,
            Zouari,R., Arnoult,C. and Ray,P.F.
  TITLE     Whole exome sequencing of men with multiple morphological
            abnormalities of the sperm flagella reveals novel homozygous QRICH2
            mutations
  JOURNAL   Clin Genet 96 (5), 394-401 (2019)
   PUBMED   31292949
  REMARK    GeneRIF: Whole exome sequencing of men with multiple morphological
            abnormalities of the sperm flagella reveals novel homozygous QRICH2
            mutations.
REFERENCE   3  (bases 1 to 5972)
  AUTHORS   Shen,Y., Zhang,F., Li,F., Jiang,X., Yang,Y., Li,X., Li,W., Wang,X.,
            Cheng,J., Liu,M., Zhang,X., Yuan,G., Pei,X., Cai,K., Hu,F., Sun,J.,
            Yan,L., Tang,L., Jiang,C., Tu,W., Xu,J., Wu,H., Kong,W., Li,S.,
            Wang,K., Sheng,K., Zhao,X., Yue,H., Yang,X. and Xu,W.
  TITLE     Loss-of-function mutations in QRICH2 cause male infertility with
            multiple morphological abnormalities of the sperm flagella
  JOURNAL   Nat Commun 10 (1), 433 (2019)
   PUBMED   30683861
  REMARK    GeneRIF: The findings strongly suggest that the genetic mutations
            of QRICH2 can lead to male infertility with multiple morphological
            abnormalities of the flagella, and that QRICH2 is essential for
            sperm flagellar formation.
            Erratum:[Nat Commun. 2019 May 20;10(1):2289. doi:
            10.1038/s41467-019-10313-x.. PMID: 31110204]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5972)
  AUTHORS   Kottgen,A., Albrecht,E., Teumer,A., Vitart,V., Krumsiek,J.,
            Hundertmark,C., Pistis,G., Ruggiero,D., O'Seaghdha,C.M., Haller,T.,
            Yang,Q., Tanaka,T., Johnson,A.D., Kutalik,Z., Smith,A.V., Shi,J.,
            Struchalin,M., Middelberg,R.P., Brown,M.J., Gaffo,A.L., Pirastu,N.,
            Li,G., Hayward,C., Zemunik,T., Huffman,J., Yengo,L., Zhao,J.H.,
            Demirkan,A., Feitosa,M.F., Liu,X., Malerba,G., Lopez,L.M., van der
            Harst,P., Li,X., Kleber,M.E., Hicks,A.A., Nolte,I.M., Johansson,A.,
            Murgia,F., Wild,S.H., Bakker,S.J., Peden,J.F., Dehghan,A.,
            Steri,M., Tenesa,A., Lagou,V., Salo,P., Mangino,M., Rose,L.M.,
            Lehtimaki,T., Woodward,O.M., Okada,Y., Tin,A., Muller,C.,
            Oldmeadow,C., Putku,M., Czamara,D., Kraft,P., Frogheri,L.,
            Thun,G.A., Grotevendt,A., Gislason,G.K., Harris,T.B., Launer,L.J.,
            McArdle,P., Shuldiner,A.R., Boerwinkle,E., Coresh,J., Schmidt,H.,
            Schallert,M., Martin,N.G., Montgomery,G.W., Kubo,M., Nakamura,Y.,
            Tanaka,T., Munroe,P.B., Samani,N.J., Jacobs,D.R. Jr., Liu,K.,
            D'Adamo,P., Ulivi,S., Rotter,J.I., Psaty,B.M., Vollenweider,P.,
            Waeber,G., Campbell,S., Devuyst,O., Navarro,P., Kolcic,I.,
            Hastie,N., Balkau,B., Froguel,P., Esko,T., Salumets,A., Khaw,K.T.,
            Langenberg,C., Wareham,N.J., Isaacs,A., Kraja,A., Zhang,Q.,
            Wild,P.S., Scott,R.J., Holliday,E.G., Org,E., Viigimaa,M.,
            Bandinelli,S., Metter,J.E., Lupo,A., Trabetti,E., Sorice,R.,
            Doring,A., Lattka,E., Strauch,K., Theis,F., Waldenberger,M.,
            Wichmann,H.E., Davies,G., Gow,A.J., Bruinenberg,M., Stolk,R.P.,
            Kooner,J.S., Zhang,W., Winkelmann,B.R., Boehm,B.O., Lucae,S.,
            Penninx,B.W., Smit,J.H., Curhan,G., Mudgal,P., Plenge,R.M.,
            Portas,L., Persico,I., Kirin,M., Wilson,J.F., Mateo Leach,I., van
            Gilst,W.H., Goel,A., Ongen,H., Hofman,A., Rivadeneira,F.,
            Uitterlinden,A.G., Imboden,M., von Eckardstein,A., Cucca,F.,
            Nagaraja,R., Piras,M.G., Nauck,M., Schurmann,C., Budde,K.,
            Ernst,F., Farrington,S.M., Theodoratou,E., Prokopenko,I.,
            Stumvoll,M., Jula,A., Perola,M., Salomaa,V., Shin,S.Y.,
            Spector,T.D., Sala,C., Ridker,P.M., Kahonen,M., Viikari,J.,
            Hengstenberg,C., Nelson,C.P., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Singleton,A.B., Kamatani,N., Zeller,T., Burnier,M., Attia,J.,
            Laan,M., Klopp,N., Hillege,H.L., Kloiber,S., Choi,H., Pirastu,M.,
            Tore,S., Probst-Hensch,N.M., Volzke,H., Gudnason,V., Parsa,A.,
            Schmidt,R., Whitfield,J.B., Fornage,M., Gasparini,P.,
            Siscovick,D.S., Polasek,O., Campbell,H., Rudan,I., Bouatia-Naji,N.,
            Metspalu,A., Loos,R.J., van Duijn,C.M., Borecki,I.B., Ferrucci,L.,
            Gambaro,G., Deary,I.J., Wolffenbuttel,B.H., Chambers,J.C., Marz,W.,
            Pramstaller,P.P., Snieder,H., Gyllensten,U., Wright,A.F., Navis,G.,
            Watkins,H., Witteman,J.C., Sanna,S., Schipf,S., Dunlop,M.G.,
            Tonjes,A., Ripatti,S., Soranzo,N., Toniolo,D., Chasman,D.I.,
            Raitakari,O., Kao,W.H., Ciullo,M., Fox,C.S., Caulfield,M.,
            Bochud,M. and Gieger,C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat Genet 45 (2), 145-154 (2013)
   PUBMED   23263486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090699.10 and AC015801.25.
            
            On Nov 3, 2020 this sequence version replaced XM_005257728.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000680821.2/ ENSP00000504874.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               AC090699.10        19491-20302         c
            813-872             AC090699.10        16908-16967         c
            873-983             AC015801.25        123-233
            984-3990            AC015801.25        10627-13633
            3991-4076           AC015801.25        14571-14656
            4077-4174           AC015801.25        16751-16848
            4175-4289           AC015801.25        17342-17456
            4290-4541           AC015801.25        22533-22784
            4542-4664           AC015801.25        23695-23817
            4665-4739           AC015801.25        23920-23994
            4740-4904           AC015801.25        24197-24361
            4905-5026           AC015801.25        24494-24615
            5027-5092           AC015801.25        25220-25285
            5093-5194           AC015801.25        25506-25607
            5195-5395           AC015801.25        26459-26659
            5396-5543           AC015801.25        27338-27485
            5544-5631           AC015801.25        27881-27968
            5632-5760           AC015801.25        28701-28829
            5761-5972           AC015801.25        30388-30599
FEATURES             Location/Qualifiers
     source          1..5972
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..5972
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /note="glutamine rich 2"
                     /db_xref="GeneID:84074"
                     /db_xref="HGNC:HGNC:25326"
                     /db_xref="MIM:618304"
     exon            1..812
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..5942
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /note="isoform 2 is encoded by transcript variant 3;
                     glutamine-rich protein 2"
                     /codon_start=1
                     /product="glutamine-rich protein 2 isoform 2"
                     /protein_id="NP_001375382.1"
                     /db_xref="CCDS:CCDS92399.1"
                     /db_xref="GeneID:84074"
                     /db_xref="HGNC:HGNC:25326"
                     /db_xref="MIM:618304"
                     /translation="MPPATTVSLRELADLSIGTPEVGAVNFTALHTLIVAMLKNLDLQ
                     NTRIDFQPSSPEPSRSLQSVRSSFSIPHLPAPKEVPKGAPREKRRGVGQAPSSALESQ
                     VKDLGGQVEDLSKQLKRVDGQVQGIATHVQHFSQASGLDLAALEWPEEQEVGVRAFDR
                     VRTGSIMKDAAEELSFARVLLQRVDELEKLFKDREQFLELVSRKLSLVPGAEEVTMVT
                     WEELEQAITDGWRASQAGSETLMGFSKHGGFTSLTSPEGTLSGDSTKQPSIEQALDSA
                     SGLGPDRTASGSGGTAHPSDGVSSREQSKVPSGTGRQQQPRARDEAGVPRLHQSSTFQ
                     FKSDSDRHRSREKLTSTQPRRNARPGPVQQDLPLARDQPSSVPASQSQVHLRPDRRGL
                     EPTGMNQPGLVPASTYPHGVVPLSMGQLGVPPPEMDDRELIPFVVDEQRMLPPSVPGR
                     DQQGLELPSTDQHGLVSVSAYQHGMTFPGTDQRSMEPLGMDQRGCVISGMGQQGLVPP
                     GIDQQGLTLPVVDQHGLVLPFTDQHGLVSPGLMPISADQQGFVQPSLEATGFIQPGTE
                     QHDLIQSGRFQRALVQRGAYQPGLVQPGADQRGLVRPGMDQSGLAQPGADQRGLVWPG
                     MDQSGLAQPGRDQHGLIQPGTGQHDLVQSGTGQGVLVQPGVDQPGMVQPGRFQRALVQ
                     PGAYQPGLVQPGADQIDVVQPGADQHGLVQSGADQSDLAQPGAVQHGLVQPGVDQRGL
                     AQPRADHQRGLVPPGADQRGLVQPGADQHGLVQPGVDQHGLAQPGEVQRSLVQPGIVQ
                     RGLVQPGAVQRGLVQPGAVQRGLVQPGVDQRGLVQPGAVQRGLVQPGAVQHGLVQPGA
                     DQRGLVQPGVDQRGLVQPGVDQRGLVQPGMDQRGLIQPGADQPGLVQPGAGQLGMVQP
                     GIGQQGMVQPQADPHGLVQPGAYPLGLVQPGAYLHDLSQSGTYPRGLVQPGMDQYGLR
                     QPGAYQPGLIAPGTKLRGSSTFQADSTGFISVRPYQHGMVPPGREQYGQVSPLLASQG
                     LASPGIDRRSLVPPETYQQGLMHPGTDQHSPIPLSTGLGSTHPDQQHVASPGPGEHDQ
                     VYPDAAQHGHAFSLFDSHDSMYPGYRGPGYLSADQHGQEGLDPNRTRASDRHGIPAQK
                     APGQDVTLFRSPDSVDRVLSEGSEVSSEVLSERRNSLRRMSSSFPTAVETFHLMGELS
                     SLYVGLKESMKDLDEEQAGQTDLEKIQFLLAQMVKRTIPPELQEQLKTVKTLAKEVWQ
                     EKAKVERLQRILEGEGNQEAGKELKAGELRLQLGVLRVTVADIEKELAELRESQDRGK
                     AAMENSVSEASLYLQDQLDKLRMIIESMLTSSSTLLSMSMAPHKAHTLAPGQIDPEAT
                     CPACSLDVSHQVSTLVRRYEQLQDMVNSLAVSRPSKKAKLQRQDEELLGRVQSAILQV
                     QGDCEKLNITTSNLIEDHRQKQKDIAMLYQGLEKLEKEKANREHLEMEIDVKADKSAL
                     ATKVSRVQFDATTEQLNHMMQELVAKMSGQEQDWQKMLDRLLTEMDNKLDRLELDPVK
                     QLLEDRWKSLRQQLRERPPLYQADEAAAMRRQLLAHFHCLSCDRPLETPVTGHAIPVT
                     PAGPGLPGHHSIRPYTVFELEQVRQHSRNLKLGSAFPRGDLAQMEQSVGRLRSMHSKM
                     LMNIEKVQIHFGGSTKASSQIIRELLHAQCLGSPCYKRVTDMADYTYSTVPRRCGGSH
                     TLTYPYHRSRPQHLPRGLYPTEEIQIAMKHDEVDILGLDGHIYKGRMDTRLPGILRKD
                     SSGTSKRKSQQPRPHVHRPPSLSSNGQLPSRPQSAQISAGNTSVSSRQQKDRPSSEGR
                     LSQPNTAHPPSSAAVANRGLERHVDMPPGEGLEEPTRGPRSSTAQ"
     exon            813..872
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            873..983
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            984..3990
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4076
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4174
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4289
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4541
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4542..4664
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4665..4739
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4740..4904
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            4905..5026
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5092
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5093..5194
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5195..5395
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5396..5543
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5631
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5760
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     exon            5761..5972
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5954..5959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /note="hexamer: AATAAA"
     polyA_site      5972
                     /gene="QRICH2"
                     /gene_synonym="SPGF35"
                     /note="major polyA site"
ORIGIN      
        1 aaacgtccgc cggcgcgggg actgggagtc cagggctcca gctcggggac ccgaggccag
       61 cgacagacag cggaggggtg gccatcgcgg accccgccgg ggagcggagg cgcagattcc
      121 ctggaggcag gagctctgtc cagtgactcg gccggacccg gggcaggggc gccccgagga
      181 cctcgcaggg cccccgaaag gccccaaggc gcggcgtgca gtgagcggga agtggttggc
      241 cggcgccccg cggcggcgca cagctcctga cagccacgat gccgcccgcg accacggtct
      301 ccctccggga gctggcggac ctctccatcg gcacgccaga ggtgggcgcc gtcaacttca
      361 cggccctgca cacgctcatc gtggccatgc tcaagaacct cgacctccaa aatacccgga
      421 tcgacttcca gccctcgtcg cccgagccca gccgctcgct gcagtccgtc cggagctcgt
      481 tcagcatccc gcacctgccc gcgcccaagg aggtgcccaa gggggcgccc cgggagaagc
      541 gcaggggcgt gggccaggcg ccttcgtcag cgctggagag ccaagtgaag gacctgggcg
      601 gccaggtgga ggacctgagc aagcagctca agcgtgtgga cggccaggtg cagggcatcg
      661 ccacgcacgt gcagcacttc tcccaggcca gcgggcttga cctggccgcg ctagagtggc
      721 cggaggagca ggaggtgggc gtgcgggcgt tcgatagggt gcggactggg agtatcatga
      781 aggacgccgc cgaggagctc agctttgcca gggtactttt acagcgggtt gatgaactag
      841 agaagctatt caaagatcgg gagcaattcc tggaactagt cagccggaag ctgagtttgg
      901 ttcctggtgc agaagaagtc accatggtca cctgggaaga gctggagcag gcgattacgg
      961 acggctggag agcctcacaa gcgggctcag aaacacttat gggattttct aagcacggag
     1021 ggttcacttc cttaacatca cctgaaggga ctctaagcgg agactctacc aagcaaccaa
     1081 gtattgagca ggctctggat tctgccagtg gtcttggccc ggatcggact gcatcaggat
     1141 ctggtggcac agcacacccc tctgatgggg tttccagtag ggaacaaagc aaggtcccct
     1201 ctggtactgg gagacagcag cagccgaggg cccgtgatga agctggcgtg ccacgactcc
     1261 atcagtcttc tacattccaa ttcaaatcag actcagatcg tcacaggagt agagagaagc
     1321 ttacctcgac acaaccaaga agaaatgcac gtcctggtcc agttcaacag gacttaccct
     1381 tggccagaga ccagcccagt agtgtgcccg ctagccagag tcaggtccat ctaaggccag
     1441 atcgtcgtgg gttagaacca actggcatga atcagcctgg attagtgcct gctagcactt
     1501 acccacatgg tgtggtaccc ctcagcatgg gtcagcttgg tgtgccacca cctgaaatgg
     1561 atgatcggga attgatacca tttgtcgtgg atgagcaacg tatgttgcca ccatcagtac
     1621 ctggcagaga ccagcaagga ttggaactac ctagcacaga ccaacatggt ctggtttcag
     1681 tcagtgcata tcagcatggt atgacatttc ctggcacaga ccaacgcagt atggaaccac
     1741 ttggcatgga tcagcgtgga tgtgtaatat caggcatggg tcagcaagga ctagtacccc
     1801 ctggtataga ccagcaagga ttgacattgc ctgtcgtcga tcaacatggc ctggttctac
     1861 cttttacaga ccagcatggt ttggtatcac ctggtttgat gccaattagt gcagatcagc
     1921 aaggttttgt gcagcccagt ttggaagcaa ctggcttcat acaacctggc acagagcagc
     1981 atgatttgat ccagtctggc agatttcagc gtgctttggt gcagcgtggt gcatatcagc
     2041 ctggcttggt ccaacctggt gcagatcagc gtggtttggt ccggcctgga atggatcagt
     2101 ctggtttggc ccaacctggt gcagatcagc gtggtttggt ctggcctgga atggatcagt
     2161 ctggtttggc ccaacctggt agagatcagc atggtttgat ccagcctggc acaggtcagc
     2221 atgatttggt ccaatctggc acaggtcagg gtgtcttggt acagcctggt gtagatcagc
     2281 ctggcatggt ccaacctggc agatttcagc gtgctttggt gcagcctggt gcatatcagc
     2341 ctggcttggt ccaacctggt gcagatcaga ttgatgtggt gcaacctggt gcagatcagc
     2401 atggtttggt acaatctggt gcagatcaga gtgatttggc tcaacctggt gcagttcagc
     2461 atggtttggt ccaacctgga gtagatcagc gtggtttggc acaacctcgt gcagatcatc
     2521 agcgtggttt ggtcccacct ggtgcagatc agcgtggttt ggtccaacct ggtgcagatc
     2581 agcatggttt ggtccaacct ggagtggatc agcatggttt ggcacaacct ggtgaagttc
     2641 agcgtagttt ggtgcaacct ggtatagttc agcgtggttt ggtgcaacct ggtgcagttc
     2701 agcgtggttt ggtgcaacct ggtgcagttc agcgtggttt ggtccaacct ggagtggatc
     2761 agcgtggttt ggttcaacct ggtgcagttc agcgtggttt ggtccaacct ggtgcagttc
     2821 agcatggttt ggtccaacct ggtgcagatc agcgtggttt ggtccaacct ggagtggatc
     2881 agcgtggttt ggtgcaacct ggagtggatc agcgtggttt ggtccaacct ggaatggacc
     2941 agcgtggttt gatccaacct ggtgcagatc agcctggttt ggtccagcct ggtgcaggtc
     3001 agctgggtat ggtgcagcct ggaataggtc agcaaggtat ggtgcaacct caggcagatc
     3061 cacatggcct ggtacaacct ggtgcctatc ctcttggttt ggtacaacct ggtgcatatt
     3121 tgcatgattt atctcaatct gggacatatc cacgtggtct ggtgcagcca ggaatggatc
     3181 agtatggttt gagacaacct ggtgcatatc agccaggctt gatagcacca ggcacaaagc
     3241 ttcgtggctc ttcaacattc caggcagatt ctacaggttt tatatcagta cgtccatatc
     3301 aacatggtat ggtacctcct ggcagagaac aatacggcca ggtgtcacca ctcctagcca
     3361 gtcaaggttt ggcatcacct ggtatagatc gaaggagttt ggtaccacca gaaacttatc
     3421 agcaaggttt gatgcatcct ggcacagacc agcacagccc aataccactg agtacaggtt
     3481 tgggatctac acacccagat caacagcatg tggcatcacc tggcccaggt gagcatgacc
     3541 aggtataccc agatgcagct cagcatggcc atgctttctc tctctttgac agtcatgatt
     3601 caatgtatcc tggttatcgt ggcccagggt atctaagtgc tgatcagcat ggccaggaag
     3661 gtttggatcc aaatagaaca cgagcctcgg accgacatgg aattcctgcc cagaaggccc
     3721 caggccaaga tgtcactctt ttcaggagtc cagactccgt cgaccgagtc ttatcagaag
     3781 ggagcgaagt ctcgagtgaa gtcctgagtg agcgacgcaa ttcactgcgt agaatgagtt
     3841 ctagtttccc cacggcagtg gagacatttc atctgatggg agagctcagt agcctctatg
     3901 tggggctaaa ggagagtatg aaggatctgg atgaggagca ggccggccaa accgacttgg
     3961 agaagatcca gttcctgctg gcacagatgg tcaaaaggac catacctcct gaactgcagg
     4021 agcagctgaa gaccgtaaag acgctagcca aagaagtttg gcaggagaaa gcaaaagtgg
     4081 aaaggctgca gaggatcctg gaaggggaag ggaatcaaga agcagggaag gaactgaaag
     4141 ctggagagct gagattgcag ctgggtgtcc tcagagtcac cgtggctgac atagaaaagg
     4201 agctggccga gttgagggag agccaagaca ggggcaaggc tgccatggaa aattctgtct
     4261 ctgaagcctc cctttacctg caggaccagt tggacaagct caggatgatc attgagagca
     4321 tgctgacctc ctcctccacg ctcctgtcca tgagcatggc cccgcacaag gcccacacct
     4381 tggctcctgg ccagatcgac cctgaggcca cctgtccagc ctgcagcctg gatgtgagcc
     4441 atcaggtcag cacgctggtg cggcgctatg agcaactcca agacatggtc aacagcctgg
     4501 ccgtctcccg accctccaag aaggccaagc tccagagaca ggacgaggag ctgctgggcc
     4561 gtgtgcagag tgccatcctg caggtgcagg gtgactgcga gaagctcaac atcaccacca
     4621 gcaacctcat cgaggaccat cggcagaaac agaaggacat tgctatgctg taccagggtc
     4681 tggagaagct cgaaaaggaa aaggccaaca gggagcacct ggagatggag atcgatgtga
     4741 aagccgacaa gagtgctctg gccaccaaag tgagccgtgt ccagtttgat gccaccacgg
     4801 agcagctgaa ccacatgatg caggagctgg tggccaagat gagcgggcag gagcaggact
     4861 ggcagaagat gctggacagg ctgctcacag agatggacaa caagctggac cgcctggagc
     4921 tggacccagt gaagcagttg ctggaggatc ggtggaaatc gctgcgacag cagctcaggg
     4981 agcgcccccc actctaccag gcagacgagg cggctgccat gcggaggcag ctcctggcac
     5041 atttccactg cctctcatgt gaccggccct tggagacacc tgtgactgga catgccatcc
     5101 ccgtgacccc cgcgggtcca ggcctacctg ggcaccattc catccgcccc tacacggtgt
     5161 ttgaactgga gcaggtccgg cagcatagcc gcaacctcaa gctgggcagc gccttccctc
     5221 ggggtgacct ggcgcagatg gagcagagcg tggggcgcct gcgctccatg cactccaaga
     5281 tgctgatgaa cattgagaag gtgcagatcc acttcggggg ctccaccaag gccagcagcc
     5341 agataatccg cgagctgctg cacgcccagt gcctgggctc cccctgctac aaacgggtga
     5401 cagatatggc tgattacacc tactcaactg tgccccggcg ctgcgggggc agccacaccc
     5461 tcacctaccc ctaccaccgc agccgcccgc agcaccttcc ccggggcctg tatcctactg
     5521 aagagatcca gattgccatg aagcatgatg aggtggacat cttgggcctg gatggccaca
     5581 tttacaaggg acggatggac acaaggctgc caggcatcct ccgaaaagac agctcaggga
     5641 cctcaaagcg caagtcccag cagcccaggc cccacgtgca caggccgcca tccctcagca
     5701 gcaatggcca gctgccctct cggccacaga gcgcccagat ttcggctggc aacacctcag
     5761 tttcttctcg tcaacagaaa gatagacctt cctccgaggg ccgtctctcc cagccgaaca
     5821 cagcccaccc gcccagctcc gccgcggtgg caaacagggg gctggagagg cacgtggaca
     5881 tgcctcctgg ggaggggctc gaggagccca cgcgggggcc gcggtccagc accgctcagt
     5941 gagcggaggt gtaaataaac attcaggagg aa
//
