LOCUS       NM_198179               2339 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens pyroglutamylated RFamide peptide receptor (QRFPR),
            mRNA.
ACCESSION   NM_198179
VERSION     NM_198179.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2339)
  AUTHORS   Li,H., Lou,R., Xu,X., Xu,C., Yu,Y., Xu,Y., Hu,L., Xiang,Y., Lin,X.
            and Tang,S.
  TITLE     The variations in human orphan G protein-coupled receptor QRFPR
            affect PI3K-AKT-mTOR signaling
  JOURNAL   J Clin Lab Anal 35 (7), e23822 (2021)
   PUBMED   34018631
  REMARK    GeneRIF: The variations in human orphan G protein-coupled receptor
            QRFPR affect PI3K-AKT-mTOR signaling.
REFERENCE   2  (bases 1 to 2339)
  AUTHORS   Wang,W., Tian,Y., Shi,X., Ma,Q., Xu,Y., Yang,G., Yi,W., Shi,Y. and
            Zhou,N.
  TITLE     N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is
            essential for ligand binding and receptor activation
  JOURNAL   J Neurochem 158 (2), 138-152 (2021)
   PUBMED   33655503
  REMARK    GeneRIF: N-glycosylation of the human neuropeptide QRFP receptor
            (QRFPR) is essential for ligand binding and receptor activation.
REFERENCE   3  (bases 1 to 2339)
  AUTHORS   Ma,Q., Cao,Z., Li,H., Wang,W., Tian,Y., Yan,L., Liao,Y., Chen,X.,
            Chen,Y., Shi,Y., Tang,S. and Zhou,N.
  TITLE     Two naturally occurring mutations of human GPR103 define distinct G
            protein selection bias
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (7), 119046 (2021)
   PUBMED   33872671
  REMARK    GeneRIF: Two naturally occurring mutations of human GPR103 define
            distinct G protein selection bias.
REFERENCE   4  (bases 1 to 2339)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2339)
  AUTHORS   Melton,P.E., Johnson,M.P., Gokhale-Agashe,D., Rea,A.J., Ariff,A.,
            Cadby,G., Peralta,J.M., McNab,T.J., Allcock,R.J., Abraham,L.J.,
            Blangero,J., Brennecke,S.P. and Moses,E.K.
  TITLE     Whole-exome sequencing in multiplex preeclampsia families
            identifies novel candidate susceptibility genes
  JOURNAL   J Hypertens 37 (5), 997-1011 (2019)
   PUBMED   30633125
  REMARK    GeneRIF: The study represents the first to use WES in multiplex
            families for preeclampsia and identifies two novel genes (QRFPR and
            C1orf35) not previously associated with preeclampsia and find
            nominal association of rs34270076 with protein levels.
REFERENCE   6  (bases 1 to 2339)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (bases 1 to 2339)
  AUTHORS   Takayasu,S., Sakurai,T., Iwasaki,S., Teranishi,H., Yamanaka,A.,
            Williams,S.C., Iguchi,H., Kawasawa,Y.I., Ikeda,Y., Sakakibara,I.,
            Ohno,K., Ioka,R.X., Murakami,S., Dohmae,N., Xie,J., Suda,T.,
            Motoike,T., Ohuchi,T., Yanagisawa,M. and Sakai,J.
  TITLE     A neuropeptide ligand of the G protein-coupled receptor GPR103
            regulates feeding, behavioral arousal, and blood pressure in mice
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7438-7443 (2006)
   PUBMED   16648250
  REMARK    GeneRIF: QRFP and GPR103A/B may regulate diverse neuroendocrine and
            behavioral functions and implicate this neuropeptide system in
            metabolic syndrome
REFERENCE   8  (bases 1 to 2339)
  AUTHORS   Fukusumi,S., Yoshida,H., Fujii,R., Maruyama,M., Komatsu,H.,
            Habata,Y., Shintani,Y., Hinuma,S. and Fujino,M.
  TITLE     A new peptidic ligand and its receptor regulating adrenal function
            in rats
  JOURNAL   J Biol Chem 278 (47), 46387-46395 (2003)
   PUBMED   12960173
REFERENCE   9  (bases 1 to 2339)
  AUTHORS   Jiang,Y., Luo,L., Gustafson,E.L., Yadav,D., Laverty,M., Murgolo,N.,
            Vassileva,G., Zeng,M., Laz,T.M., Behan,J., Qiu,P., Wang,L.,
            Wang,S., Bayne,M., Greene,J., Monsma,F. Jr. and Zhang,F.L.
  TITLE     Identification and characterization of a novel RF-amide peptide
            ligand for orphan G-protein-coupled receptor SP9155
  JOURNAL   J Biol Chem 278 (30), 27652-27657 (2003)
   PUBMED   12714592
  REMARK    GeneRIF: characterization and tissue distribution of SP9155
            (GPR103) ligand
REFERENCE   10 (bases 1 to 2339)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG169612.1, DA461055.1, AB109629.1 and AC093867.3.
            
            On May 17, 2019 this sequence version replaced NM_198179.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.27881.1,
                                           SRR1803617.3249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394427.3/ ENSP00000377948.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               BG169612.1         9-165
            158-514             DA461055.1         199-555
            515-1667            AB109629.1         144-1296
            1668-2339           AC093867.3         52460-53131         c
FEATURES             Location/Qualifiers
     source          1..2339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q27"
     gene            1..2339
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /note="pyroglutamylated RFamide peptide receptor"
                     /db_xref="GeneID:84109"
                     /db_xref="HGNC:HGNC:15565"
                     /db_xref="MIM:606925"
     exon            1..711
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..1667
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /note="QRFP receptor; G-protein coupled receptor 103;
                     orexigenic neuropeptide QRFP receptor; peptide P518
                     receptor"
                     /codon_start=1
                     /product="pyroglutamylated RF-amide peptide receptor"
                     /protein_id="NP_937822.2"
                     /db_xref="CCDS:CCDS3719.1"
                     /db_xref="GeneID:84109"
                     /db_xref="HGNC:HGNC:15565"
                     /db_xref="MIM:606925"
                     /translation="MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRA
                     KLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVT
                     MLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNR
                     RAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFI
                     LVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMV
                     TVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAF
                     MNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFS
                     DGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH"
     exon            712..870
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            871..932
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1168
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1266
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..2339
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /note="hexamer: ATTAAA"
     polyA_site      1815
                     /gene="QRFPR"
                     /gene_synonym="AQ27; GPR103; SP9155"
                     /note="major polyA site"
ORIGIN      
        1 atggccagaa ggcggggagc cagaggcgcc aggaccctcg cgtggcgctc cagcacccca
       61 gaccgtggcg gcgcctcgcc ttagggaaga gcaagggaag aactttattt gaaccgcgaa
      121 cattttttgg tcactgagat cgagtctccc agtgctttgg cttcccgcct ctttatcgtg
      181 ggtttgatcc ctgagctgct ctcctttccc gaacctcccg gggtgcagcc tagagccctc
      241 ccgcgcggct gactccagag tagaggaagg gaggcggcct ccggctggtc ccccgaagcc
      301 ctcgctgccc cgcagatgcg gatggccagc cagtagcggg cggtggcccc gcgtcccggg
      361 agcgcacagc aatgcaggcg cttaacatta ccccggagca gttctctcgg ctgctgcggg
      421 accacaacct gacgcgggag cagttcatcg ctctgtaccg gctgcgaccg ctcgtctaca
      481 ccccagagct gccgggacgc gccaagctgg ccctcgtgct caccggcgtg ctcatcttcg
      541 ccctggcgct ctttggcaat gctctggtgt tctacgtggt gacccgcagc aaggccatgc
      601 gcaccgtcac caacatcttt atctgctcct tggcgctcag tgacctgctc atcaccttct
      661 tctgcattcc cgtcaccatg ctccagaaca tttccgacaa ctggctgggg ggtgctttca
      721 tttgcaagat ggtgccattt gtccagtcta ccgctgttgt gacagaaatc ctcactatga
      781 cctgcattgc tgtggaaagg caccagggac ttgtgcatcc ttttaaaatg aagtggcaat
      841 acaccaaccg aagggctttc acaatgctag gtgtggtctg gctggtggca gtcatcgtag
      901 gatcacccat gtggcacgtg caacaacttg agatcaaata tgacttccta tatgaaaagg
      961 aacacatctg ctgcttagaa gagtggacca gccctgtgca ccagaagatc tacaccacct
     1021 tcatccttgt catcctcttc ctcctgcctc ttatggtgat gcttattctg tacagtaaaa
     1081 ttggttatga actttggata aagaaaagag ttggggatgg ttcagtgctt cgaactattc
     1141 atggaaaaga aatgtccaaa atagccagga agaagaaacg agctgtcatt atgatggtga
     1201 cagtggtggc tctctttgct gtgtgctggg caccattcca tgttgtccat atgatgattg
     1261 aatacagtaa ttttgaaaag gaatatgatg atgtcacaat caagatgatt tttgctatcg
     1321 tgcaaattat tggattttcc aactccatct gtaatcccat tgtctatgca tttatgaatg
     1381 aaaacttcaa aaaaaatgtt ttgtctgcag tttgttattg catagtaaat aaaaccttct
     1441 ctccagcaca aaggcatgga aattcaggaa ttacaatgat gcggaagaaa gcaaagtttt
     1501 ccctcagaga gaatccagtg gaggaaacca aaggagaagc attcagtgat ggcaacattg
     1561 aagtcaaatt gtgtgaacag acagaggaga agaaaaagct caaacgacat cttgctctct
     1621 ttaggtctga actggctgag aattctcctt tagacagtgg gcattaatta taacaatatc
     1681 ttcataatta atgcccttca gattgtaacc caaagagaaa attattttga gcaaaggtca
     1741 aatactcttt ttattcttaa gatgatgaca agaagaaaac aaatcatgtt tccattaaaa
     1801 aatgacacga ggctagtcca agtgcagtga tgtttacaac caattgatca caatcattta
     1861 acagatttct gtgttccttc tcattcccac tgcttcactt gactagcctt aaaaaagcaa
     1921 catggaaggc caggcacggt ggctcatgcc tgtaatccca gcactttggg aggcctagac
     1981 gggcggatca cgaggtcagg agatcaaaac catcctggct aacacggtga aaccccatct
     2041 ctgctaaaaa tacaaaaatt agccgggcgt ggtggcgggc acctgtagtc ccagctactt
     2101 gggagcctca ggcgggagaa tggtgtgaac ccgggaggcg gagcttgcag tgatccgaga
     2161 tcatgccact gcactccagc ctgggcgaaa gagcgagact ccccgtctca aaaaaaattt
     2221 ttttgaaaaa ttcgtaaacc atacttttaa gattatttca gtggattttt aaaaatcttg
     2281 tacagaaatc agggttctta gctagcagtt tttctcccac gcagtcactg taatgtgac
//
