LOCUS       NM_017659               2125 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glutaminyl-peptide cyclotransferase like (QPCTL),
            transcript variant 1, mRNA.
ACCESSION   NM_017659
VERSION     NM_017659.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2125)
  AUTHORS   Liu,Y., Lu,S., Sun,Y., Wang,F., Yu,S., Chen,X., Wu,L.L., Yang,H.,
            Shi,Y. and Zhao,K.
  TITLE     Deciphering the role of QPCTL in glioma progression and cancer
            immunotherapy
  JOURNAL   Front Immunol 14, 1166377 (2023)
   PUBMED   37063864
  REMARK    GeneRIF: Deciphering the role of QPCTL in glioma progression and
            cancer immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2125)
  AUTHORS   Schloesser,D., Lindenthal,L., Sauer,J., Chung,K.J., Chavakis,T.,
            Griesser,E., Baskaran,P., Maier-Habelsberger,U., Fundel-Clemens,K.,
            Schlotthauer,I., Watson,C.K., Swee,L.K., Igney,F., Park,J.E.,
            Huber-Lang,M.S., Thomas,M.J., El Kasmi,K.C. and Murray,P.J.
  TITLE     Senescent cells suppress macrophage-mediated corpse removal via
            upregulation of the CD47-QPCT/L axis
  JOURNAL   J Cell Biol 222 (2) (2023)
   PUBMED   36459066
  REMARK    GeneRIF: Senescent cells suppress macrophage-mediated corpse
            removal via upregulation of the CD47-QPCT/L axis.
REFERENCE   3  (bases 1 to 2125)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2125)
  AUTHORS   Logtenberg,M.E.W., Jansen,J.H.M., Raaben,M., Toebes,M., Franke,K.,
            Brandsma,A.M., Matlung,H.L., Fauster,A., Gomez-Eerland,R.,
            Bakker,N.A.M., van der Schot,S., Marijt,K.A., Verdoes,M.,
            Haanen,J.B.A.G., van den Berg,J.H., Neefjes,J., van den Berg,T.K.,
            Brummelkamp,T.R., Leusen,J.H.W., Scheeren,F.A. and Schumacher,T.N.
  TITLE     Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPalpha
            axis and a target for cancer immunotherapy
  JOURNAL   Nat Med 25 (4), 612-619 (2019)
   PUBMED   30833751
  REMARK    GeneRIF: QPCTL is critical for pyroglutamate formation on CD47 at
            the SIRPalpha binding site shortly after biosynthesis.
REFERENCE   5  (bases 1 to 2125)
  AUTHORS   Wen,W., Zheng,W., Okada,Y., Takeuchi,F., Tabara,Y., Hwang,J.Y.,
            Dorajoo,R., Li,H., Tsai,F.J., Yang,X., He,J., Wu,Y., He,M.,
            Zhang,Y., Liang,J., Guo,X., Sheu,W.H., Delahanty,R., Guo,X.,
            Kubo,M., Yamamoto,K., Ohkubo,T., Go,M.J., Liu,J.J., Gan,W.,
            Chen,C.C., Gao,Y., Li,S., Lee,N.R., Wu,C., Zhou,X., Song,H.,
            Yao,J., Lee,I.T., Long,J., Tsunoda,T., Akiyama,K., Takashima,N.,
            Cho,Y.S., Ong,R.T., Lu,L., Chen,C.H., Tan,A., Rice,T.K.,
            Adair,L.S., Gui,L., Allison,M., Lee,W.J., Cai,Q., Isomura,M.,
            Umemura,S., Kim,Y.J., Seielstad,M., Hixson,J., Xiang,Y.B.,
            Isono,M., Kim,B.J., Sim,X., Lu,W., Nabika,T., Lee,J., Lim,W.Y.,
            Gao,Y.T., Takayanagi,R., Kang,D.H., Wong,T.Y., Hsiung,C.A.,
            Wu,I.C., Juang,J.M., Shi,J., Choi,B.Y., Aung,T., Hu,F., Kim,M.K.,
            Lim,W.Y., Wang,T.D., Shin,M.H., Lee,J., Ji,B.T., Lee,Y.H.,
            Young,T.L., Shin,D.H., Chun,B.Y., Cho,M.C., Han,B.G., Hwu,C.M.,
            Assimes,T.L., Absher,D., Yan,X., Kim,E., Kuo,J.Z., Kwon,S.,
            Taylor,K.D., Chen,Y.D., Rotter,J.I., Qi,L., Zhu,D., Wu,T.,
            Mohlke,K.L., Gu,D., Mo,Z., Wu,J.Y., Lin,X., Miki,T., Tai,E.S.,
            Lee,J.Y., Kato,N., Shu,X.O. and Tanaka,T.
  TITLE     Meta-analysis of genome-wide association studies in East
            Asian-ancestry populations identifies four new loci for body mass
            index
  JOURNAL   Hum Mol Genet 23 (20), 5492-5504 (2014)
   PUBMED   24861553
REFERENCE   6  (bases 1 to 2125)
  AUTHORS   Burgdorf,K.S., Gjesing,A.P., Grarup,N., Justesen,J.M.,
            Sandholt,C.H., Witte,D.R., Jorgensen,T., Madsbad,S., Hansen,T. and
            Pedersen,O.
  TITLE     Association studies of novel obesity-related gene variants with
            quantitative metabolic phenotypes in a population-based sample of
            6,039 Danish individuals
  JOURNAL   Diabetologia 55 (1), 105-113 (2012)
   PUBMED   21953277
  REMARK    GeneRIF: genetic association studies in Danish population:
            Quantitative metabolic phenotypes in obesity are associated with
            SNP in various genes: QPCTL (rs2287019) is associated with body
            mass index and increased insulinogenic index.
REFERENCE   7  (bases 1 to 2125)
  AUTHORS   Huang,K.F., Liaw,S.S., Huang,W.L., Chia,C.Y., Lo,Y.C., Chen,Y.L.
            and Wang,A.H.
  TITLE     Structures of human Golgi-resident glutaminyl cyclase and its
            complexes with inhibitors reveal a large loop movement upon
            inhibitor binding
  JOURNAL   J Biol Chem 286 (14), 12439-12449 (2011)
   PUBMED   21288892
REFERENCE   8  (bases 1 to 2125)
  AUTHORS   Speliotes,E.K., Willer,C.J., Berndt,S.I., Monda,K.L.,
            Thorleifsson,G., Jackson,A.U., Lango Allen,H., Lindgren,C.M.,
            Luan,J., Magi,R., Randall,J.C., Vedantam,S., Winkler,T.W., Qi,L.,
            Workalemahu,T., Heid,I.M., Steinthorsdottir,V., Stringham,H.M.,
            Weedon,M.N., Wheeler,E., Wood,A.R., Ferreira,T., Weyant,R.J.,
            Segre,A.V., Estrada,K., Liang,L., Nemesh,J., Park,J.H.,
            Gustafsson,S., Kilpelainen,T.O., Yang,J., Bouatia-Naji,N., Esko,T.,
            Feitosa,M.F., Kutalik,Z., Mangino,M., Raychaudhuri,S., Scherag,A.,
            Smith,A.V., Welch,R., Zhao,J.H., Aben,K.K., Absher,D.M., Amin,N.,
            Dixon,A.L., Fisher,E., Glazer,N.L., Goddard,M.E., Heard-Costa,N.L.,
            Hoesel,V., Hottenga,J.J., Johansson,A., Johnson,T., Ketkar,S.,
            Lamina,C., Li,S., Moffatt,M.F., Myers,R.H., Narisu,N., Perry,J.R.,
            Peters,M.J., Preuss,M., Ripatti,S., Rivadeneira,F., Sandholt,C.,
            Scott,L.J., Timpson,N.J., Tyrer,J.P., van Wingerden,S.,
            Watanabe,R.M., White,C.C., Wiklund,F., Barlassina,C., Chasman,D.I.,
            Cooper,M.N., Jansson,J.O., Lawrence,R.W., Pellikka,N.,
            Prokopenko,I., Shi,J., Thiering,E., Alavere,H., Alibrandi,M.T.,
            Almgren,P., Arnold,A.M., Aspelund,T., Atwood,L.D., Balkau,B.,
            Balmforth,A.J., Bennett,A.J., Ben-Shlomo,Y., Bergman,R.N.,
            Bergmann,S., Biebermann,H., Blakemore,A.I., Boes,T.,
            Bonnycastle,L.L., Bornstein,S.R., Brown,M.J., Buchanan,T.A.,
            Busonero,F., Campbell,H., Cappuccio,F.P., Cavalcanti-Proenca,C.,
            Chen,Y.D., Chen,C.M., Chines,P.S., Clarke,R., Coin,L., Connell,J.,
            Day,I.N., den Heijer,M., Duan,J., Ebrahim,S., Elliott,P.,
            Elosua,R., Eiriksdottir,G., Erdos,M.R., Eriksson,J.G.,
            Facheris,M.F., Felix,S.B., Fischer-Posovszky,P., Folsom,A.R.,
            Friedrich,N., Freimer,N.B., Fu,M., Gaget,S., Gejman,P.V.,
            Geus,E.J., Gieger,C., Gjesing,A.P., Goel,A., Goyette,P.,
            Grallert,H., Grassler,J., Greenawalt,D.M., Groves,C.J.,
            Gudnason,V., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Hall,A.S., Havulinna,A.S., Hayward,C., Heath,A.C., Hengstenberg,C.,
            Hicks,A.A., Hinney,A., Hofman,A., Homuth,G., Hui,J., Igl,W.,
            Iribarren,C., Isomaa,B., Jacobs,K.B., Jarick,I., Jewell,E.,
            John,U., Jorgensen,T., Jousilahti,P., Jula,A., Kaakinen,M.,
            Kajantie,E., Kaplan,L.M., Kathiresan,S., Kettunen,J., Kinnunen,L.,
            Knowles,J.W., Kolcic,I., Konig,I.R., Koskinen,S., Kovacs,P.,
            Kuusisto,J., Kraft,P., Kvaloy,K., Laitinen,J., Lantieri,O.,
            Lanzani,C., Launer,L.J., Lecoeur,C., Lehtimaki,T., Lettre,G.,
            Liu,J., Lokki,M.L., Lorentzon,M., Luben,R.N., Ludwig,B.,
            Manunta,P., Marek,D., Marre,M., Martin,N.G., McArdle,W.L.,
            McCarthy,A., McKnight,B., Meitinger,T., Melander,O., Meyre,D.,
            Midthjell,K., Montgomery,G.W., Morken,M.A., Morris,A.P., Mulic,R.,
            Ngwa,J.S., Nelis,M., Neville,M.J., Nyholt,D.R., O'Donnell,C.J.,
            O'Rahilly,S., Ong,K.K., Oostra,B., Pare,G., Parker,A.N., Perola,M.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Polasek,O., Pouta,A.,
            Rafelt,S., Raitakari,O., Rayner,N.W., Ridderstrale,M., Rief,W.,
            Ruokonen,A., Robertson,N.R., Rzehak,P., Salomaa,V., Sanders,A.R.,
            Sandhu,M.S., Sanna,S., Saramies,J., Savolainen,M.J., Scherag,S.,
            Schipf,S., Schreiber,S., Schunkert,H., Silander,K., Sinisalo,J.,
            Siscovick,D.S., Smit,J.H., Soranzo,N., Sovio,U., Stephens,J.,
            Surakka,I., Swift,A.J., Tammesoo,M.L., Tardif,J.C.,
            Teder-Laving,M., Teslovich,T.M., Thompson,J.R., Thomson,B.,
            Tonjes,A., Tuomi,T., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Viikari,J., Visvikis-Siest,S., Vitart,V., Vogel,C.I., Voight,B.F.,
            Waite,L.L., Wallaschofski,H., Walters,G.B., Widen,E., Wiegand,S.,
            Wild,S.H., Willemsen,G., Witte,D.R., Witteman,J.C., Xu,J.,
            Zhang,Q., Zgaga,L., Ziegler,A., Zitting,P., Beilby,J.P.,
            Farooqi,I.S., Hebebrand,J., Huikuri,H.V., James,A.L., Kahonen,M.,
            Levinson,D.F., Macciardi,F., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Ridker,P.M., Stumvoll,M., Beckmann,J.S., Boeing,H.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Collins,F.S., Cupples,L.A., Smith,G.D., Erdmann,J., Froguel,P.,
            Gronberg,H., Gyllensten,U., Hall,P., Hansen,T., Harris,T.B.,
            Hattersley,A.T., Hayes,R.B., Heinrich,J., Hu,F.B., Hveem,K.,
            Illig,T., Jarvelin,M.R., Kaprio,J., Karpe,F., Khaw,K.T.,
            Kiemeney,L.A., Krude,H., Laakso,M., Lawlor,D.A., Metspalu,A.,
            Munroe,P.B., Ouwehand,W.H., Pedersen,O., Penninx,B.W., Peters,A.,
            Pramstaller,P.P., Quertermous,T., Reinehr,T., Rissanen,A.,
            Rudan,I., Samani,N.J., Schwarz,P.E., Shuldiner,A.R., Spector,T.D.,
            Tuomilehto,J., Uda,M., Uitterlinden,A., Valle,T.T., Wabitsch,M.,
            Waeber,G., Wareham,N.J., Watkins,H., Wilson,J.F., Wright,A.F.,
            Zillikens,M.C., Chatterjee,N., McCarroll,S.A., Purcell,S.,
            Schadt,E.E., Visscher,P.M., Assimes,T.L., Borecki,I.B.,
            Deloukas,P., Fox,C.S., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., Mohlke,K.L., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., van Duijn,C.M., Wichmann,H.E.,
            Frayling,T.M., Thorsteinsdottir,U., Abecasis,G.R., Barroso,I.,
            Boehnke,M., Stefansson,K., North,K.E., McCarthy,M.I.,
            Hirschhorn,J.N., Ingelsson,E. and Loos,R.J.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat Genet 42 (11), 937-948 (2010)
   PUBMED   20935630
REFERENCE   9  (bases 1 to 2125)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 2125)
  AUTHORS   Cynis,H., Rahfeld,J.U., Stephan,A., Kehlen,A., Koch,B., Wermann,M.,
            Demuth,H.U. and Schilling,S.
  TITLE     Isolation of an isoenzyme of human glutaminyl cyclase: retention in
            the Golgi complex suggests involvement in the protein maturation
            machinery
  JOURNAL   J Mol Biol 379 (5), 966-980 (2008)
   PUBMED   18486145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP216511.1, AK000091.1, BC011553.1, AC007191.1 and AK222636.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017659.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.104113.1,
                                           SRR1163657.41856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000012049.10/ ENSP00000012049.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP216511.1         184-191
            9-999               AK000091.1         1-991
            1000-1141           BC011553.1         687-828
            1142-2100           AC007191.1         22933-23891
            2101-2125           AK222636.1         1414-1438
FEATURES             Location/Qualifiers
     source          1..2125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2125
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /note="glutaminyl-peptide cyclotransferase like"
                     /db_xref="GeneID:54814"
                     /db_xref="HGNC:HGNC:25952"
     exon            1..245
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1187
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /EC_number="2.3.2.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glutaminyl cyclase-like; glutaminyl-peptide
                     cyclotransferase-like protein; isoQC; golgi-resident
                     glutaminyl-peptide cyclotransferase"
                     /codon_start=1
                     /product="glutaminyl-peptide cyclotransferase-like protein
                     isoform 1"
                     /protein_id="NP_060129.2"
                     /db_xref="CCDS:CCDS12672.1"
                     /db_xref="GeneID:54814"
                     /db_xref="HGNC:HGNC:25952"
                     /translation="MRSGGRGRPRLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAV
                     GSAFYTIWSGWHRRTEELPLGRELRVPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLL
                     VVRTPGSPGNLQVRKFLEATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAA
                     RHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQ
                     LLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNP
                     TFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRR
                     GVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL"
     exon            246..389
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     exon            390..671
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     exon            672..824
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     exon            825..924
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1041
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..2125
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2107..2112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /note="hexamer: AATAAA"
     polyA_site      2125
                     /gene="QPCTL"
                     /gene_synonym="gQC"
                     /note="major polyA site"
ORIGIN      
        1 aatccgtggt ctggtacagg tttcagggca aagcggccat gcgttccggg ggccgcgggc
       61 gaccccgcct gcggctgggg gaacgtggcc tcatggagcc actcttgccg ccgaagcgcc
      121 gcctgctacc gcgggttcgg ctcttgcctc tgttgctggc gctggccgtg ggctcggcgt
      181 tctacaccat ttggagcggc tggcaccgca ggactgagga gctgccgctg ggccgggagc
      241 tgcgggtccc attgatcgga agcctccccg aagcccggct gcggagggtg gtgggacaac
      301 tggatccaca gcgtctctgg agcacttatc tgcgccccct gctggttgtg cgaaccccgg
      361 gcagcccggg aaatctccaa gtcagaaagt tcctggaggc cacgctgcgg tccctgacag
      421 caggttggca cgtggagctg gatcccttca cagcctcaac acccctgggg ccagtggact
      481 ttggcaatgt ggtggccaca ctggacccaa gggctgcccg tcacctcacc cttgcctgcc
      541 attatgactc gaagctcttc ccacccggat cgaccccctt tgtaggggcc acggattcgg
      601 ctgtgccctg tgccctgctg ctggagctgg cccaagcact tgacctggag ctgagcaggg
      661 ccaaaaaaca ggcagccccg gtgaccctgc aactgctctt cttggatggt gaagaggcgc
      721 tgaaggagtg gggacccaag gactcccttt acggttcccg gcacctggcc cagctcatgg
      781 agtctatacc tcacagcccc ggccccacca ggatccaggc tattgagctc tttatgcttc
      841 ttgatctcct gggagccccc aatcccacct tctacagcca cttccctcgc acggtccgct
      901 ggttccatcg gctgaggagc attgagaagc gtctgcaccg tttgaacctg ctgcagtctc
      961 atccccagga agtgatgtac ttccaacccg gggagccctt tggctctgtg gaagacgacc
     1021 acatcccctt cctccgcaga ggggtacccg tgctccatct catctccacg cccttccctg
     1081 ctgtctggca cacccctgcg gacaccgagg tcaatctcca cccacccacg gtacacaact
     1141 tgtgccgcat tctcgctgtg ttcctggctg aatacctggg gctctagcgt gcttggccaa
     1201 tgactgtgga gaggactgtg agagagaagg tcccagcggg ggccagtgaa gctcaggcag
     1261 gatctgccta gggtgtgctg gtttgtcctt ttcatacctt tgtctcctaa ttgtgctaca
     1321 attggaagac cttctttctt ttgattgtct caagctgcca cccttcaagg acagggaaga
     1381 gaccactgtg ggatgacagc cagaggaata agaacttgct ccctccccag aggtaaacac
     1441 ttggtccaaa ggtttgcagg gaccaaatac tgttcttttt ttttttgaga cggagtctca
     1501 ctgtgttgcc caggctggag tgcagtggtg cgatctcggc tcactgcaaa ctccgcctcc
     1561 tgggttcacg ccattctcct gcctcagcct cccaagtagc tgggactaca ggtgcccgcc
     1621 accacgctgg ctaatttttt gtatttttag tagagacggg gtttcaccgt gttagccagg
     1681 atggtctcga tctcctgacc ttgtaatccg ccagcctcgg cctcccaaag tgctgggatt
     1741 acaggtgtga gccaccgcac ctggcaaaat gctgttcttt aagtcagcga actgaaaaag
     1801 taaaagactg ctgggtgtgg tggctcacac ctgtaatccc aacactttga gaggctgagg
     1861 gggaaggatc acccgaggtc aggagtttga gaccagcctg gtcaacatgg cgaaaccctg
     1921 tctctactaa aaatacaata attagctggg catggtggtg ggcgcctgta atctcagctg
     1981 cttgggaggc tgaggcagga gaatcacttg tacgcaggag gcggaggttg cagtgagcca
     2041 agatcacacc actgcactcc agcctgggca acagagcgag actccatctc aataaataaa
     2101 taaataaata aatatttttt aaaaa
//
