LOCUS       NM_032307               2468 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Q-nucleotide N-glycosylase 1 (QNG1), transcript
            variant 1, mRNA.
ACCESSION   NM_032307
VERSION     NM_032307.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Hung,S.H., Elliott,G.I., Ramkumar,T.R., Burtnyak,L.,
            McGrenaghan,C.J., Alkuzweny,S., Quaiyum,S., Iwata-Reuyl,D., Pan,X.,
            Green,B.D., Kelly,V.P., de Crecy-Lagard,V. and Swairjo,M.A.
  TITLE     Structural basis of Qng1-mediated salvage of the micronutrient
            queuine from queuosine-5'-monophosphate as the biological substrate
  JOURNAL   Nucleic Acids Res 51 (2), 935-951 (2023)
   PUBMED   36610787
  REMARK    GeneRIF: Structural basis of Qng1-mediated salvage of the
            micronutrient queuine from queuosine-5'-monophosphate as the
            biological substrate.
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Ohi,Y., Qin,H., Hong,C., Blouin,L., Polo,J.M., Guo,T., Qi,Z.,
            Downey,S.L., Manos,P.D., Rossi,D.J., Yu,J., Hebrok,M.,
            Hochedlinger,K., Costello,J.F., Song,J.S. and Ramalho-Santos,M.
  TITLE     Incomplete DNA methylation underlies a transcriptional memory of
            somatic cells in human iPS cells
  JOURNAL   Nat Cell Biol 13 (5), 541-549 (2011)
   PUBMED   21499256
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Chen,Y.C., Kelly,V.P., Stachura,S.V. and Garcia,G.A.
  TITLE     Characterization of the human tRNA-guanine transglycosylase:
            confirmation of the heterodimeric subunit structure
  JOURNAL   RNA 16 (5), 958-968 (2010)
   PUBMED   20354154
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG709062.1, BC004407.1, AL354733.15 and BX116423.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032307.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.474090.1,
                                           SRR1660807.251288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376344.8/ ENSP00000365522.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BG709062.1         6-30
            26-2029             BC004407.1         1-2004
            2030-2105           AL354733.15        139566-139641       c
            2106-2468           BX116423.1         12-374              c
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..2468
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /note="Q-nucleotide N-glycosylase 1"
                     /db_xref="GeneID:84267"
                     /db_xref="HGNC:HGNC:28144"
                     /db_xref="MIM:611342"
     exon            1..579
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1268
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0553 protein C9orf64; queuosine salvage protein;
                     queuosine-nucleotide N-glycosylase/hydrolase; queuine
                     salvage protein QNG1; queuosine 5'-phosphate
                     N-glycosylase/hydrolase"
                     /codon_start=1
                     /product="queuosine 5'-phosphate N-glycosylase/hydrolase
                     isoform 1"
                     /protein_id="NP_115683.3"
                     /db_xref="CCDS:CCDS6666.2"
                     /db_xref="GeneID:84267"
                     /db_xref="HGNC:HGNC:28144"
                     /db_xref="MIM:611342"
                     /translation="MDGLLNPRESSKFIAENSRDVFIDSGGVRRVAELLLAKAAGPEL
                     RVEGWKALHELNPRAADEAAVNWVFVTDTLNFSFWSEQDEHKCVVRYRGKTYSGYWSL
                     CAAVNRALDEGIPITSASYYATVTLDQVRNILRSDTDVSMPLVEERHRILNETGKILL
                     EKFGGSFLNCVRESENSAQKLMHLVVESFPSYRDVTLFEGKRVSFYKRAQILVADTWS
                     VLEGKGDGCFKDISSITMFADYRLPQVLAHLGALKYSDDLLKKLLKGEMLSYGDRQEV
                     EIRGCSLWCVELIRDCLLELIEQKGEKPNGEINSILLDYYLWDYAHDHREDMKGIPFH
                     RIRCIYY"
     exon            580..839
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1035
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..2468
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2441..2446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /note="hexamer: AATAAA"
     polyA_site      2468
                     /gene="QNG1"
                     /gene_synonym="C9orf64"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgctt gcggcctctg cccagcgagc tgccccgggg tctctctggt ttcctaatca
       61 gggcaacgcc gcgggagaga acctttacct tggctgcact aagttctcgg tgccactccc
      121 tggcagggcg ggaccttgtt taggccctgt gatcgcgcgg ttcgtagtag cgcaaggcgc
      181 agagtggacc ttgacccgcc tagggcggga agagtttggc ccgccgggtc ccaaagggca
      241 gaatggacgg gctcctaaat cccagggaat cctctaaatt cattgcagaa aacagtcggg
      301 atgtgtttat tgacagcgga ggcgtacgga gggtggcaga gctgctgctg gccaaggcgg
      361 cggggccaga gctgcgcgtg gaggggtgga aagcccttca tgagctgaac cccagggcgg
      421 ccgacgaggc cgcggtcaac tgggtgttcg tgacagacac gctcaacttc tccttttggt
      481 cggagcagga cgagcacaag tgtgtggtga ggtacagagg gaaaacatac agtgggtact
      541 ggtccctgtg cgccgccgtc aacagagccc tcgacgaagg gataccaata actagtgcct
      601 cgtactacgc gacagtgacc ctggatcagg ttcggaatat acttcgttct gacacagacg
      661 tttccatgcc tttagtagaa gagaggcatc ggattctcaa tgaaaccggg aaaattctgc
      721 tggagaagtt tggaggctct tttctcaact gcgtccgaga aagtgagaat agtgcgcaga
      781 agttaatgca cctggtggtt gaaagttttc cttcttacag agatgtgact ctgtttgagg
      841 ggaaaagagt ttctttttac aaacgagccc aaatccttgt agcagatacg tggagtgtat
      901 tggaaggaaa aggagatggc tgcttcaagg acatctccag tatcaccatg tttgctgatt
      961 atagattacc tcaggttctt gctcatcttg gagccctgaa atactctgat gacctactga
     1021 agaagcttct caaaggagaa atgctctcat atggagacag gcaagaggtg gaaatcagag
     1081 ggtgctcgct ttggtgtgtt gagctgatcc gggattgtct tctggagctt attgaacaaa
     1141 agggtgaaaa acctaatgga gagatcaatt ccattcttct ggattattac ttatgggact
     1201 atgcccatga ccatagggaa gatatgaaag gaattccgtt tcatcgcata cgttgcatat
     1261 attattgacc tcaagtgtaa actgatccaa agaaaacccc ctgcgtttta tatcatatca
     1321 tctgtacagt tttgctttga tatttagaga acatgatcga ggttatagga aattgattgc
     1381 ccattctcac ttgaaaaata cttcctaggc cgggcacagt ggtttatgcc tgtaatccca
     1441 gcactgtggg aggctgaggc gggtggatca tctgaggtca ggagtttgag accacctggc
     1501 caacatggtg aaaccccatc tctactaaaa atacaaaatt agctgggcgt ggtggcacgt
     1561 gcctgtaatc ccagttactt gggaggctga ggcaagagaa tcgcttgaac tcagaaggtg
     1621 gaggttgcag tgaggcgaga ttaggccatt gcactccagc ctcagcaaca agagtgaaac
     1681 tttgtctcaa aaaacaacaa caacaacaac aacaacaaca aaacttccta ggccagatgt
     1741 ggtggctcat atgtataatc ttagcacttt gggaggccaa ggcaggagga ttgcttgagg
     1801 cgaggagttc aagaccagcc taggcaacat agggagaccc ccatctctac aaaaatttaa
     1861 aaattagcct agcatggtgg cacgctctgt aatcccaaat acgcggtagg ctgaggctga
     1921 ggagggtgga ttgcttgagc ccaggggttt gaggctgcag tgagccacag tcacgccact
     1981 gcattctatc ctgggcaaca gatggagacc ttgtctcaaa aaaaaaaaat tcctgacatc
     2041 gctatgtatt cccaacttta tcatttgtct gcctgtttag ttttgactta tgtttttttt
     2101 ttttcccccc tgtggacatg tagttgacgg aaatcgtgaa ggaactttaa tattttattt
     2161 aaatttccca aaactaatca tgccttatgt gactaatctt cagtgataat atttcatcta
     2221 ctgatatatt ttcttgaggt gtgtaatttt cagtatacct taatcatttg gtataaaaaa
     2281 gagagaggtt tttgatatat gaatgctgtt cttgtaaaaa tcaatcttga cactttattt
     2341 taaacttttt attggtaatg acagtgggtt ttgtacatca tgattttcaa tttaggatat
     2401 ctgtctaatt tgttttttca gagtaactat attggaattc aataaaaata ttcaaaattt
     2461 ttcttaaa
//
