LOCUS       NM_206853              14057 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens QKI, KH domain containing RNA binding (QKI),
            transcript variant 2, mRNA.
ACCESSION   NM_206853
VERSION     NM_206853.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14057)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 14057)
  AUTHORS   Zakutansky,P.M., Ku,L., Zhang,G., Shi,L., Li,Y., Yao,B.,
            Bassell,G.J., Read,R.D. and Feng,Y.
  TITLE     Isoform balance of the long noncoding RNA NEAT1 is regulated by the
            RNA-binding protein QKI, governs the glioma transcriptome, and
            impacts cell migration
  JOURNAL   J Biol Chem 300 (8), 107595 (2024)
   PUBMED   39032650
  REMARK    GeneRIF: Isoform balance of the long noncoding RNA NEAT1 is
            regulated by the RNA-binding protein QKI, governs the glioma
            transcriptome, and impacts cell migration.
REFERENCE   3  (bases 1 to 14057)
  AUTHORS   Wu,W., Cai,Y., Jin,J., Chen,Z. and Teng,M.
  TITLE     Circular RNA Circ_0001322 inhibits gastric cancer progression by
            modulating the miR-1264/QKI axis and suppressing the Hedgehog
            pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 190-197 (2024)
   PUBMED   38814217
  REMARK    GeneRIF: Circular RNA Circ_0001322 inhibits gastric cancer
            progression by modulating the miR-1264/QKI axis and suppressing the
            Hedgehog pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14057)
  AUTHORS   Wang,H.F., Zhou,X.F., Zhang,Q.M., Wu,J.Q., Hou,J.H., Xu,X.L.,
            Li,X.M. and Liu,Y.L.
  TITLE     Involvement of circRNA Regulators MBNL1 and QKI in the Progression
            of Esophageal Squamous Cell Carcinoma
  JOURNAL   Cancer Control 31, 10732748241257142 (2024)
   PUBMED   38769028
  REMARK    GeneRIF: Involvement of circRNA Regulators MBNL1 and QKI in the
            Progression of Esophageal Squamous Cell Carcinoma.
REFERENCE   5  (bases 1 to 14057)
  AUTHORS   Min,K.W., Jo,M.H., Song,M., Lee,J.W., Shim,M.J., Kim,K., Park,H.B.,
            Ha,S., Mun,H., Polash,A., Hafner,M., Cho,J.H., Kim,D., Jeong,J.H.,
            Ko,S., Hohng,S., Kang,S.U. and Yoon,J.H.
  TITLE     Mature microRNA-binding protein QKI promotes microRNA-mediated gene
            silencing
  JOURNAL   RNA Biol 21 (1), 1-15 (2024)
   PUBMED   38372062
  REMARK    GeneRIF: Mature microRNA-binding protein QKI promotes
            microRNA-mediated gene silencing.
REFERENCE   6  (bases 1 to 14057)
  AUTHORS   Wu,J.I., Reed,R.B., Grabowski,P.J. and Artzt,K.
  TITLE     Function of quaking in myelination: regulation of alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4233-4238 (2002)
   PUBMED   11917126
REFERENCE   7  (bases 1 to 14057)
  AUTHORS   Li,Z.Z., Kondo,T., Murata,T., Ebersole,T.A., Nishi,T., Tada,K.,
            Ushio,Y., Yamamura,K. and Abe,K.
  TITLE     Expression of Hqk encoding a KH RNA binding protein is altered in
            human glioma
  JOURNAL   Jpn J Cancer Res 93 (2), 167-177 (2002)
   PUBMED   11856480
REFERENCE   8  (bases 1 to 14057)
  AUTHORS   Saccomanno,L., Loushin,C., Jan,E., Punkay,E., Artzt,K. and
            Goodwin,E.B.
  TITLE     The STAR protein QKI-6 is a translational repressor
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12605-12610 (1999)
   PUBMED   10535969
  REMARK    GeneRIF: There are many isoforms of this RNA binding protein. QKI-6
            has been shown to be a translational repressor.
REFERENCE   9  (bases 1 to 14057)
  AUTHORS   Chen,T. and Richard,S.
  TITLE     Structure-function analysis of Qk1: a lethal point mutation in
            mouse quaking prevents homodimerization
  JOURNAL   Mol Cell Biol 18 (8), 4863-4871 (1998)
   PUBMED   9671495
REFERENCE   10 (bases 1 to 14057)
  AUTHORS   Ebersole,T.A., Chen,Q., Justice,M.J. and Artzt,K.
  TITLE     The quaking gene product necessary in embryogenesis and myelination
            combines features of RNA binding and signal transduction proteins
  JOURNAL   Nat Genet 12 (3), 260-265 (1996)
   PUBMED   8589716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB067801.1, AF272349.1,
            AF142422.1, AB067799.1, AL031781.1 and AW131362.1.
            
            On May 31, 2019 this sequence version replaced NM_206853.2.
            
            Summary: The protein encoded by this gene is an RNA-binding protein
            that regulates pre-mRNA splicing, export of mRNAs from the nucleus,
            protein translation, and mRNA stability. The encoded protein is
            involved in myelinization and oligodendrocyte differentiation and
            may play a role in schizophrenia. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding region compared to variant 1, which results in a frameshift.
            The resulting isoform (2; also known as HQK-6 and QKI-6) is shorter
            and has a distinct C-terminus compared to isoform 1. Isoforms 2 and
            4 are the same length but have different C-termini.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067799.1, SRR1660809.20691.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AB067801.1         76-479
            405-1410            AF272349.1         362-1367
            1411-1436           AF142422.1         1046-1071
            1437-5610           AB067799.1         1513-5686
            5611-14014          AL031781.1         4352-12755          c
            14015-14057         AW131362.1         21-63               c
FEATURES             Location/Qualifiers
     source          1..14057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q26"
     gene            1..14057
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="QKI, KH domain containing RNA binding"
                     /db_xref="GeneID:9444"
                     /db_xref="HGNC:HGNC:21100"
                     /db_xref="MIM:609590"
     exon            1..618
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1436
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     homolog of mouse quaking QKI (KH domain RNA binding
                     protein); RNA binding protein HQK; quaking homolog, KH
                     domain RNA binding; QKI/LOC100132735 fusion; KH
                     domain-containing RNA-binding protein QKI"
                     /codon_start=1
                     /product="KH domain-containing RNA-binding protein QKI
                     isoform 2"
                     /protein_id="NP_996735.1"
                     /db_xref="CCDS:CCDS5286.1"
                     /db_xref="GeneID:9444"
                     /db_xref="HGNC:HGNC:21100"
                     /db_xref="MIM:609590"
                     /translation="MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERL
                     LDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
                     LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA
                     QNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSL
                     AATAQAAPRIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVP
                     PGPEAGLIYTPYEYPYTLAPATSILEYPIEPSGVLGMAFPTKG"
     exon            619..761
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..878
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1022
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1110
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1410
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..14057
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5585..5590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      5610
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="major polyA site"
     regulatory      9238..9243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      9261
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="major polyA site"
     regulatory      9317..9322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      9329
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      12120..12125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      12141
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      13973..13978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: ATTAAA"
     polyA_site      13992
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      14033..14038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: ATTAAA"
     polyA_site      14057
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
ORIGIN      
        1 gcagtcggag cgcggcggca gcggcagagg cgccgcggcg gggaccagcc cagagagacc
       61 ccccgagccc gcggcacagg cggcggcggc gctgagcggg ctcgaccagc cgagcgagcg
      121 gcggccccgg ctcctcctcg tccggcgcca gcagcccgcg ccccgcgccc gcactcggcc
      181 agccgagacc cgcctcccgc ccgcccgccg gcctcgtgag ggacgcgccg agccgggcgg
      241 ccgagagcgg cggcggctgg gagcgcgtcg ggcccgggcg gaaagtgcct gcggggggcg
      301 ggcgagcgcg cggtgccggc cgccccgggg ctcggcgcgg gagccagagc gggagccggc
      361 gcggagcggg acgccgggtc ccgagcggcc cgcggccggg gctcgccccc gcccctccct
      421 cctctccggc ggcggcggcg gcggcggcgg gcggagtgag ctgcggagcc tggaatatgg
      481 tcggggaaat ggaaacgaag gagaagccga agcccacccc agattacctg atgcagctga
      541 tgaacgacaa gaagctcatg agcagcctgc ccaacttctg cgggatcttc aaccacctcg
      601 agcggctgct ggacgaagaa attagcagag tacggaaaga catgtacaat gacacattaa
      661 atggcagtac agagaaaagg agtgcagaat tgcctgatgc tgtgggacct attgttcagt
      721 tacaagagaa actttatgtg cctgtaaaag aatacccaga ttttaatttt gttgggagaa
      781 tccttggacc tagaggactt acagccaaac aacttgaagc agaaaccgga tgtaaaatca
      841 tggtccgagg caaaggctca atgagggata aaaaaaagga ggagcaaaat agaggcaagc
      901 ccaattggga gcatctaaat gaagatttac atgtactaat cactgtggaa gatgctcaga
      961 acagagcaga aatcaaattg aagagagcag ttgaagaagt gaagaaatta ttggtacctg
     1021 cagcagaagg agaagacagc ctgaagaaga tgcagctgat ggagcttgcg attctgaatg
     1081 gcacctacag agatgccaac attaaatcac cagcccttgc cttttctctt gcagcaacag
     1141 cccaggctgc tccaaggatc attactgggc ctgcgccggt tctcccacca gctgccctgc
     1201 gtactcctac gccagctggc cctaccataa tgcctttgat cagacaaata cagaccgctg
     1261 tcatgccaaa cggaactcct cacccaactg ctgcaatagt tcctccaggg cccgaagctg
     1321 gtttaatcta tacaccctat gagtacccct acacattggc accagctaca tcaatccttg
     1381 agtatcctat tgaacctagt ggtgtattag gtatggcttt cccaacgaaa ggctaagaat
     1441 tcaagaacgg tcttaactga accctcatca gatctgaatt taacaaatgc ttagtctcag
     1501 cagcctccgg gggaaaaaag cttagcctag cagtcagtga cttacttgca ctttttgcac
     1561 atagatataa agtaaaatta tgttattaat ttggtttagt ctgtaatatt acacagtaat
     1621 ggtaatttat aaaggagtgt atagtagtat actgactgct aagtgtacta tactgtttgc
     1681 tttactaatc acctaattca ttgcagttca tacttattga ctcagagttt aaaaccacaa
     1741 tctgtaggct ttaagaattg cttttaaacc tttttaagtg ataaactctt gaagtggtct
     1801 taaggttagc aaataattgt ctgtattaaa catggcgtta tttaagtagt cctgctgcaa
     1861 gaaaggcact tcagtgaata tgtgactagt aaagcttaaa tatgtttgga tctaatagag
     1921 ctcatgaaat actgtaactt ggggattgta aatgaatgga tacaataggt taaggcccaa
     1981 gatgtttgaa atgaatgcaa tattaataga tgcatatata catgacatat tgtggttaat
     2041 tttaaaacta ctgtgcctta acgtgtttct taaacttttg tagtaaatga acatttgaaa
     2101 tccattttga taaacctgct gttaatgttt tttcccccct tgtgaatgtt ttctaacttt
     2161 gtcttggtaa ttgcaattta actaggtgcg gtggctacta aagttcgaag gcacgatatg
     2221 cgtgtccatc cttaccaaag gattgtgacc gcagaccgag gttagtttag ttctgcagtt
     2281 cttgtctata agaaatgcgt tgggtgtcca taaaatttgc aacaccacac ctgatggaaa
     2341 aatgtaattg cttacctgca cacagttttt tttccttttc taaatttgtt tgtgatcatt
     2401 gacagattta agggttgggt tttttgtttt ggtttggttt tttctccctt catattttaa
     2461 cttattaaat cttctattat tatgtactat gatttattcc tactaaaaca taaattagtc
     2521 aatttgggga gctattaaat tttgatgttg cctcagttat tttcattaat aacttttgct
     2581 aaaatttacc ttttaaaagt tctgaaattt ggggttggta ttgcaaaatg aattgaacgg
     2641 atggtgcttt aatgagagaa gtaaaggaat atatgcctcc tgtgtacttt tggagaaaac
     2701 tgaagattta gtttccattt ttctttataa taaaatattt gagccactgt ataaacatga
     2761 gggtgcacat gtcaagtact tagctaaaat caacaaagtg aggactgtga agataacttt
     2821 catgtagttg gattttttta tataaattag agcgtcaatt cccttttatt cttacattct
     2881 cttgccaaaa tggatccttt gatttttgtc atttgctgct aaaatatatt atctgaaggt
     2941 aaactgtctc ttgaagttct gtggtggtat gagatccagc tgtgtgaata taatttttga
     3001 ctaacctgtg actggaaaat aagtcttcat ttttctcctt tacaactttt ataatttgtg
     3061 tcctgtatat gcccttggac ccttttataa attatttttg cttattgagg aatggtattt
     3121 tcggtttatt gacattgaat tgttttctaa gtttttccat cacaagatag gaatatcaag
     3181 catggtagta aaaaaggatt ttttacaagt ttctattatg gcacatttgt ttcctacaaa
     3241 ttaaattgat caaagtctca aatattagtg gaggaaaaag tgctggattt gtacttcaat
     3301 tgtacatctt ctatgaattt atgaaggacc tacctgcttt atgtgattac cttgagtact
     3361 gatgataaat actagacaca gctgttgtcc acatcagaaa taacatgcct ttcccaaaga
     3421 cattgttaat atttgtttag cataatccat aaagaacgtt gaagactttt aaactaatgt
     3481 attcatcact aacagtgatt gttcagtgaa caaaatagac cccagctccg tggtcgtcta
     3541 tgaggatggt attccttgta agtgttctgt atgagcacgt ctcataggga tggggaagtt
     3601 ttttggaaag tcacttgagt tttaaagaaa ctggacaatt ccatgaataa tttgaggttt
     3661 tattcatatt gctaatgtct acaattgttc taaagagtat tttaaagtag tttttttccc
     3721 ccagctaatc tttccctatg tatgccccct tttaggagat ttctcaccat tttgctttaa
     3781 cacaataatt attggcctac ttaatactcc agtgccttga gatagttgga catattttag
     3841 gaagatttta ttgtatttgg aaaattacga cacattccat gcatggatct tttgtagtta
     3901 cgtgttttga ttagtcctgt cactgttttt atttaaaatg cagtgtcagc aaaccgaaat
     3961 gctcatttct tttttagtaa cagagtactc gtatacttat cactgtatgc actcattggg
     4021 tctaagggag atgtctgaag tccttcactt aaattatttt atgatactac tgttttctct
     4081 atttttgagg ttaaaattat tttaaaaaaa tattttgaag agaagtttat tagtataagc
     4141 attcatttaa tgcaaaaaaa ctcagccctt ggacatataa ccatgtaatt ctatatgaac
     4201 gtttagagta ctacatggtt gaccaatatc tagttcttta ctaaaagtaa actcacctct
     4261 ttatatatat ttcaaaactg aatttgaagc ctattagaga ccaactgacc ttttagttgt
     4321 aatgaactgt atggtcttgc atggtgacac acctgtgtag gaggccaaga cttggcagag
     4381 gatgtagtct aggtgtcctg gtatatataa atggtcactc acttcgttta tatattccac
     4441 actcagaaaa gaagtcagag ttttttctga gtaatacaaa aaccatcact tacataattt
     4501 gtataagaaa ctttaaacag ttttaatcaa aactatgagt aacatcaaaa atgctttaag
     4561 attctatatt ttggaatacc tgtgaagtag tatgactaca tcatgttaaa tatttatttt
     4621 cttctatgat tttggagcag caatttttat tttaaataaa attccacttt taagaaattc
     4681 agggaagatt tggtcacatt gaagatacag tatttttgta gtatttataa actgttctaa
     4741 atgatagact atagaaaaca tttttgtcat atgaaggtaa atcagtccat tattttggat
     4801 catttaaact gaacattaca ccttctgggc tttgatttat gaagtggcac agaatctaac
     4861 tttgcactga atatcttttc attcacatct cctctgcctt agtcacaatg gcaacagtac
     4921 agaaaattct atcaaacctc agaatatagt agaaataatt aagctgttga atgagtctta
     4981 aaaattatac tactgttaag tggaccaagt ttggtgaagc agaatgtgac aaaggttgat
     5041 taaggaagga acaactcaag gacattggga atgataactt ttccacttga gaactacttt
     5101 atgttttact gtaattttta aagttttttt gtcctttttg ttattttgca aaagaaaata
     5161 gtatttacag gtggcttctt ttaaaatata aaaatataaa gcaggaatgt atatgaaatg
     5221 tcagatttta ttgtatttgc agagtattag ctttgaaatt gaataaagaa agctgtttgt
     5281 agttttaaaa tgccttattg gtatcaatta gaaatttctt ctattttttg atgtacttag
     5341 agctttttga gtgtagaatt ttaaatggca ggattttaca gtgtttacat gcaagtgcat
     5401 tttataagtg ttctatatgt gtaaaatagt attttcaact ggaaagtgtt ggctagtgca
     5461 aaaggcctgg ccattttctg gttcccatga tgttgcctac actgctagac tacagtttag
     5521 tatcgctttg tatcatgagg ccaagaaatt ccatgttgtt tgtaaataga ataattgaaa
     5581 aagcaataaa catttattga acaaaagaaa ccttgtttgg cccagagttt atgttgaacc
     5641 aaatggttca tagaattttg aatttcttta gattcatttc tgttaatcat cagttattaa
     5701 taatcacatc catcattaat agttgcttta atgcttgcat cttagagaat actaatgctt
     5761 aatagcagtc agatactgat aactgcactg actgtttaaa aattctgtat accaaaccta
     5821 ttcattgttg tttttcaatt tccttcattg actgctacta actattagtt gttagttgta
     5881 ttttatttct attttttctt gttaaccagt tttttttttt tttttgtggg agtgggctct
     5941 tcttcatttg ttcaaatcat gatacgaaat tgtcatgatt ttaattgtat tctgtagatg
     6001 gtgtcaatca gtttgtcaga attaaacatg cttttttttt tattagttgt gattagtttt
     6061 tcatgttgtc attaagccgt cactagctga aactaatctc ttctctatct tttcttttct
     6121 tttttttgtt ttgttttttt ttgtttctaa ccacccagcc gccaccggca actaacctat
     6181 gaccttctga cctctgaact cttcacccaa tgatgacctg accatgcctg cctgctgatc
     6241 agttaactgg taatcgcctt tgcttgcctg tcgtcagtgc agcgagctga ggcacttgtc
     6301 cgttcgtctt accatctaac caaacaaaag acaaagaaat tgttgtcctc caactcagct
     6361 tttttttttt ttttttcctg tttgggtgaa agtggttcta gaaactgcac tgaatagtag
     6421 taaagcaata aggcccaatt catcccacag cactgatcat cttttaatat cccaccctaa
     6481 gcgaacggta agaaggcctc tcttaagaag gggagacaga tggtccttaa ctactcaatg
     6541 acagaggcag ttactgtgag agacttctag gaatcttttt cttctcatag cgaagtcaaa
     6601 gctctctctg aatgtactgt gtgatgatgc atcatgcatg aaccttcggt cagggatatc
     6661 attggtgaag tgatttcaaa aagtattcaa aatttgatat gctgtttagt cactacagtg
     6721 ccctcaaagg gcagaagttg cagccttttt tatattgcct gccaaaattt gaagtattag
     6781 aagaaagtgt gccatgagag aaaaacttaa ggagttttga aaagtaatgc aaataacaaa
     6841 actgcaacac tatttttaaa aagataaata tctgagttaa aattactgaa tctttatttt
     6901 acacctaaaa aaatatgaga acaaggtaca tgcattatgt gtcacattac tgggcaaact
     6961 gttcaagtat ttttttttaa acctccctgt atagaaaaaa atcattaagg atgtaaaagc
     7021 catgcttgcc tatttgctgt atacatgtaa tgaaattgta gataaagtgt agtgcattga
     7081 aacaaatgaa caaaaagtag atacttttac tatacaaggg tgctggtgca gaaaaaaata
     7141 tatatatttt tggaaatgta gcattttata ctttcaagtg ttataaaaaa aaagaaaaag
     7201 aacaaagaaa ccctttattt cattaaatga ttttttctgg tggttgtcaa gaaacaaaag
     7261 accaaaagag cctttttgtc tttctttttt attttttaag tattggaata agtctaaaga
     7321 aaagaaagtg ccttattttc cttcatggtc attcagtcaa gtgtctcata aagatcagct
     7381 cctccctcag aatacaagtt aatgcatgtt actcagtcgc ccagtatgtg aaagaagata
     7441 tgagggagac aaatgagttg atagtttgaa ttataggatt tttgccacgt taccttgatg
     7501 caaatttgcc aaatctgata ctgtgaaaag atttgataac ttttctaatg cctgactagt
     7561 aagttttaaa acatcattct ttaaaagaat agtttaatac ttttggttat tccaatcttc
     7621 aatgttaacc caaaggattc tgagataaaa attatgtgtc atctaaactt cagtttacag
     7681 acaaaattag agctttgttt tatttggaga agggggatgc attcatttga ttttgttttt
     7741 tgtttttaat taattgaata taataggata cctagcaaat gttttcacaa aagtgaatct
     7801 ttgtgatttt cattctagaa aacaatgttt taaatcaccc aaatttaatc acatgtcttt
     7861 atatcatacc agataactgg tgtagtgtat ccttttactg tttcaataac ctctgcctcc
     7921 cccacccctt aactttaaaa gaatgtgaaa aactagcatc atagtgcata taaatactca
     7981 accacatttc agcttaagct tctaatttct caagaagttg aaacagttag ttatgtagtt
     8041 gaagcaattt gtgtgcaaag cctacatcta aacacttgag tgaataatca ttaactgctc
     8101 agtaccagac gtggcaaatc tcaagtgaca gtggaccccc ccccccgccc agcttatcaa
     8161 ctcgtcccct cttccacacc ttcccagcat cacagtcaga ggtcagcagg aagctgagtc
     8221 attaccttct tggtgacctc ccccaccatc ttgtctcact tggaaaccgt tgtcagttta
     8281 tttactatgc aatagacatt cattgttttg tatccagcta gctttggttt aatatgccac
     8341 tgctttgtct ttctgttaca catacagttt tgatttattt acaatatatg ctgtgccatt
     8401 ttgattttta tattgtttgg ttggttgaat aaatttgcga cactcaaaca cttgaggtga
     8461 tagttgttaa aaacaatacc agtatttgat ccagtttcat ctcaactatg ttatacctgg
     8521 acattttaga tgtttatcaa aggtctttta tggggaagaa agtaaatgta tgaaataata
     8581 aatgtgtgac atttataggg aatgttggct ctgaacaaac ttttgaaaac ttggttgaca
     8641 aaattttgga tcaactgaaa aaagcatgac ttttgaaatc tctgaatgcc ttggttctca
     8701 gtattatcat tctttattga atttatttct tattaaaata tgtagttttt aagacttttt
     8761 ttctgacagt attatgtaat tttttagcgt gggtagatgg gagtgtcgct tgtatgttat
     8821 cgtacagctg acatgtattt ttgtctattc tttattatct tagtttcatg ctatgtatgt
     8881 accataacca acctattgcc tatgagaaac atgtaagata atgtatttac agccattgtt
     8941 acaagtttat aatgtatttt tctatcttgt tttatatgta tgttatataa cattcaaaaa
     9001 gaattttttt cttgattgag aaaaggatac aaaatgcaaa atccacaatt ttgataactg
     9061 aaaattgcca attgttttgc agtactttat tatattgggt gtcttgtctt ttttgggctt
     9121 ttagttagct aatgaatgaa tacattagac acttttgggt tttagttggg attttacata
     9181 gcttgcattt taattctttg gttctttgct gtttctatta acccacagca ttattttaat
     9241 aaatgttata ataccaacct actaactctg gactttgtct gtttattaac ctttatatgt
     9301 ttaattaaaa taaacaaata aagacaaaag aatgtaaagt cttgagttac tggactaacc
     9361 ctgaagaacg tgaccacaga taacatagtg tgacttgttt ttatgttgtt tgtcagctga
     9421 cagttttgca cactactgtt aaaatggctt tggttattct ggtcttttag cttgggggcc
     9481 ggggcgggtg tgggtgtagg tgcagtagag atgggaacaa agtagccttt gtttgaggca
     9541 ttcttctctt gccacttgcc tttcagcatc tgcattacta attccacacc ttatttttcc
     9601 ttctccaaaa taatcactgt ctgctcacag catcgagtaa aaagatacat tgtcatggta
     9661 tatacctgga gaaaccagtt tgattctttg ttgaaccatt tcttttaatt tctgtaaata
     9721 agtaatttta tggtcacatt gtaaagcaga gaaactgttg atattttacc tttatttaga
     9781 tttttgtttt aacttgacct ttttcctttg gaaagcgttg aacttgttta gctaactact
     9841 cctattaggg gagcttaact tgggtaaagt caaaggccca ctggctgttt ctcatggtgg
     9901 cctgaagccc cgctgctttc cagtgaggaa aagaaccctc agcacgttac tgagctttcc
     9961 tcaggtattt ttttctctgt cacctacttt acaaatacag tcagactaaa acattaaaca
    10021 agaagtttaa gggggaataa cattgggatt tgaaaagttg tatgtgatta atttcttgca
    10081 tgcaaatcaa tttaagattt cttaaatatc ttcatgcttt tcttggctgg aacttgggta
    10141 aattaacctg taattatgaa ttatttagtt taactcaagg tgcattttta tttcacagat
    10201 tgatacttgc ttttttctgt gaaacagttc tcctagatac caaaatcctc aggatgaatt
    10261 tttgcatttg taaataacaa tttatctttg taaattacat tttatttatt tagagttcta
    10321 aaattgaggg ctgaaatgaa tgacatgtaa tagaagacaa aactgtacca atacgctgtt
    10381 aaccaatcag actgtccagg tattctcatt tcataaatat gtatacacac atataaatac
    10441 acagagtagt gttagctgat gtgagtgata acagcgaatc accattgaga tggtcatttg
    10501 gatcatgtaa acaaaccgtg tcatgtctct gatgggagcg gtgggtagtg tactgttagg
    10561 tggacaggtc ttttaacatg ctactatttg taaaagtttc cgttgccata acagttcatg
    10621 tagtagtctg tgaaaattcg aagctgtctg tcaagctgct aatatacaag ttgtcatggt
    10681 accatgtaac ttaaattgat gaatttctat gcaatttact attctctgaa gcctatgaat
    10741 gcagcctcat ctcattttca gttaagggta ctttatgtat aattatgtca ttgctgcctt
    10801 ttatgtagga aatgtaaaaa agttttaaaa ggcgaaaata acattacaga tttcattttt
    10861 atacaggtta caatattaaa catgaaacta ccaaattcca agaatagtaa aattctagag
    10921 tcagttgatt gattgaaact atttgacaaa acagttgaaa gctgagcttt cagtcaagaa
    10981 gttggtgaaa ttaatgtcct taaacttttc ctttaggcaa aatgtcaggg aaaacttaac
    11041 atgaaagtag ttactcccat acgcaccagt gcagtagctc caggtgtaag aggtcacgaa
    11101 ggcaccctgc ccataaaacc aggatgtgca tacgtacaca caatcggtgt ctggttatgg
    11161 ttttctaaac actacataag gatctgaatt ttttagtgtg ccaaaagcaa acgataggtt
    11221 taaatgaaat tgctcactac caaatcaaga ctcttcatat atatacgtgt gtgtatatat
    11281 atatgtcata acactttcac gtgtgacagc ctaaggtttc tttagtttta ggatggggtg
    11341 gggtgggagt ggttttgcat gtttgaccag gatgtgatgc ctgtctttat tccttgataa
    11401 gaagtagctg ttacagcatt tcaagcaaat tattttaggt agaatagaac ttactgccaa
    11461 atgattattt atttagcaaa aattattctc caacttttcg aattcacaat ttttctaagt
    11521 gcatagagta gttttttaca ttgtcacgaa ttccttaata cctttattta aaatggaaaa
    11581 aatatggaca atattttaga aatatgtgct acacatctaa ttttatctgt agtttaagtg
    11641 atctaaattg agatgccttt gatatgaaga gatttaccaa cattatatgc actcgtgcct
    11701 tcaatgtgga atcaaactgg ttaacctcag cacagtcctc tcgtttctgt gtttctgctg
    11761 cactaattgc cagggggtgg gggagaaggc gaatgaatta attcatagta gaaggaggcg
    11821 ataggtgcag caaagggcag ccacagtgtt gattccacat tataatgttg ttgcctcttc
    11881 ttggcaaaag acaccacatt gtgggaagat ctcagcttcc agggtaaaag ttaatttata
    11941 acttaaaagt gctattaagt ttttattacc aaatatatct tttatggttt atattgtagt
    12001 ggtatgtatg aaacatttaa aattttactg tggaaattgt gtatatatat atatatagtc
    12061 gaaataggtg ttcacaggtc acatgtgaac ggagaactgc atgaccgtac atgaaatgca
    12121 ataaaccaac tggaaaaagt gcatgtgctt catcctctca agccaactgc agctggaaag
    12181 tgctgcttat cctccacccc cagaaaatgc atgtatcaat atgagaataa agaacgcaca
    12241 ctttcaattt tattgaggct ttcaacacta tttaaaagaa aatgtaagaa tttgacattc
    12301 tggagttatt ataacattag aaaatgagca taacattcac tctgatttta gccattaagg
    12361 gagattagta aacagactgc tacagtgttc catagttgga ctgtgcatcc aaaacatttt
    12421 tttatcttta ataaatggta cagtttttat gtagttttcg aatgtaagaa gaaaggaatg
    12481 ctgaccaaaa cttgatttca tcagcttcat gaaaaggact agtgtcatta acctgttgaa
    12541 cagaattggt ttattaaaaa aatcatttcc agtagtgtga aacctttacg agtctttaac
    12601 atctaaatgt tatgactcct tgtaccttaa gttttccagt ctttcttatt tatatcatct
    12661 ccaagtacct ctggctcctt tcctcttgct caccggaacc ttagttttcc tcaacagaat
    12721 gctttgttaa agtagcccac agttgcagga tccatagcac cgtcgtgcag actagcagcc
    12781 caaaggtgtg tttggtttgg cttatacggt gttttgcttt ttaaactact tgccataatt
    12841 taaaagtggc aacactagac ttaaaaaaaa aaaagtctga ttgcccatat tagatttttt
    12901 ttttaattct tcacaaaatc tgctcttcct gaaagatcaa agtgtctaga aagcccaaac
    12961 atgtattctt aacatagtag gcaccagctg aaactgagta attaaacggt cccctgaagc
    13021 caagtattcc ctggttagtc gccaccccac cactccttcc tgtctctagt gtcacacttg
    13081 ggctgttgat tttcttactc ttctcttgct ttaatccttc cccccggctc tctggctcct
    13141 gtggatatct gtgcttgttt cctggtccag gatggtgatc tgactttcaa accagcttct
    13201 caaaaggggt gacataaaat cagttttgat gtttttcctc ctgaaaaatc agatgaatat
    13261 tttagtcact gttactcatg cacattgtgt tcttatgttt acagaagtgc ttaagtgaat
    13321 ggaagcacta gacatttgga tttccttcct aacgtaattt ttaatgatta ccccttttat
    13381 acagtaattt gtggtcttta gaaagcagtt aaactaattg accatctaat agttgtacta
    13441 tacatatgtc taaaataata gtcatggtaa gtttggcatc atatcttccc caaaaaatgt
    13501 ttattaaaat tagattattc cagtttaatg ctattttgtg aactgtatac cctctgaaag
    13561 cgcttatttt tacatgctac acaacagttc caattttaag gagtgtctcc taaaattggg
    13621 atgaaaatct actgtagtct gttttaaagt atgctatact atgttcattg gttacttaac
    13681 tggatattaa tataaaggtt attacaagaa aaatgatgaa gagcaaaagg agaagaaaat
    13741 atttgcaagt gaatccacaa ttcttgcaga actatttgag ttgatactaa agattttatg
    13801 ttcactcctt taccttagaa ctgtcaagct tgggaatgag gaaagtgcct tggctgtgct
    13861 tgaaacctga attttagtgc ttcccttatt acattcattg ttttcaatga ttgatttata
    13921 aaattaagac atactggtag tacaagttga aagttggttt gaatacattt taattaaatg
    13981 ataatatgtt aatatgcttt tgttcattgc tttctcactg aggtaaaaca gcattaaaaa
    14041 gttgtccaga atttaaa
//
