LOCUS       NM_001301085            9360 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens QKI, KH domain containing RNA binding (QKI),
            transcript variant 5, mRNA.
ACCESSION   NM_001301085 XM_005267224
VERSION     NM_001301085.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9360)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360)
  AUTHORS   Zakutansky,P.M., Ku,L., Zhang,G., Shi,L., Li,Y., Yao,B.,
            Bassell,G.J., Read,R.D. and Feng,Y.
  TITLE     Isoform balance of the long noncoding RNA NEAT1 is regulated by the
            RNA-binding protein QKI, governs the glioma transcriptome, and
            impacts cell migration
  JOURNAL   J Biol Chem 300 (8), 107595 (2024)
   PUBMED   39032650
  REMARK    GeneRIF: Isoform balance of the long noncoding RNA NEAT1 is
            regulated by the RNA-binding protein QKI, governs the glioma
            transcriptome, and impacts cell migration.
REFERENCE   3  (bases 1 to 9360)
  AUTHORS   Wu,W., Cai,Y., Jin,J., Chen,Z. and Teng,M.
  TITLE     Circular RNA Circ_0001322 inhibits gastric cancer progression by
            modulating the miR-1264/QKI axis and suppressing the Hedgehog
            pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 190-197 (2024)
   PUBMED   38814217
  REMARK    GeneRIF: Circular RNA Circ_0001322 inhibits gastric cancer
            progression by modulating the miR-1264/QKI axis and suppressing the
            Hedgehog pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9360)
  AUTHORS   Wang,H.F., Zhou,X.F., Zhang,Q.M., Wu,J.Q., Hou,J.H., Xu,X.L.,
            Li,X.M. and Liu,Y.L.
  TITLE     Involvement of circRNA Regulators MBNL1 and QKI in the Progression
            of Esophageal Squamous Cell Carcinoma
  JOURNAL   Cancer Control 31, 10732748241257142 (2024)
   PUBMED   38769028
  REMARK    GeneRIF: Involvement of circRNA Regulators MBNL1 and QKI in the
            Progression of Esophageal Squamous Cell Carcinoma.
REFERENCE   5  (bases 1 to 9360)
  AUTHORS   Min,K.W., Jo,M.H., Song,M., Lee,J.W., Shim,M.J., Kim,K., Park,H.B.,
            Ha,S., Mun,H., Polash,A., Hafner,M., Cho,J.H., Kim,D., Jeong,J.H.,
            Ko,S., Hohng,S., Kang,S.U. and Yoon,J.H.
  TITLE     Mature microRNA-binding protein QKI promotes microRNA-mediated gene
            silencing
  JOURNAL   RNA Biol 21 (1), 1-15 (2024)
   PUBMED   38372062
  REMARK    GeneRIF: Mature microRNA-binding protein QKI promotes
            microRNA-mediated gene silencing.
REFERENCE   6  (bases 1 to 9360)
  AUTHORS   Wu,J.I., Reed,R.B., Grabowski,P.J. and Artzt,K.
  TITLE     Function of quaking in myelination: regulation of alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 99 (7), 4233-4238 (2002)
   PUBMED   11917126
REFERENCE   7  (bases 1 to 9360)
  AUTHORS   Li,Z.Z., Kondo,T., Murata,T., Ebersole,T.A., Nishi,T., Tada,K.,
            Ushio,Y., Yamamura,K. and Abe,K.
  TITLE     Expression of Hqk encoding a KH RNA binding protein is altered in
            human glioma
  JOURNAL   Jpn J Cancer Res 93 (2), 167-177 (2002)
   PUBMED   11856480
REFERENCE   8  (bases 1 to 9360)
  AUTHORS   Saccomanno,L., Loushin,C., Jan,E., Punkay,E., Artzt,K. and
            Goodwin,E.B.
  TITLE     The STAR protein QKI-6 is a translational repressor
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12605-12610 (1999)
   PUBMED   10535969
  REMARK    GeneRIF: There are many isoforms of this RNA binding protein. QKI-6
            has been shown to be a translational repressor.
REFERENCE   9  (bases 1 to 9360)
  AUTHORS   Chen,T. and Richard,S.
  TITLE     Structure-function analysis of Qk1: a lethal point mutation in
            mouse quaking prevents homodimerization
  JOURNAL   Mol Cell Biol 18 (8), 4863-4871 (1998)
   PUBMED   9671495
REFERENCE   10 (bases 1 to 9360)
  AUTHORS   Ebersole,T.A., Chen,Q., Justice,M.J. and Artzt,K.
  TITLE     The quaking gene product necessary in embryogenesis and myelination
            combines features of RNA binding and signal transduction proteins
  JOURNAL   Nat Genet 12 (3), 260-265 (1996)
   PUBMED   8589716
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356119.31, DQ323998.1,
            AL031781.1 and AW131362.1.
            
            On May 31, 2019 this sequence version replaced NM_001301085.1.
            
            Summary: The protein encoded by this gene is an RNA-binding protein
            that regulates pre-mRNA splicing, export of mRNAs from the nucleus,
            protein translation, and mRNA stability. The encoded protein is
            involved in myelinization and oligodendrocyte differentiation and
            may play a role in schizophrenia. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (5) lacks an in-frame segment in
            the 3' coding region, compared to variant 1. The resulting isoform
            (5) is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1748056.1,
                                           SRR3476690.461812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-564               AL356119.31        23790-24353
            565-1478            DQ323998.1         89-1002
            1479-9317           AL031781.1         4352-12190          c
            9318-9360           AW131362.1         21-63               c
FEATURES             Location/Qualifiers
     source          1..9360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q26"
     gene            1..9360
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="QKI, KH domain containing RNA binding"
                     /db_xref="GeneID:9444"
                     /db_xref="HGNC:HGNC:21100"
                     /db_xref="MIM:609590"
     exon            1..618
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..1478
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="isoform 5 is encoded by transcript variant 5;
                     homolog of mouse quaking QKI (KH domain RNA binding
                     protein); RNA binding protein HQK; quaking homolog, KH
                     domain RNA binding; QKI/LOC100132735 fusion; KH
                     domain-containing RNA-binding protein QKI"
                     /codon_start=1
                     /product="KH domain-containing RNA-binding protein QKI
                     isoform 5"
                     /protein_id="NP_001288014.1"
                     /db_xref="CCDS:CCDS75546.1"
                     /db_xref="GeneID:9444"
                     /db_xref="HGNC:HGNC:21100"
                     /db_xref="MIM:609590"
                     /translation="MVGEMETKEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERL
                     LDEEISRVRKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRI
                     LGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA
                     QNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPTAQAAP
                     RIITGPAPVLPPAALRTPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAIVPPGPEAGLI
                     YTPYEYPYTLAPATSILEYPIEPSGVLGAVATKVRRHDMRVHPYQRIVTADRAATGN"
     exon            619..761
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..878
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1022
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1110
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1386
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1461
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..9360
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4541..4546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      4564
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="major polyA site"
     regulatory      4620..4625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      4632
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      7423..7428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: AATAAA"
     polyA_site      7444
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      9276..9281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: ATTAAA"
     polyA_site      9295
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
     regulatory      9336..9341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
                     /note="hexamer: ATTAAA"
     polyA_site      9360
                     /gene="QKI"
                     /gene_synonym="Hqk; hqkI; QK; QK1; QK3"
ORIGIN      
        1 gcagtcggag cgcggcggca gcggcagagg cgccgcggcg gggaccagcc cagagagacc
       61 ccccgagccc gcggcacagg cggcggcggc gctgagcggg ctcgaccagc cgagcgagcg
      121 gcggccccgg ctcctcctcg tccggcgcca gcagcccgcg ccccgcgccc gcactcggcc
      181 agccgagacc cgcctcccgc ccgcccgccg gcctcgtgag ggacgcgccg agccgggcgg
      241 ccgagagcgg cggcggctgg gagcgcgtcg ggcccgggcg gaaagtgcct gcggggggcg
      301 ggcgagcgcg cggtgccggc cgccccgggg ctcggcgcgg gagccagagc gggagccggc
      361 gcggagcggg acgccgggtc ccgagcggcc cgcggccggg gctcgccccc gcccctccct
      421 cctctccggc ggcggcggcg gcggcggcgg gcggagtgag ctgcggagcc tggaatatgg
      481 tcggggaaat ggaaacgaag gagaagccga agcccacccc agattacctg atgcagctga
      541 tgaacgacaa gaagctcatg agcagcctgc ccaacttctg cgggatcttc aaccacctcg
      601 agcggctgct ggacgaagaa attagcagag tacggaaaga catgtacaat gacacattaa
      661 atggcagtac agagaaaagg agtgcagaat tgcctgatgc tgtgggacct attgttcagt
      721 tacaagagaa actttatgtg cctgtaaaag aatacccaga ttttaatttt gttgggagaa
      781 tccttggacc tagaggactt acagccaaac aacttgaagc agaaaccgga tgtaaaatca
      841 tggtccgagg caaaggctca atgagggata aaaaaaagga ggagcaaaat agaggcaagc
      901 ccaattggga gcatctaaat gaagatttac atgtactaat cactgtggaa gatgctcaga
      961 acagagcaga aatcaaattg aagagagcag ttgaagaagt gaagaaatta ttggtacctg
     1021 cagcagaagg agaagacagc ctgaagaaga tgcagctgat ggagcttgcg attctgaatg
     1081 gcacctacag agatgccaac attaaatcac caacagccca ggctgctcca aggatcatta
     1141 ctgggcctgc gccggttctc ccaccagctg ccctgcgtac tcctacgcca gctggcccta
     1201 ccataatgcc tttgatcaga caaatacaga ccgctgtcat gccaaacgga actcctcacc
     1261 caactgctgc aatagttcct ccagggcccg aagctggttt aatctataca ccctatgagt
     1321 acccctacac attggcacca gctacatcaa tccttgagta tcctattgaa cctagtggtg
     1381 tattaggtgc ggtggctact aaagttcgaa ggcacgatat gcgtgtccat ccttaccaaa
     1441 ggattgtgac cgcagaccga gccgccaccg gcaactaacc tatgaccttc tgacctctga
     1501 actcttcacc caatgatgac ctgaccatgc ctgcctgctg atcagttaac tggtaatcgc
     1561 ctttgcttgc ctgtcgtcag tgcagcgagc tgaggcactt gtccgttcgt cttaccatct
     1621 aaccaaacaa aagacaaaga aattgttgtc ctccaactca gctttttttt tttttttttc
     1681 ctgtttgggt gaaagtggtt ctagaaactg cactgaatag tagtaaagca ataaggccca
     1741 attcatccca cagcactgat catcttttaa tatcccaccc taagcgaacg gtaagaaggc
     1801 ctctcttaag aaggggagac agatggtcct taactactca atgacagagg cagttactgt
     1861 gagagacttc taggaatctt tttcttctca tagcgaagtc aaagctctct ctgaatgtac
     1921 tgtgtgatga tgcatcatgc atgaaccttc ggtcagggat atcattggtg aagtgatttc
     1981 aaaaagtatt caaaatttga tatgctgttt agtcactaca gtgccctcaa agggcagaag
     2041 ttgcagcctt ttttatattg cctgccaaaa tttgaagtat tagaagaaag tgtgccatga
     2101 gagaaaaact taaggagttt tgaaaagtaa tgcaaataac aaaactgcaa cactattttt
     2161 aaaaagataa atatctgagt taaaattact gaatctttat tttacaccta aaaaaatatg
     2221 agaacaaggt acatgcatta tgtgtcacat tactgggcaa actgttcaag tatttttttt
     2281 taaacctccc tgtatagaaa aaaatcatta aggatgtaaa agccatgctt gcctatttgc
     2341 tgtatacatg taatgaaatt gtagataaag tgtagtgcat tgaaacaaat gaacaaaaag
     2401 tagatacttt tactatacaa gggtgctggt gcagaaaaaa atatatatat ttttggaaat
     2461 gtagcatttt atactttcaa gtgttataaa aaaaaagaaa aagaacaaag aaacccttta
     2521 tttcattaaa tgattttttc tggtggttgt caagaaacaa aagaccaaaa gagccttttt
     2581 gtctttcttt tttatttttt aagtattgga ataagtctaa agaaaagaaa gtgccttatt
     2641 ttccttcatg gtcattcagt caagtgtctc ataaagatca gctcctccct cagaatacaa
     2701 gttaatgcat gttactcagt cgcccagtat gtgaaagaag atatgaggga gacaaatgag
     2761 ttgatagttt gaattatagg atttttgcca cgttaccttg atgcaaattt gccaaatctg
     2821 atactgtgaa aagatttgat aacttttcta atgcctgact agtaagtttt aaaacatcat
     2881 tctttaaaag aatagtttaa tacttttggt tattccaatc ttcaatgtta acccaaagga
     2941 ttctgagata aaaattatgt gtcatctaaa cttcagttta cagacaaaat tagagctttg
     3001 ttttatttgg agaaggggga tgcattcatt tgattttgtt ttttgttttt aattaattga
     3061 atataatagg atacctagca aatgttttca caaaagtgaa tctttgtgat tttcattcta
     3121 gaaaacaatg ttttaaatca cccaaattta atcacatgtc tttatatcat accagataac
     3181 tggtgtagtg tatcctttta ctgtttcaat aacctctgcc tcccccaccc cttaacttta
     3241 aaagaatgtg aaaaactagc atcatagtgc atataaatac tcaaccacat ttcagcttaa
     3301 gcttctaatt tctcaagaag ttgaaacagt tagttatgta gttgaagcaa tttgtgtgca
     3361 aagcctacat ctaaacactt gagtgaataa tcattaactg ctcagtacca gacgtggcaa
     3421 atctcaagtg acagtggacc cccccccccg cccagcttat caactcgtcc cctcttccac
     3481 accttcccag catcacagtc agaggtcagc aggaagctga gtcattacct tcttggtgac
     3541 ctcccccacc atcttgtctc acttggaaac cgttgtcagt ttatttacta tgcaatagac
     3601 attcattgtt ttgtatccag ctagctttgg tttaatatgc cactgctttg tctttctgtt
     3661 acacatacag ttttgattta tttacaatat atgctgtgcc attttgattt ttatattgtt
     3721 tggttggttg aataaatttg cgacactcaa acacttgagg tgatagttgt taaaaacaat
     3781 accagtattt gatccagttt catctcaact atgttatacc tggacatttt agatgtttat
     3841 caaaggtctt ttatggggaa gaaagtaaat gtatgaaata ataaatgtgt gacatttata
     3901 gggaatgttg gctctgaaca aacttttgaa aacttggttg acaaaatttt ggatcaactg
     3961 aaaaaagcat gacttttgaa atctctgaat gccttggttc tcagtattat cattctttat
     4021 tgaatttatt tcttattaaa atatgtagtt tttaagactt tttttctgac agtattatgt
     4081 aattttttag cgtgggtaga tgggagtgtc gcttgtatgt tatcgtacag ctgacatgta
     4141 tttttgtcta ttctttatta tcttagtttc atgctatgta tgtaccataa ccaacctatt
     4201 gcctatgaga aacatgtaag ataatgtatt tacagccatt gttacaagtt tataatgtat
     4261 ttttctatct tgttttatat gtatgttata taacattcaa aaagaatttt tttcttgatt
     4321 gagaaaagga tacaaaatgc aaaatccaca attttgataa ctgaaaattg ccaattgttt
     4381 tgcagtactt tattatattg ggtgtcttgt cttttttggg cttttagtta gctaatgaat
     4441 gaatacatta gacacttttg ggttttagtt gggattttac atagcttgca ttttaattct
     4501 ttggttcttt gctgtttcta ttaacccaca gcattatttt aataaatgtt ataataccaa
     4561 cctactaact ctggactttg tctgtttatt aacctttata tgtttaatta aaataaacaa
     4621 ataaagacaa aagaatgtaa agtcttgagt tactggacta accctgaaga acgtgaccac
     4681 agataacata gtgtgacttg tttttatgtt gtttgtcagc tgacagtttt gcacactact
     4741 gttaaaatgg ctttggttat tctggtcttt tagcttgggg gccggggcgg gtgtgggtgt
     4801 aggtgcagta gagatgggaa caaagtagcc tttgtttgag gcattcttct cttgccactt
     4861 gcctttcagc atctgcatta ctaattccac accttatttt tccttctcca aaataatcac
     4921 tgtctgctca cagcatcgag taaaaagata cattgtcatg gtatatacct ggagaaacca
     4981 gtttgattct ttgttgaacc atttctttta atttctgtaa ataagtaatt ttatggtcac
     5041 attgtaaagc agagaaactg ttgatatttt acctttattt agatttttgt tttaacttga
     5101 cctttttcct ttggaaagcg ttgaacttgt ttagctaact actcctatta ggggagctta
     5161 acttgggtaa agtcaaaggc ccactggctg tttctcatgg tggcctgaag ccccgctgct
     5221 ttccagtgag gaaaagaacc ctcagcacgt tactgagctt tcctcaggta tttttttctc
     5281 tgtcacctac tttacaaata cagtcagact aaaacattaa acaagaagtt taagggggaa
     5341 taacattggg atttgaaaag ttgtatgtga ttaatttctt gcatgcaaat caatttaaga
     5401 tttcttaaat atcttcatgc ttttcttggc tggaacttgg gtaaattaac ctgtaattat
     5461 gaattattta gtttaactca aggtgcattt ttatttcaca gattgatact tgcttttttc
     5521 tgtgaaacag ttctcctaga taccaaaatc ctcaggatga atttttgcat ttgtaaataa
     5581 caatttatct ttgtaaatta cattttattt atttagagtt ctaaaattga gggctgaaat
     5641 gaatgacatg taatagaaga caaaactgta ccaatacgct gttaaccaat cagactgtcc
     5701 aggtattctc atttcataaa tatgtataca cacatataaa tacacagagt agtgttagct
     5761 gatgtgagtg ataacagcga atcaccattg agatggtcat ttggatcatg taaacaaacc
     5821 gtgtcatgtc tctgatggga gcggtgggta gtgtactgtt aggtggacag gtcttttaac
     5881 atgctactat ttgtaaaagt ttccgttgcc ataacagttc atgtagtagt ctgtgaaaat
     5941 tcgaagctgt ctgtcaagct gctaatatac aagttgtcat ggtaccatgt aacttaaatt
     6001 gatgaatttc tatgcaattt actattctct gaagcctatg aatgcagcct catctcattt
     6061 tcagttaagg gtactttatg tataattatg tcattgctgc cttttatgta ggaaatgtaa
     6121 aaaagtttta aaaggcgaaa ataacattac agatttcatt tttatacagg ttacaatatt
     6181 aaacatgaaa ctaccaaatt ccaagaatag taaaattcta gagtcagttg attgattgaa
     6241 actatttgac aaaacagttg aaagctgagc tttcagtcaa gaagttggtg aaattaatgt
     6301 ccttaaactt ttcctttagg caaaatgtca gggaaaactt aacatgaaag tagttactcc
     6361 catacgcacc agtgcagtag ctccaggtgt aagaggtcac gaaggcaccc tgcccataaa
     6421 accaggatgt gcatacgtac acacaatcgg tgtctggtta tggttttcta aacactacat
     6481 aaggatctga attttttagt gtgccaaaag caaacgatag gtttaaatga aattgctcac
     6541 taccaaatca agactcttca tatatatacg tgtgtgtata tatatatgtc ataacacttt
     6601 cacgtgtgac agcctaaggt ttctttagtt ttaggatggg gtggggtggg agtggttttg
     6661 catgtttgac caggatgtga tgcctgtctt tattccttga taagaagtag ctgttacagc
     6721 atttcaagca aattatttta ggtagaatag aacttactgc caaatgatta tttatttagc
     6781 aaaaattatt ctccaacttt tcgaattcac aatttttcta agtgcataga gtagtttttt
     6841 acattgtcac gaattcctta atacctttat ttaaaatgga aaaaatatgg acaatatttt
     6901 agaaatatgt gctacacatc taattttatc tgtagtttaa gtgatctaaa ttgagatgcc
     6961 tttgatatga agagatttac caacattata tgcactcgtg ccttcaatgt ggaatcaaac
     7021 tggttaacct cagcacagtc ctctcgtttc tgtgtttctg ctgcactaat tgccaggggg
     7081 tgggggagaa ggcgaatgaa ttaattcata gtagaaggag gcgataggtg cagcaaaggg
     7141 cagccacagt gttgattcca cattataatg ttgttgcctc ttcttggcaa aagacaccac
     7201 attgtgggaa gatctcagct tccagggtaa aagttaattt ataacttaaa agtgctatta
     7261 agtttttatt accaaatata tcttttatgg tttatattgt agtggtatgt atgaaacatt
     7321 taaaatttta ctgtggaaat tgtgtatata tatatatata gtcgaaatag gtgttcacag
     7381 gtcacatgtg aacggagaac tgcatgaccg tacatgaaat gcaataaacc aactggaaaa
     7441 agtgcatgtg cttcatcctc tcaagccaac tgcagctgga aagtgctgct tatcctccac
     7501 ccccagaaaa tgcatgtatc aatatgagaa taaagaacgc acactttcaa ttttattgag
     7561 gctttcaaca ctatttaaaa gaaaatgtaa gaatttgaca ttctggagtt attataacat
     7621 tagaaaatga gcataacatt cactctgatt ttagccatta agggagatta gtaaacagac
     7681 tgctacagtg ttccatagtt ggactgtgca tccaaaacat ttttttatct ttaataaatg
     7741 gtacagtttt tatgtagttt tcgaatgtaa gaagaaagga atgctgacca aaacttgatt
     7801 tcatcagctt catgaaaagg actagtgtca ttaacctgtt gaacagaatt ggtttattaa
     7861 aaaaatcatt tccagtagtg tgaaaccttt acgagtcttt aacatctaaa tgttatgact
     7921 ccttgtacct taagttttcc agtctttctt atttatatca tctccaagta cctctggctc
     7981 ctttcctctt gctcaccgga accttagttt tcctcaacag aatgctttgt taaagtagcc
     8041 cacagttgca ggatccatag caccgtcgtg cagactagca gcccaaaggt gtgtttggtt
     8101 tggcttatac ggtgttttgc tttttaaact acttgccata atttaaaagt ggcaacacta
     8161 gacttaaaaa aaaaaaagtc tgattgccca tattagattt tttttttaat tcttcacaaa
     8221 atctgctctt cctgaaagat caaagtgtct agaaagccca aacatgtatt cttaacatag
     8281 taggcaccag ctgaaactga gtaattaaac ggtcccctga agccaagtat tccctggtta
     8341 gtcgccaccc caccactcct tcctgtctct agtgtcacac ttgggctgtt gattttctta
     8401 ctcttctctt gctttaatcc ttccccccgg ctctctggct cctgtggata tctgtgcttg
     8461 tttcctggtc caggatggtg atctgacttt caaaccagct tctcaaaagg ggtgacataa
     8521 aatcagtttt gatgtttttc ctcctgaaaa atcagatgaa tattttagtc actgttactc
     8581 atgcacattg tgttcttatg tttacagaag tgcttaagtg aatggaagca ctagacattt
     8641 ggatttcctt cctaacgtaa tttttaatga ttaccccttt tatacagtaa tttgtggtct
     8701 ttagaaagca gttaaactaa ttgaccatct aatagttgta ctatacatat gtctaaaata
     8761 atagtcatgg taagtttggc atcatatctt ccccaaaaaa tgtttattaa aattagatta
     8821 ttccagttta atgctatttt gtgaactgta taccctctga aagcgcttat ttttacatgc
     8881 tacacaacag ttccaatttt aaggagtgtc tcctaaaatt gggatgaaaa tctactgtag
     8941 tctgttttaa agtatgctat actatgttca ttggttactt aactggatat taatataaag
     9001 gttattacaa gaaaaatgat gaagagcaaa aggagaagaa aatatttgca agtgaatcca
     9061 caattcttgc agaactattt gagttgatac taaagatttt atgttcactc ctttacctta
     9121 gaactgtcaa gcttgggaat gaggaaagtg ccttggctgt gcttgaaacc tgaattttag
     9181 tgcttccctt attacattca ttgttttcaa tgattgattt ataaaattaa gacatactgg
     9241 tagtacaagt tgaaagttgg tttgaataca ttttaattaa atgataatat gttaatatgc
     9301 ttttgttcat tgctttctca ctgaggtaaa acagcattaa aaagttgtcc agaatttaaa
//
