LOCUS       NM_001394028             608 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens peptide YY (PYY), transcript variant 2, mRNA.
ACCESSION   NM_001394028
VERSION     NM_001394028.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Shepherd,A., Feinstein,L., Sabel,S., Rastelli,D., Mezhibovsky,E.,
            Matthews,L., Muppirala,A., Robinson,A., Sharma,K.R., ElSeht,A.,
            Zeve,D., Breault,D.T., Gershon,M.D. and Rao,M.
  TITLE     RET Signaling Persists in the Adult Intestine and Stimulates
            Motility by Limiting PYY Release From Enteroendocrine Cells
  JOURNAL   Gastroenterology 166 (3), 437-449 (2024)
   PUBMED   37995867
  REMARK    GeneRIF: RET Signaling Persists in the Adult Intestine and
            Stimulates Motility by Limiting PYY Release From Enteroendocrine
            Cells.
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Xu,X., Zhou,W., Tian,X., Jiang,Z., Fu,X., Cao,J., Sun,Y., Yang,B.,
            Li,X., Li,Y., Zhang,C. and Liu,G.
  TITLE     Peptide YY inhibits transcription and replication of hepatitis B
            virus by suppressing promoter/enhancer activity
  JOURNAL   Virus Genes 59 (5), 678-687 (2023)
   PUBMED   37380814
  REMARK    GeneRIF: Peptide YY inhibits transcription and replication of
            hepatitis B virus by suppressing promoter/enhancer activity.
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Kang,H., Park,C., Choi,Y.K., Bae,J., Kwon,S., Kim,J., Choi,C.,
            Seok,C., Im,W. and Choi,H.J.
  TITLE     Structural basis for Y2 receptor-mediated neuropeptide Y and
            peptide YY signaling
  JOURNAL   Structure 31 (1), 44-57 (2023)
   PUBMED   36525977
  REMARK    GeneRIF: Structural basis for Y2 receptor-mediated neuropeptide Y
            and peptide YY signaling.
REFERENCE   4  (bases 1 to 608)
  AUTHORS   Graybeal,A.J., Willis,J.L., Morales-Marroquin,E., Tinsley,G.M.,
            Messiah,S.E. and Shah,M.
  TITLE     Emerging evidence of the relationship between fat-free mass and
            ghrelin, glucagon-like peptide-1, and peptide-YY
  JOURNAL   Nutrition 103-104, 111815 (2022)
   PUBMED   36088864
  REMARK    GeneRIF: Emerging evidence of the relationship between fat-free
            mass and ghrelin, glucagon-like peptide-1, and peptide-YY.
            Review article
REFERENCE   5  (bases 1 to 608)
  AUTHORS   Manning,S. and Batterham,R.L.
  TITLE     The role of gut hormone peptide YY in energy and glucose
            homeostasis: twelve years on
  JOURNAL   Annu Rev Physiol 76, 585-608 (2014)
   PUBMED   24188711
  REMARK    GeneRIF: We critically discuss recent findings relating to the role
            of PYY in mediating the beneficial effects of bariatric surgery,
            the role of PYY in glucose homeostasis, the role of hepatoportal
            PYY in mediating its central physiological effects--{REVIEW}
            Review article
REFERENCE   6  (bases 1 to 608)
  AUTHORS   Hort,Y., Baker,E., Sutherland,G.R., Shine,J. and Herzog,H.
  TITLE     Gene duplication of the human peptide YY gene (PYY) generated the
            pancreatic polypeptide gene (PPY) on chromosome 17q21.1
  JOURNAL   Genomics 26 (1), 77-83 (1995)
   PUBMED   7782089
REFERENCE   7  (bases 1 to 608)
  AUTHORS   Facer,P., Bishop,A.E., Cole,G.A., Aitchison,M., Kendall,C.H., van
            Aswegen,G., Penketh,R.J., Rodek,C.H., McKeever,P. and Polak,J.M.
  TITLE     Developmental profile of chromogranin, hormonal peptides, and
            5-hydroxytryptamine in gastrointestinal endocrine cells
  JOURNAL   Gastroenterology 97 (1), 48-57 (1989)
   PUBMED   2721879
REFERENCE   8  (bases 1 to 608)
  AUTHORS   Eberlein,G.A., Eysselein,V.E., Schaeffer,M., Layer,P., Grandt,D.,
            Goebell,H., Niebel,W., Davis,M., Lee,T.D., Shively,J.E. et al.
  TITLE     A new molecular form of PYY: structural characterization of human
            PYY(3-36) and PYY(1-36)
  JOURNAL   Peptides 10 (4), 797-803 (1989)
   PUBMED   2587421
REFERENCE   9  (bases 1 to 608)
  AUTHORS   Tatemoto,K., Nakano,I., Makk,G., Angwin,P., Mann,M., Schilling,J.
            and Go,V.L.
  TITLE     Isolation and primary structure of human peptide YY
  JOURNAL   Biochem Biophys Res Commun 157 (2), 713-717 (1988)
   PUBMED   3202875
REFERENCE   10 (bases 1 to 608)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007993.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a member of the neuropeptide Y (NPY)
            family of peptides. The encoded preproprotein is proteolytically
            processed to generate two alternative peptide products that differ
            in length by three amino acids. These peptides, secreted by
            endocrine cells in the gut, exhibit different binding affinities
            for each of the neuropeptide Y receptors. Binding of the encoded
            peptides to these receptors mediates regulation of pancreatic
            secretion, gut mobility and energy homeostasis. Rare variations in
            this gene could increase susceptibility to obesity and elevated
            serum levels of the encoded peptides may be associated with
            anorexia nervosa. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13899.1, SRR18074967.3344798.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692052.1/ ENSP00000509262.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC007993.15        47580-47670
            92-279              AC007993.15        48037-48224
            280-360             AC007993.15        48331-48411
            361-608             AC007993.15        48540-48787
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..608
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /note="peptide YY"
                     /db_xref="GeneID:5697"
                     /db_xref="HGNC:HGNC:9748"
                     /db_xref="MIM:600781"
     exon            1..91
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..385
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 2; peptide tyrosine tyrosine; prepro-PYY"
                     /codon_start=1
                     /product="peptide YY isoform 1 preproprotein"
                     /protein_id="NP_001380957.1"
                     /db_xref="CCDS:CCDS32662.1"
                     /db_xref="GeneID:5697"
                     /db_xref="HGNC:HGNC:9748"
                     /db_xref="MIM:600781"
                     /translation="MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEE
                     LNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW"
     exon            92..279
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..360
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..608
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      580..585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /note="hexamer: AATAAA"
     polyA_site      608
                     /gene="PYY"
                     /gene_synonym="PYY-I; PYY1"
                     /note="major polyA site"
ORIGIN      
        1 agaggaggcc tcagcttgac ctgcggcagt gcagcccttg ggacttccct cgccttccac
       61 ctcctgctcg tctgcttcac aagctatcgc tatggtgttc gtgcgcaggc cgtggcccgc
      121 cttgaccaca gtgcttctgg ccctgctcgt ctgcctaggg gcgctggtcg acgcctaccc
      181 catcaaaccc gaggctcccc gcgaagacgc ctcgccggag gagctgaacc gctactacgc
      241 ctccctgcgc cactacctca acctggtcac ccggcagcgg tatgggaaaa gagacggccc
      301 ggacacgctt ctttccaaaa cgttcttccc cgacggcgag gaccgccccg tcaggtcgcg
      361 gtcggagggc ccagacctgt ggtgaggacc cctgaggcct cctgggagat ctgccaacca
      421 cgcccacgtc atttgcatac gcactcccga ccccagaaac ccggattctg cctcccgacg
      481 gcggcgtctg ggcagggttc gggtgcggcc ctccgcccgc gtctcggtgc ccccgccccc
      541 tgggctggag ggctgtgtgt ggtccttccc tggtcccaaa ataaagagca aattccacag
      601 aaacggaa
//
