LOCUS       NM_032709               2023 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens pyridine nucleotide-disulphide oxidoreductase domain 2
            (PYROXD2), mRNA.
ACCESSION   NM_032709 XM_001714371 XM_001725107 XM_001725403
VERSION     NM_032709.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Wang,T., Xie,X., Liu,H., Chen,F., Du,J., Wang,X., Jiang,X., Yu,F.
            and Fan,H.
  TITLE     Pyridine nucleotide-disulphide oxidoreductase domain 2 (PYROXD2):
            Role in mitochondrial function
  JOURNAL   Mitochondrion 47, 114-124 (2019)
   PUBMED   31170524
  REMARK    GeneRIF: data illustrated that PYROXD2 localizes to the
            mitochondrial inner membrane/matrix, and it plays important roles
            in regulating mitochondrial function.
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Liu,H., Jiang,X., Wang,T., Yu,F., Wang,X., Chen,J., Xie,X. and
            Fan,H.
  TITLE     Myeloid zinc finger 1 protein is a key transcription stimulating
            factor of PYROXD2 promoter
  JOURNAL   Oncol Rep 38 (5), 3245-3253 (2017)
   PUBMED   29048625
  REMARK    GeneRIF: MZF1 gene expression was not significantly correlated with
            PYROXD2 protein expression in the samples of resected tumor
            tissues, which revealed that the PYROXD2 promoter transcription
            activity was determined by the aggregated effect of numerous
            transcription factors. This finding may be helpful in understanding
            the underlying mechanism which regulates the PYROXD2 expression.
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Rueedi,R., Ledda,M., Nicholls,A.W., Salek,R.M., Marques-Vidal,P.,
            Morya,E., Sameshima,K., Montoliu,I., Da Silva,L., Collino,S.,
            Martin,F.P., Rezzi,S., Steinbeck,C., Waterworth,D.M., Waeber,G.,
            Vollenweider,P., Beckmann,J.S., Le Coutre,J., Mooser,V.,
            Bergmann,S., Genick,U.K. and Kutalik,Z.
  TITLE     Genome-wide association study of metabolic traits reveals novel
            gene-metabolite-disease links
  JOURNAL   PLoS Genet 10 (2), e1004132 (2014)
   PUBMED   24586186
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Hong,M.G., Karlsson,R., Magnusson,P.K., Lewis,M.R., Isaacs,W.,
            Zheng,L.S., Xu,J., Gronberg,H., Ingelsson,E., Pawitan,Y.,
            Broeckling,C., Prenni,J.E., Wiklund,F. and Prince,J.A.
  TITLE     A genome-wide assessment of variability in human serum metabolism
  JOURNAL   Hum Mutat 34 (3), 515-524 (2013)
   PUBMED   23281178
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Nicholson,G., Rantalainen,M., Li,J.V., Maher,A.D., Malmodin,D.,
            Ahmadi,K.R., Faber,J.H., Barrett,A., Min,J.L., Rayner,N.W.,
            Toft,H., Krestyaninova,M., Viksna,J., Neogi,S.G., Dumas,M.E.,
            Sarkans,U., Donnelly,P., Illig,T., Adamski,J., Suhre,K., Allen,M.,
            Zondervan,K.T., Spector,T.D., Nicholson,J.K., Lindon,J.C.,
            Baunsgaard,D., Holmes,E., McCarthy,M.I. and Holmes,C.C.
  CONSRTM   MolPAGE Consortium
  TITLE     A genome-wide metabolic QTL analysis in Europeans implicates two
            loci shaped by recent positive selection
  JOURNAL   PLoS Genet 7 (9), e1002270 (2011)
   PUBMED   21931564
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC361966.1, AK074429.1 and AL139243.11.
            
            On Nov 22, 2018 this sequence version replaced NM_032709.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074429.1, BC006131.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370575.5/ ENSP00000359607.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DC361966.1         40-150
            112-552             AK074429.1         112-552
            553-553             AL139243.11        42251-42251         c
            554-1749            AK074429.1         554-1749
            1750-1750           AL139243.11        28628-28628         c
            1751-2023           AK074429.1         1751-2023
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..2023
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /note="pyridine nucleotide-disulphide oxidoreductase
                     domain 2"
                     /db_xref="GeneID:84795"
                     /db_xref="HGNC:HGNC:23517"
                     /db_xref="MIM:617889"
     exon            1..174
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1793
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /codon_start=1
                     /product="pyridine nucleotide-disulfide oxidoreductase
                     domain-containing protein 2"
                     /protein_id="NP_116098.2"
                     /db_xref="CCDS:CCDS7474.1"
                     /db_xref="GeneID:84795"
                     /db_xref="HGNC:HGNC:23517"
                     /db_xref="MIM:617889"
                     /translation="MAASGRGLCKAVAASPFPAWRRDNTEARGGLKPEYDAVVIGAGH
                     NGLVAAAYLQRLGVNTAVFERRHVIGGAAVTEEIIPGFKFSRASYLLSLLRPQIYTDL
                     ELKKHGLRLHLRNPYSFTPMLEEGAGSKVPRCLLLGTDMAENQKQIAQFSQKDAQVFP
                     KYEEFMHRLALAIDPLLDAAPVDMAAFQHGSLLQRMRSLSTLKPLLKAGRILGAQLPR
                     YYEVLTAPITKVLDQWFESEPLKATLATDAVIGAMTSPHTPGSGYVLLHHVMGGLEGM
                     QGAWGYVQGGMGALSDAIASSATTHGASIFTEKTVAKVQVNSEGCVQGVVLEDGTEVR
                     SKMVLSNTSPQITFLKLTPQEWLPEEFLERISQLDTRSPVTKINVAVDRLPSFLAAPN
                     APRGQPLPHHQCSIHLNCEDTLLLHQAFEDAMDGLPSHRPVIELCIPSSLDPTLAPPG
                     CHVVSLFTQYMPYTLAGGKAWDEQERDAYADRVFDCIEVYAPGFKDSVVGRDILTPPD
                     LERIFGLPGGNIFHCAMSLDQLYFARPVPLHSGYRCPLQGLYLCGSGAHPGGGVMGAA
                     GRNAAHVAFRDLKSM"
     exon            175..194
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            195..288
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            289..362
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            363..518
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            519..672
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            673..734
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            735..832
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            833..974
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1109
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1182
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1339
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1494
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1601
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1722
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..2023
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2000..2005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /note="hexamer: ATTAAA"
     polyA_site      2023
                     /gene="PYROXD2"
                     /gene_synonym="C10orf33; FP3420; YUEF"
                     /note="major polyA site"
ORIGIN      
        1 aatcgctagc aaactccctg cctagcaagg cccagcctgg ggcagaaatg gctgcaagtg
       61 gccgaggtct ctgcaaggct gtggccgcct ctcccttccc ggcgtggaga cgagataaca
      121 cggaagccag gggaggtctg aagcctgagt atgatgcggt ggtgatagga gcaggacaca
      181 acggactggt ggctgcagcg tacctgcaga gactgggggt gaacaccgcc gtcttcgaga
      241 ggcgccatgt gatcgggggt gcagctgtca ctgaggagat catcccaggg tttaagttct
      301 cccgcgcgtc ctacctgctc agcctgctga ggccgcagat ttacactgat ctggagctga
      361 agaaacatgg gctgaggctt catcttcgaa acccctactc cttcaccccc atgctggaag
      421 agggtgcagg cagcaaggtg cccaggtgcc ttctgctggg cacagacatg gcagaaaacc
      481 agaagcagat cgcccagttc tcccagaagg atgcccaggt ctttcccaaa tatgaggagt
      541 tcatgcatcg cttggcatta gccattgacc ctctgctgga tgcggccccc gtggacatgg
      601 cggccttcca gcatggctcc ttgctgcaaa ggatgaggtc gctctccacc ctcaagcccc
      661 tgctgaaggc aggccgcatc ctgggagccc agcttccccg atattatgag gtcctcacag
      721 ctcccattac caaggtgctg gatcagtggt tcgagtctga gcctttaaaa gccactctag
      781 ccacagatgc agtgattgga gccatgacaa gtccccacac tccggggagt gggtatgtgc
      841 tgctgcacca tgtgatgggg ggcctggagg gaatgcaggg ggcctggggc tacgtccagg
      901 ggggcatggg tgccctctct gatgcgatcg caagctcagc caccacacat ggagcaagca
      961 tcttcactga aaagacagtg gcgaaggtgc aggtgaacag tgaaggctgt gttcaaggag
     1021 ttgtgctgga agatggcaca gaggtgagaa gcaaaatggt gctgtccaac acatcaccgc
     1081 agatcacctt cctgaagctg acgccacagg agtggcttcc tgaggagttc ctggagagaa
     1141 tctctcagct ggacacccgg tcgcctgtca ccaagatcaa tgtggccgta gacaggctgc
     1201 ccagcttcct ggcggccccc aatgctccca ggggccagcc gctgccccat caccaatgct
     1261 ccatccacct gaactgtgaa gacaccctcc tccttcatca ggcctttgaa gatgccatgg
     1321 atggcctgcc ttcccacagg cctgtgattg agctctgcat cccttcctcg ctggacccca
     1381 ccctggctcc ccctggctgc catgtagtct ccctcttcac tcagtacatg ccctatacgc
     1441 tggctggagg caaggcctgg gacgagcagg agagagacgc ttatgcagac agagtgtttg
     1501 attgcatcga ggtctatgcc cctggcttca aggactctgt ggttggcaga gacatcctca
     1561 caccaccaga tttggagaga atcttcgggc ttcctggagg gaacatattc cactgcgcca
     1621 tgtccctgga ccagctctac ttcgcccgcc ccgtgcccct gcattctggc taccgctgcc
     1681 ctctccaggg cctgtatctc tgtggaagtg gggctcatcc tggaggaggt gtgatgggag
     1741 ctgctgggcg aaatgcagca catgtggcct ttagggacct caagagcatg tgaccctgaa
     1801 ccagctctga cccaggaaga agactccacc cctgaattcc aagtgctcca ttggatcagc
     1861 ttcccaggaa gttcagcttc gggttagtac ataaggccac cacaatgctc aagaaattat
     1921 tttagaaaaa acgtacgagt tacatttagt gcaagttgac cttatgccca tgcctccata
     1981 catggactgg ttctgtttta ttaaaactaa tatttcatac aga
//
