LOCUS       NM_138300               3180 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pygopus family PHD finger 2 (PYGO2), mRNA.
ACCESSION   NM_138300
VERSION     NM_138300.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3180)
  AUTHORS   Ardalan Moghadam Al,F., Forghanifard,M.M. and Zarrinpour,V.
  TITLE     PYGO2 increases proliferation and migration capacities through
            critical signaling pathways in esophageal squamous cell carcinoma
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23625 (2024)
   PUBMED   38229324
  REMARK    GeneRIF: PYGO2 increases proliferation and migration capacities
            through critical signaling pathways in esophageal squamous cell
            carcinoma.
REFERENCE   2  (bases 1 to 3180)
  AUTHORS   Ling,J., Tang,Z., Yang,W., Li,Y. and Dong,X.
  TITLE     Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain
            malignant progression in colon cancer
  JOURNAL   Exp Cell Res 431 (1), 113696 (2023)
   PUBMED   37423512
  REMARK    GeneRIF: Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to
            maintain malignant progression in colon cancer.
REFERENCE   3  (bases 1 to 3180)
  AUTHORS   Shi,Y., Qin,B., Fan,X., Li,Y., Wang,Y., Yuan,W., Jiang,Z., Zhu,P.,
            Chen,J., Chen,Y., Li,F., Wan,Y., Wu,X. and Zhuang,J.
  TITLE     Novel biphasic mechanism of the canonical Wnt signalling component
            PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs
  JOURNAL   Cell Tissue Res 393 (1), 163-179 (2023)
   PUBMED   37233752
  REMARK    GeneRIF: Novel biphasic mechanism of the canonical Wnt signalling
            component PYGO2 promotes cardiomyocyte differentiation from
            hUC-MSCs.
REFERENCE   4  (bases 1 to 3180)
  AUTHORS   Soleymani Moud,S., Kamal Seraji,K., Ramezani,M. and Piravar,Z.
  TITLE     Association of Single Nucleotide Polymorphisms in the PYGO2 and
            PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male
            Patients
  JOURNAL   Iran J Med Sci 48 (1), 77-84 (2023)
   PUBMED   36688188
  REMARK    GeneRIF: Association of Single Nucleotide Polymorphisms in the
            PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian
            Infertile Male Patients.
REFERENCE   5  (bases 1 to 3180)
  AUTHORS   Yuan,W., Zhao,H., Zhou,A. and Wang,S.
  TITLE     Interference of EFNA4 suppresses cell proliferation, invasion and
            angiogenesis in hepatocellular carcinoma by downregulating PYGO2
  JOURNAL   Cancer Biol Ther 23 (1), 1-12 (2022)
   PUBMED   36404439
  REMARK    GeneRIF: Interference of EFNA4 suppresses cell proliferation,
            invasion and angiogenesis in hepatocellular carcinoma by
            downregulating PYGO2.
REFERENCE   6  (bases 1 to 3180)
  AUTHORS   Popadiuk,C.M., Xiong,J., Wells,M.G., Andrews,P.G., Dankwa,K.,
            Hirasawa,K., Lake,B.B. and Kao,K.R.
  TITLE     Antisense suppression of pygopus2 results in growth arrest of
            epithelial ovarian cancer
  JOURNAL   Clin Cancer Res 12 (7 Pt 1), 2216-2223 (2006)
   PUBMED   16609037
  REMARK    GeneRIF: The Expression of pygopus 2 protein mRNA levels were
            significantly higher in the epithelial ovarian cancer cell lines.
REFERENCE   7  (bases 1 to 3180)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   8  (bases 1 to 3180)
  AUTHORS   Townsley,F.M., Thompson,B. and Bienz,M.
  TITLE     Pygopus residues required for its binding to Legless are critical
            for transcription and development
  JOURNAL   J Biol Chem 279 (7), 5177-5183 (2004)
   PUBMED   14612447
REFERENCE   9  (bases 1 to 3180)
  AUTHORS   Thompson,B., Townsley,F., Rosin-Arbesfeld,R., Musisi,H. and
            Bienz,M.
  TITLE     A new nuclear component of the Wnt signalling pathway
  JOURNAL   Nat Cell Biol 4 (5), 367-373 (2002)
   PUBMED   11988739
REFERENCE   10 (bases 1 to 3180)
  AUTHORS   Kramps,T., Peter,O., Brunner,E., Nellen,D., Froesch,B.,
            Chatterjee,S., Murone,M., Zullig,S. and Basler,K.
  TITLE     Wnt/wingless signaling requires BCL9/legless-mediated recruitment
            of pygopus to the nuclear beta-catenin-TCF complex
  JOURNAL   Cell 109 (1), 47-60 (2002)
   PUBMED   11955446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN260857.1 and BC006132.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138300.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006132.1, SRR3476690.786079.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368457.3/ ENSP00000357442.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               CN260857.1         4-263
            261-3180            BC006132.1         227-3146
FEATURES             Location/Qualifiers
     source          1..3180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3180
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /note="pygopus family PHD finger 2"
                     /db_xref="GeneID:90780"
                     /db_xref="HGNC:HGNC:30257"
                     /db_xref="MIM:606903"
     exon            1..309
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1427
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /note="pygopus 2"
                     /codon_start=1
                     /product="pygopus homolog 2"
                     /protein_id="NP_612157.1"
                     /db_xref="CCDS:CCDS1075.1"
                     /db_xref="GeneID:90780"
                     /db_xref="HGNC:HGNC:30257"
                     /db_xref="MIM:606903"
                     /translation="MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKK
                     RRKSNTQGPAYSHLTEFAPPPTPMVDHLVASNPFEDDFGAPKVGVAAPPFLGSPVPFG
                     GFRVQGGMAGQVPPGYSTGGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNM
                     NFPSQPFNQPLGQNFSPPSGQMMPGPVGGFGPMISPTMGQPPRAELGPPSLSQRFAQP
                     GAPFGPSPLQRPGQGLPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPASTAFPQEPH
                     SGSPAAAVNGNQPSFPPNSSGRGGGTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACR
                     SEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVY
                     IREGMGQLVAANDG"
     exon            310..359
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..3180
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3158..3163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3180
                     /gene="PYGO2"
                     /gene_synonym="1190004M21Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggttccggtt gctgccgccg ctggcgggcg gcgagtctgg agagagcgcg cagtttgcgc
       61 ggcggctcgg cgcttccctg tcgtcgcact ttgtggttgc tgcagctcgg gggcctgggc
      121 tgcccctgac accccttctg ggcgatggtg cagcccaagg gcgcctccat cccccgccgc
      181 tgccgctaac ccgggtcccc cactccatgg ccgcctcggc gccgccccca ccggacaagc
      241 tggagggagg tggcggcccc gcaccgcccc ctgcgccgcc cagcaccggg aggaagcagg
      301 gcaaggccgg tctgcaaatg aagagtccag aaaagaagcg aaggaagtca aatactcagg
      361 gccctgcata ctcacatctg acggagtttg caccaccccc aactcccatg gtggatcacc
      421 tggttgcatc caaccctttt gaagatgact tcggagcccc caaagtgggg gttgcagccc
      481 ctccattcct tggcagtcct gtgcccttcg gaggcttccg tgtgcagggg ggcatggcgg
      541 gccaggtacc cccaggctac agcactggag gtggaggggg cccccagcca ctccgtcgac
      601 agccaccccc cttccctccc aatcctatgg gccctgcttt caacatgccc ccccagggtc
      661 ctggctaccc acccccaggc aacatgaact ttcccagcca acccttcaac cagcctctgg
      721 gtcaaaactt tagtcctccc agtgggcaga tgatgccggg cccagtgggg ggatttggtc
      781 ccatgatctc acccaccatg ggacagcctc ccagagcaga gctgggccca ccttctctgt
      841 cccaacgatt tgctcagcca ggggctcctt ttggcccttc tcctctccag agacctggtc
      901 aggggctccc cagcctgccg cctaacacaa gtccctttcc tggtccggac cctggctttc
      961 ctggccctgg tggtgaggat ggggggaagc ccttgaatcc acctgcttct actgcttttc
     1021 cccaggagcc ccactcaggc tccccggctg ctgctgttaa tgggaaccag cccagtttcc
     1081 ccccgaacag cagtgggcgg ggtgggggca ctccagatgc caacagcttg gcaccccctg
     1141 gcaaggcagg tgggggctcc gggccccagc ctcccccagg cttggtgtac ccatgtggtg
     1201 cctgtcggag tgaggtgaac gatgaccagg atgccattct gtgtgaggcc tcctgccaga
     1261 aatggttcca ccgtgagtgc acaggcatga ctgagagcgc ctatgggctg ctgaccactg
     1321 aagcttctgc cgtctgggcc tgcgatctct gcctcaagac caaggagatc cagtctgtct
     1381 acatccgtga gggcatgggg cagctggtgg ctgctaacga tgggtgacgc tggtgaagtg
     1441 gcccagggaa gtgcacatgt ctctccctgc tcttccaggg tgattttttt gatgtttggc
     1501 tcttggtcct tgtttccact ggctttccat ccccatgggg cagaaacagt ggctcctggg
     1561 agcagaaaag gaattgaggt gggcaggcag aagagcctgg attgctcact gttttgggaa
     1621 acttacatgt tgagatctac agagatccag gaaaccaaag ccctgctgag cagagccatt
     1681 ttgtggctat ttctggaggc ccaggagtgt ggctgcaaga gaaaaggggc tggaggaaga
     1741 tccggagggc aggggtgttc cctctgctga tgatggatgc ccctaacacc tgtgcctaac
     1801 acccctactg aaccccacag ctccagcctt agtttttgga gtcaagtgtt aaaggtttct
     1861 ggccagagga attggggtct tgccatccct gcaatagccc ttttatgggc tctgggagac
     1921 agctttaggg aataaatggg gattttcccc tttttctacc cactcctttg cttcctccaa
     1981 gacttaccca actccttccc cctcagagaa ccaaatagcc tgaggaagca ggagagttcc
     2041 tggttatggc agtttcttgg tgatttgggg cttcaagaca gtaggtgaga gatgctgtca
     2101 ggacgtatct tcttcatacc aaagtcactg gtcctttctc agcctctctc gtgcttttct
     2161 cctaatgacc atatttttgc caaaaattgg gatatgttat ctgacagacc agaatatttg
     2221 aagtttgggc tgtcctgaaa gtctggactt tggtggtacc ctcctccccc agcccatctg
     2281 ttgcacatta tactccgtgt gttcttcaac tttcggcgcc cttattcccc tgccttcctg
     2341 gcttgattga aggaaagctt gaaaaggcgc agagccctat acctcatttc ctccatgata
     2401 aaaggatcca agtgaggccc tgtcacagcc tgtgggtagg ggatgcggcg ggatcctcat
     2461 tgccatggta ctcaaaggta gaagagcctg gagtttgttg cttctctttg ctattctttc
     2521 atatcctctt gggcctggtg attaattagc aattctcatt cctctcagcc aaaggcctgc
     2581 actgggcttt atttgtcttt ttttattttt taagcactgc ctgccagaga tgggcctggg
     2641 gcctgatgag gaccttagcg ctgctcgttc tccttttctg ttcatgcaca cattcctcca
     2701 tggggtgggg aaggcaggca tggggtgtgg ccctcggaga agttaggagt cccccagctc
     2761 aagatacagt ggcaaagacc tagtggtccc ctacccccac ttctctcagt tcctggcatg
     2821 aggagagaag accctgctct ggtggagctg acaacctttg aggctgggag gagagcagcc
     2881 tctgggcatc gttcccagtg tccctcacac taaaacggcg tagatggcaa ccccccaccc
     2941 ccaccccgct gctcaactct tgtgtttgtt gttctgtttg ccccatttat ctgttgctgt
     3001 ttttgtgttg tcttcccctg ctccgcattt tgtaaaatgg cccctggggg agtgtttttg
     3061 ctggatctgc tccctctcgc tctctcactc cactactttt tggaacaaag tgatggcaga
     3121 atgcggtggt ggtgggggtc ttttgtactg ttggattaat aaaatgattt taaaatccca
//
