LOCUS       NM_001367806            8861 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens pygopus family PHD finger 1 (PYGO1), transcript
            variant 3, mRNA.
ACCESSION   NM_001367806 XM_011521446
VERSION     NM_001367806.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8861)
  AUTHORS   Wen,Y., Li,Y., Yang,B., Guo,X., Lin,L., Liang,J., Zhang,K., Li,X.,
            Jiang,Z., Wang,Y., Li,Y., Wu,X., Fan,X., Li,F. and Yuan,W.
  TITLE     Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer
            via the Wnt/beta-Catenin Pathway
  JOURNAL   Dis Markers 2022, 6993994 (2022)
   PUBMED   36398031
  REMARK    GeneRIF: Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung
            Cancer via the Wnt/beta-Catenin Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8861)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8861)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   4  (bases 1 to 8861)
  AUTHORS   Frank,B., Hoffmeister,M., Klopp,N., Illig,T., Chang-Claude,J. and
            Brenner,H.
  TITLE     Single nucleotide polymorphisms in Wnt signaling and cell death
            pathway genes and susceptibility to colorectal cancer
  JOURNAL   Carcinogenesis 31 (8), 1381-1386 (2010)
   PUBMED   20403915
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 8861)
  AUTHORS   Fiedler,M., Sanchez-Barrena,M.J., Nekrasov,M., Mieszczanek,J.,
            Rybin,V., Muller,J., Evans,P. and Bienz,M.
  TITLE     Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt
            signaling complex
  JOURNAL   Mol Cell 30 (4), 507-518 (2008)
   PUBMED   18498752
  REMARK    GeneRIF: Data show that human and Drosophila Pygo PHD fingers
            associate with their cognate HD1 domains from BCL9/Legless to bind
            specifically to the histone H3 tail methylated at lysine 4
            (H3K4me).
REFERENCE   6  (bases 1 to 8861)
  AUTHORS   Townsley,F.M., Thompson,B. and Bienz,M.
  TITLE     Pygopus residues required for its binding to Legless are critical
            for transcription and development
  JOURNAL   J Biol Chem 279 (7), 5177-5183 (2004)
   PUBMED   14612447
REFERENCE   7  (bases 1 to 8861)
  AUTHORS   Thompson,B., Townsley,F., Rosin-Arbesfeld,R., Musisi,H. and
            Bienz,M.
  TITLE     A new nuclear component of the Wnt signalling pathway
  JOURNAL   Nat Cell Biol 4 (5), 367-373 (2002)
   PUBMED   11988739
REFERENCE   8  (bases 1 to 8861)
  AUTHORS   Kramps,T., Peter,O., Brunner,E., Nellen,D., Froesch,B.,
            Chatterjee,S., Murone,M., Zullig,S. and Basler,K.
  TITLE     Wnt/wingless signaling requires BCL9/legless-mediated recruitment
            of pygopus to the nuclear beta-catenin-TCF complex
  JOURNAL   Cell 109 (1), 47-60 (2002)
   PUBMED   11955446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012378.10 and AC022083.6.
            
            On Dec 19, 2018 this sequence version replaced XM_011521446.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.153189.1,
                                           SRR1803617.351206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000563719.4/ ENSP00000457777.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               AC012378.10        49743-50253         c
            512-597             AC022083.6         113320-113405       c
            598-8861            AC022083.6         103294-111557       c
FEATURES             Location/Qualifiers
     source          1..8861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.3"
     gene            1..8861
                     /gene="PYGO1"
                     /note="pygopus family PHD finger 1"
                     /db_xref="GeneID:26108"
                     /db_xref="HGNC:HGNC:30256"
                     /db_xref="MIM:606902"
     exon            1..511
                     /gene="PYGO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             463..1722
                     /gene="PYGO1"
                     /note="isoform 2 is encoded by transcript variant 3;
                     pygopus-like protein 1; pygopus homolog 1"
                     /codon_start=1
                     /product="pygopus homolog 1 isoform 2"
                     /protein_id="NP_001354735.1"
                     /db_xref="CCDS:CCDS81885.1"
                     /db_xref="GeneID:26108"
                     /db_xref="HGNC:HGNC:30256"
                     /db_xref="MIM:606902"
                     /translation="MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKANT
                     QGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYS
                     TFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPS
                     YNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLES
                     NHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNV
                     NRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGH
                     SSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGC
                     DTCMADKDVQLMRTRETFGPSAVGSDA"
     exon            512..597
                     /gene="PYGO1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..8861
                     /gene="PYGO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8835..8840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PYGO1"
                     /note="hexamer: AATAAA"
     polyA_site      8861
                     /gene="PYGO1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtctgcga ctcgggagcg gcgagagagc agacctcctc ctcagagggc gctgtgagtg
       61 tgccgccagg gccgggccgc gagcctcctg cttcccctgt cagcggctcc tgaggcggcg
      121 gcgaagaaga aggagtggga ggaggcggcg gcggcggcgg cgcactcgcc ctcagcacat
      181 gccggccccg ggtggggggc cgcccccagg ccgcgctccc ggccaccgcc gctgagcccc
      241 gccggtgccc gcacgccgcc ccgccgcccc gccgccccga ggcctcgtcc tcctcccaaa
      301 ctttgcaaag tcggcccgcg tccccaccgc cctcggccgt gcctcggctc cgaggcttgc
      361 ctcgcagccg cagcggcccc gcgaggagga ggagccgccg ccgcagcatc aaagagaccg
      421 aattcccgcg gcctgggggg gagtcatgct ttgcggtctg taatgtcagc agaacaggag
      481 aaggatccca tttcgctgaa gagagttcga ggtggtgata gtggactgga tgggttagga
      541 ggaccaggtg tacaactagg aagcccagat aagaaaaagc gcaaggcaaa tacacaggga
      601 ccttctttcc ctccattgtc tgagtatgct ccaccaccga atccaaactc tgaccatcta
      661 gtggctgcta atccatttga tgacaactat aatactattt cctataaacc actaccttcg
      721 tcaaatccat atcttggccc tggttatcct ggctttggag gctatagtac attcagaatg
      781 ccacctcacg ttcccccaag aatgtcttcc ccatactgtg gtccttactc actcaggaac
      841 cagccacacc catttcctca gaatcctctg ggcatgggtt ttaatcgacc tcatgctttt
      901 aactttgggc cacatgataa ttcaagtttc ggtaatccat cttataataa tgcactaagt
      961 cagaatgtca acatgcctaa tcaacatttt agacaaaatc ctgctgaaaa tttcagtcaa
     1021 attcctccac agaatgctag ccaagtttct aaccccgatt tggcatctaa ttttgttcct
     1081 ggaaataatt caaattttac ttctccgtta gaatctaatc attcttttat tcctccccca
     1141 aacacttttg gtcaagcaaa agcaccaccc ccaaaacaag actttactca aggagcaacc
     1201 aaaaacacta atcaaaattc ctctgctcat ccacctcact tgaatatgga tgacacagtg
     1261 aatcagagta atattgaatt aaaaaatgtt aatcgaaaca atgcagtaaa tcaggagaac
     1321 agccgttcaa gtagcactga agccacaaac aataaccctg caaatgggac gcagaataag
     1381 ccacgacaac caagaggtgc agcagatgcc tgcaccacag aaaaaagcaa taaatcctct
     1441 cttcacccaa accgtcatgg ccattcgtct tctgacccag tgtatccttg tggaatttgt
     1501 acaaacgagg tgaacgatga tcaggatgcc atcttatgtg aggcctcttg tcagaaatgg
     1561 tttcatcgga tctgtactgg aatgactgaa acagcttatg gcctcttaac tgcagaagca
     1621 tctgcagtat ggggctgtga tacctgtatg gctgacaaag atgtccagtt aatgcgtact
     1681 agagaaactt ttggtccatc tgcagtgggc agtgatgctt aatcaaaggc attaactaaa
     1741 gtgggtttat tttcctgtgc attgcagaag ttcattgaca caggatttta atgttttaca
     1801 ttattttttt aaatgcatac acaaaaacat tatttactta gtttttatta atcacttcat
     1861 cactagagca aattttttat tgtctttgct tgctgtctta aatgagaata atgtatatgg
     1921 gggtgcttta gaaacataaa taaatgttag ttgttgttat ttatcacaaa cataaaagcc
     1981 tcttgaaact tcaaaataat atataacaaa tgtaggcaag ttttaacttt taaaagttag
     2041 aatcattgaa aaacgtgtat ttcagtgctg aactttggtt gtaccatatt aaagatttag
     2101 ttcaaaaagt ttatcaagga tccacttaac acgtcttcac aacataatat atgtaactgt
     2161 aacatggggg aaagcataca tttttatgga ttaaaaaaat aatagtatga caccagattc
     2221 ctcctccact agggtctttg gaatcaatga atttcatatt tcaagtgagt tttcaggata
     2281 tctgtttgta cagatacgag acagatctta gcatatagta aattctcagt aagtattgtt
     2341 gattaacttg tggatggtac cacatgaaat tgctaatatt agatcagttg aaaattgact
     2401 gcaattagta aagttggtat aacgtacgtt cccagttgtg ctatttagaa ttatgatagt
     2461 attatgctcc tacttttctt tgatattgag ttgtcttgtt attgtttatt gttttccaga
     2521 gaaatactat agtatccaca gaagaattgt gaatactttt ttataatttt gaactgggac
     2581 atattgcaga tgaggaaggt agaaacatcc atttggcctt agagggctct gctagtaaaa
     2641 gaactactca gtggtggttt gaaaaatctt gttctgggga tctgaatttc aaaaatgaac
     2701 cctaggggag atcaaaatcc attttaaaca aagatcaatt aagagccaaa gtgaaatcta
     2761 acttgcaaac aacaatttga agccttgcag cagacttaag gaattcccgc tctgactggg
     2821 gaaaagtata aaaatggacc tgagagtacc ctcttgaggg atgatcaaga atggagacag
     2881 ttggagttgt gctcattaag attcaaaaca gcagaaatcc atttttggag cagattataa
     2941 cctgtggcca aaaaaaaaaa atgtgtgctg tttgacagct aatggcaatt tatacaatca
     3001 ttggaggctg gtaaagctcc ctaatatgtt gccaccatta tcattgcaac caaaaaaatt
     3061 ctgaagattg tgtggtgatc tacgaaagag ataaataatt actgttattt aaacccaagt
     3121 gaaacaatga cggcagcagc atattatcaa gaaatttaaa ttatgcatga aaatgtgatt
     3181 taaaaacaat gtcctttggg taacacacaa gaacctacac tttcacagac aaggactcga
     3241 cctcacatgt cacaagctac taaagcaaag ttaagtgact tgggctatga aattttgtca
     3301 tgtccatttt agtcactgga cctttattcc atggactact gtctatcatt tggagctttt
     3361 tctaagaaac aatgcattcc ccaatcgaga tgaagtaact ggaagatgtt aacaatttat
     3421 acagcctaac aaatgatgaa ttttataaaa gttagacctt taatattctg ttggaagaaa
     3481 actattcatg ctcctgatgc atattttgat tgaataaaac ttattttttt aaatacattg
     3541 ttttaatttt gacctacaaa aacagcaatt tcatatggta caaggtaata caaggttttc
     3601 tccatttacc cttgactagt tagaggtgag tacaaaatat tttcagtagt tgtaaaatat
     3661 ttatctttac aattttagga aacaaaatga tataaactat acttctaggt actcctttgt
     3721 gtgaaaactt taccagttga agcaggttaa aatgcagtat tttgggctga caggcatttg
     3781 atggtgttca gtagtgtact tgaagatctc attttacttg gattttttat tatacatatt
     3841 tctctaaatg tttaaggacc tagttatgtt gctcctgaaa gtttaatgag tgctgatttt
     3901 taataaatga tgcactgtat gctgtatgcc tagttgtagc atcagatcat gatttattat
     3961 taccctgaat agagctagat gatagatatt ttgagtagaa ctttccagtg ttctcaggag
     4021 ttaacacttt acatggtagt acttgagttg tgatcattac taaaatcaat tatgcagttt
     4081 cttaaaccct ttatctcttt aagtttcagt agttagctgt ttttgtgaaa atgaaataac
     4141 ttctcccaag ctagtctaaa ggtatgtgtt atgcaatata attcattttc tatttccaca
     4201 tagttgtttt taaaaaccta caaacaggtg aatttttatt caggtgttta ggtcttcaaa
     4261 gcaccttact taaataagaa tctgtaaata ttcaaaagaa aaactcacgg ttcattctga
     4321 tagtgaatca tagccaaact gtaatcatag ctgatgaata gcgttcatgt gtttgaatta
     4381 attttcctgc tagttctaca tttgtctcta cataatgcta agtcaaaagt tatatagatg
     4441 cttttggatg gaataagtga tgaactgtaa gaatagccag atgataattt gtctgaagaa
     4501 ggctattata caaactgaaa tggcttctta ggataaatga taagctgcct tcaactttaa
     4561 aaatatgcag tgatggaaaa aaacacaggt ggaattgtac cttttttggt ataatccctt
     4621 tccttcactg aaagtcctca tcttacacac acacacacac acacacaccc cccacagttt
     4681 ctccaacatc cttgagtttt gcttaaattc aacctggcta actatgagca tctaggttta
     4741 ctcaccaaag ctaggttatt gacagaaagg tgggtttttt tttgtttttt ttgttttgtt
     4801 ttgttttgtt tttgtttttt gccagtcttg ctctgttgcc caggctggag tgcagtgatg
     4861 agatctcggc tcactgcaac gtctgccttc ctggttcaag tgattctcct gcctcagcct
     4921 cctgagtagc tgggattaca gtcgcccacc atcacacctg gctaattttt gtatttttag
     4981 tagagacggg ttcaccatgt tggccaggct ggtgtcaaac tcctgacctc aagtgatctg
     5041 cccgcctcag cctcccaaag tgctgggatt acaggtgtaa gccaccacgc ctggccagac
     5101 agaaaatttt aaaaagcatc agttcctttc tcagaacttg acttgctcat gcactagaga
     5161 atttgtggtc cacatgcttc taggtgttac tcgattcact aatactgaaa cagctcagct
     5221 tgtgaaagat aaattgttct tcagacagag tgcttagaat tagatttgtg atcagtgttt
     5281 tccttttgtg tgaaatactt tagagtactg ctataattgt tattcaaatt agaaggttat
     5341 atacataaaa ctaaagattt tcttgtacta gtgcttattc ttcataaaca cagtgtaaag
     5401 aaatctactt ttttggtggt ttgttttaga ctcccaactc tgcctagtgg cagaaaaacc
     5461 tcttaatagt gtgggtcatc ataaaatctg ccaactttaa tccaaataag tatcaagagt
     5521 cttcattcaa tattctttca aacttgtttg tctcgaacaa attagagttt tagcacttat
     5581 tgttcaatgt actatagtaa ttgtatttaa tagtaagaaa atatataagc aatgattttt
     5641 taaaagggag ttctcaagag ttttggattt ctttctgccg tgtatagagg tttcttatgc
     5701 atggacattt gtgctgtttt atatcttttt caattaaaaa aaaatttaaa ggcatcaggc
     5761 tccctaagtt catttgtaaa tagtggcttg gaactctaca caatagggaa gctcctaaag
     5821 gctcatttag accataatct agttaatagt atcatgctga actctcagtt ttctttagga
     5881 aaccaatcaa tcagtgtagg agggagaaag aagcagaggt cttgtctttt tcctgatgtg
     5941 attaggaggt taagttcttt ggtgtgggtt tctttgcatt tgccccctta ccatgctaaa
     6001 ctctggtgaa atgtataagc agccttggct tttcctctcc tgggtgctct gtgcttcaac
     6061 attttatatc tttcctccca tcagaaatcc tgtgtctttg tgtggcagta gtagttggct
     6121 agactttaag agaaaagcat tttctactaa ggtatgaatg aagatagtgg gaaaagtgtc
     6181 attaaatttc ttttttaaaa aagtatgttt attaagaatg aatctttaat atctaacatt
     6241 tcagacaata tgaccgcatt tcagatacca tgggaagcag tacatttagt gaattagctg
     6301 gtactgtctg agggtacttc cagtttcctt taggctgttg tgacttttca cagcttcctc
     6361 tcctctaatt ctgaacttag agattttctt ctcatttcta atttttagta gcttattgtt
     6421 ccatccagta gagcattata aaagtcacat ctgcatcttc caacttatgg tacagtgatg
     6481 ggaatttgga agcacccctg gagcaaagag gctagggata gcattaacat ctcccaagac
     6541 aagtggtata ggggaaatga aggaaagact gtggccatgt atatgccagg cgttaataca
     6601 tcagagctgc ctgtatttaa tttaaaactt ttgatgaaac tcagtggata agcatctttg
     6661 tcatattttg tcaataatac attacttgca attatattaa aacttattct aaatacctgt
     6721 acctttcttg ttctgtagat gtgtagatga tgttgcttgt ttgtcaaaat attatctttt
     6781 ataaaagaaa gtcctgcttc ttatcatgat gtatgtgact taaatgattg tttcatatta
     6841 aaactatttc ttccttatgt actgtttaca tatacctctt tttgggatat tagttcagta
     6901 cttttataca aatctgagtg tgttccacat tggtgacatg tatttttgca gtaacttttt
     6961 gttttgttct tagaacatgt ctaaagtaac acatgcacta gtgctgtggt ctgtggcaaa
     7021 attactgtaa ttcaaattgg aaaaaaaaat gtttccagac tttgtccaac atttattcct
     7081 atggcaaagg aaattactat gtaatactaa ttatttctta tgctggtatg ttttaagcta
     7141 ctctatgaag tatgtgaaac atcaatattt atggattaat agatggcctg atgtctttca
     7201 aatgggagag gagtaaattt tagtgttacc aactcatgac acttgtaata caataaatct
     7261 taaaattttt attttccact tacaggtata ctttactaaa taattacctt aaatggcagt
     7321 gcatattagg attttttagc acatactact aaaattatat agtaactttt aacttgtgct
     7381 gatatttccc aaccaaaaaa gacatcattc acttcatcat aaccaaaata agtagtactg
     7441 taatatttat cttcatttat ttagacatga ttaagatacc gtaagactcc tctaatttac
     7501 ctggaatttt tagccattga ttcaaggact tgaatgctgt ttacttggta ctacctaatg
     7561 aaaggatttg gtaataaagg ttataatcac gattttaaag aaaaatgttt catcttgaag
     7621 gcaaattttt aagcttttta tttagaggtg tttacttaag aatagtaatt taaaagcatt
     7681 cttattttgt cattaagaca agtacccaaa agaattgtaa taagtaatac ttggccaatg
     7741 caaatttgta catttgaaat catacacttg aaagaaaaaa atgaaggctt gtgagtgctt
     7801 aaactgcata tctttttaaa aattcaaatt ttagacatat cagtttaaat tatccttaat
     7861 aaggttttac tatgtcagtg atgtatatta caaaatgtct acctatgtta tgttaatgat
     7921 atctctatac tgcatcatat tcggcatggt tatggtatat tttgtacttt tgattgtgga
     7981 ctattgatag gattgatata gcaataaatc tgattcagac ttaatatttt ttaaaacgct
     8041 agataccata ctgtatcata atcctattat atttgacttg aatgcccaaa attttcatag
     8101 ttctatattt tatgttaaaa atttagtatt acatgttagg gatttatttt tgtctgctat
     8161 tttcacatac attcttttag aactgagtct gtttctattt agatcataga cgtctaaaga
     8221 agtattatta attcatgaac tgctttgtgg aaaaatttaa ataaagtatg aaatgactag
     8281 attaccccaa attgtttatt tttttttttg gttaatgacc aggttacaat tctcagacaa
     8341 atgaaattgg cttgataact gattgaatat agtagataat ggaaagtttg actctttaag
     8401 ggcttccaag tgttaaatac attctcaatt ctgaattact tcatagtaac tacttaaata
     8461 atggtaagcc aattctcctt tttctttttg agatatttaa cacaatttgc gtcttctgat
     8521 cccattccct tcttccccaa aaaccatgct agaatttaaa attggaagag tttaatttgt
     8581 catctacatt ttagtttttt tattctatag ataagtaaga agacaagtag acgttctgct
     8641 gtcaagacag tccatgttat tgttggccat tcttttcagg gataatgctt aatgttattt
     8701 gtgcgttgta taaggaatgt tgtttatcag tatatagacc taccattagt agaaatgatg
     8761 tatggcaggc tttcttgaat aatatgtatt gtaagtttgt ttcctatagt gttattatgg
     8821 ttcagattct tttaaataaa gctagttttt aaagagaaaa a
//
