LOCUS       NM_002862               4116 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens glycogen phosphorylase B (PYGB), mRNA.
ACCESSION   NM_002862
VERSION     NM_002862.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Ren,L.K., Lu,R.S., Fei,X.B., Chen,S.J., Liu,P., Zhu,C.H., Wang,X.
            and Pan,Y.Z.
  TITLE     Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic
            biomarker and gene therapy target
  JOURNAL   J Cancer Res Clin Oncol 150 (3), 127 (2024)
   PUBMED   38483604
  REMARK    GeneRIF: Unveiling the role of PYGB in pancreatic cancer: a novel
            diagnostic biomarker and gene therapy target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Xia,B., Zhang,K. and Liu,C.
  TITLE     PYGB Promoted Tumor Progression by Regulating Wnt/beta-Catenin
            Pathway in Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 19, 1533033820926592 (2020)
   PUBMED   32462986
  REMARK    GeneRIF: PYGB Promoted Tumor Progression by Regulating
            Wnt/beta-Catenin Pathway in Gastric Cancer.
REFERENCE   6  (bases 1 to 4116)
  AUTHORS   Nihira,M., Anderson,K., Gorin,F.A. and Burns,M.S.
  TITLE     Primate rod and cone photoreceptors may differ in glucose
            accessibility
  JOURNAL   Invest Ophthalmol Vis Sci 36 (7), 1259-1270 (1995)
   PUBMED   7775103
REFERENCE   7  (bases 1 to 4116)
  AUTHORS   Yasuda,K., Espinosa,R. 3rd, Davis,E.M., Le Beau,M.M. and Bell,G.I.
  TITLE     Human somatostatin receptor genes: localization of SSTR5 to human
            chromosome 20p11.2
  JOURNAL   Genomics 17 (3), 785-786 (1993)
   PUBMED   8244401
REFERENCE   8  (bases 1 to 4116)
  AUTHORS   Gelinas,R.P., Froman,B.E., McElroy,F., Tait,R.C. and Gorin,F.A.
  TITLE     Human brain glycogen phosphorylase: characterization of fetal cDNA
            and genomic sequences
  JOURNAL   Brain Res Mol Brain Res 6 (2-3), 177-185 (1989)
   PUBMED   2615594
REFERENCE   9  (bases 1 to 4116)
  AUTHORS   Newgard,C.B., Littman,D.R., van Genderen,C., Smith,M. and
            Fletterick,R.J.
  TITLE     Human brain glycogen phosphorylase. Cloning, sequence analysis,
            chromosomal mapping, tissue expression, and comparison with the
            human liver and muscle isozymes
  JOURNAL   J Biol Chem 263 (8), 3850-3857 (1988)
   PUBMED   3346228
REFERENCE   10 (bases 1 to 4116)
  AUTHORS   Rath,V.L., Newgard,C.B., Sprang,S.R., Goldsmith,E.J. and
            Fletterick,R.J.
  TITLE     Modeling the biochemical differences between rabbit muscle and
            human liver phosphorylase
  JOURNAL   Proteins 2 (3), 225-235 (1987)
   PUBMED   3447179
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121772.19.
            
            On Nov 26, 2018 this sequence version replaced NM_002862.3.
            
            Summary: The protein encoded by this gene is a glycogen
            phosphorylase found predominantly in the brain. The encoded protein
            forms homodimers which can associate into homotetramers, the
            enzymatically active form of glycogen phosphorylase. The activity
            of this enzyme is positively regulated by AMP and negatively
            regulated by ATP, ADP, and glucose-6-phosphate. This enzyme
            catalyzes the rate-determining step in glycogen degradation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.211977.1,
                                           SRR1660807.231969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216962.9/ ENSP00000216962.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AL121772.19        17463-17799
            338-439             AL121772.19        28615-28716
            440-518             AL121772.19        38507-38585
            519-622             AL121772.19        40761-40864
            623-754             AL121772.19        43970-44101
            755-866             AL121772.19        46024-46135
            867-949             AL121772.19        46622-46704
            950-1093            AL121772.19        47697-47840
            1094-1186           AL121772.19        48435-48527
            1187-1333           AL121772.19        49644-49790
            1334-1497           AL121772.19        50327-50490
            1498-1612           AL121772.19        51411-51525
            1613-1714           AL121772.19        52554-52655
            1715-1862           AL121772.19        53482-53629
            1863-1921           AL121772.19        57803-57861
            1922-2063           AL121772.19        59859-60000
            2064-2271           AL121772.19        61784-61991
            2272-2406           AL121772.19        63536-63670
            2407-2473           AL121772.19        64982-65048
            2474-4116           AL121772.19        65748-67390
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..4116
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /note="glycogen phosphorylase B"
                     /db_xref="GeneID:5834"
                     /db_xref="HGNC:HGNC:9723"
                     /db_xref="MIM:138550"
     exon            1..337
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2626
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /EC_number="2.4.1.1"
                     /note="phosphorylase, glycogen; brain"
                     /codon_start=1
                     /product="glycogen phosphorylase, brain form"
                     /protein_id="NP_002853.2"
                     /db_xref="CCDS:CCDS13171.1"
                     /db_xref="GeneID:5834"
                     /db_xref="HGNC:HGNC:9723"
                     /db_xref="MIM:138550"
                     /translation="MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDR
                     NVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVN
                     LGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGI
                     RYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLD
                     TQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENI
                     SRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKV
                     AIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSM
                     FEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
                     HAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKI
                     GEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDV
                     HVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLV
                     TSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKF
                     MLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELK
                     QAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEW
                     TKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNIPRD"
     exon            338..439
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            440..518
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            519..622
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            623..754
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            755..866
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            867..949
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1093
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1186
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1333
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1497
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1612
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1714
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1862
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1921
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2063
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2271
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2406
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2473
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..4116
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /note="hexamer: ATTAAA"
     polyA_site      4116
                     /gene="PYGB"
                     /gene_synonym="GPBB"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcgg cgccagagca gctgcaccat cccggcgttc gcgtgtgccg ccgctttcct
       61 cctccatctc ttttcctccg cctccgccgg cgcgatggcg aagccgctga cggacagcga
      121 gaagcggaag cagatcagcg tgcgcggcct ggcggggcta ggcgacgtgg ccgaggtgcg
      181 gaagagcttc aaccggcact tgcacttcac gctggtcaag gaccgcaatg tggccacgcc
      241 ccgcgactac ttcttcgcgc tggcgcacac ggtgcgcgac cacctcgtgg gccgctggat
      301 ccgcacgcag cagcactact acgagcgcga ccccaagcgc atttattatc tttccctgga
      361 attctacatg ggtcgcacgc tgcagaacac gatggtgaac ctgggccttc agaatgcctg
      421 cgatgaagcc atctatcagt tggggttaga cttggaggaa ctcgaggaga tagaagaaga
      481 tgctggcctt gggaatggag gcctggggag gctggcagcg tgtttccttg actcaatggc
      541 taccttgggc ctggcagcat acggctatgg aatccgctat gaatttggga tttttaacca
      601 gaagattgtc aatggctggc aggtagagga ggccgatgac tggctgcgct acggcaaccc
      661 ctgggagaaa gcgcggcctg agtatatgct tcccgtgcac ttctacggac gcgtggagca
      721 cacccccgac ggcgtgaagt ggctggacac acaggtggtg ctggccatgc cctacgacac
      781 cccagtgccc ggctacaaga acaacaccgt caacaccatg cggctgtggt ccgccaaggc
      841 tcccaacgac ttcaagctgc aggacttcaa cgtgggagac tacatcgagg cggtcctgga
      901 ccggaacttg gctgagaaca tctccagggt cctgtatcca aatgataact tctttgaggg
      961 gaaggagctg cggctgaagc aggagtactt cgtggtggcc gccacgctcc aggacatcat
     1021 ccgccgcttc aagtcgtcca agttcggctg ccgggaccct gtgagaacct gtttcgagac
     1081 gttcccagac aaggtggcca tccagctgaa cgacacccac cccgccctct ccatccctga
     1141 gctcatgcgg atcctggtgg acgtggagaa ggtggactgg gacaaggcct gggaaatcac
     1201 gaagaagacc tgtgcataca ccaaccacac tgtgctgcct gaggccttgg agcgctggcc
     1261 cgtgtccatg tttgagaagc tgctgccgcg gcacctggag ataatctatg ccatcaacca
     1321 gcggcacctg gaccacgtgg ccgcgctgtt tcccggcgat gtggaccgcc tgcgcaggat
     1381 gtctgtgatc gaggaggggg actgcaagcg gatcaacatg gcccacctgt gtgtgattgg
     1441 gtcccatgct gtcaatggtg tggcgaggat ccactcggag atcgtgaaac agtcggtctt
     1501 taaggatttt tatgaactgg agccagagaa gttccagaat aagaccaatg gcatcacccc
     1561 ccgccggtgg ctgctgctgt gcaacccggg gctggccgat accatcgtgg agaaaattgg
     1621 ggaggagttc ctgactgacc tgagccagct gaagaagctg ctgccgctgg tcagtgacga
     1681 ggtgttcatc agggacgtgg ccaaggtcaa acaggagaac aagctcaagt tctcggcctt
     1741 cctggagaag gagtacaagg tgaagatcaa cccctcctcc atgttcgatg tgcatgtgaa
     1801 gaggatccac gagtacaagc ggcagctgct caactgcctg cacgtcgtca ccctgtacaa
     1861 tcgaatcaag agagacccgg ccaaggcttt tgtgcccagg actgttatga ttgggggcaa
     1921 ggcagcgccc ggttaccaca tggccaagct gatcatcaag ttggtcacct ccatcggcga
     1981 cgtcgtcaat catgacccag ttgtgggtga caggttgaaa gtgatcttcc tggagaacta
     2041 ccgtgtgtcc ttggctgaga aagtgatccc ggccgctgat ctgtcgcagc agatctccac
     2101 tgcaggcacc gaggcctcag gcacaggcaa catgaagttc atgctcaacg gggccctcac
     2161 catcggcacc atggacggcg ccaacgtgga gatggccgag gaggccgggg ccgagaacct
     2221 cttcatcttc ggcctgcggg tggaggatgt cgaggccttg gaccggaaag ggtacaatgc
     2281 cagggagtac tacgaccacc tgcccgagct gaagcaggcc gtggaccaga tcagcagtgg
     2341 ctttttttct cccaaggagc cagactgctt caaggacatc gtgaacatgc tgatgcacca
     2401 tgacaggttc aaggtgtttg cagactatga agcctacatg cagtgccagg cacaggtgga
     2461 ccagctgtac cggaacccca aggagtggac caagaaggtc atcaggaaca tcgcctgctc
     2521 gggcaagttc tccagtgacc ggaccatcac ggagtatgca cgggagatct ggggtgtgga
     2581 gccctccgac ctgcagatcc cgccccccaa catcccccgg gactaggcac accctgcctt
     2641 ggcgggacca gcgggcattt gttttcttgc tgactttgca cctccttttt tccccaaaca
     2701 ctttgccagc cactggtggt ccctgctttt ctgagtacca tgtttccagg aggggccatg
     2761 ggggtcaggg tggttttgag agagcagggt aaggaaggaa tgtgctagaa gtgctcctag
     2821 tttcttgtaa aggaagccag agttgacagt acaaagggtc gtggccagcc ctgcagcttc
     2881 agcacctgcc ccacccagag tgggagtcag gtggagccac ctgctgggct cccccagaac
     2941 tttgcacaca tcttgctatg tattagccga tgtctttagt gttgagcctc tggattctgg
     3001 ggtctgggcc agtggccata gtgaagcctg ggaatgagtg ttactgcagc atctgggctg
     3061 ccagccacag ggaagggcca agccccatgt agccccagtc atcctgccca gccctgcctc
     3121 ctggccatgc cgggaggggt cggatcctct aggcatcgcc ttcacagccc cctgccccct
     3181 gccctctgtc ctggctctgc acctggtata tgggtcatgg acccagatgg ggctttccct
     3241 ttgtagccat ccaatgggca ttgtgtgggt gcttggaacc cgggatgact gagggggaca
     3301 ctggagtggg tgcttgtgtc tgctgtctca gaggccttgg tcaggatgaa gttggctgac
     3361 acagcttagc ttggttttgc ttattcaaaa gagaaaataa ctacacatgg aaatgaaact
     3421 agctgaagcc ttttcttgtt ttagcaactg aaaattgtac ttggtcactt ttgtgcttga
     3481 ggaggcccat tttctgcctg gcagggggca ggtctgtgcc ctcccgctga ctcctgctgt
     3541 gtcctgaggt gcatttcctg ttgtacacac aagggccagg ctccattctc cctccctttc
     3601 caccagtgcc acagcctcgt ctggaaaaag gaccaggggt cccggaggaa cccatttgtg
     3661 ctctgcttgg acagcaggcc tggcactggg aggtgggggt gagcccctca cagccttgcc
     3721 cctccccaag gctggcaacc tgcctcccat tgcccaagag agagggcagg gaacaggcta
     3781 ctgtccttcc ctgtggaatt gccgagaaat ctagcacctt gcatgctgga tctgggctgc
     3841 ggggaggctc tttttctccc tggcctccag tgcccaccag gaggatctgc gcacggtgca
     3901 cagcccacca gagcactaca gccttttatt gagtggggca agtgctgggc tgtggtcgtg
     3961 ccctgacagc atcttcccca ggcagcggct ctgtggagga ggccatactc ccctagttgg
     4021 ccactggggc caccaccctg accaccactg tgcccctcat tgttactgcc ttgtgagata
     4081 aaaactgatt aaacctttgt ggctgtggtt ggctga
//
