LOCUS       NM_001083308             294 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens pyrin domain containing 2 (PYDC2), mRNA.
ACCESSION   NM_001083308 XR_017825 XR_017829
VERSION     NM_001083308.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 294)
  AUTHORS   Kocaaga,A., Cakmak Genc,G., Karakas Celik,S., Koca,R. and Dursun,A.
  TITLE     Association of NOD1, NOD2, PYDC1 and PYDC2 genes with Behcet's
            disease susceptibility and clinical manifestations
  JOURNAL   Ophthalmic Genet 42 (6), 691-697 (2021)
   PUBMED   34294014
  REMARK    GeneRIF: Association of NOD1, NOD2, PYDC1 and PYDC2 genes with
            Behcet's disease susceptibility and clinical manifestations.
REFERENCE   2  (bases 1 to 294)
  AUTHORS   Ratsimandresy,R.A., Chu,L.H., Khare,S., de Almeida,L.,
            Gangopadhyay,A., Indramohan,M., Misharin,A.V., Greaves,D.R.,
            Perlman,H., Dorfleutner,A. and Stehlik,C.
  TITLE     The PYRIN domain-only protein POP2 inhibits inflammasome priming
            and activation
  JOURNAL   Nat Commun 8, 15556 (2017)
   PUBMED   28580931
  REMARK    GeneRIF: POP2 inhibits inflammasome priming and activation
            GeneRIF: PYDC2 inhibits NF-kB activation through the non-canonical
            kinase IKK epsilon. PYDC2 interferes with ASC oligomerization and
            with ASC-inflammasome activation resulting in reduced production of
            Interleukin-1-beta and reduced IL-18 secretion, as well as reduced
            pyroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 294)
  AUTHORS   Porter,K.A., Duffy,E.B., Nyland,P., Atianand,M.K., Sharifi,H. and
            Harton,J.A.
  TITLE     The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative
            regulator of NF-kappaB, pyrin-only protein 4
  JOURNAL   Genes Immun 15 (6), 392-403 (2014)
   PUBMED   24871464
REFERENCE   4  (bases 1 to 294)
  AUTHORS   Atianand,M.K., Fuchs,T. and Harton,J.A.
  TITLE     Recent evolution of the NF-kappaB and inflammasome regulating
            protein POP2 in primates
  JOURNAL   BMC Evol Biol 11, 56 (2011)
   PUBMED   21362197
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 294)
  AUTHORS   Bedoya,F., Sandler,L.L. and Harton,J.A.
  TITLE     Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR
            interactions
  JOURNAL   J Immunol 178 (6), 3837-3845 (2007)
   PUBMED   17339483
  REMARK    GeneRIF: POP2 inhibits both the interaction of ASC with various NLR
            pyrin domains and inhibits NF-kappaB p65 (RelA).
REFERENCE   6  (bases 1 to 294)
  AUTHORS   Dorfleutner,A., Bryan,N.B., Talbott,S.J., Funya,K.N., Rellick,S.L.,
            Reed,J.C., Shi,X., Rojanasakul,Y., Flynn,D.C. and Stehlik,C.
  TITLE     Cellular pyrin domain-only protein 2 is a candidate regulator of
            inflammasome activation
  JOURNAL   Infect Immun 75 (3), 1484-1492 (2007)
   PUBMED   17178784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY858112.1.
            
            On or before Mar 23, 2007 this sequence version replaced
            XR_017829.1, XR_017825.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY858112.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518817.1/ ENSP00000492367.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..294
                     /gene="PYDC2"
                     /gene_synonym="cPOP2; POP2"
                     /note="pyrin domain containing 2"
                     /db_xref="GeneID:152138"
                     /db_xref="HGNC:HGNC:33512"
                     /db_xref="MIM:615701"
     CDS             1..294
                     /gene="PYDC2"
                     /gene_synonym="cPOP2; POP2"
                     /note="pyrin-only protein 2; cellular POP2"
                     /codon_start=1
                     /product="pyrin domain-containing protein 2"
                     /protein_id="NP_001076777.1"
                     /db_xref="GeneID:152138"
                     /db_xref="HGNC:HGNC:33512"
                     /db_xref="MIM:615701"
                     /translation="MASSAELDFNLQALLEQLSQDELSKFKSLIRTISLGKELQTVPQ
                     TEVDKANGKQLVEIFTSHSCSYWAGMAAIQVFEKMNQTHLSGRADEHCVMPPP"
     exon            1..294
                     /gene="PYDC2"
                     /gene_synonym="cPOP2; POP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcatctt ctgcagagct ggacttcaac ctgcaggctc ttctggagca gctcagccag
       61 gatgagttga gcaagttcaa gtctctgatc agaacaatct ccctgggaaa ggagctacag
      121 accgtccccc agacagaggt agacaaggct aatgggaagc aactggtaga aatcttcacc
      181 agccactcct gcagctactg ggcagggatg gcagccatcc aggtctttga aaagatgaat
      241 caaacgcatc tgtctgggag agctgatgaa cactgtgtga tgcccccacc ttaa
//
