LOCUS       XM_024450849            1938 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens pyrroline-5-carboxylate reductase 1
            (PYCR1), transcript variant X2, mRNA.
ACCESSION   XM_024450849
VERSION     XM_024450849.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024450849.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..1938
                     /gene="PYCR1"
                     /gene_synonym="ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222;
                     PRO3; PYCR"
                     /note="pyrroline-5-carboxylate reductase 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 9 mRNAs, 65 ESTs, 1452 long SRA reads, 12 Proteins,
                     and 97% coverage of the annotated genomic feature by
                     RNAseq alignments, including 5 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:5831"
                     /db_xref="HGNC:HGNC:9721"
                     /db_xref="MIM:179035"
     CDS             156..1115
                     /gene="PYCR1"
                     /gene_synonym="ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222;
                     PRO3; PYCR"
                     /codon_start=1
                     /product="pyrroline-5-carboxylate reductase 1,
                     mitochondrial isoform X1"
                     /protein_id="XP_024306617.1"
                     /db_xref="GeneID:5831"
                     /db_xref="HGNC:HGNC:9721"
                     /db_xref="MIM:179035"
                     /translation="MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSA
                     LRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTIS
                     SIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCT
                     EVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLL
                     HSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQ
                     VSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD"
ORIGIN      
        1 ctgggtgcgg gtgccgcgtg gcggccgcag cgctgagggg tgggtacgac ccgcgcacgg
       61 tagctgggtt ggggtcgggc tccgggaatg gtgggcggcg gtcgccggag ccggtgccat
      121 ctgtgggggc tttgggccag gggtctccgg acagcatgag cgtgggcttc atcggcgctg
      181 gccagctggc ttttgccctg gccaagggct tcacagcagc aggcgtcttg gctgcccaca
      241 agataatggc tagctcccca gacatggacc tggccacagt ttctgctctc aggaagatgg
      301 gggtgaagtt gacaccccac aacaaggaga cggtgcagca cagtgatgtg ctcttcctgg
      361 ctgtgaagcc acacatcatc cccttcatcc tggatgaaat aggcgccgac attgaggaca
      421 gacacattgt ggtgtcctgc gcggccggcg tcaccatcag ctccattgag aagaagctgt
      481 cagcgtttcg gccagccccc agggtcatcc gctgcatgac caacactcca gtcgtggtgc
      541 gggagggggc caccgtgtat gccacaggca cgcacgccca ggtggaggac gggaggctca
      601 tggagcagct gctgagcagc gtgggcttct gcacggaggt ggaagaggac ctgattgatg
      661 ccgtcacggg gctcagtggc agcggccccg cctacgcatt cacagccctg gatgccctgg
      721 ctgatggggg tgtgaagatg ggacttccaa ggcgcctggc agtccgcctc ggggcccagg
      781 ccctcctggg ggctgccaag atgctgctgc actcagaaca gcacccaggc cagctcaagg
      841 acaacgtcag ctctcctggt ggggccacca tccatgcctt gcatgtgctg gagagtgggg
      901 gcttccgctc cctgctcatc aacgctgtgg aggcctcctg catccgcaca cgggagctgc
      961 agtccatggc tgaccaggag caggtgtcac cagccgccat caagaagacc atcctggaca
     1021 aggtgaagct ggactcccct gcagggaccg ctctgtcacc ttctggccac accaagctgc
     1081 tcccccgcag cctggcccca gcgggcaagg attgacacgt cctgcctgac caccatcctg
     1141 ccaccacctt ctcttctctt gtcactaggg ggactagggg gtccccaaag tggcccactt
     1201 tctgtggctc tgatcagcgc aggggccagc cagggacata gccagggagg ggccacatca
     1261 cttcccactg gaaatctctg tggtctgcaa gtgcttccca gcccagaaca ggggtggatt
     1321 ccccaacctc aacctccttt cttctctgct cccaaaccat gtcaggacca ccttcctcta
     1381 gagctcggga gcccggaggg tcttcaccca ctcctactcc agtatcagct ggcacgggct
     1441 ccttcctgag agcaaaggtc aaggaccccc tctgtgaagg ctcagcagag gtgggatccc
     1501 acgccccctc ccggcccctc cctgccctcc attcagggag aaacctctcc ttcccgtgtg
     1561 agaagggcca gagggtccag gcatcccaag tccagcgtga agggccacag cccctcttgg
     1621 ctgccaagca cgcagatccc atggacattt ggggaaaggg ctccttgggc tgctggtgaa
     1681 cttctgtggc caccacctcc tgctcctgac ctccctggga gggtgctatc agttctgtcc
     1741 tggccctttc agttttataa gttggtttcc agcccccagt gtcctgactt ctgtctgcca
     1801 catgaggagg gaggccctgc ctgtgtggga gggtggttac tgtgggtgga atagtggagg
     1861 ccttcaactg attagacaag gcccgcccac atcttggagg gcatctgcct tactgattaa
     1921 aatgtcaatg taatctaa
//
