LOCUS       NM_001037172            3302 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 2-phosphoxylose phosphatase 1 (PXYLP1), transcript
            variant 2, mRNA.
ACCESSION   NM_001037172
VERSION     NM_001037172.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Koike,T., Izumikawa,T., Sato,B. and Kitagawa,H.
  TITLE     Identification of phosphatase that dephosphorylates xylose in the
            glycosaminoglycan-protein linkage region of proteoglycans
  JOURNAL   J Biol Chem 289 (10), 6695-6708 (2014)
   PUBMED   24425863
  REMARK    GeneRIF: this study describes the cloning of a human cDNA encoding
            a novel protein designated 2-phosphoxylose phosphatase capable of
            dephosphorylating this Xyl residue.
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX762355.1, DC409719.1, AK074331.1, AL137529.1, BX647621.1 and
            AC117383.4.
            
            On Nov 24, 2018 this sequence version replaced NM_001037172.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.37693.1,
                                           SRR1803612.102380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286353.9/ ENSP00000286353.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CX762355.1         1-3
            4-596               DC409719.1         1-593
            597-2803            AK074331.1         577-2783
            2804-3011           AL137529.1         2052-2259
            3012-3152           BX647621.1         2980-3120
            3153-3153           AC117383.4         138533-138533
            3154-3281           BX647621.1         3122-3249
            3282-3302           AC117383.4         138662-138682
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q23"
     gene            1..3302
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="2-phosphoxylose phosphatase 1"
                     /db_xref="GeneID:92370"
                     /db_xref="HGNC:HGNC:26303"
                     /db_xref="MIM:619732"
     exon            1..87
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            88..219
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1583
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /EC_number="3.1.3.2"
                     /note="isoform 1 is encoded by transcript variant 2; acid
                     phosphatase-like protein 2; epididymis luminal protein
                     124; xylosyl phosphatase; acid phosphatase-like 2"
                     /codon_start=1
                     /product="2-phosphoxylose phosphatase 1 isoform 1"
                     /protein_id="NP_001032249.1"
                     /db_xref="CCDS:CCDS3116.1"
                     /db_xref="GeneID:92370"
                     /db_xref="HGNC:HGNC:26303"
                     /db_xref="MIM:619732"
                     /translation="MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSR
                     KRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYP
                     LYVIPKTKRPEIDCTLVANRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLC
                     EMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALL
                     YGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYG
                     EMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERE
                     RREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLS
                     EARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLE
                     NLVRFVKRDMFVALGGSGTNYYDACHREGF"
     exon            220..378
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            379..505
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..645
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     exon            646..3302
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2671..2676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="major polyA site"
     regulatory      2993..2998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="hexamer: AATAAA"
     polyA_site      3011
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="major polyA site"
     regulatory      3267..3272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
                     /note="hexamer: AATAAA"
     polyA_site      3302
                     /gene="PXYLP1"
                     /gene_synonym="ACPL2; HEL124; XYLP"
ORIGIN      
        1 gcctcccctc gcgccgggag gagctggcgg cgagcgccga gccgggcgcg cagcgacgga
       61 gctggggccg gcctgggacc atgggcggac atgttcccga tttgaggtga aaccatgaag
      121 agaaaataga atacttaata atgcttttcc gcaaccgctt cttgctgctg ctggccctgg
      181 ctgcgctgct ggcctttgtg agcctcagcc tgcagttctt ccacctgatc ccggtgtcga
      241 ctcctaagaa tggaatgagt agcaagagtc gaaagagaat catgcccgac cctgtgacgg
      301 agccccctgt gacagacccc gtttatgaag ctcttttgta ctgcaacatc cccagcgtgg
      361 ccgagcgcag catggaaggt catgccccgc atcattttaa gctggtctca gtgcatgtgt
      421 tcattcgcca cggagacagg tacccactgt atgtcattcc caaaacaaag cgaccagaaa
      481 ttgactgcac tctggtggct aacaggaaac cgtatcaccc aaaactggaa gctttcatta
      541 gtcacatgtc aaaaggatcc ggagcctctt tcgaaagccc cttgaactcc ttgcctcttt
      601 acccaaatca cccattgtgt gagatgggag agctcacaca gacaggagtt gtgcagcatt
      661 tgcagaacgg tcagctgctg agggatatct atctaaagaa acacaaactc ctgcccaatg
      721 attggtctgc agaccagctc tatttagaga ccactgggaa aagccggacc ctacaaagtg
      781 ggctggcctt gctttatggc tttctcccag attttgactg gaagaagatt tatttcaggc
      841 accagccaag tgcgctgttc tgctctggaa gctgctattg cccggtaaga aaccagtatc
      901 tggaaaagga gcagcgtcgt cagtacctcc tacgtttgaa aaacagccag ctggagaaga
      961 cctacgggga gatggccaag atcgtggatg tccccaccaa gcagcttaga gctgccaacc
     1021 ccatagactc catgctctgc cacttctgcc acaatgtcag ctttccctgt accagaaatg
     1081 gctgtgttga catggagcac ttcaaggtaa ttaagaccca tcagatcgag gatgaaaggg
     1141 aaagacggga gaagaaattg tacttcgggt attctctcct gggtgcccac cccatcctga
     1201 accaaaccat cggccggatg cagcgtgcca ccgagggcag gaaagaagag ctctttgccc
     1261 tctactctgc tcatgatgtc actctgtcac cagttctcag tgccttgggc ctttcagaag
     1321 ccaggttccc aaggtttgca gccaggttga tctttgagct ttggcaagac agagaaaagc
     1381 ccagtgaaca ttccgtccgg attctttaca atggcgtcga tgtcacattc cacacctctt
     1441 tctgccaaga ccaccacaag cgttctccca agcccatgtg cccgcttgaa aacttggtcc
     1501 gctttgtgaa aagggacatg tttgtagccc tgggtggcag tggtacaaat tattatgatg
     1561 catgtcacag ggaaggattc taaaaggtat gcagtacagc agtatagaat ccatgccaat
     1621 acagagcata gggaaaggtc cacttctagt tttgtctgtt actaagggta gaagattatt
     1681 gctttttaaa ggctaaatat tgtttgtggg aaccacagat ggttggggtt gaacagtaag
     1741 cacattgctg caatgtggta cgtgaattgc ttggtacaaa atggccagtt cacagaggaa
     1801 tagaaggtac tttatcatag ccagacttcg cttagaatgc cagaataata tagttcaaga
     1861 cctgaagttg ccaatccaag tttgcactct tctggcctgc cccatgttac tatgtgatgg
     1921 aaccagcaca cctcaaccaa aattttttta atcttagaca tttttacctt gtccttgtta
     1981 agaatttctt gaagtgattt atctaaaata aaggttggca aactttttct gtaaagggcc
     2041 agattgtaaa tatttcagac tgtgtggacc aaaaggccac atacagtctc tgtcataact
     2101 actcaactct gtttctgaag caggaaagcc accacagaca gtacataaag gaatatgtgt
     2161 agctgggttc ccaggccgga caaaacagat ggtgaccaga tttggcccct gggctgtagt
     2221 ttgctgaccc ctcatctaaa aaataggcta tactacaatt gcacttccag cactttgaga
     2281 acgagttgaa taccaagaat tattcaatgg ttcctccagt aacttctgct agaaacacag
     2341 aatttggtct gtatctgaca ctagaacaaa acttgagggt aaataaacat tgaattagaa
     2401 tgaatcatag aaaactgatt agaagaatac ttgatgttta tgatgattgt ggtacaagat
     2461 agttttaagt atgttctaaa tatttgtctg ctgtagtcta tttgctgtat atgctgaaat
     2521 ttttgtatgc catttagtat ttttatagtt taggaaaata ttttctaaga ccagttttag
     2581 atgactctta ttcctgtagt aatattcaat ttgctgtacc tgcttggtgg ttagaaggag
     2641 gctagaagat gaattcaggc actttcttcc aataaaacta attatggctc attccctttg
     2701 acaagctgta gaactggatt catttttaaa ccattttcat cagtttcaaa tggtaaattc
     2761 tgattgattt ttaaatgcgt ttttggaaga actttgctat tagatagttt acagatcttt
     2821 ataaggtgtt ttatatatta gaagcaatta taattacatc tgtgatttct gaactaatgg
     2881 tgctaattca gagaaatgga aagtgaaagt gagattctct gttgtcatcg gcattccaac
     2941 tttttctctt tgtttttgtc cagtgttgca tttgaatatg tctgtttcta taaataaatt
     3001 ttttaagaat acctatacta tacaactaat ggtttgtacc tataagtcac tcgagttatt
     3061 ttcaagtgag agccagtatt ttatttttcc cccttcattc aaatgtcatg cagagaacca
     3121 gtattttaaa attttatttt aactgcttta ctaactgctg aaagttgtgt tatctctcaa
     3181 gtattcaaag actaaatgtg ttttctttcc ttcccactca caatatatct gaattagaac
     3241 tgctaaacac agcttgaaga cttaaaaata aaagtgactc ggaagatttt ttaaaaaatc
     3301 aa
//
