LOCUS       NM_152990               2073 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens peroxisomal testis enriched protein 1 (PXT1), mRNA.
ACCESSION   NM_152990
VERSION     NM_152990.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2073)
  AUTHORS   Kaczmarek,K., Niedzialkowska,E., Studencka,M., Schulz,Y. and
            Grzmil,P.
  TITLE     Ccdc33, a predominantly testis-expressed gene, encodes a putative
            peroxisomal protein
  JOURNAL   Cytogenet Genome Res 126 (3), 243-252 (2009)
   PUBMED   20068295
  REMARK    GeneRIF: Data show that CCDC33-dsRED fusion protein co-localized
            with a known peroxisomal protein, namely PXT1, and showed punctuate
            intracellular distribution.
REFERENCE   3  (bases 1 to 2073)
  AUTHORS   Grzmil,P., Burfeind,C., Preuss,T., Dixkens,C., Wolf,S., Engel,W.
            and Burfeind,P.
  TITLE     The putative peroxisomal gene Pxt1 is exclusively expressed in the
            testis
  JOURNAL   Cytogenet Genome Res 119 (1-2), 74-82 (2007)
   PUBMED   18160785
  REMARK    GeneRIF: Pxt1 gene is so far the first gene coding for a putative
            peroxisomal protein which is expressed in later steps of
            spermatogenesis, namely in pachytene spermatocytes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031105.1 and AL133263.8.
            
            On Nov 23, 2018 this sequence version replaced NM_152990.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454782.3/ ENSP00000419944.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               BC031105.1         36-330
            296-492             BC031105.1         332-528
            493-493             AL133263.8         28170-28170         c
            494-2073            BC031105.1         530-2109
FEATURES             Location/Qualifiers
     source          1..2073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..2073
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /note="peroxisomal testis enriched protein 1"
                     /db_xref="GeneID:222659"
                     /db_xref="HGNC:HGNC:18312"
     exon            1..320
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            321..440
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            441..618
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..854
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /note="small testis-specific peroxisomal protein;
                     peroxisomal, testis specific 1"
                     /codon_start=1
                     /product="peroxisomal testis-specific protein 1"
                     /protein_id="NP_694535.2"
                     /db_xref="CCDS:CCDS4820.2"
                     /db_xref="GeneID:222659"
                     /db_xref="HGNC:HGNC:18312"
                     /translation="MKKKHDGIVYETKEVLNPSPKVTHCCKSLWLKYSFQKAYMTQLV
                     SSQPVPAMSRNPDHNLLSQPKEHSIVQKHHQEEIIHKLAMQLRHIGDNIDHRMVREDL
                     QQDGRDALDHFVFFFFRRVQVLLHFFWNNHLL"
     exon            619..749
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /inference="alignment:Splign:2.1.0"
     exon            750..2073
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /note="hexamer: AATAAA"
     polyA_site      2073
                     /gene="PXT1"
                     /gene_synonym="STEPP"
                     /note="major polyA site"
ORIGIN      
        1 agtccactct gcacccaacc tcagcgggcg cacttttctg agttgcgcat accctctcaa
       61 ttattaaagg ttgcagacgg aaaagttagt agttttcgga attgtagaat acgctcgtgc
      121 agcgccagga cggctaatgc ttacccgaaa atgtggaacc ctgatctccc catgcgtgga
      181 gcgaggttgg aggtagcgta gtaagaatac tggagttgct taaacgcatt tgctcgaaag
      241 tcactaccct ggatatacat tctggccaaa agaaaggggg aaaaactcca catttttctc
      301 aaatactgag tttcatgaag agaacctcca acaaatggta tataaaggaa aacaaagcaa
      361 acaaaagagg gaaactttgc aatttattaa ctcaagcatg aaaatacaga aaataaagag
      421 ggctcaacat acttggaaaa ggaaaaaaca tgaagaaaaa acatgatggc attgtttatg
      481 aaactaaaga agttctcaat ccatctccca aagtaacaca ttgttgcaaa tcactgtggt
      541 taaaatacag ttttcagaag gcatacatga cccaacttgt cagctcccag ccagttccag
      601 ccatgtcaag gaacccagat cataatctac tttctcagcc caaggagcat agcattgttc
      661 agaagcatca ccaggaggaa ataattcaca agttggccat gcagctgaga cacattgggg
      721 acaacattga tcataggatg gttcgagagg atcttcaaca ggatggcaga gatgcactag
      781 atcattttgt cttctttttc tttagaagag ttcaggtgtt gctgcatttt ttctggaaca
      841 accatttgct gtaaaaggaa agtaaaggtc aagtggtcaa gttctgtttt ctttttaccc
      901 tctgagaaac atgaatccca ctgggacaga tgggaagaac acccttctcc gtctccctct
      961 ttttgtaccc atcactgttg gtctacaccc agtttgttga agaactgcgg gttcacgagc
     1021 catttgtctc ttcggaggag ctagctatga gatgtctgcg atcacatcac ggtaaagccc
     1081 aaggagtaat taggacccca ggaagccttg ctgcccagaa aacaccagcg ctgtggatgg
     1141 tcccagggct ccttgtgagg aaaccttgaa catttccttc caggaatgaa agagaacctc
     1201 gtcctcaaac taaaggccac agaaatgggc actacctcct ggcccactcc ctgggcacca
     1261 tgccctctgg tgacctgttg gctccactct tgtcactcat gtccagatct gcagtgccag
     1321 cttctccttc tcggtgacat gtcacctccc tgccccaatc ctggctccaa ccctctctgg
     1381 aaaatcgaag tgaaacattt gtctctaata ctcaaattca acatatggct catctcatct
     1441 accttcccat ttccatgcct agaggcccca ctactaccac tagcaccgtt gggtgtttcc
     1501 ttctcaggct ctgattctac aacatttacg ttcttttctc acctttgatc ccctcactcc
     1561 tctgtgaccc ccttcaagtc ttccttcacc actccagtgt tttcccatac cactcgaccc
     1621 tgctcgaagg tatctttccc tgctctgtca tcctctttta ggcatgcctg cttaaaatcg
     1681 ggagtgctta gtccttggcc aacagtcctg ccttctagaa gaatgtaaga cctgaaagag
     1741 ttatgaatct atcactaggc aaaaacttct cttttcctat tgctggatgg ttttgctatt
     1801 attggttggt gggccctttg cctgtggaat gtatttcact cattctctcc tgcacgctgt
     1861 taggcagttc tttcacctgc atgcttcttc ttttaccttt ttgtctacct catagtccct
     1921 ctctcccctc ctttaaaaga attataaata ttaggaaagc ttgttgttat aaattaaaag
     1981 tttacatatg tatcttgagt tcttcatagg ggaagtgtta ttttaaaaaa ttctaaaaat
     2041 gaaataaata ttgttatttt attgagcatg aaa
//
