LOCUS       NM_001385981            5214 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens paxillin (PXN), transcript variant 5, mRNA.
ACCESSION   NM_001385981
VERSION     NM_001385981.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5214)
  AUTHORS   Weidner,A.E., Roy,A., Vann,K., Walczyk,A.C. and Astapova,O.
  TITLE     Paxillin regulates androgen receptor expression associated with
            granulosa cell focal adhesions
  JOURNAL   Mol Hum Reprod 30 (5) (2024)
   PUBMED   38718206
  REMARK    GeneRIF: Paxillin regulates androgen receptor expression associated
            with granulosa cell focal adhesions.
REFERENCE   2  (bases 1 to 5214)
  AUTHORS   Liang,P., Wu,Y., Zheng,S., Zhang,J., Yang,S., Wang,J., Ma,S.,
            Zhang,M., Gu,Z., Liu,Q., Jiang,W., Xing,Q. and Wang,B.
  TITLE     Paxillin phase separation promotes focal adhesion assembly and
            integrin signaling
  JOURNAL   J Cell Biol 223 (4) (2024)
   PUBMED   38466167
  REMARK    GeneRIF: Paxillin phase separation promotes focal adhesion assembly
            and integrin signaling.
REFERENCE   3  (bases 1 to 5214)
  AUTHORS   Saikia,B.B., Bhowmick,S., Malat,A., Preetha Rani,M.R., Thaha,A. and
            Abdul-Muneer,P.M.
  TITLE     ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic
            Brain Injury-Induced Inflammatory Leukocyte Adhesion and
            Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent
            Rho GTPase Pathway
  JOURNAL   J Neurosci 44 (11), e1742232024 (2024)
   PUBMED   38326036
  REMARK    GeneRIF: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from
            Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and
            Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent
            Rho GTPase Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5214)
  AUTHORS   Zheng,H., Tsunedomi,R., Xu,M., Zhang,Y., Kishi,H., Kobayashi,S.,
            Tomochika,S., Nakajima,M., Matsui,H., Tokumitsu,Y., Shindo,Y.,
            Iida,M., Ioka,T. and Nagano,H.
  TITLE     Effect of Paxillin Expression and Phosphorylation on Colorectal
            Cancer Prognosis and Metastasis
  JOURNAL   Anticancer Res 44 (2), 511-520 (2024)
   PUBMED   38307570
  REMARK    GeneRIF: Effect of Paxillin Expression and Phosphorylation on
            Colorectal Cancer Prognosis and Metastasis.
REFERENCE   5  (bases 1 to 5214)
  AUTHORS   Zhang,Y., Li,N. and Kobayashi,S.
  TITLE     Paxillin participates in the sphingosylphosphorylcholine-induced
            abnormal contraction of vascular smooth muscle by regulating
            Rho-kinase activation
  JOURNAL   Cell Commun Signal 22 (1), 58 (2024)
   PUBMED   38254202
  REMARK    GeneRIF: Paxillin participates in the
            sphingosylphosphorylcholine-induced abnormal contraction of
            vascular smooth muscle by regulating Rho-kinase activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5214)
  AUTHORS   Ganju,R.K., Munshi,N., Nair,B.C., Liu,Z.Y., Gill,P. and
            Groopman,J.E.
  TITLE     Human immunodeficiency virus tat modulates the Flk-1/KDR receptor,
            mitogen-activated protein kinases, and components of focal adhesion
            in Kaposi's sarcoma cells
  JOURNAL   J Virol 72 (7), 6131-6137 (1998)
   PUBMED   9621077
REFERENCE   7  (bases 1 to 5214)
  AUTHORS   Tong,X. and Howley,P.M.
  TITLE     The bovine papillomavirus E6 oncoprotein interacts with paxillin
            and disrupts the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4412-4417 (1997)
   PUBMED   9114003
REFERENCE   8  (bases 1 to 5214)
  AUTHORS   Mazaki,Y., Hashimoto,S. and Sabe,H.
  TITLE     Monocyte cells and cancer cells express novel paxillin isoforms
            with different binding properties to focal adhesion proteins
  JOURNAL   J Biol Chem 272 (11), 7437-7444 (1997)
   PUBMED   9054445
REFERENCE   9  (bases 1 to 5214)
  AUTHORS   Tachibana,K., Sato,T., D'Avirro,N. and Morimoto,C.
  TITLE     Direct association of pp125FAK with paxillin, the focal
            adhesion-targeting mechanism of pp125FAK
  JOURNAL   J Exp Med 182 (4), 1089-1099 (1995)
   PUBMED   7561682
REFERENCE   10 (bases 1 to 5214)
  AUTHORS   Salgia,R., Li,J.L., Lo,S.H., Brunkhorst,B., Kansas,G.S.,
            Sobhany,E.S., Sun,Y., Pisick,E., Hallek,M., Ernst,T. et al.
  TITLE     Molecular cloning of human paxillin, a focal adhesion protein
            phosphorylated by P210BCR/ABL
  JOURNAL   J Biol Chem 270 (10), 5039-5047 (1995)
   PUBMED   7534286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004263.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a cytoskeletal protein involved in
            actin-membrane attachment at sites of cell adhesion to the
            extracellular matrix (focal adhesion). Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. These isoforms exhibit different expression pattern,
            and have different biochemical, as well as physiological properties
            (PMID:9054445). [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000637617.2/ ENSP00000489840.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC004263.1         73336-73449         c
            115-341             AC004263.1         31870-32096         c
            342-457             AC004263.1         31437-31552         c
            458-594             AC004263.1         30582-30718         c
            595-796             AC004263.1         30268-30469         c
            797-932             AC004263.1         29342-29477         c
            933-1817            AC004263.1         26926-27810         c
            1818-2093           AC004263.1         24560-24835         c
            2094-2402           AC004263.1         23992-24300         c
            2403-2504           AC004263.1         23279-23380         c
            2505-2675           AC004263.1         22822-22992         c
            2676-2849           AC004263.1         22544-22717         c
            2850-2931           AC004263.1         21855-21936         c
            2932-3080           AC004263.1         21561-21709         c
            3081-5214           AC004263.1         18166-20299         c
FEATURES             Location/Qualifiers
     source          1..5214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..5214
                     /gene="PXN"
                     /note="paxillin"
                     /db_xref="GeneID:5829"
                     /db_xref="HGNC:HGNC:9718"
                     /db_xref="MIM:602505"
     exon            1..114
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3347
                     /gene="PXN"
                     /note="isoform 5 is encoded by transcript variant 5;
                     testicular tissue protein Li 134"
                     /codon_start=1
                     /product="paxillin isoform 5"
                     /protein_id="NP_001372910.1"
                     /db_xref="CCDS:CCDS91759.1"
                     /db_xref="GeneID:5829"
                     /db_xref="HGNC:HGNC:9718"
                     /db_xref="MIM:602505"
                     /translation="MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIA
                     VPPPVPPPPSSEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQD
                     SVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPP
                     GFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVE
                     SLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDF
                     KTSSSTVALSAPGLSSSAPSSYCSLPPSPPPMPSVFLPPTTIPSPRGQGHTPEFPCTE
                     QSGRGLLPPVAPSWLDLAGLGVMPDTFNSRSPSVEGSLWAVGTESQGRDWRHLPTITS
                     ELSGAPRCHTVPCAGSTALQEPGEPQGPPASPSCPEEALAATWEQPWASEVFGPERMP
                     PSGAARSFQEVTEPAVVAVDRQAIFPDTWTLTEEHGLQQERPRPEPGRLGSSSPASVT
                     TEQLGAKMTERGSVARPTQGPETPRSPEGTTEAATQDGKEQPELPCAMAMGTPSTTER
                     ISTSGQIRSVIRRSWESGHAHPMSREPSPRRRLDPATLSRTPSQEQLIAELQGRLGIQ
                     PEAEEPAEAAGPSAQDWLTEGVIITVQPRGKRAGGQLVEKVVFPPGSPIPLRRTISVL
                     ASPSVPLLQHRTDAAASSSSPLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGP
                     ALPIPAPHTMRSVGCQTDEDPLFPPMQIQGLEQRADGERCWAAGWPRDGGRSSPGGQD
                     EGGFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIA
                     GQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPI
                     LDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARA
                     ILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQK
                     PITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC"
     exon            115..341
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            342..457
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            458..594
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            595..796
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            797..932
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1817
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..2093
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2402
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2504
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2675
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2849
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..2931
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3080
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..5214
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5191..5196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXN"
                     /note="hexamer: AATAAA"
     polyA_site      5214
                     /gene="PXN"
                     /note="major polyA site"
ORIGIN      
        1 gttccgggcc gaggctcgcg gcggaaaagt tgcggggcat agacgagcgg ccccgggacg
       61 ggcagctagc gcgaccctga gccggcgccc gtggtccggc catggacgac ctcgacgccc
      121 tgctggcgga cttggagtct accacctccc acatctccaa acggcctgtg ttcttgtcgg
      181 aggagacccc ctactcatac ccaactggaa accacacata ccaggagatt gccgtgccac
      241 cccccgtccc cccacccccg tccagcgagg ccctcaatgg cacaatcctt gaccccttag
      301 accagtggca gcccagcagc tcccgattca tccaccagca gcctcagtcc tcatcacctg
      361 tgtacggctc cagtgccaaa acttccagtg tctccaaccc tcaggacagt gttggctctc
      421 cgtgctcccg agtgggtgag gaggagcacg tctacagctt ccccaacaag cagaaatcag
      481 ctgagccttc acccaccgta atgagcacgt ccctgggcag caacctttct gaactcgacc
      541 gcctgctgct ggaactgaac gctgtacagc ataacccgcc aggcttccct gcagatgagg
      601 ccaactcaag ccccccgctt cctggggccc tgagccccct ctatggtgtc ccagagacta
      661 acagcccctt gggaggcaaa gctgggcccc tgacgaaaga gaagcctaag cggaatgggg
      721 gccggggcct ggaggacgtg cggcccagtg tggagagtct cttggatgaa ctggagagct
      781 ccgtgcccag ccccgtccct gccatcactg tgaaccaggg cgagatgagc agcccgcagc
      841 gcgtcacctc cacccaacag cagacacgca tctcggcctc ctctgccacc agggagctgg
      901 acgagctgat ggcttcgctg tcggatttca agaccagctc ctccactgtg gctctgagtg
      961 ccccggggct gtccagctct gctccgtcct catactgctc ccttcctcct tctcctcctc
     1021 ccatgccatc tgtatttctg ccacccacca ctataccctc ccctcgaggc cagggccaca
     1081 ctccggagtt cccttgtact gagcagagtg gacgaggcct tctacctcct gtagccccca
     1141 gctggcttga tttggctggt cttggggtga tgcctgacac cttcaactca aggtctccct
     1201 ctgtggaggg ttctctgtgg gcagtgggca cagagagtca gggtcgagat tggaggcacc
     1261 tgccgaccat cacaagtgag ctctctgggg ctccccgctg ccacactgta ccctgtgctg
     1321 ggagcacagc tctccaagag cctggggagc cccaggggcc accagccagc ccttcgtgcc
     1381 cagaggaggc cttggctgcc acatgggagc agccatgggc ttcggaggta ttcgggcctg
     1441 agagaatgcc cccctctgga gctgctcgaa gcttccaaga agtaacagag ccagctgtag
     1501 tggcagtgga ccggcaggcc atcttcccag atacctggac tctcacggag gaacatggcc
     1561 tacagcagga gaggccaagg ccagagccag ggaggctggg aagcagctcc cctgcctcag
     1621 ttaccacgga gcagctaggt gcaaagatga ccgagagggg aagtgtggcc aggccaaccc
     1681 agggacctga aaccccaagg agcccagagg gcaccacgga agctgccacc caggacggga
     1741 aggaacagcc agagcttcca tgtgccatgg ccatgggcac acccagcacc acggagagga
     1801 tttccacctc tggccagatc cgatctgtga tcaggaggag ctgggagtct ggccacgcac
     1861 accccatgtc ccgggagccc tcccctcgcc gccggctgga ccctgccacc ttgagcagga
     1921 ccccatccca ggaacagctc atcgcggagc tgcaggggcg gctgggcatc cagcctgagg
     1981 cagaggagcc ggcggaggcg gcggggccct ctgcccagga ctggctgacc gagggcgtca
     2041 tcatcactgt gcagccacgt gggaagcggg ccggggggca gctcgtagag aaggttgtct
     2101 tccctcctgg ctctcccatt cccctgagaa gaaccatctc tgtcctggct tctccttctg
     2161 tccctttgct ccagcatcgc acagacgccg cggccagcag ctcttctccc ctgcccagcc
     2221 tgctcgcctc ctcccccctg gggccctcag cttatacctg tggttcttct ggggtccaga
     2281 gtgcagggga agagccccat gatgaggggg tgcagggccc tgcccttccc attcctgcac
     2341 cccacaccat gaggtccgtg ggctgccaga ctgatgagga cccgctcttc cccccgatgc
     2401 agatccaggg cctggagcaa agagcggatg gggagcggtg ctgggcggcc ggctggcctc
     2461 gggacggcgg gcggagcagc cccggagggc aggacgaggg agggttcatg gcccagggga
     2521 agacagggag cagctcaccc cctggggggc ccccgaagcc cgggagccag ctggacagca
     2581 tgctggggag cctgcagtct gacctgaaca agctgggggt cgccacagtc gccaaaggag
     2641 tctgcggggc ctgcaagaag cccatcgccg ggcaggttgt gaccgccatg gggaagacgt
     2701 ggcaccccga gcacttcgtc tgcacccact gccaggagga gatcggatcc cggaacttct
     2761 tcgagcggga tggacagccc tactgtgaaa aggactacca caacctcttc tccccgcgct
     2821 gctactactg caacggcccc atcctggata aagtggtgac agcccttgac cggacgtggc
     2881 accctgaaca cttcttctgt gcacagtgtg gagccttctt tggtcccgaa gggttccacg
     2941 agaaggacgg caaggcctac tgtcgcaagg actacttcga catgttcgca cccaagtgtg
     3001 gcggctgcgc ccgggccatc ctggagaact atatctcagc cctcaacacg ctgtggcatc
     3061 ctgagtgctt tgtgtgccgg gaatgcttca cgccattcgt gaacggcagc ttcttcgagc
     3121 acgacgggca gccctactgt gaggtgcact accacgagcg gcgcggctcg ctgtgttctg
     3181 gctgccagaa gcccatcacc ggccgctgca tcaccgccat ggccaagaag ttccaccccg
     3241 agcacttcgt ctgtgccttc tgcctcaagc agctcaacaa gggcaccttc aaggagcaga
     3301 acgacaagcc ttactgtcag aactgcttcc tcaagctctt ctgctaggtg ccctgcccct
     3361 gtctctgccc cccttcccca gccagcatcc ccaactgcga ctgtgaccta gagacttcac
     3421 ccgggggtga aggggtaaac ccgactgaaa ctggaaccct tgtcctccgc tggtgcggga
     3481 tggacagagg gccgtgaggg gtccccctgc ttgtcttcac ccctgccaga gcctctgggc
     3541 cccctcctcc ctcctgtagc tctccctagg ctgcccactc tccatcctcc ccaggggtag
     3601 aggctggggg ctccacccca gcccatgtac gtccccacga actggcctgg ccagcacccc
     3661 acactggagc catctcttcc tcatatttca gcagtgcagc cggggggcag ggaagggcag
     3721 gcagggtctg ttggggtctc tttttatcct tattcctccc ccgacctaat tgtctttgtt
     3781 ctgtgattat tgggggacac ccggctccct ccagacaatg ccagcataaa tccatccatc
     3841 caaaggcaga gaaccaaagg ggccatggaa ggttctctgt gctcctccta cccttccagt
     3901 gccctaggcc tggcgactgc ccctgccttt tagacccgcc ctcccctttt atacctgctc
     3961 ttgttctact gagaaaagcc tctccagcaa taatgttttc tagtcacttc ctccgtctcc
     4021 gggacggcgt gcctggacac tgtaccgact ttgatagatt tctacactga ggtttgaatt
     4081 catatcgcct gagttgcttt tacttctcta tacaaaatga ttttgaagag attttaaaga
     4141 cgttcccttt tgtattctct tcctcatcca ccgccactgg gcctgtcact gatggtggct
     4201 ctggtgtgaa gtttgctttg tactgagggt tggggtgggg aagcaatttg tattttattg
     4261 tttcttagca caagcaggtg aactgggagc agctctgtga ctccccctct ttcacttcat
     4321 agctcaccag gactgtttta taaactgctg tatttggaaa ccccttcttt acttcccagg
     4381 ccagcaagct cttcactgaa actggttgaa gggtgttgca cccttttggg cctagaattc
     4441 tgaactttat ctgttctgtt tctgtgggag gagaagggga agtatgtttt ggggggctgc
     4501 ttcctgtctg agtaagccct caggagcctc tgctcccctg tgaacccact gaaccttctg
     4561 agcccccact gcttctatgg ggctctctct tctgccttct caggaaagct ggtgtctgat
     4621 tttggccatc aggactctga cgtctctttg gtcttgttga tttcctctgg gcatatccct
     4681 tccccagatc tgctcctccc ctttcacagg tgggatcggc actcaggggg tctggaaaga
     4741 aggtcataag ggagcatgat aggatttggg gcagagggac aggctcctct ggggaaaccc
     4801 cccagagctc tttaccaagg atgaaagagg agccaggcct tgggctcctg atgaggagaa
     4861 aggggcccca ccggggtcta atggtgacag tccaaaccac tccactggcc tcctggcaga
     4921 agccgagtgt gctggggtct ccgaagaggg tccctccttt ttgggggaag gtcagcccag
     4981 cccctccaaa ggtctgatgt ctccactttc acccgcaggc cttaccgctc tgtttatagt
     5041 gacccaccct agatcttccc caagagggac tggggtttct ggggtccatt ctctgagtca
     5101 gtggttattt gaaaatttga ttttgatttt attttttctc tgtaaacttc caagctggct
     5161 tttcccattt caattcctgt gatttatgcc aataaagttt gcccatgatt ttca
//
