LOCUS       NM_007238               5690 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens peroxisomal membrane protein 4 (PXMP4), transcript
            variant 1, mRNA.
ACCESSION   NM_007238
VERSION     NM_007238.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5690)
  AUTHORS   Li,W., Dong,X., Wan,Z., Wang,W., Zhang,J., Mi,Y., Li,R., Xu,Z.,
            Wang,B., Li,N. and He,G.
  TITLE     PXMP4 promotes gastric cancer cell epithelial-mesenchymal
            transition via the PI3K/AKT signaling pathway
  JOURNAL   Mol Biol Rep 51 (1), 350 (2024)
   PUBMED   38401002
  REMARK    GeneRIF: PXMP4 promotes gastric cancer cell epithelial-mesenchymal
            transition via the PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5690)
  AUTHORS   Zhao,M.M., Awang,Z. and Jumuddin,F.A.B.
  TITLE     High Expression of PXMP4 in Hepatocellular Carcinoma Tissues
  JOURNAL   Asian Pac J Cancer Prev 25 (2), 603-608 (2024)
   PUBMED   38415547
  REMARK    GeneRIF: High Expression of PXMP4 in Hepatocellular Carcinoma
            Tissues.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5690)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   4  (bases 1 to 5690)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     PEX19 is a predominantly cytosolic chaperone and import receptor
            for class 1 peroxisomal membrane proteins
  JOURNAL   J Cell Biol 164 (1), 57-67 (2004)
   PUBMED   14709540
REFERENCE   5  (bases 1 to 5690)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   6  (bases 1 to 5690)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   7  (bases 1 to 5690)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   8  (bases 1 to 5690)
  AUTHORS   Reguenga,C., Oliveira,M.E., Gouveia,A.M., Eckerskorn,C.,
            Sa-Miranda,C. and Azevedo,J.E.
  TITLE     Identification of a 24 kDa intrinsic membrane protein from
            mammalian peroxisomes
  JOURNAL   Biochim Biophys Acta 1445 (3), 337-341 (1999)
   PUBMED   10366717
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB495125.1, AF072864.1, AL050349.27, AL121906.18 and AI985147.1.
            
            On Nov 23, 2018 this sequence version replaced NM_007238.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316589.1, SRR1660809.88246.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2144120,
                                           SAMEA2155770 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409299.8/ ENSP00000386385.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DB495125.1         21-78
            59-1387             AF072864.1         1-1329
            1388-2970           AL050349.27        101-1683            c
            2971-5420           AL121906.18        79465-81914         c
            5421-5690           AI985147.1         18-287              c
FEATURES             Location/Qualifiers
     source          1..5690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..5690
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="peroxisomal membrane protein 4"
                     /db_xref="GeneID:11264"
                     /db_xref="HGNC:HGNC:15920"
                     /db_xref="MIM:616397"
     exon            1..216
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..742
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="isoform a is encoded by transcript variant 1; 24
                     kDa peroxisomal intrinsic membrane protein; peroxisomal
                     membrane protein 4, 24kDa"
                     /codon_start=1
                     /product="peroxisomal membrane protein 4 isoform a"
                     /protein_id="NP_009169.3"
                     /db_xref="CCDS:CCDS13225.1"
                     /db_xref="GeneID:11264"
                     /db_xref="HGNC:HGNC:15920"
                     /db_xref="MIM:616397"
                     /translation="MAAPPQLRALLVVVNALLRKRRYHAALAVLKGFRNGAVYGAKIR
                     APHALVMTFLFRNGSLQEKLWAILQATYIHSWNLARFVFTYKGLRALQSYIQGKTYPA
                     HAFLAAFLGGILVFGENNNINSQINMYLLSRVLFALSRLAVEKGYIPEPRWDPFPLLT
                     AVVWGLVLWLFEYHRSTLQPSLQSSMTYLYEDSNVWHDISDFLVYNKSRPSN"
     exon            217..279
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            280..478
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /inference="alignment:Splign:2.1.0"
     exon            479..5690
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="hexamer: AGTAAA"
     polyA_site      892
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="major polyA site"
     regulatory      4314..4319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="hexamer: AATAAA"
     polyA_site      4336
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
     regulatory      5673..5678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
                     /note="hexamer: AATAAA"
     polyA_site      5690
                     /gene="PXMP4"
                     /gene_synonym="PMP24"
ORIGIN      
        1 acgagtcggc ggcgctaccg aggggctgtg ggcgcgcagc tggaacctcc ggctgtcagt
       61 gcgcttacag ttcctaaccc cgaccctgcg cgcagcccgc actatggcag ccccgccgca
      121 gctaagggct ctgctcgtag tcgtcaacgc actgctgcgc aagcgccgct accacgctgc
      181 gttggccgtg cttaagggct tccggaacgg ggctgtctat ggagccaaaa tccgggcccc
      241 tcacgcgctg gtcatgacct ttctcttccg gaatggcagc ctccaggaga agctgtgggc
      301 catactgcag gccacatata tccactcctg gaacctggca cggtttgtgt tcacctacaa
      361 gggtctccgt gccctgcagt cctacataca aggcaagacc tacccagcac acgcattcct
      421 ggcggccttc ctcgggggta tcctggtgtt tggagaaaac aataacatca acagccagat
      481 caacatgtac ctgttgtcac gcgtcctgtt tgccctgagc cgcctggctg tagagaaggg
      541 ctacatccct gaacccaggt gggacccgtt cccgctgctc actgcggtgg tgtgggggct
      601 ggtgctgtgg ctctttgagt atcaccgatc caccctgcag ccctcgctgc agtcctccat
      661 gacctacctc tatgaggaca gcaatgtatg gcacgacatc tcagacttcc tcgtctataa
      721 caagagccgt ccctccaatt aatgcagccc tgaggtgtct ggctgtggct caagatttgg
      781 ccccatgcag accctcccaa aggatactgc cttctcaaga tcataggcct cagactccaa
      841 ctggtgttat cccagggttc cgtttgctga agtaaaaaca ctgattttaa aatcccagtg
      901 ggtacctttg tatggtggca caagtggccg aatcaggctg aggaatctac ggcttggttc
      961 cagctgtgca gctgacttct gtgagactgg ggccagccac actactctct aggcctcagg
     1021 ggtcaaggag ctcagaggag ggccctgagg tctctttccg gtgggtatgt tcattcttca
     1081 actgttctta tgtcacagag ggctccttgc tggtgggcag tgggttgtaa atacttttta
     1141 aaaaacacta agttccttat ctcagatgct gttctactgg agaagttcta gattcccact
     1201 gtccaataga aacacgtgag ccatatatgt aattaaaatg tttctagtag ctgcattaca
     1261 aaaaagaagc ctgggcactg tggctcactc ctgtaatctc agaactttgg gaggctgagg
     1321 caggtggatc acttgagctc aggagcttga gaccagcctg ggcaacatgg tgaaacccag
     1381 tttctacaaa aaatacaaaa aattagccgg gttccatcac ctgtggttcc agctgaggtg
     1441 ggaggatcac ttgagcctat gaggtcgagg ctacagtgag caaagatcac gccactgcac
     1501 tccagcctgg gcgacagtga gaccctgtct caccaaagaa aaaaaaaagg tgagattaat
     1561 cttcactata tattttaaca caaatttcta aaagttattt caacatataa ttaacatcat
     1621 tagatatttt gtactctttt ttgtattaag tattcaaaat tgggtgtata ttttgccacc
     1681 cacattttca ggacccagta gccacatgtg gctagtggct gctgtgacgg gcaacacaga
     1741 tatggaacac ttgtatcctc acagattatt ctagtggaca gtgcagatct agagctagag
     1801 gacatgggtt tgagtcccca ctcccccact gtgtaacctt ggggaaggtt ctggacctct
     1861 cagagcctca atttatcata aaatgaggat aatcataatg ccgtggtcct cactggactt
     1921 gtgcaactac cactgatgtg ctactaatta ctttcattta gtgcattcat acttccactt
     1981 gggtgttttc cacatattat tattattttt tttttttaag tagcgacagg gtctcgctct
     2041 gtcactaggg ctagtctcga cctcctagcc tcaagcaatc ttcctgcctc agtctcccaa
     2101 agtgccatga ttacaggcat gagccactgc ccctagcctg cacatattat ttttaaacca
     2161 tacagtggcc ttgcaaatgt gtgttttcgt ccccatttta cagatgtaga aactgagggt
     2221 caggccaggt gcagtggctc acgcctgtaa tcccagcact ttgggaggct gaggcaggca
     2281 gataacctga gatcaggagt tcttgaccag cctggccaac atggtaaaac cccatctcta
     2341 ctaaaaatac aaaaattagc caggcatggt ggcacgtccc tgtaatccca gctactgggg
     2401 aggctgaggc aggagaatcg cttgaacctg ggaggcagag gctgcagtga gctgagatcg
     2461 cacgactgca ctccagcctg ggccacagag cgagactgtg tctaaaaaaa aaataaaaaa
     2521 agaaaagaaa agaaactgag aatcagagag gagagtaact tgcccaaggt aatacagcta
     2581 gtataacagc cgaatcaaga tttgaactca gattcgtctg atttcaaagc ccatgttttt
     2641 tccagtgcct tgtttcaaat ttagaaacct aagccatgct atgcaaatgt tagctcatta
     2701 taggatatgg gccagaaagg ggtacacatt caaatgccca taggggccta caatgacata
     2761 gtgctatgcg atgaggagtg atggggacat agggaactgg agacttgtgt accagtctga
     2821 ttttttcttt tttttttttt tttgagacag agtcttgctc tctcgcccag gctggagtgc
     2881 agtggcgcga tcttggctca ctgcaagctc tgcctcccag gtttacttac accattctcc
     2941 tgcctcagcc tccggagtag ctgggcctac aggtgcccgc caccacaccc ggctaatttt
     3001 ttgtattttt agtagagatg gggtttcacc gtgttagcca ggatggtctc aatctcctga
     3061 cctcatgatc cacccacctt ggcctcccaa aatgctggga ttacaggtgt gagccaccat
     3121 gcctggccaa gtctgctttt ttcgaaacca cgatcctaga ccaggcacgg tggcttgcac
     3181 ctgtaatccc agcactttgg gaggccgagg cgggtggatc acctgaggtc aggagttcga
     3241 gaccagcctg gccaacatgg cgaaatcctg tctctactaa aaatacaaaa attagctgga
     3301 catggtggca ggcacctgta attccagcta cttgggaggc tgaggtggga gaatctcttg
     3361 aacctggggg gctgctgtga gccgagatag ttccattaca cttcagcctg ggtgacagag
     3421 taagactctg tctcaaaaaa aaaaaaaaaa aaaaaaacac aatcctggac aaatcaaaca
     3481 agtctccagg aaaatctggt ccatgggcta ccaatttgag accattggtc tggtagatac
     3541 actttcatta atatacttac tccatcactc tttctatatt ttagaagtta ctagtagaaa
     3601 tgtatgcagg agtcactgga gaccttatta aaatgcagct tctgattcag tgagctgggg
     3661 tggggcctga gagtctgcat ttctcccagg ctccctggtg ctgccagtgg tgctgctctg
     3721 agtaacaagg gggtggggaa tgatatggag ccgtccatta ttatcccatc tgacaaatga
     3781 gtcacagagc ccttaggtaa ttgaggtggg atcagtctga ttctgtaagc tgtgttttca
     3841 gccacaacat ttactgcaaa cttggagtag gtaattatga agttccttta acttgctgtg
     3901 gaggttgaat gagctctaga gtaaggggtc cgcaaccccg gtaccggtcc atggcctgtt
     3961 cggaaccagg ccacgcagca ggagttgaaa ggtgggtgag ctagcgaagc ttcatctgta
     4021 tgtacagcca ctccccactg ctcacattac cacctgagct ctgccttctg tcagatcagt
     4081 ggtggcatta gatgctcgta ggaatgcaaa ccctattgtg aactgcgcat gcaagggatc
     4141 taggttgcat gctccttatg agaatctaat gcctgatgat ctgtcactgt ctcccgtcac
     4201 gccttgatgg gactgtctag ttgctggaaa acaaactcag ggctcccact gattctacat
     4261 tatggtgtgt tgtacaatta tttcattata tattacaagg taataataat agaaataaaa
     4321 tccacagtaa atgcaatgtg cttgaatcat cctgaaacca cgtcccctcc ccagtggtcc
     4381 gtggaaaaat tatcttcccc aaaactggtc cctggtgcca aaaaggttgg ggactgctgc
     4441 tctaggggtt ggggagggca gagggcttgg gccatcacca ggcaggtttt atagcagatg
     4501 gtgggggtgc cctgcctata gctcctctaa ataacgactc tggtgcacac tagccagctt
     4561 tgccagtggc cgcccctctg tctttctgcc tgaggactct agcttgtcac tggtgcctcc
     4621 tttgccagcc tctggcaggc ctgaagggct ggagaatgaa cacatccttg gagcaacctt
     4681 caaccaatga ctgataaata cccccactcc cacagcccgc atccctcacc cctcgggtgg
     4741 gataactcag aggtgcgtgc tccacactga ctcccagggc cgcccagcag ggctgagcct
     4801 caaacaccct ccccatctcc cttcctcatg cccctaccag tgcttcctgg gaccacttcc
     4861 catatgaacc acttgcactc aaacccttgt cttagagtct gctattgggg gaacccaaac
     4921 taaaactggc ctctgtacag caggttgaga ggcaatatag catggtggtc agggacatag
     4981 gctttggagc cagagtgcct gggctcaagc cctggcccca cagtttcctt gggcaagtga
     5041 ctgagccatt ctgtgcctct atttcctcat tgataaagta ggcgttgtcg tagcacacac
     5101 ctcatcgagt ggtgtggagg gttaaagaat atgacacagt taaagtgagt ccccaataaa
     5161 tgctgttatt tctaagagca tccaaatgta gaggaagtgt gcccctgagg actgagcaca
     5221 ccctgctttt agcctgtcct gcccccagct gaaggtgaaa ccttggccgc ctgccctcct
     5281 gaagtcccgc cactgctgct gggggttggc caactccgct accgactgtc tctgctctct
     5341 aagaataggt ttccctcaca gatggcatct ctctggatgc tgctagagca tctggtgctt
     5401 ccaactgcac actccaggga ggaaggcagt gtggtctgtg ccggggagca gggctctgcc
     5461 ttccagcaga tctgagagga gtcccatttg gctccttcct agctgccctc cattctctaa
     5521 gacctgtaaa acagggatgg ccagagggct cttgttgcac agtaagtgct atgcttccta
     5581 aatgctagtt cctgaaatag aatggtttaa cctctactta ctaaacacct gctacaatcc
     5641 tgttaattct tttgacatgt aagactaaaa taaataaata aataaataaa
//
