LOCUS       NM_018663                970 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens peroxisomal membrane protein 2 (PXMP2), mRNA.
ACCESSION   NM_018663 XM_936468
VERSION     NM_018663.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 970)
  AUTHORS   Lismont,C., Koster,J., Provost,S., Baes,M., Van Veldhoven,P.P.,
            Waterham,H.R. and Fransen,M.
  TITLE     Deciphering the potential involvement of PXMP2 and PEX11B in
            hydrogen peroxide permeation across the peroxisomal membrane
            reveals a role for PEX11B in protein sorting
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (10), 182991 (2019)
   PUBMED   31129117
  REMARK    GeneRIF: Authors provide evidence that PXMP2 is not essential for
            H2O2 permeation across the peroxisomal membrane, neither in control
            cells nor in cells lacking PEX11B, a peroxisomal membrane-shaping
            protein whose yeast homologue facilitates the permeation of
            molecules up to 400Da.
REFERENCE   3  (bases 1 to 970)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 970)
  AUTHORS   Sato,Y., Shibata,H., Nakatsu,T., Nakano,H., Kashiwayama,Y.,
            Imanaka,T. and Kato,H.
  TITLE     Structural basis for docking of peroxisomal membrane protein
            carrier Pex19p onto its receptor Pex3p
  JOURNAL   EMBO J 29 (24), 4083-4093 (2010)
   PUBMED   21102411
REFERENCE   5  (bases 1 to 970)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 970)
  AUTHORS   Nestler,M., Martin,U., Hortschansky,P., Saluz,H.P., Henke,A. and
            Munder,T.
  TITLE     The zinc containing pro-apoptotic protein siva interacts with the
            peroxisomal membrane protein pmp22
  JOURNAL   Mol Cell Biochem 287 (1-2), 147-155 (2006)
   PUBMED   16683188
REFERENCE   7  (bases 1 to 970)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     PEX19 is a predominantly cytosolic chaperone and import receptor
            for class 1 peroxisomal membrane proteins
  JOURNAL   J Cell Biol 164 (1), 57-67 (2004)
   PUBMED   14709540
REFERENCE   8  (bases 1 to 970)
  AUTHORS   Brosius,U., Dehmel,T. and Gartner,J.
  TITLE     Two different targeting signals direct human peroxisomal membrane
            protein 22 to peroxisomes
  JOURNAL   J Biol Chem 277 (1), 774-784 (2002)
   PUBMED   11590176
REFERENCE   9  (bases 1 to 970)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   10 (bases 1 to 970)
  AUTHORS   Miyawaki,T., Sohma,O., Suzuki,Y. and Takashima,S.
  TITLE     Developmental immunohistochemistry of the 22 kDa peroxisomal
            membrane protein in the human brain
  JOURNAL   Brain Res 700 (1-2), 285-288 (1995)
   PUBMED   8624723
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135586.8, AF250136.1 and BC073997.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018663.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.498838.1,
                                           SRR1163657.33268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317479.8/ ENSP00000321271.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC135586.8         61347-61365         c
            20-48               AF250136.1         1-29
            49-964              BC073997.1         1-916
            965-970             AF250136.1         946-951
FEATURES             Location/Qualifiers
     source          1..970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..970
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /note="peroxisomal membrane protein 2"
                     /db_xref="GeneID:5827"
                     /db_xref="HGNC:HGNC:9716"
                     /db_xref="MIM:617399"
     exon            1..206
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..672
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /note="22 kDa peroxisomal membrane protein; peroxisomal
                     membrane protein 2, 22kDa"
                     /codon_start=1
                     /product="peroxisomal membrane protein 2"
                     /protein_id="NP_061133.1"
                     /db_xref="CCDS:CCDS9279.1"
                     /db_xref="GeneID:5827"
                     /db_xref="HGNC:HGNC:9716"
                     /db_xref="MIM:617399"
                     /translation="MAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGIL
                     SALGNFLAQMIEKKRKKENSRSLDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEV
                     PLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWT
                     PLQFININYVPLKFRVLFANLAALFWYAYLASLGK"
     exon            207..320
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            321..483
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            484..603
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /inference="alignment:Splign:2.1.0"
     exon            604..970
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      945..950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /note="hexamer: AATAAA"
     polyA_site      970
                     /gene="PXMP2"
                     /gene_synonym="MPV17L3; PMP22"
                     /note="major polyA site"
ORIGIN      
        1 actccgctct cggcgcctcg ggctccgcgc ccggccagcc tgaggtgggg tcggtgcccc
       61 cggcggcacg gcgctgggga ggcgatggcg ccggccgcgt ccaggctgcg ggccgaagcc
      121 gggctcgggg cgctgccgcg gcgggcgctc gcccagtacc tgctcttcct gcggctctac
      181 ccggtgctca ccaaggcggc caccagtggc attttgtcag cacttgggaa cttcctggcc
      241 cagatgattg agaagaagcg gaaaaaagaa aactctagaa gtctggatgt cggtgggcct
      301 ctgagatatg ccgtttacgg gttcttcttc acagggccgc tgagtcactt cttctacttc
      361 ttcatggaac attggatccc tcctgaggtc cccctggcag ggctcaggag gcttctcctg
      421 gaccgcctcg tctttgcacc ggccttcctc atgttgttct tcctcatcat gaactttctg
      481 gaggggaaag acgcctcagc cttcgccgcc aagatgaggg ggggcttctg gccggcgctg
      541 aggatgaact ggcgggtgtg gacgccacta cagttcatca acatcaacta cgtccctctg
      601 aagttccggg tgctcttcgc caacctggca gctctgttct ggtatgccta cctggcctcc
      661 ttggggaagt gacgaccgct gggagaacat caggtgcact gtggacgtgg gtctgggggt
      721 ctcacccgcc cagcgagagc agaaccaatc cagtcaggat gtcactgact ctaaatcagg
      781 tgattcaaga tgcccaaaaa tgatggatag agaaacagaa atctctgaat gtcagaaccc
      841 tgtcttttaa aaaggcagtc gctgccttca ggtggtgctg ccccagaaac ttaaaattta
      901 gtcgaggcag tttcaattgt tactgtggac cgaattagga tcacaataaa cgataatgca
      961 ggttcttcaa
//
