LOCUS       NM_144651               4807 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens peroxidasin like (PXDNL), mRNA.
ACCESSION   NM_144651
VERSION     NM_144651.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4807)
  AUTHORS   Lu,M., Liu,B., Li,D., Gao,Z., Li,W., Zhou,X. and Zhan,H.
  TITLE     PXDNL activates the motility of urothelial bladder carcinoma cells
            through the Wnt/beta-catenin pathway and has a prognostic value
  JOURNAL   Life Sci 312, 121270 (2023)
   PUBMED   36493879
  REMARK    GeneRIF: PXDNL activates the motility of urothelial bladder
            carcinoma cells through the Wnt/beta-catenin pathway and has a
            prognostic value.
REFERENCE   2  (bases 1 to 4807)
  AUTHORS   Li,A.H., Hanchard,N.A., Azamian,M., D'Alessandro,L.C.A.,
            Coban-Akdemir,Z., Lopez,K.N., Hall,N.J., Dickerson,H., Nicosia,A.,
            Fernbach,S., Boone,P.M., Gambin,T., Karaca,E., Gu,S., Yuan,B.,
            Jhangiani,S.N., Doddapaneni,H., Hu,J., Dinh,H., Jayaseelan,J.,
            Muzny,D., Lalani,S., Towbin,J., Penny,D., Fraser,C., Martin,J.,
            Lupski,J.R., Gibbs,R.A., Boerwinkle,E., Ware,S.M. and Belmont,J.W.
  TITLE     Genetic architecture of laterality defects revealed by whole exome
            sequencing
  JOURNAL   Eur J Hum Genet 27 (4), 563-573 (2019)
   PUBMED   30622330
  REMARK    GeneRIF: We also observe evidence for an excess burden of rare,
            predicted loss-of-function variation in PXDNL and BMS1- two genes
            relevant to the broader laterality phenotype. These findings
            highlight potential new genes in the development of laterality
            defects, and suggest extensive locus heterogeneity and complex
            genetic models in this class of birth defects.
REFERENCE   3  (bases 1 to 4807)
  AUTHORS   Nikoletopoulou,V. and Tavernarakis,N.
  TITLE     The PMR1 pump in alpha-synuclein toxicity and neurodegeneration
  JOURNAL   Neurosci Lett 663, 66-71 (2018)
   PUBMED   28780169
  REMARK    GeneRIF: the PMR1 pump, a Golgi resident Ca(2+)/Mn(2+) P-type
            ATPase, plays a pivotal role in regulating the intracellular levels
            of calcium and manganese ions.
            Review article
REFERENCE   4  (bases 1 to 4807)
  AUTHORS   Gu,S.Q., Gallego-Perez,D., McClory,S.P., Shi,J., Han,J., Lee,L.J.
            and Schoenberg,D.R.
  TITLE     The human PMR1 endonuclease stimulates cell motility by down
            regulating miR-200 family microRNAs
  JOURNAL   Nucleic Acids Res 44 (12), 5811-5819 (2016)
   PUBMED   27257068
  REMARK    GeneRIF: The human PXDN endonuclease stimulates cell motility by
            down regulating miR-200 family microRNAs.
REFERENCE   5  (bases 1 to 4807)
  AUTHORS   Peterfi,Z. and Geiszt,M.
  TITLE     Peroxidasins: novel players in tissue genesis
  JOURNAL   Trends Biochem Sci 39 (7), 305-307 (2014)
   PUBMED   24924147
REFERENCE   6  (bases 1 to 4807)
  AUTHORS   Gu,S.Q., Bakthavachalu,B., Han,J., Patil,D.P., Otsuka,Y., Guda,C.
            and Schoenberg,D.R.
  TITLE     Identification of the human PMR1 mRNA endonuclease as an
            alternatively processed product of the gene for peroxidasin-like
            protein
  JOURNAL   RNA 18 (6), 1186-1196 (2012)
   PUBMED   22543864
REFERENCE   7  (bases 1 to 4807)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4807)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4807)
  AUTHORS   Cheng,G., Salerno,J.C., Cao,Z., Pagano,P.J. and Lambeth,J.D.
  TITLE     Identification and characterization of VPO1, a new animal
            heme-containing peroxidase
  JOURNAL   Free Radic Biol Med 45 (12), 1682-1694 (2008)
   PUBMED   18929642
REFERENCE   10 (bases 1 to 4807)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090186.7, AC103958.11, AC107374.3, AC011128.7 and AC012413.10.
            
            On Nov 23, 2018 this sequence version replaced NM_144651.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU170240.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356297.5/ ENSP00000348645.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AC090186.7         35980-36244
            266-337             AC103958.11        51393-51464         c
            338-409             AC107374.3         86444-86515         c
            410-481             AC107374.3         50657-50728         c
            482-553             AC011128.7         24111-24182
            554-625             AC011128.7         40167-40238
            626-795             AC011128.7         48740-48909
            796-913             AC011128.7         51577-51694
            914-1083            AC011128.7         66214-66383
            1084-1350           AC011128.7         70096-70362
            1351-1467           AC011128.7         74763-74879
            1468-1626           AC011128.7         76719-76877
            1627-1739           AC011128.7         97123-97235
            1740-1896           AC011128.7         100150-100306
            1897-2005           AC011128.7         110623-110731
            2006-2163           AC011128.7         112474-112631
            2164-3658           AC011128.7         114320-115814
            3659-3793           AC011128.7         149150-149284
            3794-4002           AC011128.7         151800-152008
            4003-4117           AC011128.7         177934-178048
            4118-4247           AC012413.10        165164-165293       c
            4248-4361           AC012413.10        146324-146437       c
            4362-4807           AC012413.10        145117-145562       c
FEATURES             Location/Qualifiers
     source          1..4807
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.22-q11.23"
     gene            1..4807
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /note="peroxidasin like"
                     /db_xref="GeneID:137902"
                     /db_xref="HGNC:HGNC:26359"
                     /db_xref="MIM:615904"
     exon            1..265
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..4493
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /EC_number="1.11.1.7"
                     /note="peroxidasin-like protein; cardiovascular peroxidase
                     2; cardiac peroxidase; vascular peroxidase 2; peroxidasin
                     homolog-like; polysomal ribonuclease 1 homolog; inactive
                     peroxidasin-like protein; probable oxidoreductase PXDNL"
                     /codon_start=1
                     /product="probable oxidoreductase PXDNL precursor"
                     /protein_id="NP_653252.4"
                     /db_xref="CCDS:CCDS47855.1"
                     /db_xref="GeneID:137902"
                     /db_xref="HGNC:HGNC:26359"
                     /db_xref="MIM:615904"
                     /translation="MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDH
                     IPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLY
                     LYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSK
                     IPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHG
                     RAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL
                     EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVI
                     QPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRD
                     HGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVI
                     VWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPK
                     ALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLT
                     IYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSA
                     INSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTV
                     DLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQP
                     TWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHS
                     YTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTH
                     APCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPS
                     VPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHT
                     LWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRML
                     RGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSP
                     SRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGR
                     DHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVED
                     LIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGD
                     SIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRS
                     AQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITA
                     LREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPC
                     PSPELVKGTCCPVCRDRGMPSDSPEKR"
     exon            266..337
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..409
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..481
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..553
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..625
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..795
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..913
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1083
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1350
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1467
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1626
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1739
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1896
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2005
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2163
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..3658
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3793
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3794..4002
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4117
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4247
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4361
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4362..4807
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4696..4701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /note="hexamer: AATAAA"
     polyA_site      4726
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
     regulatory      4774..4779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /note="hexamer: AATAAA"
     polyA_site      4807
                     /gene="PXDNL"
                     /gene_synonym="PMR1; PRM1; VPO2"
                     /note="major polyA site"
ORIGIN      
        1 agtccagcag ccaccatcac caccactgcg gttgctgctg cagctgcagc tgctgctctc
       61 cctccggctg cttcttcgcg tggccagcag cgaatggagc gatggagccc agactgttct
      121 gctggaccac tctctttctc ctggccgggt ggtgcctgcc agggttgccc tgccccagcc
      181 ggtgcctttg ctttaagagc accgtccgct gcatgcactt gatgctggac cacattcctc
      241 aggtaccaca gcagaccaca gttctagact tgaggtttaa cagaataaga gaaattccag
      301 ggagcgcctt caagaaactc aagaatttga acacacttct gctgaacaac aaccacatca
      361 gaaagatttc cagaaatgct tttgaaggac ttgaaaattt gctatatctg tacctgtata
      421 agaatgaaat ccatgcacta gataagcaaa catttaaagg actcatatct ttggaacatc
      481 tgtatattca tttcaaccaa ctagaaatgc tacagccaga gacctttgga gaccttctga
      541 gattagagcg actatttttg cataacaaca aattatctaa aattccagct gggagctttt
      601 ctaatctgga ttcattaaaa agattgcgtc tggattccaa cgccctggtt tgtgactgtg
      661 atctgatgtg gctgggggag cttttacaag gctttgccca acacggccac acccaggctg
      721 cggctacctg cgaatatccc aggagactcc atgggcgtgc agttgcttca gtaacagtag
      781 aggaattcaa ttgccagagc ccccgaatta cttttgagcc gcaggatgtg gaggtaccat
      841 caggaaatac cgtctacttc acctgccggg cggaaggaaa ccccaaacct gagattattt
      901 ggatacacaa caaccactca ttggatttgg aagatgatac tcgacttaat gtgtttgatg
      961 atggcacact catgatccga aacaccagag agtcagacca aggtgtctat cagtgcatgg
     1021 ccagaaattc cgctggggaa gccaagacac agagtgccat gctcagatac tccagtcttc
     1081 cagccaaacc aagctttgta atccagcctc aggacacaga ggttttaatt ggcaccagca
     1141 caactttgga atgtatggcc acaggccacc cacaccctct tatcacttgg accagggaca
     1201 atggattgga gctggatgga tccaggcacg tggcaacgtc cagtggactt tacttacaga
     1261 acatcacaca acgggatcat ggtcgattta cctgtcatgc caacaatagc cacggcactg
     1321 ttcaagctgc agcaaacata attgtacaag ctcctccaca atttacagta acccccaagg
     1381 atcaagtggt gctggaagaa catgctgtag agtggctctg tgaagctgac ggcaacccac
     1441 ctcctgttat tgtctggaca aaaacaggag ggcagctccc tgtggaaggc cagcatacag
     1501 ttctctcctc tggcactttg agaattgacc gtgcagcaca gcacgatcaa ggccaatatg
     1561 aatgtcaagc agtcagttcg ttgggggtga aaaaggtgtc tgtgcagctg actgtaaaac
     1621 ccaaagctct tgcagtgttt actcaacttc ctcaggatac aagtgtcgag gttggaaaga
     1681 atataaacat ttcatgtcat gctcaaggag aaccacagcc cataattact tggaataagg
     1741 aaggtgtgca gattactgag agtggtaaat tccatgtgga tgatgaaggc acgctgacta
     1801 tctacgacgc agggttccct gaccagggaa gatatgaatg tgtggctcgg aattcttttg
     1861 gccttgctgt gaccaacatg tttcttacag tcacggctat acagggtaga caagctggcg
     1921 atgactttgt tgaatcttcc attcttgatg ctgtacagag agttgacagt gcaattaact
     1981 ccacacgaag acatttgttt tcacaaaaac ctcacacctc cagtgacctg ctggctcaat
     2041 ttcattaccc gcgtgaccca ctgattgtgg aaatggcaag agcaggggag atttttgagc
     2101 acacgctgca gctgatacgg gaacgtgtga agcaggggct cactgtggac ttggaaggca
     2161 aagaattccg gtacaatgac ttggtgtccc cgcgctccct cagcctcatc gccaatttat
     2221 ctggatgcac agctcgcagg cctctgccaa actgctccaa ccggtgtttc catgcgaagt
     2281 accgcgccca cgacggcacg tgcaacaacc tgcagcagcc cacgtggggc gcggcgctga
     2341 ccgccttcgc gcgcctgctg cagccagcct accgggacgg catccgcgcg ccccgcgggc
     2401 tcggccttcc tgtgggctcc cgccagcccc tcccgccgcc ccggctggtc gccacagtgt
     2461 gggcgcgcgc ggcggccgtc acccccgacc acagctacac gcgcatgctc atgcactggg
     2521 gctggtttct agagcacgac ttggaccaca cagtgcctgc gctgagcaca gcccgcttct
     2581 cggatgggcg gccgtgcagc tccgtctgca ccaacgaccc tccttgtttc cccatgaaca
     2641 cccggcacgc cgacccccgg ggcacccacg cgccctgcat gctcttcgcg cgctccagcc
     2701 ccgcgtgtgc cagcggccgt ccctctgcga cggtggattc agtctatgca cgagagcaga
     2761 tcaaccagca aacagcctac atcgatggct ccaacgttta cgggagctcg gagcgggaat
     2821 cccaggctct cagagaccct tcggtgcctc ggggtctcct gaagacaggc tttccttggc
     2881 ctccctccgg aaagccctta ttgccctttt ctacaggccc acccaccgag tgcgcgcgac
     2941 aggagcagga gagcccctgt ttcctggccg gggaccaccg ggccaacgag catctggctc
     3001 tggccgccat gcacaccctg tggttccggg aacacaacag gatggccacg gagctgtccg
     3061 ccctgaaccc ccactgggag ggaaacacgg tttaccagga agccaggaag atcgtgggcg
     3121 cggagctgca gcacatcacc tacagccact ggctgcctaa ggtcctgggg gaccctggca
     3181 ctaggatgct gaggggttac cgaggctaca accccaacgt gaatgcaggc atcattaact
     3241 cttttgctac tgcagccttt agatttggcc acacattaat caatcctatt ctttaccgac
     3301 tgaatgccac cttaggtgaa atttccgaag gccaccttcc gttccataaa gcgctctttt
     3361 caccgtccag aataatcaag gaaggtggga tagacccggt tctccggggg ctgtttggcg
     3421 tggctgctaa atggcgggca ccctcctacc ttctcagtcc tgagctgacc cagaggctct
     3481 tctccgcggc ttattctgcg gccgtggatt cggctgccac catcattcaa aggggtagag
     3541 accacgggat cccaccatat gttgacttca gagttttctg taatttgact tcagttaaga
     3601 actttgagga tcttcaaaat gaaattaaag attcagagat tagacaaaaa ctgagaaagt
     3661 tgtacggctc tccaggtgac attgacctct ggcccgccct tatggttgaa gacctgattc
     3721 ctggtacaag agtgggacca acacttatgt gcctgtttgt tacccagttt cagcggctaa
     3781 gagatggaga taggttctgg tatgaaaacc ctggagtatt taccccggca caactcactc
     3841 agctgaagca ggcgtccctg agccgggtgc tttgtgacaa tggtgacagc attcagcaag
     3901 tgcaggctga tgtctttgta aaggcagaat acccacagga ttacctgaac tgcagcgaga
     3961 tcccgaaggt ggacctgcga gtgtggcaag actgctgtgc agactgtagg agtagaggac
     4021 agttcagagc agtgacgcaa gagtctcaaa agaaacgctc agctcaatac agctatcctg
     4081 ttgataagga tatggagtta agtcatctaa gaagtaggca acaagataaa atatatgtgg
     4141 gtgaagatgc tagaaatgtg acagttctgg caaaaacaaa gttctcccaa gatttcagca
     4201 cgtttgcagc ggaaattcag gaaaccatca cagcactcag agagcagata aacaagctgg
     4261 aggcacgcct gaggcaggca gggtgtacag atgttagagg ggttccaagg aaggccgagg
     4321 agcgctggat gaaagaagac tgcactcact gcatttgtga gagtggccag gtcacctgtg
     4381 tggtggagat ttgtcccccg gctccctgtc ccagtcctga attggtgaaa ggaacctgct
     4441 gtccagtttg cagagaccga ggaatgccaa gtgattcccc agagaagcgc taataaaagt
     4501 tttgtgctgt tgagccccaa atgggaaatt tctcaggaag agacatttag gacttcagaa
     4561 cttttaactt gtagtcacat tgttgatatg gaaaccactg acttaagcaa cttagttcat
     4621 ctaatcttac atatacttac gatcttttat tttttcattt tctaacatac cttgaaataa
     4681 ttcaaaacta aaagcaataa agtgcatatg aagtgtttga tcataagaaa tatttcttac
     4741 tgtaagctgt cagttttata tgccacacct ggaaataaaa agaatatcat ggaatattta
     4801 aaaaata
//
